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1. Full Text The IκB kinase complex in NF‐κB regulation and beyond
by Hinz, Michael and Scheidereit, Claus
EMBO reports, ISSN 1469-221X, 01/2014, Volume 15, Issue 1, pp. 46 - 61
development | cancer | differentiation | immunity | inflammation | Development | Inflammation | Differentiation | Immunity | Cancer | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Feedback, Physiological | Phosphorylation | Ubiquitination | Animals | Signal Transduction | Humans | Protein Multimerization | NF-kappa B - metabolism | Ubiquitin - physiology | I-kappa B Kinase - physiology | Protein Interaction Maps | Index Medicus | Reviews
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2. Full Text Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase
by Gantke, Thorsten and Sriskantharajah, Srividya and Ley, Steven C
Cell research, ISSN 1001-0602, 01/2011, Volume 21, Issue 1, pp. 131 - 145
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Index Medicus | TPL-2 | NF-κB | ABIN-2 | p105 | IKK | COT | MAP kinase | MAP3K8 | Review | TLR
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3. Full Text I kappa B Kinase alpha/beta Control Biliary Homeostasis and Hepatocarcinogenesis in Mice by Phosphorylating the Cell-Death Mediator Receptor-Interacting Protein Kinase 1
by Koppe, Christiane and Verheugd, Patricia and Gautheron, Jeremie and Reisinger, Florian and Kreggenwinkel, Karina and Roderburg, Christoph and Quagliata, Luca and Terracciano, Luigi and Gassler, Nikolaus and Tolba, Rene H and Boege, Yannick and Weber, Achim and Karin, Michael and Luedde, Mark and Neumann, Ulf P and Weiskirchen, Ralf and Tacke, Frank and Vucur, Mihael and Trautwein, Christian and Luescher, Bernhard and Preisinger, Christian and Heikenwalder, Mathias and Luedde, Tom
Hepatology (Baltimore, Md.), ISSN 0270-9139, 10/2016, Volume 64, Issue 4, pp. 1217 - 1231
Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Liver Neoplasms - etiology | Phosphorylation | Animals | Ubiquitin-Protein Ligases - metabolism | Homeostasis | Bile Ducts, Intrahepatic | Male | Mice | Carcinogenesis | I-kappa B Kinase - physiology | Index Medicus
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4. Full Text Resibufogenin suppresses transforming growth factor‐β‐activated kinase 1‐mediated nuclear factor‐κB activity through protein kinase C‐dependent inhibition of glycogen synthase kinase 3
by Liu, Lu and Liu, Yang and Liu, Xiaojia and Zhang, Na and Mao, Genxiang and Zeng, Qingxuan and Yin, Mingxiao and Song, Danqing and Deng, Hongbin
Cancer science, ISSN 1347-9032, 11/2018, Volume 109, Issue 11, pp. 3611 - 3622
glycogen synthase kinase‐3 | nuclear factor‐κB | transforming growth factor‐β‐activated kinase 1 | protein kinase C | resibufogenin | nuclear factor-κB | glycogen synthase kinase-3 | transforming growth factor-β-activated kinase 1 | Life Sciences & Biomedicine | Oncology | Science & Technology | Cell Survival - drug effects | Pancreatic Neoplasms - metabolism | MAP Kinase Kinase Kinases - genetics | Humans | NF-kappa B - metabolism | Pancreatic Neoplasms - genetics | MAP Kinase Kinase Kinases - metabolism | Bufanolides - administration & dosage | I-kappa B Proteins - metabolism | Pancreatic Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Bufanolides - pharmacology | Cell Proliferation - drug effects | Mice | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation | Protein kinase C | TAK1 protein | Glycogen | Glycogen synthase kinase 3 | Traditional Chinese medicine | Caspase | AKT protein | Gene expression | Kinases | Proteins | Plasmids | Pancreatic cancer | Medical prognosis | Xenografts | Growth factors | Apoptosis | Index Medicus | Original
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5. Full Text An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation
by Zhang, Jiazhen and Clark, Kristopher and Lawrence, Toby and Peggie, Mark W and Cohen, Philip
Biochemical journal, ISSN 0264-6021, 08/2014, Volume 461, Issue 3, pp. 531 - 537
Inhibitor of nuclear factor κB kinase (IKK) | Linear ubiquitin chain assembly complex (LUBAC) | Nuclear factor κB(NF-κB) | Transforming growth factor β-activated kinase-1 (TAK1) | Interleukin-1 (IL-1) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | I-kappa B Kinase - antagonists & inhibitors | HEK293 Cells | Protein Interaction Domains and Motifs | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Mutant Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cells, Cultured | Mutant Proteins - genetics | Recombinant Proteins - chemistry | Mice, Transgenic | Mutant Proteins - metabolism | MAP Kinase Kinase Kinases - metabolism | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Serine - metabolism | Gene Knock-In Techniques | Animals | Embryo, Mammalian - cytology | Mutant Proteins - chemistry | Mice | Protein Kinase Inhibitors - pharmacology | I-kappa B Kinase - chemistry | Amino Acid Substitution | Index Medicus | linear ubiquitin chain assembly complex (LUBAC) | NEMO, NF-κB essential modulator | TLR, Toll-like receptor | IKK, IκB kinase | TNF, tumour necrosis factor | transforming growth factor β-activated kinase-1 (TAK1) | HEK, human embryonic kidney | interleukin-1 (IL-1) | IL-1, interleukin-1 | JNK, c-Jun N-terminal kinase | PP1γ, protein phosphatase 1γ | TRAF, TNF receptor-associated factor | inhibitor of nuclear factor κB kinase (IKK) | LUBAC, linear ubiquitin chain assembly complex | HOIP, HOIL1 [haem-oxidized IRP2 (iron regulatory protein 2) ubiquitin ligase 1]-interacting protein | IκB, inhibitor of NF-κB | TAB, TAK1-binding protein | TAK1, transforming growth factor β-activated kinase-1 | BMDM, bone-marrow-derived macrophage | NF-κB, nuclear factor κB | M-CSF, macrophage colony-stimulating factor | MKK, MAPK kinase | Accelerated Publication | E, embryonic day | MEF, mouse embryonic fibroblast | HA, haemaglutinnin | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase
