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International Immunopharmacology, ISSN 1567-5769, 09/2011, Volume 11, Issue 9, pp. 1166 - 1172
(AS), an herb used in traditional Chinese medicine, is thought to have anti-inflammatory activities. Ligustilide is its most abundant ingredient. This study... 
Mitogen-activated protein kinase | Activator protein-1 | Ligustilide | Nitric oxide | Nuclear factor κB | ACTIVATION | NITRIC-OXIDE SYNTHASE | DYSMENORRHEA | IMMUNOLOGY | ENDOMETRIOSIS | Nuclear factor kappa B | ISOBENZOFURANONE | PATHOGENESIS | ANTIOXIDANT | PHARMACOLOGY & PHARMACY | TNF-ALPHA | ANGELICA-SINENSIS | PROSTAGLANDIN E-2 | Nitric Oxide Synthase Type II - biosynthesis | Reactive Oxygen Species - metabolism | Transcription Factor RelA - antagonists & inhibitors | Dinoprostone - biosynthesis | Transcription Factor AP-1 - genetics | Transcription Factor AP-1 - metabolism | Transcription Factor RelA - genetics | Mitogen-Activated Protein Kinase Kinases - metabolism | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Nitric Oxide Synthase Type II - antagonists & inhibitors | MAP Kinase Kinase 4 - antagonists & inhibitors | Phosphorylation - drug effects | Cell Line | Nitric Oxide - biosynthesis | Nitric Oxide - antagonists & inhibitors | 4-Butyrolactone - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | I-kappa B Kinase - genetics | Down-Regulation - drug effects | Macrophages - enzymology | Macrophages - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Transcription Factor AP-1 - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Nitric Oxide Synthase Type II - genetics | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | 4-Butyrolactone - analogs & derivatives | Dinoprostone - antagonists & inhibitors | Tumor Necrosis Factor-alpha - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 31, pp. 11365 - 11370
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 09/2012, Volume 342, Issue 3, pp. 654 - 664
Nodakenin, a coumarin isolated from the roots of Angelicae gigas, has been reported to possess neuroprotective, antiaggregatory, antibacterial, and... 
ACTIVATION | CYTOKINES | CYCLOOXYGENASE-2 | RAW264.7 CELLS | NITRIC-OXIDE SYNTHASE | KINASE | SEPTIC SHOCK | PHARMACOLOGY & PHARMACY | MEDIATORS | SEPSIS | ANGELICA-GIGAS | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Tumor Necrosis Factor-alpha - genetics | Male | NF-kappa B - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Interleukin-1beta - genetics | Promoter Regions, Genetic - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Inflammation - metabolism | Phosphorylation - genetics | Drug Interactions | Ubiquitination - drug effects | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Phosphorylation - drug effects | TNF Receptor-Associated Factor 6 - genetics | Interleukin-6 - metabolism | Interleukin-1beta - antagonists & inhibitors | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Interleukin-6 - genetics | Anti-Inflammatory Agents - pharmacology | Dinoprostone - genetics | MAP Kinase Kinase Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Down-Regulation - genetics | Coumarins - pharmacology | Dinoprostone - metabolism | Macrophages - metabolism | Signal Transduction - drug effects | Nitric Oxide - genetics | Lipopolysaccharides - pharmacology | Mice | Transcription, Genetic - genetics | Dinoprostone - antagonists & inhibitors | Nitric Oxide Synthase Type II - metabolism | Tumor Necrosis Factor-alpha - metabolism | Mitogen-Activated Protein Kinase Kinases - genetics | Shock, Septic - prevention & control | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Shock, Septic - metabolism | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Inflammation - drug therapy | Nitric Oxide Synthase Type II - antagonists & inhibitors | I-kappa B Proteins - antagonists & inhibitors | Shock, Septic - drug therapy | Glucosides - pharmacology | Nitric Oxide - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | I-kappa B Kinase - genetics | Down-Regulation - drug effects | Animals | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Inflammation - genetics | Macrophages - drug effects | Nitric Oxide - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Ubiquitination - genetics
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2014, Volume 461, Issue 3, pp. 531 - 537
IKK beta {I kappa B [inhibitor of NF-kappa B (nuclear factor kappa B)] kinase beta} is required to activate the transcription factor NF-kappa B, but how IKK... 
