EMBO reports, ISSN 1469-221X, 01/2014, Volume 15, Issue 1, pp. 46 - 61
The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed of two serine‐threonine kinases (IKKα and IKKβ) and the regulatory...
development | cancer | differentiation | immunity | inflammation | Development | Inflammation | Differentiation | Immunity | Cancer | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANHIDROTIC ECTODERMAL DYSPLASIA | NECROSIS-FACTOR-ALPHA | NEGATIVE FEEDBACK LOOP | TUMOR-INITIATING CELLS | CELL BIOLOGY | UBIQUITIN CHAINS | GENE-EXPRESSION | GAMMA-DEPENDENT PHOSPHORYLATION | SQUAMOUS-CELL CARCINOMAS | NUCLEAR IKK ACTIVITY | Feedback, Physiological | Phosphorylation | Ubiquitination | Animals | Signal Transduction | Humans | Protein Multimerization | NF-kappa B - metabolism | Ubiquitin - physiology | I-kappa B Kinase - physiology | Protein Interaction Maps | Reviews
development | cancer | differentiation | immunity | inflammation | Development | Inflammation | Differentiation | Immunity | Cancer | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANHIDROTIC ECTODERMAL DYSPLASIA | NECROSIS-FACTOR-ALPHA | NEGATIVE FEEDBACK LOOP | TUMOR-INITIATING CELLS | CELL BIOLOGY | UBIQUITIN CHAINS | GENE-EXPRESSION | GAMMA-DEPENDENT PHOSPHORYLATION | SQUAMOUS-CELL CARCINOMAS | NUCLEAR IKK ACTIVITY | Feedback, Physiological | Phosphorylation | Ubiquitination | Animals | Signal Transduction | Humans | Protein Multimerization | NF-kappa B - metabolism | Ubiquitin - physiology | I-kappa B Kinase - physiology | Protein Interaction Maps | Reviews
Journal Article
Cell Research, ISSN 1001-0602, 01/2011, Volume 21, Issue 1, pp. 131 - 145
The I kappa B kinase (IKK) complex plays a well-documented role in innate and adaptive immunity. This function has been widely attributed to its role as the...
SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | ABIN-2 | P105 REQUIRES PHOSPHORYLATION | LIPOPOLYSACCHARIDE ACTIVATION | IKK | COT | MAP kinase | NF-KAPPA-B1 P105 | TUMOR PROGRESSION LOCUS-2 | CELL BIOLOGY | TPL-2 | LPS-STIMULATED MACROPHAGES | NF-kappa B | p105 | T-CELL LYMPHOMAS | MAP3K8 | TLR | TNF-ALPHA | A20-BINDING INHIBITOR | Proto-Oncogene Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | I-kappa B Kinase - metabolism | Signal Transduction | Antigens, Nuclear - metabolism | Humans | NF-kappa B - physiology | Proto-Oncogene Proteins - physiology | MAP Kinase Kinase Kinases - physiology | NF-kappa B - metabolism | MAP Kinase Kinase Kinases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | NF-κB | Review
SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | ABIN-2 | P105 REQUIRES PHOSPHORYLATION | LIPOPOLYSACCHARIDE ACTIVATION | IKK | COT | MAP kinase | NF-KAPPA-B1 P105 | TUMOR PROGRESSION LOCUS-2 | CELL BIOLOGY | TPL-2 | LPS-STIMULATED MACROPHAGES | NF-kappa B | p105 | T-CELL LYMPHOMAS | MAP3K8 | TLR | TNF-ALPHA | A20-BINDING INHIBITOR | Proto-Oncogene Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | I-kappa B Kinase - metabolism | Signal Transduction | Antigens, Nuclear - metabolism | Humans | NF-kappa B - physiology | Proto-Oncogene Proteins - physiology | MAP Kinase Kinase Kinases - physiology | NF-kappa B - metabolism | MAP Kinase Kinase Kinases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | NF-κB | Review
Journal Article
Hepatology, ISSN 0270-9139, 10/2016, Volume 64, Issue 4, pp. 1217 - 1231
The IκB‐Kinase (IKK) complex—consisting of the catalytic subunits, IKKα and IKKβ, as well as the regulatory subunit, NEMO—mediates activation of the nuclear...
