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Journal of Experimental Medicine, ISSN 0022-1007, 03/2001, Volume 193, Issue 5, pp. 631 - 636
Both nuclear factor (NF)-kappaB-inducing kinase (NIK) and inhibitor of kappaB (I kappaB) kinase (IKK) have been implicated as essential components for... 
IκB | Akt kinase | Peyer's patch | Cytokine signaling | Alymphoplasia | PATHWAYS | MEDICINE, RESEARCH & EXPERIMENTAL | COMPLEX | IKK-ALPHA | DEFICIENT MICE | IMMUNOLOGY | ALYMPHOPLASIA ALY MICE | TNF | ORGANOGENESIS | alymphoplasia | CELL-DEATH | LETHALITY | akt kinase | cytokine signaling | PROTEINS | I kappa B | Brief Definitive Report
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2014, Volume 461, Issue 3, pp. 531 - 537
IKK beta {I kappa B [inhibitor of NF-kappa B (nuclear factor kappa B)] kinase beta} is required to activate the transcription factor NF-kappa B, but how IKK... 
Inhibitor of nuclear factor κB kinase (IKK) | Linear ubiquitin chain assembly complex (LUBAC) | Nuclear factor κB(NF-κB) | Transforming growth factor β-activated kinase-1 (TAK1) | Interleukin-1 (IL-1) | nuclear factor kappa B (NF-kappa B) | linear ubiquitin chain assembly complex (LUBAC) | COMPLEX | PROTEIN | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | INNATE | interleukin-1 (IL-1) | POLYUBIQUITIN BINDING | FAMILY | transforming growth factor beta-activated kinase-1 (TAK1) | UBIQUITIN CHAINS | inhibitor of nuclear factor kappa B kinase (IKK) | NF-KAPPA-B | NEMO | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | I-kappa B Kinase - antagonists & inhibitors | HEK293 Cells | Protein Interaction Domains and Motifs | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Mutant Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cells, Cultured | Mutant Proteins - genetics | Recombinant Proteins - chemistry | Mice, Transgenic | Mutant Proteins - metabolism | MAP Kinase Kinase Kinases - metabolism | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Serine - metabolism | Gene Knock-In Techniques | Animals | Embryo, Mammalian - cytology | Mutant Proteins - chemistry | Mice | Protein Kinase Inhibitors - pharmacology | I-kappa B Kinase - chemistry | Amino Acid Substitution | NEMO, NF-κB essential modulator | TLR, Toll-like receptor | IKK, IκB kinase | TNF, tumour necrosis factor | transforming growth factor β-activated kinase-1 (TAK1) | HEK, human embryonic kidney | IL-1, interleukin-1 | JNK, c-Jun N-terminal kinase | PP1γ, protein phosphatase 1γ | TRAF, TNF receptor-associated factor | inhibitor of nuclear factor κB kinase (IKK) | LUBAC, linear ubiquitin chain assembly complex | HOIP, HOIL1 [haem-oxidized IRP2 (iron regulatory protein 2) ubiquitin ligase 1]-interacting protein | IκB, inhibitor of NF-κB | TAB, TAK1-binding protein | TAK1, transforming growth factor β-activated kinase-1 | BMDM, bone-marrow-derived macrophage | NF-κB, nuclear factor κB | M-CSF, macrophage colony-stimulating factor | MKK, MAPK kinase | Accelerated Publication | E, embryonic day | MEF, mouse embryonic fibroblast | HA, haemaglutinnin | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2004, Volume 382, Issue 2, pp. 393 - 409
Two members of the NF-kappaB (nuclear factor kappaB)/Rel transcription factor family, NF-kappaB1 and NF-kappaB2, are produced as precursor proteins, NF-kappaB1... 
