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Journal of Biological Chemistry, ISSN 0021-9258, 02/2007, Volume 282, Issue 7, pp. 4524 - 4532
The stability and transcriptional activity of the hypoxia-inducible factors (HIFs) are regulated by two oxygen-dependent events that are catalyzed by three HIF... 
Gene Expression Regulation, Enzymologic - drug effects | Transcription, Genetic - drug effects | Vascular Endothelial Growth Factor A - biosynthesis | Fibroblasts - enzymology | Fumarate Hydratase - chemistry | Mixed Function Oxygenases - metabolism | Fumarate Hydratase - deficiency | Mixed Function Oxygenases - chemistry | Succinate Dehydrogenase - chemistry | Procollagen-Proline Dioxygenase - metabolism | Dose-Response Relationship, Drug | Fumarate Hydratase - metabolism | Neoplasms - chemistry | Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | Erythropoietin - biosynthesis | Fibroblasts - chemistry | Cell Line | Enzyme Inhibitors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Citric Acid Cycle - drug effects | Neoplasms - enzymology | Mixed Function Oxygenases - antagonists & inhibitors | Fibroblasts - pathology | Succinate Dehydrogenase - deficiency | p300-CBP Transcription Factors - metabolism | Citric Acid Cycle - genetics | Procollagen-Proline Dioxygenase - genetics | Gene Expression Regulation, Enzymologic - genetics | Succinate Dehydrogenase - metabolism | Mixed Function Oxygenases - genetics | Neoplasms - pathology | Procollagen-Proline Dioxygenase - chemistry | Index Medicus
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 06/2006, Volume 66, Issue 12, pp. 6264 - 6270
Overexpression of hypoxia-inducible factors (HIF), HIF-1 alpha and HIF-2 alpha, leads to the up-regulation of genes involved in proliferation, angiogenesis,... 
COLON-CANCER CELLS | FACTOR-2-ALPHA | HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | FACTOR-1-ALPHA | ONCOLOGY | TRANSCRIPTION | TOPOISOMERASE-I | OSTEOBLAST-LIKE CELLS | INDUCTION | HIF-1-ALPHA | EXPRESSION
Journal Article
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 08/2017, Volume 199, Issue 3, pp. 1206 - 1206
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2010, Volume 285, Issue 2, pp. 1333 - 1342
The biology of the α subunits of hypoxia-inducible factors (HIFα) has expanded from their role in angiogenesis to their current position in the self-renewal... 
IN-VITRO | EMBRYONIC-DEVELOPMENT | FACTOR-1-ALPHA | ADULT SPINAL-CORD | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOWERED OXYGEN | IDENTIFICATION | TUMOR-GROWTH | EXPRESSION | CANCER | PROLYL HYDROXYLASES | Embryonic Stem Cells - metabolism | Transcription, Genetic - drug effects | Cell Hypoxia - physiology | Embryonic Stem Cells - cytology | Benzoates - metabolism | Homeodomain Proteins - metabolism | Humans | Benzamides - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Male | SOXB1 Transcription Factors - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Ependyma - cytology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Response Elements - physiology | Transforming Growth Factor alpha - metabolism | Adult Stem Cells - cytology | Cell Hypoxia - drug effects | Nanog Homeobox Protein | Gene Expression Regulation - physiology | Rats | Ependyma - metabolism | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Rats, Sprague-Dawley | Gene Expression Regulation - drug effects | p300-CBP Transcription Factors - metabolism | Acetylation - drug effects | Adult Stem Cells - metabolism | Transcription, Genetic - physiology | Animals | Cell Differentiation - drug effects | Octamer Transcription Factor-3 - metabolism | Pharmaceutical Preparations | HeLa Cells | Histones - metabolism | Index Medicus | Molecular Basis of Cell and Developmental Biology | Neurological | Oxygen | Stem Cell | Diseases | Stem Cells | Development Differentiation | Histones | Acetylase | Hypoxia | Differentiation | Cell | Neural
Journal Article
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 09/2008, Volume 27, Issue 40, pp. 5354 - 5358
The von Hippel-Lindau tumor suppressor pVHL regulates the stability of hypoxia-inducible factors (HIF)-1 and-2, oxygen-sensitive basic helix-loop-helix... 
Cre-loxP recombination | Liver angiogenesis | Von Hippel-Lindau (VHL) tumor suppressor | Hemangioma | Mouse model | Hypoxia-inducible factor (HIF) | hemangioma | ERYTHROPOIETIN | mouse model | CYCLIN D1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIPPEL-LINDAU-DISEASE | HEMANGIOBLASTOMAS | IDENTIFICATION | von Hippel-Lindau (VHL) tumor suppressor | CELL BIOLOGY | INACTIVATION | TARGET GENES | hypoxia-inducible factor (HIF) | HIF-2-ALPHA | ONCOLOGY | liver angiogenesis | GENETICS & HEREDITY | TUMOR-SUPPRESSOR | EXPRESSION | Hemangioma - pathology | Oligonucleotide Array Sequence Analysis | Humans | Gene Expression Regulation, Neoplastic | Neovascularization, Pathologic | Male | Gene Expression Profiling | Vascular Endothelial Growth Factor A - metabolism | Hepatocytes - metabolism | Vascular Endothelial Growth Factor A - genetics | Hemangioma - metabolism | Biomarkers, Tumor - metabolism | Female | Integrases - metabolism | Liver Neoplasms - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Hemangioma - blood supply | Basic Helix-Loop-Helix Transcription Factors - physiology | Mice, Inbred C57BL | Von Hippel-Lindau Tumor Suppressor Protein - physiology | von Hippel-Lindau Disease | Animals | Liver Neoplasms - blood supply | Liver Neoplasms - metabolism | Biomarkers, Tumor - genetics | Mice | Mice, Inbred BALB C | Complications and side effects | Care and treatment | Cardiovascular tumors | Tumor suppressor genes | Genetic aspects | DNA binding proteins | Research | Health aspects | Risk factors | Von Hippel-Lindau disease | Oncology | Genetics | Hypoxia | Rodents | Tumors | Index Medicus
Journal Article