INACTIVATION | RIP1 KINASE | APOPTOSIS | HEPATOCELLULAR-CARCINOMA | NECROSIS | IKK-ALPHA | STEATOHEPATITIS | PROLIFERATION | IDENTIFICATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Liver Neoplasms - etiology | Phosphorylation | Animals | Ubiquitin-Protein Ligases - metabolism | Homeostasis | Bile Ducts, Intrahepatic | Male | Mice | Carcinogenesis | I-kappa B Kinase - physiology | Index Medicus
INACTIVATION | RIP1 KINASE | APOPTOSIS | HEPATOCELLULAR-CARCINOMA | NECROSIS | IKK-ALPHA | STEATOHEPATITIS | PROLIFERATION | IDENTIFICATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Liver Neoplasms - etiology | Phosphorylation | Animals | Ubiquitin-Protein Ligases - metabolism | Homeostasis | Bile Ducts, Intrahepatic | Male | Mice | Carcinogenesis | I-kappa B Kinase - physiology | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2011, Volume 31, Issue 1, pp. 314 - 321
The neurobiological underpinnings of mood and anxiety disorders have been linked to the nucleus accumbens (NAc), a region important in processing the rewarding...
DENDRITIC SPINES | DEPRESSION | AMPA RECEPTORS | SENSITIZATION | CONNECTIVITY | SYNAPSES | COCAINE | EXPRESSION | NEUROSCIENCES | MORPHOLOGY | RAT NUCLEUS-ACCUMBENS | Neurons - pathology | Isoquinolines | Microscopy, Electron, Transmission - methods | Male | Dendritic Spines - metabolism | Green Fluorescent Proteins - genetics | Statistics as Topic | Gene Expression Regulation, Enzymologic - physiology | Behavior, Animal | Exploratory Behavior - physiology | Neuronal Plasticity - physiology | Neurons - ultrastructure | I-kappa B Kinase - metabolism | Neurons - physiology | Interpersonal Relations | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Nucleus Accumbens - pathology | Gene Transfer Techniques | Mice, Inbred C57BL | I-kappa B Kinase - genetics | Mutation - genetics | Microscopy, Confocal - methods | Stress, Psychological - pathology | Patch-Clamp Techniques | Animals | Analysis of Variance | Signal Transduction - drug effects | Dendritic Spines - pathology | Signal Transduction - physiology | Mice | Dendritic Spines - ultrastructure | Stress, Psychological - physiopathology
DENDRITIC SPINES | DEPRESSION | AMPA RECEPTORS | SENSITIZATION | CONNECTIVITY | SYNAPSES | COCAINE | EXPRESSION | NEUROSCIENCES | MORPHOLOGY | RAT NUCLEUS-ACCUMBENS | Neurons - pathology | Isoquinolines | Microscopy, Electron, Transmission - methods | Male | Dendritic Spines - metabolism | Green Fluorescent Proteins - genetics | Statistics as Topic | Gene Expression Regulation, Enzymologic - physiology | Behavior, Animal | Exploratory Behavior - physiology | Neuronal Plasticity - physiology | Neurons - ultrastructure | I-kappa B Kinase - metabolism | Neurons - physiology | Interpersonal Relations | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Nucleus Accumbens - pathology | Gene Transfer Techniques | Mice, Inbred C57BL | I-kappa B Kinase - genetics | Mutation - genetics | Microscopy, Confocal - methods | Stress, Psychological - pathology | Patch-Clamp Techniques | Animals | Analysis of Variance | Signal Transduction - drug effects | Dendritic Spines - pathology | Signal Transduction - physiology | Mice | Dendritic Spines - ultrastructure | Stress, Psychological - physiopathology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2013, Volume 288, Issue 27, pp. 19450 - 19458
1,25-Dihydroxyvitamin D (1,25(OH)(2)D-3) is known to suppress NF-kappa B activity, but the underlying mechanism remains poorly understood. Here we show that...
