X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (733) 733
Dissertation (418) 418
Publication (189) 189
Book / eBook (26) 26
Book Chapter (10) 10
Conference Proceeding (8) 8
Web Resource (6) 6
Magazine Article (5) 5
Government Document (4) 4
Newspaper Article (3) 3
Manuscript (2) 2
Paper (2) 2
Book Review (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (70) 70
relacoes i?internacionais, bilaterais e multilaterais (67) 67
index medicus (58) 58
cardiac & cardiovascular systems (55) 55
humans (48) 48
pharmacology & pharmacy (46) 46
late i-na (43) 43
late sodium current (36) 36
1900-1999 (34) 34
male (33) 33
ranolazine (33) 33
i-na (26) 26
world war i (24) 24
heart (23) 23
rats (23) 23
sodium channel blockers - pharmacology (21) 21
sodium channels - drug effects (21) 21
arrhythmias (20) 20
igf-i (20) 20
sodium channels - metabolism (20) 20
history (19) 19
htlv-i (19) 19
patch-clamp techniques (19) 19
action potentials (18) 18
female (18) 18
sodium - metabolism (18) 18
anàlisi numèrica (17) 17
dose-response relationship, drug (17) 17
i seccao: conceito de filosofia (17) 17
matemàtiques i estadística::anàlisi numèrica [àrees temàtiques de la upc] (17) 17
numerical analysis (17) 17
brazilian literature (16) 16
engenharias (16) 16
ina (16) 16
myocytes, cardiac - metabolism (16) 16
neurosciences (16) 16
rabbits (16) 16
veterinary sciences (16) 16
anti-arrhythmia agents - pharmacology (15) 15
ciències humanes i socials (15) 15
long-qt syndrome (15) 15
myocytes, cardiac - drug effects (15) 15
ventricular myocytes (15) 15
arrhythmia (14) 14
cardiovascular (14) 14
electrophysiology (14) 14
insulin-like growth factor i (14) 14
poetry (14) 14
cell biology (13) 13
dentistry, oral surgery & medicine (13) 13
geotecnica (13) 13
ischemia (13) 13
physiology (13) 13
portuguese literature (13) 13
troponina i (13) 13
action potential (12) 12
action potentials - drug effects (12) 12
brasil (12) 12
early afterdepolarizations (12) 12
heart failure (12) 12
i (12) 12
novel (12) 12
seccion monografica i: o comparatismo na américa latina: abordagem cultural/situações coloniais e pós-coloniais (12) 12
sodium (12) 12
sodium channels - physiology (12) 12
surgery (12) 12
troponin i (12) 12
arrhythmias, cardiac - drug therapy (11) 11
cells, cultured (11) 11
electrocardiography (11) 11
i na (11) 11
sodium current (11) 11
article (10) 10
atrial fibrillation (10) 10
biochemistry & molecular biology (10) 10
brazil (10) 10
collagen type i (10) 10
dogs (10) 10
engenharia de materiais e metalurgica (10) 10
fibrillation (10) 10
imunologia (10) 10
in vitro techniques (10) 10
mucopolysaccharidosis i (10) 10
myocardium - metabolism (10) 10
ortodontia corretiva (10) 10
política externa brasileira (10) 10
angina (9) 9
anti-arrhythmia agents - therapeutic use (9) 9
antianginal agent (9) 9
bioquimica (9) 9
calcium (9) 9
channel (9) 9
chronic heart-failure (9) 9
educacao (9) 9
education (9) 9
heart-failure (9) 9
international relations (9) 9
italian literature (9) 9
mice (9) 9
processos de fabricacao (9) 9
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
Portuguese (917) 917
English (233) 233
Spanish (21) 21
Latin (15) 15
Chinese (9) 9
Italian (8) 8
German (3) 3
Japanese (3) 3
Polish (3) 3
Catalan (2) 2
Croatian (2) 2
Dutch (2) 2
Korean (2) 2
Arabic (1) 1
French (1) 1
Icelandic (1) 1
Russian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


NuklearMedizin, ISSN 0029-5566, 2012, Volume 51, Issue 4, pp. 111 - 115
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/2010, Volume 160, Issue 1, pp. 60 - 76
Background and purpose:  The regulatory guidelines (ICHS7B) for the identification of only drug-induced long QT and pro-arrhythmias have certain limitations.... 