Inhibitor of nuclear factor κB kinase (IKK) | Linear ubiquitin chain assembly complex (LUBAC) | Nuclear factor κB(NF-κB) | Transforming growth factor β-activated kinase-1 (TAK1) | Interleukin-1 (IL-1) | nuclear factor kappa B (NF-kappa B) | linear ubiquitin chain assembly complex (LUBAC) | SIGNALING PATHWAYS | PROTEIN | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | interleukin-1 (IL-1) | KINASE COMPLEX | transforming growth factor beta-activated kinase-1 (TAK1) | UBIQUITIN CHAINS | INFLAMMATION | inhibitor of nuclear factor kappa B kinase (IKK) | POLYUBIQUITIN CHAINS | NF-KAPPA-B | NEMO | BINDING | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | I-kappa B Kinase - antagonists & inhibitors | HEK293 Cells | Protein Interaction Domains and Motifs | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - genetics | Mutant Proteins - antagonists & inhibitors | Recombinant Proteins - metabolism | Cells, Cultured | Mutant Proteins - genetics | Recombinant Proteins - chemistry | Mice, Transgenic | Mutant Proteins - metabolism | MAP Kinase Kinase Kinases - metabolism | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Serine - metabolism | Gene Knock-In Techniques | Animals | Embryo, Mammalian - cytology | Mutant Proteins - chemistry | Mice | Protein Kinase Inhibitors - pharmacology | I-kappa B Kinase - chemistry | Amino Acid Substitution | Index Medicus | NEMO, NF-κB essential modulator | TLR, Toll-like receptor | IKK, IκB kinase | TNF, tumour necrosis factor | transforming growth factor β-activated kinase-1 (TAK1) | HEK, human embryonic kidney | IL-1, interleukin-1 | JNK, c-Jun N-terminal kinase | PP1γ, protein phosphatase 1γ | TRAF, TNF receptor-associated factor | inhibitor of nuclear factor κB kinase (IKK) | LUBAC, linear ubiquitin chain assembly complex | HOIP, HOIL1 [haem-oxidized IRP2 (iron regulatory protein 2) ubiquitin ligase 1]-interacting protein | IκB, inhibitor of NF-κB | TAB, TAK1-binding protein | TAK1, transforming growth factor β-activated kinase-1 | BMDM, bone-marrow-derived macrophage | NF-κB, nuclear factor κB | M-CSF, macrophage colony-stimulating factor | MKK, MAPK kinase | Accelerated Publication | E, embryonic day | MEF, mouse embryonic fibroblast | HA, haemaglutinnin | LPS, lipopolysaccharide | nuclear factor κB (NF-κB) | MAPK, mitogen-activated protein kinase
Journal Article
Oncogene, ISSN 0950-9232, 03/2006, Volume 25, Issue 10, pp. 1463 - 1473
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2011, Volume 44, Issue 4, pp. 559 - 571
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 45, pp. 18689 - 18698
Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in innate immune signaling by Toll-like receptors (TLRs), and loss of IRAK4 activity... 
cytokine | GENE-EXPRESSION SIGNATURE | INTERLEUKIN-1 | ACTIVATION | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IKK | IKK-BETA | PERIPHERAL-BLOOD | NFB | IRAK4 | INDUCTION | LUPUS | TAK1 | inflammation | interferon regulatory factor | IRF5 | TLR | NF-KAPPA-B | Toll-like receptor | Interleukin-1 Receptor-Associated Kinases - metabolism | Monocytes - cytology | Humans | Interferon Regulatory Factors - metabolism | Monocytes - metabolism | NF-kappa B - metabolism | Monocytes - immunology | MAP Kinase Kinase Kinases - chemistry | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | I-kappa B Kinase - antagonists & inhibitors | Interferon Regulatory Factors - agonists | Phosphorylation - drug effects | MAP Kinase Kinase Kinases - antagonists & inhibitors | Single-Cell Analysis | Cytokines - genetics | Toll-Like Receptor 8 - agonists | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - metabolism | Cytokines - metabolism | NF-kappa B p50 Subunit - metabolism | Cytokines - agonists | Cells, Cultured | Computational Biology | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Gene Expression Regulation - drug effects | Monocytes - drug effects | Models, Immunological | Animals | Active Transport, Cell Nucleus - drug effects | Interleukin-1 Receptor-Associated Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | I-kappa B Kinase - chemistry | Toll-Like Receptor 8 - metabolism | Signal Transduction | NFκB | IKKβ
Journal Article
International Immunopharmacology, ISSN 1567-5769, 02/2012, Volume 12, Issue 2, pp. 368 - 377
Nuclear factor kappa B (NF-κB) is a key signaling molecule in the elaboration of the inflammatory response. Data indicate that curcumin, a natural ingredient... 
NF-κB | Curcumin | Inflammation | Anti-cancer | Macrophages | APOPTOSIS | CELLS | EF24 | PANCREATIC-CANCER | IMMUNOLOGY | PTEN EXPRESSION | NF-kappa B | IMMUNE-SYSTEM | CARDIOVASCULAR-DISEASE | LIPOPOLYSACCHARIDE | PHARMACOLOGY & PHARMACY | TNF-ALPHA | Tumor Necrosis Factor-alpha - metabolism | Curcumin - analogs & derivatives | Interleukin-6 - antagonists & inhibitors | NF-kappa B - metabolism | Protein Transport - drug effects | DNA-Binding Proteins - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Interleukin-1beta - metabolism | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Interleukin-6 - metabolism | Interleukin-1beta - antagonists & inhibitors | Cell Survival - drug effects | NF-kappa B - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Anti-Inflammatory Agents - pharmacology | Curcumin - pharmacology | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Piperidones - pharmacology | Animals | Benzylidene Compounds - pharmacology | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Cell Line, Tumor | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Tumor Necrosis Factor-alpha - antagonists & inhibitors
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2012, Volume 122, Issue 7, pp. 2601 - 2612
Journal Article