CELLS | P65 SUBUNIT | HORMONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA ELEMENT | TRANSCRIPTIONAL REPRESSION | DOWN-REGULATION | 1,25-DIHYDROXYVITAMIN D-3 | EXPRESSION | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | GENE-TRANSCRIPTION | Protein Structure, Tertiary | NF-kappa B p50 Subunit - metabolism | Humans | I-kappa B Kinase - genetics | NF-kappa B p50 Subunit - genetics | Receptors, Calcitriol - metabolism | Receptors, Calcitriol - genetics | Transcription Factor RelA - genetics | Mice, Knockout | Phosphorylation - genetics | Animals | Cell Nucleus - metabolism | Cell Nucleus - genetics | I-kappa B Kinase - metabolism | Peptide Mapping | Transcription Factor RelA - metabolism | Active Transport, Cell Nucleus - drug effects | Calcitriol - pharmacology | HEK293 Cells | Mice | Phosphorylation - drug effects | Active Transport, Cell Nucleus - genetics | NF-κB | Signal Transduction | Vitamin D | Inflammation | IKKβ | Nuclear Receptors | Protein-Protein Interactions
CELLS | P65 SUBUNIT | HORMONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA ELEMENT | TRANSCRIPTIONAL REPRESSION | DOWN-REGULATION | 1,25-DIHYDROXYVITAMIN D-3 | EXPRESSION | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | GENE-TRANSCRIPTION | Protein Structure, Tertiary | NF-kappa B p50 Subunit - metabolism | Humans | I-kappa B Kinase - genetics | NF-kappa B p50 Subunit - genetics | Receptors, Calcitriol - metabolism | Receptors, Calcitriol - genetics | Transcription Factor RelA - genetics | Mice, Knockout | Phosphorylation - genetics | Animals | Cell Nucleus - metabolism | Cell Nucleus - genetics | I-kappa B Kinase - metabolism | Peptide Mapping | Transcription Factor RelA - metabolism | Active Transport, Cell Nucleus - drug effects | Calcitriol - pharmacology | HEK293 Cells | Mice | Phosphorylation - drug effects | Active Transport, Cell Nucleus - genetics | NF-κB | Signal Transduction | Vitamin D | Inflammation | IKKβ | Nuclear Receptors | Protein-Protein Interactions
Journal Article
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7343, pp. 325 - 330
Inhibitor of kappa B (I kappa B) kinase (IKK) phosphorylates I kappa B proteins, leading to their degradation and the liberation of nuclear factor kappa B for...
CATALYTIC SUBUNIT | COMPLEX | ACTIVATION | UBIQUITIN-LIKE DOMAIN | DOCKING INTERACTIONS | PHOSPHORYLATION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | IKK-BETA | ALPHA | BINDING | Protein Structure, Tertiary | Biocatalysis | Humans | Protein Multimerization | Xenopus laevis | Ubiquitin - chemistry | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Amino Acid Motifs | Animals | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Protein Binding | Enzyme Activation | I-kappa B Kinase - chemistry
CATALYTIC SUBUNIT | COMPLEX | ACTIVATION | UBIQUITIN-LIKE DOMAIN | DOCKING INTERACTIONS | PHOSPHORYLATION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | IKK-BETA | ALPHA | BINDING | Protein Structure, Tertiary | Biocatalysis | Humans | Protein Multimerization | Xenopus laevis | Ubiquitin - chemistry | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Amino Acid Motifs | Animals | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Protein Binding | Enzyme Activation | I-kappa B Kinase - chemistry
Journal Article
BLOOD, ISSN 0006-4971, 05/2013, Volume 121, Issue 22, pp. 4567 - 4574
Platelet secretion plays a key role in thrombosis, thus the platelet secretory machinery offers a unique target to modulate hemostasis. We report the...
