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1. Full Text The IκB kinase complex in NF‐κB regulation and beyond
by Hinz, Michael and Scheidereit, Claus
EMBO reports, ISSN 1469-221X, 01/2014, Volume 15, Issue 1, pp. 46 - 61
The IκB kinase (IKK) complex is the signal integration hub for NF‐κB activation. Composed of two serine‐threonine kinases (IKKα and IKKβ) and the regulatory... 
development | cancer | differentiation | immunity | inflammation | Development | Inflammation | Differentiation | Immunity | Cancer | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANHIDROTIC ECTODERMAL DYSPLASIA | NECROSIS-FACTOR-ALPHA | NEGATIVE FEEDBACK LOOP | TUMOR-INITIATING CELLS | CELL BIOLOGY | UBIQUITIN CHAINS | GENE-EXPRESSION | GAMMA-DEPENDENT PHOSPHORYLATION | SQUAMOUS-CELL CARCINOMAS | NUCLEAR IKK ACTIVITY | Feedback, Physiological | Phosphorylation | Ubiquitination | Animals | Signal Transduction | Humans | Protein Multimerization | NF-kappa B - metabolism | Ubiquitin - physiology | I-kappa B Kinase - physiology | Protein Interaction Maps | Reviews
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2. Full Text Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase
by Gantke, T and Sriskantharajah, S and Ley, SC
Cell Research, ISSN 1001-0602, 01/2011, Volume 21, Issue 1, pp. 131 - 145
The I kappa B kinase (IKK) complex plays a well-documented role in innate and adaptive immunity. This function has been widely attributed to its role as the... 
SIGNALING PATHWAYS | ACTIVATED PROTEIN-KINASE | ABIN-2 | P105 REQUIRES PHOSPHORYLATION | LIPOPOLYSACCHARIDE ACTIVATION | IKK | COT | MAP kinase | NF-KAPPA-B1 P105 | TUMOR PROGRESSION LOCUS-2 | CELL BIOLOGY | TPL-2 | LPS-STIMULATED MACROPHAGES | NF-kappa B | p105 | T-CELL LYMPHOMAS | MAP3K8 | TLR | TNF-ALPHA | A20-BINDING INHIBITOR | Proto-Oncogene Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | I-kappa B Kinase - metabolism | Signal Transduction | Antigens, Nuclear - metabolism | Humans | NF-kappa B - physiology | Proto-Oncogene Proteins - physiology | MAP Kinase Kinase Kinases - physiology | NF-kappa B - metabolism | MAP Kinase Kinase Kinases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | NF-κB | Review
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3. Full Text I kappa B Kinase alpha/beta Control Biliary Homeostasis and Hepatocarcinogenesis in Mice by Phosphorylating the Cell-Death Mediator Receptor-Interacting Protein Kinase 1
by Koppe, Christiane and Verheugd, Patricia and Gautheron, Jeremie and Reisinger, Florian and Kreggenwinkel, Karina and Roderburg, Christoph and Quagliata, Luca and Terracciano, Luigi and Gassler, Nikolaus and Tolba, Rene H and Boege, Yannick and Weber, Achim and Karin, Michael and Luedde, Mark and Neumann, Ulf P and Weiskirchen, Ralf and Tacke, Frank and Vucur, Mihael and Trautwein, Christian and Luescher, Bernhard and Preisinger, Christian and Heikenwalder, Mathias and Luedde, Tom
Hepatology, ISSN 0270-9139, 10/2016, Volume 64, Issue 4, pp. 1217 - 1231
The IκB‐Kinase (IKK) complex—consisting of the catalytic subunits, IKKα and IKKβ, as well as the regulatory subunit, NEMO—mediates activation of the nuclear... 
INACTIVATION | RIP1 KINASE | APOPTOSIS | HEPATOCELLULAR-CARCINOMA | NECROSIS | IKK-ALPHA | STEATOHEPATITIS | PROLIFERATION | IDENTIFICATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Liver Neoplasms - etiology | Phosphorylation | Animals | Ubiquitin-Protein Ligases - metabolism | Homeostasis | Bile Ducts, Intrahepatic | Male | Mice | Carcinogenesis | I-kappa B Kinase - physiology | Index Medicus
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4. Full Text IκB kinase regulates social defeat stress-induced synaptic and behavioral plasticity
by Christoffel, Daniel J and Golden, Sam A and Dumitriu, Dani and Robison, Alfred J and Janssen, William G and Ahn, H. Francisca and Krishnan, Vaishnav and Reyes, Cindy M and Han, Ming-Hu and Ables, Jessica L and Eisch, Amelia J and Dietz, David M and Ferguson, Deveroux and Neve, Rachael L and Greengard, Paul and Kim, Yong and Morrison, John H and Russo, Scott J
Journal of Neuroscience, ISSN 0270-6474, 01/2011, Volume 31, Issue 1, pp. 314 - 321
The neurobiological underpinnings of mood and anxiety disorders have been linked to the nucleus accumbens (NAc), a region important in processing the rewarding... 
