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1. Full Text Delirium after coronary artery bypass graft surgery and late mortality
by Gottesman, Rebecca F and Grega, Maura A and Bailey, Maryanne M and Pham, Luu D and Zeger, Scott L and Baumgartner, William A and Selnes, Ola A and McKhann, Guy M
Annals of Neurology, ISSN 0364-5134, 03/2010, Volume 67, Issue 3, pp. 338 - 344
Objective: Delirium is common after cardiac surgery, although under-recognized, and its long-term consequences are likely underestimated. The primary goal of... 
POSTOPERATIVE DELIRIUM | RISK-FACTORS | OUTCOMES | NEUROSCIENCES | CARDIAC-SURGERY | CLINICAL NEUROLOGY | Delirium - etiology | Prospective Studies | Brain - physiopathology | Risk Factors | Survival Rate | Time | Postoperative Complications - mortality | Hypoxia-Ischemia, Brain - etiology | Brain - blood supply | Coronary Artery Bypass - adverse effects | Time Factors | Hypoxia-Ischemia, Brain - mortality | Survival Analysis | Coronary Artery Bypass - statistics & numerical data | Delirium - mortality | Cohort Studies | Hypoxia-Ischemia, Brain - physiopathology
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2. Full Text Continuous EEG monitoring enhances multimodal outcome prediction in hypoxic–ischemic brain injury
by Amorim, Edilberto and Rittenberger, Jon C and Zheng, Julia J and Westover, M. Brandon and Baldwin, Maria E and Callaway, Clifton W and Popescu, Alexandra and Post Cardiac Arrest Service
Resuscitation, ISSN 0300-9572, 2016, Volume 109, pp. 121 - 126
Abstract Objective Hypoxic brain injury is the largest contributor to disability and mortality after cardiac arrest. We aim to identify electroencephalogram... 
Emergency | EEG background reactivity | Burst–suppression | Prognosis | Status epilepticus | EEG | Cardiac arrest | ILLNESS SEVERITY SCORE | TARGETED TEMPERATURE MANAGEMENT | CLINICAL EXAMINATION | CARDIAC-ARREST | THERAPEUTIC HYPOTHERMIA | EMERGENCY MEDICINE | Burst-suppression | COMATOSE SURVIVORS | ASSOCIATION | CONSORTIUM ROC | RESUSCITATION | CRITICAL CARE MEDICINE | Predictive Value of Tests | Prospective Studies | Hospital Mortality | Humans | Middle Aged | Male | Electroencephalography | Coma - mortality | Hypoxia-Ischemia, Brain - complications | Heart Arrest - mortality | Hypoxia-Ischemia, Brain - mortality | Hypothermia, Induced | Status Epilepticus - complications | Adult | Female | ROC Curve | Aged | Neurophysiological Monitoring - methods | Brain | Neurosciences | Cardiac patients | Emergency medicine | Mortality | Injuries | Medical research | Epilepsy | Medicine, Experimental | Seizures (Medicine) | status epilepticus | burst-suppression | cardiac arrest | prognosis
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3. Full Text Cooling for newborns with hypoxic ischaemic encephalopathy
by Jacobs, Susan E and Berg, Marie and Hunt, Rod and Tarnow-Mordi, William O and Inder, Terrie E and Davis, Peter G
Cochrane Database of Systematic Reviews, ISSN 1469-493X, 01/2013, Volume 2013, Issue 1, p. CD003311
Background Newborn animal studies and pilot studies in humans suggest that mild hypothermia following peripartum hypoxia-ischaemia in newborn infants may... 