COMPLEX | EXOCYTOSIS | GRANULE RELEASE | INFLAMMATION | MICE | SYNTAXIN 2 | PROTEINS | HEMATOLOGY | ACTIVATED PLATELETS | MOLECULAR-MECHANISMS | SNARE | Phosphorylation - physiology | Hemostasis - physiology | Platelet Activation - physiology | Qb-SNARE Proteins - metabolism | I-kappa B Kinase - genetics | Blood Platelets - secretion | Mice, Knockout | Animals | I-kappa B Kinase - metabolism | Qc-SNARE Proteins - metabolism | Blood Platelets - metabolism | Cytoplasmic Granules - metabolism | Signal Transduction - physiology | Mice | Membrane Fusion - physiology | Enzyme Activation - physiology | SNARE Proteins - metabolism | Platelets and Thrombopoiesis
COMPLEX | EXOCYTOSIS | GRANULE RELEASE | INFLAMMATION | MICE | SYNTAXIN 2 | PROTEINS | HEMATOLOGY | ACTIVATED PLATELETS | MOLECULAR-MECHANISMS | SNARE | Phosphorylation - physiology | Hemostasis - physiology | Platelet Activation - physiology | Qb-SNARE Proteins - metabolism | I-kappa B Kinase - genetics | Blood Platelets - secretion | Mice, Knockout | Animals | I-kappa B Kinase - metabolism | Qc-SNARE Proteins - metabolism | Blood Platelets - metabolism | Cytoplasmic Granules - metabolism | Signal Transduction - physiology | Mice | Membrane Fusion - physiology | Enzyme Activation - physiology | SNARE Proteins - metabolism | Platelets and Thrombopoiesis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 31, pp. 11365 - 11370
In the activated B-cell—like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), NF-κB activity is essential for viability of the malignant cells and is...
Betting | B lymphocytes | Genes | B cell lymphoma | Cell lines | Multiple myeloma | Signatures | Viability | Heterologous transplantation | Tumors | Cancer therapy | Drug synergism | SELECTIVE-INHIBITION | TARGET | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | DISCOVERY | cancer therapy | SUPER-ENHANCERS | MYC | GENE-EXPRESSION | drug synergism | LEUKEMIA | BET BROMODOMAINS | BRD4 | Humans | Triazoles - toxicity | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Death - drug effects | Azepines - toxicity | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Protein Structure, Tertiary | Lymphoma, Large B-Cell, Diffuse - pathology | Cell Survival | Lymphoma, Large B-Cell, Diffuse - enzymology | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Pyrimidines - pharmacology | Mice, SCID | Azepines - pharmacology | Drug Synergism | Transcription Factors - metabolism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | I-kappa B Kinase - chemistry | Biological Sciences
Betting | B lymphocytes | Genes | B cell lymphoma | Cell lines | Multiple myeloma | Signatures | Viability | Heterologous transplantation | Tumors | Cancer therapy | Drug synergism | SELECTIVE-INHIBITION | TARGET | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | DISCOVERY | cancer therapy | SUPER-ENHANCERS | MYC | GENE-EXPRESSION | drug synergism | LEUKEMIA | BET BROMODOMAINS | BRD4 | Humans | Triazoles - toxicity | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Death - drug effects | Azepines - toxicity | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Protein Structure, Tertiary | Lymphoma, Large B-Cell, Diffuse - pathology | Cell Survival | Lymphoma, Large B-Cell, Diffuse - enzymology | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Pyrimidines - pharmacology | Mice, SCID | Azepines - pharmacology | Drug Synergism | Transcription Factors - metabolism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | I-kappa B Kinase - chemistry | Biological Sciences
Journal Article
Immunological Reviews, ISSN 0105-2896, 03/2012, Volume 246, Issue 1, pp. 168 - 182
Nuclear factor‐κB (NF‐κB) and mitogen‐activated protein kinase (MAPK) activation play central roles in the induction of gene expression in innate immune cells...