DENDRITIC SPINES | DEPRESSION | AMPA RECEPTORS | SENSITIZATION | CONNECTIVITY | SYNAPSES | COCAINE | EXPRESSION | NEUROSCIENCES | MORPHOLOGY | RAT NUCLEUS-ACCUMBENS | Neurons - pathology | Isoquinolines | Microscopy, Electron, Transmission - methods | Male | Dendritic Spines - metabolism | Green Fluorescent Proteins - genetics | Statistics as Topic | Gene Expression Regulation, Enzymologic - physiology | Behavior, Animal | Exploratory Behavior - physiology | Neuronal Plasticity - physiology | Neurons - ultrastructure | I-kappa B Kinase - metabolism | Neurons - physiology | Interpersonal Relations | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Nucleus Accumbens - pathology | Gene Transfer Techniques | Mice, Inbred C57BL | I-kappa B Kinase - genetics | Mutation - genetics | Microscopy, Confocal - methods | Stress, Psychological - pathology | Patch-Clamp Techniques | Animals | Analysis of Variance | Signal Transduction - drug effects | Dendritic Spines - pathology | Signal Transduction - physiology | Mice | Dendritic Spines - ultrastructure | Stress, Psychological - physiopathology
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5. Full Text Vitamin D receptor inhibits nuclear factor κb activation by interacting with IκB kinase β protein
by Chen, Yunzi and Zhang, Jing and Ge, Xin and Du, Jie and Deb, Dilip K and Li, Yan Chun
Journal of Biological Chemistry, ISSN 0021-9258, 07/2013, Volume 288, Issue 27, pp. 19450 - 19458
1,25-Dihydroxyvitamin D (1,25(OH)(2)D-3) is known to suppress NF-kappa B activity, but the underlying mechanism remains poorly understood. Here we show that... 
CELLS | P65 SUBUNIT | HORMONE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA ELEMENT | TRANSCRIPTIONAL REPRESSION | DOWN-REGULATION | 1,25-DIHYDROXYVITAMIN D-3 | EXPRESSION | 1-ALPHA,25-DIHYDROXYVITAMIN D-3 | GENE-TRANSCRIPTION | Protein Structure, Tertiary | NF-kappa B p50 Subunit - metabolism | Humans | I-kappa B Kinase - genetics | NF-kappa B p50 Subunit - genetics | Receptors, Calcitriol - metabolism | Receptors, Calcitriol - genetics | Transcription Factor RelA - genetics | Mice, Knockout | Phosphorylation - genetics | Animals | Cell Nucleus - metabolism | Cell Nucleus - genetics | I-kappa B Kinase - metabolism | Peptide Mapping | Transcription Factor RelA - metabolism | Active Transport, Cell Nucleus - drug effects | Calcitriol - pharmacology | HEK293 Cells | Mice | Phosphorylation - drug effects | Active Transport, Cell Nucleus - genetics | NF-κB | Signal Transduction | Vitamin D | Inflammation | IKKβ | Nuclear Receptors | Protein-Protein Interactions
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6. Full Text Crystal structure of inhibitor of κb kinase β
by Xu, Guozhou and Lo, Yu-Chih and Li, Qiubai and Napolitano, Gennaro and Wu, Xuefeng and Jiang, Xuliang and Dreano, Michel and Karin, Michael and Wu, Hao
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7343, pp. 325 - 330
Inhibitor of kappa B (I kappa B) kinase (IKK) phosphorylates I kappa B proteins, leading to their degradation and the liberation of nuclear factor kappa B for... 
CATALYTIC SUBUNIT | COMPLEX | ACTIVATION | UBIQUITIN-LIKE DOMAIN | DOCKING INTERACTIONS | PHOSPHORYLATION | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | IKK-BETA | ALPHA | BINDING | Protein Structure, Tertiary | Biocatalysis | Humans | Protein Multimerization | Xenopus laevis | Ubiquitin - chemistry | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Amino Acid Motifs | Animals | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Protein Binding | Enzyme Activation | I-kappa B Kinase - chemistry
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7. Full Text I kappa B kinase phosphorylation of SNAP-23 controls platelet secretion
by Karim, ZA and Zhang, JC and Banerjee, M and Chicka, MC and Al Hawas, R and Hamilton, TR and Roche, PA and Whiteheart, SW
BLOOD, ISSN 0006-4971, 05/2013, Volume 121, Issue 22, pp. 4567 - 4574
Platelet secretion plays a key role in thrombosis, thus the platelet secretory machinery offers a unique target to modulate hemostasis. We report the... 