Developmental Disabilities [prevention & control] | PROVIDES PARTIAL NEUROPROTECTION | CEREBRAL OXIDATIVE-METABOLISM | Humans | MODERATE HYPOTHERMIA | Randomized Controlled Trials as Topic | TERM INFANTS | WHOLE-BODY HYPOTHERMIA | MEDICINE, GENERAL & INTERNAL | THERAPEUTIC HYPOTHERMIA | NEONATAL ENCEPHALOPATHY | Hypoxia-Ischemia, Brain [mortality; therapy] | SUBCUTANEOUS FAT NECROSIS | Asphyxia Neonatorum [complications] | PERINATAL ASPHYXIAL ENCEPHALOPATHY | Hypothermia, Induced [adverse effects; methods] | Infant, Newborn | MILD SYSTEMIC HYPOTHERMIA | Hypothermia, Induced - adverse effects | Hypothermia, Induced - methods | Infant, Premature | Hypoxia-Ischemia, Brain - mortality | Developmental Disabilities - prevention & control | Asphyxia Neonatorum - complications | Hypoxia-Ischemia, Brain - therapy | Infant | Term Birth
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4. Full Text Hypothermia and neonatal encephalopathy
by Papile, Lu-Ann and Baley, Jill E and Benitz, William and Cummings, James and Carlo, Waldemar A and Eichenwald, Eric and Kumar, Praveen and Polin, Richard A and Tan, Rosemarie C and Wang, Kasper S and Barfield, Wanda Denise and Macones, George and Jefferies, Ann L and Keels, Erin L and Raju, Tonse N. K and Couto, Jim and COMM FETUS & NEWBORN and Committee on Fetus and Newborn and COMMITTEE ON FETUS AND NEWBORN
Pediatrics, ISSN 0031-4005, 06/2014, Volume 133, Issue 6, pp. 1146 - 1150
Data from large randomized clinical trials indicate that therapeutic hypothermia, using either selective head cooling or systemic cooling, is an effective... 
Neonatal encephalopathy | Infant | Hyperthermia | Head cooling | Hypothermia | hyperthermia | head cooling | SAFETY | RISK | infant | PERINATAL ASPHYXIA | TRIAL | WHOLE-BODY HYPOTHERMIA | TRANSPORT | hypothermia | neonatal encephalopathy | HYPOXIC-ISCHEMIC ENCEPHALOPATHY | INFANTS | PEDIATRICS | OUTCOMES | SYSTEMIC HYPOTHERMIA | Asphyxia Neonatorum - therapy | Follow-Up Studies | Risk Assessment | Humans | Asphyxia Neonatorum - mortality | Cooperative Behavior | Infant, Premature, Diseases - diagnosis | Survival Rate | Infant, Premature, Diseases - mortality | Infant, Premature, Diseases - therapy | Hospitals, Community | Randomized Controlled Trials as Topic | Interdisciplinary Communication | Hypoxia-Ischemia, Brain - diagnosis | Hypoxia-Ischemia, Brain - congenital | Asphyxia Neonatorum - diagnosis | Hypothermia, Induced - methods | Hypoxia-Ischemia, Brain - mortality | Hypoxia-Ischemia, Brain - therapy | Referral and Consultation | Infant, Newborn | Care and treatment | Usage | Encephalopathy | Clinical trials | Infants | Research | Health aspects | Babies | Pediatrics | Cooling | Risk assessment
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5. Full Text Acute Postischemic Seizures Are Associated with Increased Mortality and Brain Damage in Adult Mice
by El-Hayek, Youssef Hanna and Wu, Chiping and Chen, Rick and Al-Sharif, Abdel Rahman and Huang, Shelley and Patel, Nisarg and Du, Chao and Ruff, Crystal Ann and Fehlings, Michael G and Carlen, Peter L and Zhang, Liang
Cerebral Cortex, ISSN 1047-3211, 12/2011, Volume 21, Issue 12, pp. 2863 - 2875
Postischemic seizures are associated with worsened outcome following stroke, but the underlying pathophysiology is poorly understood. Here we examined acute... 
seizure | anticonvulsant | stroke | EEG | cerebral blood flow measurement | ARTERY OCCLUSION | MOUSE | EPILEPTIFORM DISCHARGES | INJURY | FOCAL ISCHEMIA | NEUROSCIENCES | RAT MODEL | NONCONVULSIVE SEIZURES | ISCHEMIC-STROKE | EMBOLIC MODEL | In Situ Nick-End Labeling | Mice, Inbred C57BL | Male | Electroencephalography | Hypoxia-Ischemia, Brain - pathology | Hypoxia-Ischemia, Brain - complications | Excitatory Postsynaptic Potentials - physiology | Seizures - physiopathology | Animals | Seizures - pathology | Seizures - etiology | Mice | Hypoxia-Ischemia, Brain - physiopathology
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6. Full Text Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy
by Azzopardi, Denis V and Strohm, Brenda and Edwards, A. David and Dyet, Leigh and Halliday, Henry L and Juszczak, Edmund and Kapellou, Olga and Levene, Malcolm and Marlow, Neil and Porter, Emma and Thoresen, Marianne and Whitelaw, Andrew and Brocklehurst, Peter and TOBY Study Grp and TOBY Study Group
The New England Journal of Medicine, ISSN 0028-4793, 10/2009, Volume 361, Issue 14, pp. 1349 - 1358
In this randomized trial involving newborn infants with asphyxial encephalopathy, hypothermic therapy did not significantly reduce the rate of the primary... 