IκB kinase (IKK) | p100 | Tumour progression locus-2 (TPL-2) | Nuclear factor κB (NF-κB) | p105 | Toll-like receptor (TLR) | nuclear factor kappa B (NF-kappa B) | SIGNALING PATHWAYS | TRANSCRIPTIONAL ACTIVITY | I kappa B kinase (IKK) | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | P105 REQUIRES PHOSPHORYLATION | IKK-ALPHA | P50 SUBUNIT | GLYCINE-RICH REGION | TUMOR-NECROSIS-FACTOR | PRECURSOR P105 | tumour progression locus-2 (TPL-2) | NF-KAPPA-B | TNF, tumour necrosis factor | GC, germinal centre | NEMO, nuclear factor κB essential modulator | MAP 3-kinase, MAP kinase kinase kinase | BAFF, B-cell activating factor | ERK, extracellular-signal-regulated kinase | Fn14, fibroblast-growth-factor-inducible 14 | ABIN, A20-binding inhibitor of nuclear factor κB | GM-CSF, granulocyte–macrophage colony-stimulating factor | GSK, glycogen synthase kinase | Dif, Dorsal-related immunity factor | EBNA1, EBV nuclear antigen 1 | BMDM, bone-marrow-derived macrophage | NF-κB, nuclear factor κB | SCF, Skp1 | Imd, immune deficiency | F-box | IL, interleukin | MAP kinase, mitogen-activated protein kinase | EBV, Epstein–Barr virus | LPS, lipopolysaccharide | IFNβ, interferon-β | IκB, inhibitor of nuclear factor κB | TRAF, TNF-receptor-associated factor | TLR, Toll-like receptor | DC, dendritic cell | IKK, IκB kinase | GRR, glycine-rich region | Review | JNK, c-Jun N-terminal kinase | PGRP-LC, peptidoglycan recognition protein LC | ERK kinase | RANKL, receptor activator of NF-κB ligand | LTβR, lymphotoxin-β receptor | MIP, macrophage inflammatory protein | DD, death domain | HTLV-1, human T-cell leukaemia virus type 1 | MEK, MAP kinase | COX-2, cyclo-oxygenase-2 | TH2, T-helper 2 | TH1, T-helper 1 | LMP1, latent membrane protein 1 | TPL-2, tumour progression locus-2 | TWEAK, TNF-like weak inducer of apoptosis | Cul1 | PEST region, polypeptide sequence enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) | RHD, Rel homology domain | nuclear factor κB (NF-κB) | NIK, NF-κB-inducing kinase | MEF, mouse embryo fibroblast | βTrCP, β-transducin repeat-containing protein
Journal Article
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2013, Volume 451, Issue 3, pp. 427 - 437
The compound BAY 11-7082 inhibits I kappa B alpha [inhibitor of NF-kappa B (nuclear factor kappa B)alpha] phosphorylation in cells and has been used to... 
Linear ubiquitin assembly complex (LUBAC) | Myeloid differentiation factor 88 (MyD88) | Nuclear factor κB (NF-κB) | Lymphoma | Ubiquitin conjugating 13 (Ubc13) | Proteasome | nuclear factor kappa B (NF-kappa B) | proteasome | ACTIVATION | CELL LYMPHOMA-CELLS | LINEAR POLYUBIQUITIN CHAINS | linear ubiquitin assembly complex (LUBAC) | BIOCHEMISTRY & MOLECULAR BIOLOGY | lymphoma | KINASE | IKK | myeloid differentiation factor 88 (MyD88) | CROSS-TALK | IN-VIVO | CONJUGATING ENZYMES | NF-KAPPA-B | NEMO | ubiquitin conjugating 13 (Ubc13) | Nitriles - pharmacology | Humans | Receptors, Interleukin-1 - genetics | Ubiquitin - metabolism | Molecular Sequence Data | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | I-kappa B Proteins - metabolism | Sulfones - pharmacology | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Amino Acid Sequence | NF-KappaB Inhibitor alpha | Ubiquitin - antagonists & inhibitors | NF-kappa B p50 Subunit - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Conjugating Enzymes - genetics | Macrophages - cytology | Interleukin-1 - pharmacology | Receptors, Interleukin-1 - metabolism | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Mice | Proteasome Endopeptidase Complex - metabolism | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Myeloid Differentiation Factor 88 - metabolism | TRAF, tumour-necrosis-factor-receptor-associated factor | HRMS, high-resolution mass spectra | K48-pUb, Lys48-linked polyubiquitin | UBE, ubiquitin-activating enzyme | IKK, IκB kinase | NEMO, NF-κB essential modifier | HEK, human embryonic kidney | TBK1, tumour-necrosis-factor-receptor-associated factor-associated NF-κB activator-binding kinase 1 | JNK, c-Jun N-terminal kinase | HOIP, haem-oxidized IRP2 ligase-1-interacting protein | LUBAC, linear ubiquitin assembly complex | ERK, extracellular-signal-regulated kinase | HTLV-1, human T-cell lymphotropic virus 1 | K63-pUb, Lys63-linked polyubiquitin | IRAK, IL-receptor-associated kinase | pUb, polyubiquitin | IκB, inhibitor of NF-κB | MALDI–TOF, matrix-assisted laser-desorption ionization–time-of-flight | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | MyD88, myeloid differentiation factor 88 | DLBCL, diffuse large B-cell lymphoma | GFP, green fluorescent protein | NF-κB, nuclear factor κB | MS, tandem MS | Ubc, ubiquitin conjugating | TAK1, transforming growth factor β-activated kinase 1 | DAPI, 4′,6-diamidino-2-phenylindole | IL-1R, IL-1 receptor | DMEM, Dulbecco’s modified Eagle’s medium | HIF1α, hypoxia-inducible factor 1α | IL, interleukin | NEDD8, neural-precursor-cell-expressed developmentally down-regulated 8 | RBR, RING-between-RING, TAB, TAK1-binding protein | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase | PAMP, pathogen-associated molecular pattern
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 03/2011, Volume 20, Issue 3, pp. 395 - 405
Introduction: NF-κB is a key regulator of inflammation and immunity in cancer development. The IκB kinase (IKK) is a multisubunit complex containing catalytic... 