COMPLEX | EXOCYTOSIS | GRANULE RELEASE | INFLAMMATION | MICE | SYNTAXIN 2 | PROTEINS | HEMATOLOGY | ACTIVATED PLATELETS | MOLECULAR-MECHANISMS | SNARE | Phosphorylation - physiology | Hemostasis - physiology | Platelet Activation - physiology | Qb-SNARE Proteins - metabolism | I-kappa B Kinase - genetics | Blood Platelets - secretion | Mice, Knockout | Animals | I-kappa B Kinase - metabolism | Qc-SNARE Proteins - metabolism | Blood Platelets - metabolism | Cytoplasmic Granules - metabolism | Signal Transduction - physiology | Mice | Membrane Fusion - physiology | Enzyme Activation - physiology | SNARE Proteins - metabolism | Platelets and Thrombopoiesis
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8. Full Text Blockade of oncogenic IκB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors
by Michele Ceribelli and Priscilla N. Kelly and Arthur L. Shaffer and George W. Wright and Wenming Xiao and Yibin Yang and Lesley A. Mathews Griner and Rajarshi Guha and Paul Shinn and Jonathan M. Keller and Dongbo Liu and Paresma R. Patel and Marc Ferrer and Shivangi Joshi and Sujata Nerle and Peter Sandy and Emmanuel Normant and Craig J. Thomas and Louis M. Staudt
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 31, pp. 11365 - 11370
In the activated B-cell—like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), NF-κB activity is essential for viability of the malignant cells and is... 
Betting | B lymphocytes | Genes | B cell lymphoma | Cell lines | Multiple myeloma | Signatures | Viability | Heterologous transplantation | Tumors | Cancer therapy | Drug synergism | SELECTIVE-INHIBITION | TARGET | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | DISCOVERY | cancer therapy | SUPER-ENHANCERS | MYC | GENE-EXPRESSION | drug synergism | LEUKEMIA | BET BROMODOMAINS | BRD4 | Humans | Triazoles - toxicity | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Death - drug effects | Azepines - toxicity | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Protein Structure, Tertiary | Lymphoma, Large B-Cell, Diffuse - pathology | Cell Survival | Lymphoma, Large B-Cell, Diffuse - enzymology | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Pyrimidines - pharmacology | Mice, SCID | Azepines - pharmacology | Drug Synergism | Transcription Factors - metabolism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | I-kappa B Kinase - chemistry | Biological Sciences
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9. Full Text IκB kinase regulation of the TPL‐2/ERK MAPK pathway
by Gantke, Thorsten and Sriskantharajah, Srividya and Sadowski, Michael and Ley, Steven C
Immunological Reviews, ISSN 0105-2896, 03/2012, Volume 246, Issue 1, pp. 168 - 182
Nuclear factor‐κB (NF‐κB) and mitogen‐activated protein kinase (MAPK) activation play central roles in the induction of gene expression in innate immune cells... 
IKK | ABIN‐2 | TLR | NF‐κB1 | MAPK | TPL‐2/COT | NF-κB1 | TPL-2/COT | ABIN-2 | INFLAMMATORY RESPONSES | PROTEIN-KINASE | P105 REQUIRES PHOSPHORYLATION | LIPOPOLYSACCHARIDE ACTIVATION | COT | IKK-BETA | IMMUNOLOGY | NF-KAPPA-B1 P105 | TPL-2 | NF-?B1 | TOLL-LIKE RECEPTORS | TUMOR-ASSOCIATED MACROPHAGES | TNF-ALPHA | PHARMACOLOGICAL INHIBITION | Autoimmunity | Neoplasms - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Phosphorylation | Humans | Inflammation - immunology | Proto-Oncogene Proteins - chemistry | Extracellular Signal-Regulated MAP Kinases - metabolism | MAP Kinase Signaling System | Inflammation - complications | Neoplasms - complications | Inflammation - metabolism | Animals | I-kappa B Kinase - metabolism | Neoplasms - immunology | Protein Stability | Adaptor Proteins, Signal Transducing - metabolism | Tumor necrosis factor receptors | Pathogens | Antiinflammatory agents | proteasomes | Extracellular signal-regulated kinase | MAP kinase | Gene expression | Nuclei | IKK protein | Inflammatory diseases | Signal transduction | NF- Kappa B protein | Toll-like receptors | I Kappa B kinase | Cancer
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10. Full Text Integration of Apoptosis Signal-Regulating Kinase 1-Mediated Stress Signaling with the Akt/Protein Kinase B-IκB Kinase Cascade
by Mary C. Puckett and Erinn H. Goldman and Lisa M. Cockrell and Bei Huang and Andrea L. Kasinski and Yuhong Du and Cun-Yu Wang and Anning Lin and Hidenori Ichijo and Fadlo Khuri and Haian Fu
Molecular and Cellular Biology, ISSN 0270-7306, 06/2013, Volume 33, Issue 11, pp. 2252 - 2259
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
SURVIVAL | ACTIVATION | INHIBITION | ASK1 | INFLAMMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHORYLATES | IKK | DIFFERENTIATION | SUPPRESSION | CELL-DEATH | CELL BIOLOGY | Phosphorylation | MAP Kinase Kinase Kinase 5 - genetics | Neurites - physiology | Signal Transduction | Hydrogen Peroxide - pharmacology | Cercopithecus aethiops | Morpholines - pharmacology | Rats | COS Cells - drug effects | I-kappa B Kinase - genetics | PC12 Cells | Serine - metabolism | Proto-Oncogene Proteins c-akt - genetics | COS Cells - metabolism | Animals | I-kappa B Kinase - metabolism | Mice | Apoptosis - physiology | MAP Kinase Kinase Kinase 5 - metabolism | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Proto-Oncogene Proteins c-akt - antagonists & inhibitors
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