TRIAL | WHOLE-BODY HYPOTHERMIA | MEDICINE, GENERAL & INTERNAL | NEONATAL ENCEPHALOPATHY | SAFETY | HYPOXIC-ISCHEMIC ENCEPHALOPATHY | INFANTS | MILD HYPOTHERMIA | OUTCOMES | MODEL | NEWBORN PIGLET | Hypothermia, Induced - adverse effects | Follow-Up Studies | Developmental Disabilities - etiology | Humans | Developmental Disabilities - prevention & control | Infant | Male | Risk | Gestational Age | Hypoxia-Ischemia, Brain - etiology | Nervous System Diseases - prevention & control | Hypothermia, Induced - methods | Hypoxia-Ischemia, Brain - mortality | Nervous System Diseases - etiology | Asphyxia Neonatorum - complications | Critical Care | Female | Hypoxia-Ischemia, Brain - therapy | Infant, Newborn | Care and treatment | Nervous system diseases | Patient outcomes | Asphyxia neonatorum | Infants | Health aspects | Hypothermia | Babies | Ethics | Intensive care | Cooling | Consent | Mortality | Electroencephalography
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7. Full Text Childhood Outcomes after Hypothermia for Neonatal Encephalopathy
by Shankaran, Seetha and Pappas, Athina and McDonald, Scott A and Vohr, Betty R and Hintz, Susan R and Yolton, Kimberly and Gustafson, Kathryn E and Leach, Theresa M and Green, Charles and Bara, Rebecca and Huitema, Carolyn M. Petrie and Ehrenkranz, Richard A and Tyson, Jon E and Das, Abhik and Hammond, Jane and Peralta-Carcelen, Myriam and Evans, Patricia W and Heyne, Roy J and Wilson-Costello, Deanne E and Vaucher, Yvonne E and Bauer, Charles R and Dusick, Anna M and Adams-Chapman, Ira and Goldstein, Ricki F and Guillet, Ronnie and Papile, Lu-Ann and Higgins, Rosemary D and Eunice Kennedy Shriver NICHD Neona and Eunice Kennedy Shriver NICHD Neonatal Research Network
The New England Journal of Medicine, ISSN 0028-4793, 05/2012, Volume 366, Issue 22, pp. 2085 - 2092
A prior report on hypothermia for neonatal hypoxic–ischemic encephalopathy showed a reduced rate of death or disability at 18 to 22 months of age. In this... 
WHOLE-BODY HYPOTHERMIA | MEDICINE, GENERAL & INTERNAL | HYPOXIC-ISCHEMIC ENCEPHALOPATHY | SCHOOL-AGE | TERM | CEREBRAL-PALSY | EMERGENCY CARDIOVASCULAR CARE | SYSTEMIC HYPOTHERMIA | ASSOCIATION | CARDIOPULMONARY-RESUSCITATION | PERINATAL ASPHYXIA | Intelligence | Cerebral Palsy - epidemiology | Developmental Disabilities - etiology | Humans | Child, Preschool | Male | Intelligence Tests | Hypoxia-Ischemia, Brain - complications | Developmental Disabilities - epidemiology | Cerebral Palsy - etiology | Hypoxia-Ischemia, Brain - mortality | Asphyxia Neonatorum | Hypothermia, Induced | Female | Hypoxia-Ischemia, Brain - therapy | Intellectual Disability - etiology | Infant, Newborn | Intellectual Disability - epidemiology | Infants (Newborn) | Care and treatment | Health aspects | Encephalopathy | Patient outcomes | Hypothermia | Neonates | Cerebral palsy | Body temperature | Mortality | Childrens health | Cognitive ability | Infants | Manuscripts | Esophagus | Children & youth | Disability | Walking | Parents & parenting | Ischemia | Hypoxia | Death | Children | Quantitative psychology | Age
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8. Full Text Brain injury following trial of hypothermia for neonatal hypoxic-ischaemic encephalopathy
by Shankaran, Seetha and Barnes, Patrick D and Hintz, Susan R and Laptook, Abbott R and Zaterka-Baxter, Kristin M and McDonald, Scott A and Ehrenkranz, Richard A and Walsh, Michele C and Tyson, Jon E and Donovan, Edward F and Goldberg, Ronald N and Bara, Rebecca and Das, Abhik and Finer, Neil N and Sanchez, Pablo J and Poindexter, Brenda B and Van Meurs, Krisa P and Carlo, Waldemar A and Stoll, Barbara J and Duara, Shahnaz and Guillet, Ronnie and Higgins, Rosemary D and Eunice Kennedy Shriver Natl Inst C and Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network and for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Archives of Disease in Childhood: Fetal and Neonatal Edition, ISSN 1359-2998, 11/2012, Volume 97, Issue 6, pp. F398 - F404
Objective The objective of our study was to examine the relationship between brain injury and outcome following neonatal hypoxic-ischaemic encephalopathy... 