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6. Full Text TGFβ-activated kinase 1 (TAK1) inhibition by 5Z-7-oxozeaenol attenuates early brain injury after experimental subarachnoid hemorrhage
by Zhang, Dingding and Yan, Huiying and Li, Hua and Hao, Shuangying and Zhuang, Zong and Liu, Ming and Sun, Qing and Yang, Yiqing and Zhou, Mengliang and Li, Kuanyu and Hang, Chunhua
The Journal of biological chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19900 - 19909
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neurons - pathology | Phosphorylation | Transcription Factor RelA - antagonists & inhibitors | Apoptosis - drug effects | Injections, Intraventricular | Male | Cerebrovascular Trauma - metabolism | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Transcription Factor RelA - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | MAP Kinase Kinase 4 - metabolism | Neuroprotective Agents - pharmacology | I-kappa B Proteins - antagonists & inhibitors | MAP Kinase Kinase 4 - antagonists & inhibitors | Neurons - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | MAP Kinase Kinase Kinases - antagonists & inhibitors | Neurons - drug effects | Subarachnoid Hemorrhage - drug therapy | Disease Models, Animal | NF-KappaB Inhibitor alpha | Signal Transduction | MAP Kinase Kinase Kinases - genetics | Gene Expression Regulation | Rats | p38 Mitogen-Activated Protein Kinases - genetics | Zearalenone - analogs & derivatives | MAP Kinase Kinase Kinases - metabolism | Subarachnoid Hemorrhage - genetics | Subarachnoid Hemorrhage - pathology | Rats, Sprague-Dawley | Stereotaxic Techniques | Subarachnoid Hemorrhage - metabolism | Animals | Transcription Factor RelA - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cerebrovascular Trauma - pathology | MAP Kinase Kinase 4 - genetics | Cerebrovascular Trauma - prevention & control | Protein Kinase Inhibitors - pharmacology | Cerebrovascular Trauma - genetics | Zearalenone - pharmacology | Index Medicus | TAK1 | neuroprotection | 5Z-7-oxozeaenol | subarachnoid hemorrhage | Neurobiology | mitogen-activated protein kinase (MAPK) | apoptosis | brain | NF-κB (NF-KB)
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7. Full Text Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-IκB Kinase Cascade
by Mary C. Puckett and Erinn H. Goldman and Lisa M. Cockrell and Bei Huang and Andrea L. Kasinski and Yuhong Du and Cun-Yu Wang and Anning Lin and Hidenori Ichijo and Fadlo Khuri and Haian Fu
Molecular and Cellular Biology, ISSN 0270-7306, 06/2013, Volume 33, Issue 11, pp. 2252 - 2259
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphorylation | MAP Kinase Kinase Kinase 5 - genetics | Neurites - physiology | Signal Transduction | Hydrogen Peroxide - pharmacology | Cercopithecus aethiops | Morpholines - pharmacology | Rats | COS Cells - drug effects | I-kappa B Kinase - genetics | PC12 Cells | Serine - metabolism | Proto-Oncogene Proteins c-akt - genetics | COS Cells - metabolism | Animals | I-kappa B Kinase - metabolism | Mice | Apoptosis - physiology | MAP Kinase Kinase Kinase 5 - metabolism | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Index Medicus
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8. Full Text Conditional deletion of NF-κB-Inducing kinase (NIK) in adult mice disrupts mature B cell survival and activation
by Brightbill, Hans D and Jackman, Janet K and Suto, Eric and Kennedy, Heather and Jones, Charles and Chalasani, Sreedevi and Lin, Zhonghua and Tam, Lucinda and Roose-Girma, Meron and Balazs, Mercedesz and Austin, Cary D and Lee, Wyne P and Wu, Lawren C
The Journal of immunology (1950), ISSN 0022-1767, 08/2015, Volume 195, Issue 3, pp. 953 - 964
Life Sciences & Biomedicine | Immunology | Science & Technology | Sequence Deletion | B-Lymphocytes - cytology | NF-kappa B p52 Subunit - biosynthesis | Protein-Serine-Threonine Kinases - genetics | Cell Survival - genetics | Signal Transduction - genetics | Spleen - cytology | Cell Survival - immunology | Lymph Nodes - cytology | Mice, Knockout | Cell Differentiation - immunology | Signal Transduction - immunology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | Animals | B-Lymphocytes - immunology | I-kappa B Kinase - metabolism | B-Cell Activating Factor - genetics | NF-kappa B p52 Subunit - genetics | Tamoxifen - pharmacology | Germ-Line Mutation | Immunoglobulin A - blood | Mice | Index Medicus | Abridged Index Medicus
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