ventricular fibrillation (VF) | conduction time | INa | ventricular tachycardia (VT) | drug | Drug | Conduction time | Ventricular fibrillation (VF) | Ventricular tachycardia (VT) | FIBRILLATION | FLECAINIDE | VENTRICULAR-TACHYCARDIA | MECHANISMS | PROLONGATION | SUDDEN UNEXPECTED DEATH | BRUGADA-SYNDROME | I-Na | LIDOCAINE | ACUTE MYOCARDIAL-INFARCTION | PHARMACOLOGY & PHARMACY | CHANNELS | Lidocaine - pharmacology | Lidocaine - adverse effects | Arrhythmias, Cardiac - chemically induced | Cricetulus | Myocardial Reperfusion Injury - chemically induced | Anti-Arrhythmia Agents - pharmacology | Tachycardia, Ventricular - chemically induced | Electric Conductivity | Sodium Channels - physiology | Purkinje Fibers - drug effects | Sodium Channel Blockers - adverse effects | Ventricular Fibrillation - physiopathology | Ether-A-Go-Go Potassium Channels - physiology | CHO Cells | Drug Evaluation, Preclinical - methods | Rabbits | Cricetinae | Sodium Channel Blockers - pharmacology | Flecainide - pharmacology | Heart Conduction System - drug effects | Myocardial Reperfusion Injury - physiopathology | Flecainide - adverse effects | Patch-Clamp Techniques | Tachycardia, Ventricular - physiopathology | Animals | Anti-Arrhythmia Agents - adverse effects | Ventricular Fibrillation - chemically induced | In Vitro Techniques | Purkinje Fibers - physiology | Sodium | Cardiac arrhythmia | Research Papers | I Na
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/2007, Volume 152, Issue 8, pp. 1215 - 1227
Background and purpose: Torsade de pointes (TdP) can be induced by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether I... 
ATX‐II | IKs | K+ channel blockers | IKr | HMR1556 | repolarization reserve | torsade de pointes | E‐4031 | INa | proarrhythmia | Repolarization reserve | E-4031 | channel blockers | ATX-II | Proarrhythmia | Torsade de pointes | INDUCED ARRHYTHMIAS | I-Kr | LONG-QT SYNDROME | I-Ks | PROARRHYTHMIC RISK | VENTRICULAR-MUSCLE | ANTIARRHYTHMIC AGENTS | TO-BEAT VARIABILITY | IN-VIVO MODEL | EARLY AFTERDEPOLARIZATIONS | I-Na | PHARMACOLOGICAL BLOCK | PHARMACOLOGY & PHARMACY | Electrophysiology | Long QT Syndrome - chemically induced | Male | Cnidarian Venoms - administration & dosage | Delayed Rectifier Potassium Channels - metabolism | Dose-Response Relationship, Drug | Potassium Channels, Voltage-Gated - metabolism | Electrocardiography | Chromans - administration & dosage | Action Potentials - drug effects | Piperidines - toxicity | Rabbits | Piperidines - administration & dosage | Delayed Rectifier Potassium Channels - antagonists & inhibitors | Pyridines - administration & dosage | Torsades de Pointes - chemically induced | Potassium Channels, Voltage-Gated - antagonists & inhibitors | Sodium Channels - drug effects | Forecasting | Drug Synergism | Animals | Pyridines - toxicity | Sulfonamides - toxicity | Cnidarian Venoms - toxicity | Chromans - toxicity | Sulfonamides - administration & dosage | Research Papers | I Na | I Ks | I Kr
Journal Article
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 07/2016, Volume 26, Issue 13, pp. 3202 - 3206
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and beta-blocker activity and identified... 
Late I-Na current inhibitor | GS-458967 | CHEMISTRY, MEDICINAL | PHARMACOLOGY | Anti-arrhythmic | Ventricular arrhythmia | CHEMISTRY, ORGANIC | Ranolazine
Journal Article
HEART RHYTHM, ISSN 1547-5271, 12/2015, Volume 12, Issue 12, pp. 2508 - 2514
BACKGROUND Catecholamines can elicit early and delayed afterdepolarizations (EADs and DADs), resulting in ventricular tachyarrhythmias. OBJECTIVE As inhibition... 
FIBRILLATION | SODIUM CURRENT | CARDIAC & CARDIOVASCULAR SYSTEMS | Sodium | Ventricular tachycardia | Catecholamines | T-wave alternans | Late I-Na inhibition
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 07/2016, Volume 26, Issue 13, pp. 3207 - 3211
Previously we disclosed the discovery of potent Late I-Na current inhibitor 2 (GS-458967, IC50 of 333 nM) that has a good separation of late versus peak... 
GS-462808 | Late I-Na current inhibitor | CHEMISTRY, MEDICINAL | PHARMACOLOGY | CHEMISTRY, ORGANIC | Angina | Anti-ischemic | Ranolazine
Journal Article