WHOLE-BODY HYPOTHERMIA | TERM NEWBORNS | MRI | INFANTS | PATTERNS | PEDIATRICS | SYSTEMIC HYPOTHERMIA | AGE | Severity of Illness Index | Humans | Infant | Male | Treatment Outcome | Hypoxia-Ischemia, Brain - complications | Magnetic Resonance Imaging | Hypoxia-Ischemia, Brain - mortality | Hypothermia, Induced | Female | Hypoxia-Ischemia, Brain - therapy | Brain Injuries - etiology | Brain Injuries - pathology | Infant, Newborn | Brain research | Traumatic brain injury | Hearing impairment | Age | Watersheds | Childrens health
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9. Full Text Whole-Body Hypothermia for Neonates with Hypoxic–Ischemic Encephalopathy
by Shankaran, Seetha and Laptook, Abbot R and Ehrenkranz, Richard A and Tyson, Jon E and McDonald, Scott A and Donovan, Edward F and Fanaroff, Avroy A and Poole, W. Kenneth and Wright, Linda L and Higgins, Rosemary D and Finer, Neil N and Carlo, Waldemar A and Duara, Shahnaz and Oh, William and Cotten, C. Michael and Stevenson, David K and Stoll, Barbara J and Lemons, James A and Guillet, Ronnie and Jobe, Alan H and Natl Inst Child Hlth Human Dev Neo and National Institute of Child Health and Human Development Neonatal Research Network
The New England Journal of Medicine, ISSN 0028-4793, 10/2005, Volume 353, Issue 15, pp. 1574 - 1584
In this multicenter, randomized trial, neonates with moderate or severe hypoxic–ischemic encephalopathy randomly assigned to whole-body hypothermia had a... 
MEDICINE, GENERAL & INTERNAL | BRAIN TEMPERATURE | CARDIAC-ARREST | CEREBRAL BLOOD-FLOW | POSTHYPOXIC HYPOTHERMIA | POSTISCHEMIC HYPOTHERMIA | MILD HYPOTHERMIA | SELECTIVE HEAD | MODERATE HYPOTHERMIA | NEURONAL DAMAGE | PERINATAL ASPHYXIA | Hypothermia, Induced - adverse effects | Acidosis - etiology | Follow-Up Studies | Humans | Pregnancy Complications | Developmental Disabilities - prevention & control | Male | Obstetric Labor Complications | Blindness - prevention & control | Cerebral Palsy - prevention & control | Hypoxia-Ischemia, Brain - complications | Pregnancy | Hypoxia-Ischemia, Brain - mortality | Asphyxia Neonatorum - complications | Female | Hypoxia-Ischemia, Brain - therapy | Infant, Newborn | Hearing Loss - prevention & control | Care and treatment | Hypoxia | Diagnosis | Research | Children | Health aspects | Risk factors | Hypothermia | Babies | Intensive care | Cooling | Brain research | Ischemia | Consciousness | Consent | Nitric oxide | Brain damage | Age
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10. Full Text Systemic Hypothermia after Neonatal Encephalopathy: Outcomes of neo.nEURO.network RCT
by Simbruner, Georg and Mittal, Rashmi A and Rohlmann, Friederike and Muche, Rainer and Obladen, Obladen and Schmitz, T and Muench, G and Flemmer, A and Knuepfer, M and Hanssler, L and Schaible, T and Teig, N and Pohlandt, F and Schloesser, R and Heckmann, M and Ahrens, P and Kirchner, L and Francois, A and Cooper, P.A and Debillon, T and Zupan-Simunek, V and Achour, S and Daoud, P and Cantagrel, S and Beuchee, A and Magny, J.F and Devaux, A and Gomez, J.M and Pomero, G and Greisen, G and Neo nEURO Network Trial and neo.nEURO.network Trial Participants
Pediatrics, ISSN 0031-4005, 10/2010, Volume 126, Issue 4, pp. e771 - e778
OBJECTIVE: Mild hypothermia after perinatal hypoxic-ischemic encephalopathy (HIE) reduces neurologic sequelae without significant adverse effects, but studies... 