NF-κB | inflammation | chemical compounds | IκB kinase
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2006, Volume 12, Issue 3, pp. 950 - 960
Purpose: Constitutive activation of inhibitor of κB kinase (IKK) confers melanoma resistance to apoptosis and chemotherapy. Whether IKK is able to serve as a... 
Effectors of apoptosis | Apoptosis-inducing factor | Melanoma | Protein kinase and phosphatases as targets for therapy | BMS-345541 | Melanoma/skin cancers | Novel antitumor agents | Novel mechanisms | IκB kinase | Apoptosis | BCL-2 | CELLS | ACTIVATION | ONCOLOGY | INTERACTS | TRANSCRIPTION | SUSCEPTIBILITY | ALPHA | PROTEINS | BINDING | EXPRESSION
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2013, Volume 449, Issue 1, pp. 275 - 284
The IKK [inhibitor of NF-kappa B (nuclear factor kappa B) kinase] complex has an essential role in the activation of the family of NF-kappa B transcription... 
Inhibitor of nuclear factor κB kinase (IKK) | Transferrin | Iron | Nuclear factor κB (NF-κB) | Transferrin receptor 1 (TfR1) | Tumour necrosis factor α (TNFα) | nuclear factor kappa B (NF-kappa B) | ACTIVATION | GAMBOGIC ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | transferrin | TNF-INDUCED APOPTOSIS | DEFICIENT MICE | CROSS-TALK | transferrin receptor 1 (TfR1) | IN-VITRO | TRANSFERRIN RECEPTOR | tumour necrosis factor alpha (TNF alpha) | LIVER DEGENERATION | iron | inhibitor of nuclear factor kappa B kinase (IKK) | KINASE IKK | BETA SUBUNIT | NF-kappa B - antagonists & inhibitors | Receptors, Transferrin - deficiency | Humans | Iron - chemistry | NF-kappa B - metabolism | Iron - metabolism | Receptors, Transferrin - metabolism | I-kappa B Kinase - physiology | Antigens, CD - metabolism | I-kappa B Kinase - metabolism | HEK293 Cells | NF-kappa B - physiology | Cell Line, Tumor | Signal Transduction - physiology | Protein Binding - physiology | IKK, IκB kinase | HEK, human embryonic kidney | PCNA, proliferating-cell nuclear antigen | RT, reverse transcription | tumour necrosis factor α (TNFα) | ChIP, chromatin immunoprecipitation | inhibitor of nuclear factor κB kinase (IKK) | IAP2, inhibitor of apoptosis protein 2 | HSP90, heat-shock protein 90 | TAP, tandem affinity purification | TNFα, tumour necrosis factor α | GFP, green fluorescent protein | NF-κB, nuclear factor κB | TfR1, transferrin receptor 1 | siRNA, small interfering RNA | EMSA, electrophoretic mobility-shift assay | DFX, desferoxamine | DMEM, Dulbecco’s modified Eagle’s medium | MEF, mouse embryonic fibroblast | nuclear factor κB (NF-κB) | c-IAP2, cellular IAP2 | HIF-1, hypoxia-inducible factor-1 | PARP, poly(ADP-ribose) polymerase | IκB, inhibitor of nuclear factor κB
Journal Article