IKK | ABIN‐2 | TLR | NF‐κB1 | MAPK | TPL‐2/COT | NF-κB1 | TPL-2/COT | ABIN-2 | INFLAMMATORY RESPONSES | PROTEIN-KINASE | P105 REQUIRES PHOSPHORYLATION | LIPOPOLYSACCHARIDE ACTIVATION | COT | IKK-BETA | IMMUNOLOGY | NF-KAPPA-B1 P105 | TPL-2 | NF-?B1 | TOLL-LIKE RECEPTORS | TUMOR-ASSOCIATED MACROPHAGES | TNF-ALPHA | PHARMACOLOGICAL INHIBITION | Autoimmunity | Neoplasms - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Phosphorylation | Humans | Inflammation - immunology | Proto-Oncogene Proteins - chemistry | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Inflammation - complications | Neoplasms - complications | Inflammation - metabolism | Animals | I-kappa B Kinase - metabolism | Neoplasms - immunology | Protein Stability | Adaptor Proteins, Signal Transducing - metabolism | Tumor necrosis factor receptors | Pathogens | Antiinflammatory agents | proteasomes | Extracellular signal-regulated kinase | MAP kinase | Gene expression | Nuclei | IKK protein | Inflammatory diseases | Signal transduction | NF- Kappa B protein | Toll-like receptors | I Kappa B kinase | Cancer
IKK | ABIN‐2 | TLR | NF‐κB1 | MAPK | TPL‐2/COT | NF-κB1 | TPL-2/COT | ABIN-2 | INFLAMMATORY RESPONSES | PROTEIN-KINASE | P105 REQUIRES PHOSPHORYLATION | LIPOPOLYSACCHARIDE ACTIVATION | COT | IKK-BETA | IMMUNOLOGY | NF-KAPPA-B1 P105 | TPL-2 | NF-?B1 | TOLL-LIKE RECEPTORS | TUMOR-ASSOCIATED MACROPHAGES | TNF-ALPHA | PHARMACOLOGICAL INHIBITION | Autoimmunity | Neoplasms - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Phosphorylation | Humans | Inflammation - immunology | Proto-Oncogene Proteins - chemistry | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Inflammation - complications | Neoplasms - complications | Inflammation - metabolism | Animals | I-kappa B Kinase - metabolism | Neoplasms - immunology | Protein Stability | Adaptor Proteins, Signal Transducing - metabolism | Tumor necrosis factor receptors | Pathogens | Antiinflammatory agents | proteasomes | Extracellular signal-regulated kinase | MAP kinase | Gene expression | Nuclei | IKK protein | Inflammatory diseases | Signal transduction | NF- Kappa B protein | Toll-like receptors | I Kappa B kinase | Cancer
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 06/2013, Volume 33, Issue 11, pp. 2252 - 2259
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SURVIVAL | ACTIVATION | INHIBITION | ASK1 | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHORYLATES | IKK | DIFFERENTIATION | SUPPRESSION | CELL-DEATH | CELL BIOLOGY | Phosphorylation | MAP Kinase Kinase Kinase 5 - genetics | Neurites - physiology | Signal Transduction | Hydrogen Peroxide - pharmacology | Cercopithecus aethiops | Morpholines - pharmacology | Rats | COS Cells - drug effects | I-kappa B Kinase - genetics | PC12 Cells | Serine - metabolism | Proto-Oncogene Proteins c-akt - genetics | COS Cells - metabolism | Animals | I-kappa B Kinase - metabolism | Mice | Apoptosis - physiology | MAP Kinase Kinase Kinase 5 - metabolism | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
SURVIVAL | ACTIVATION | INHIBITION | ASK1 | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHORYLATES | IKK | DIFFERENTIATION | SUPPRESSION | CELL-DEATH | CELL BIOLOGY | Phosphorylation | MAP Kinase Kinase Kinase 5 - genetics | Neurites - physiology | Signal Transduction | Hydrogen Peroxide - pharmacology | Cercopithecus aethiops | Morpholines - pharmacology | Rats | COS Cells - drug effects | I-kappa B Kinase - genetics | PC12 Cells | Serine - metabolism | Proto-Oncogene Proteins c-akt - genetics | COS Cells - metabolism | Animals | I-kappa B Kinase - metabolism | Mice | Apoptosis - physiology | MAP Kinase Kinase Kinase 5 - metabolism | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
Journal Article