Neonates | Asphyxia | Developmental outcome | Hypoxic-ischemic encephalopathy | Hypothermia | hypothermia | hypoxic-ischemic encephalopathy | EEG | PEDIATRICS | developmental outcome | neonates | BIRTH | MODERATE HYPOTHERMIA | asphyxia | Hypothermia, Induced - adverse effects | Neurologic Examination | Humans | Hypoxia-Ischemia, Brain - mortality | Hypoxia-Ischemia, Brain - therapy | Survival Rate | Electroencephalography | Morphine - administration & dosage | Cause of Death | Infant, Newborn | Hypoxia-Ischemia, Brain - physiopathology | Babies | Disability | Pediatrics | Body temperature | Suffocation | Clinical outcomes
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11. Full Text Feasibility of Autologous Cord Blood Cells for Infants with Hypoxic-Ischemic Encephalopathy
by Cotten, C. Michael, MD and Murtha, Amy P., MD and Goldberg, Ronald N., MD and Grotegut, Chad A., MD and Smith, P. Brian, MD and Goldstein, Ricki F., MD and Fisher, Kimberley A., PhD and Gustafson, Kathryn E., PhD and Waters-Pick, Barbara, BS, MT(ASCP) and Swamy, Geeta K., MD and Rattray, Benjamin, MD and Tan, Siddhartha, MD and Kurtzberg, Joanne, MD
Journal of Pediatrics, The, ISSN 0022-3476, 2014, Volume 164, Issue 5, pp. 973 - 979.e1
Objective To assess feasibility and safety of providing autologous umbilical cord blood (UCB) cells to neonates with hypoxic-ischemic encephalopathy (HIE).... 
Pediatrics | Cerebral palsy | Eunice Kennedy Shriver National Institute of Child Health and Human Development | FDA | Bayley Scales of Infant and Toddler Development, III edition | Umbilical cord blood | DMSO | Duke University hospital | NICHD | Bayley III | Duke University Health System | RBC | MFM | DUH | Intensive care nursery | Food and Drug Administration | Hypoxic-ischemic encephalopathy | Stem Cell Laboratory | HIE | Red blood cell | Maternal-fetal medicine | CP | ICN | UCB | Dimethyl sulfoxide | DUHS | SCL | IND | Carolinas Cord Blood Bank | CCBB | Investigational new drug | WHOLE-BODY HYPOTHERMIA | CONTROLLED-TRIAL | RECOVERY | RATS | PEDIATRICS | BRAIN-DAMAGE | CEREBRAL-PALSY | MODERATE HYPOTHERMIA | EXPRESSION | TRANSPLANTATION | CHILDREN | Follow-Up Studies | Humans | Child, Preschool | Infant | Male | Infant, Premature, Diseases - mortality | Infant, Premature, Diseases - surgery | Infant, Premature, Diseases - therapy | Feasibility Studies | Female | Hypoxia-Ischemia, Brain - therapy | Developmental Disabilities - diagnosis | Infant, Newborn | Severity of Illness Index | Developmental Disabilities - etiology | Hypoxia-Ischemia, Brain - surgery | Treatment Outcome | Combined Modality Therapy | Transplantation, Autologous - methods | Hypoxia-Ischemia, Brain - complications | Cord Blood Stem Cell Transplantation - methods | Pilot Projects | Infant, Premature | Hypoxia-Ischemia, Brain - mortality | Hypothermia, Induced | Infants (Newborn) | Medical colleges | Encephalopathy | Stem cells | Neonatal encephalopathy | Neonate | Asphyxia
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