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The Journal of biological chemistry, ISSN 1083-351X, 2007, Volume 282, Issue 50, pp. 36223 - 36229
The Rip2 kinase contains a caspase recruitment domain and has been implicated in the activation of the transcriptional factor NF... 
PEPTIDOGLYCAN | PROTEIN | INNATE IMMUNE-RESPONSES | HOST RECOGNITION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | TOLL-LIKE RECEPTOR | SYSTEMS | NF-KAPPA-B | TLR4 | MYD88 | Mycobacterium tuberculosis - immunology | Ubiquitin - metabolism | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Ubiquitination - drug effects | TNF Receptor-Associated Factor 6 - genetics | Toll-Like Receptors - metabolism | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Macrophages - microbiology | MAP Kinase Kinase Kinases - genetics | Toll-Like Receptors - immunology | Myeloid Differentiation Factor 88 - genetics | Ubiquitin-Protein Ligases - metabolism | Nod2 Signaling Adaptor Protein - immunology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ubiquitin - genetics | MAP Kinase Kinase Kinases - immunology | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Macrophages - metabolism | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Toll-Like Receptors - genetics | I-kappa B Kinase - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Adjuvants, Immunologic - pharmacology | NF-kappa B - immunology | TNF Receptor-Associated Factor 6 - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Enzyme Activation - immunology | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | I-kappa B Kinase - metabolism | Myeloid Differentiation Factor 88 - immunology | Ubiquitin-Conjugating Enzymes - immunology | Tuberculosis - metabolism | Macrophages - immunology | Cells, Cultured | Ubiquitination - immunology | I-kappa B Kinase - genetics | Enzyme Activation - drug effects | Tuberculosis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | NF-kappa B - genetics | Tuberculosis - genetics | TNF Receptor-Associated Factor 6 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Ubiquitin - immunology
Journal Article
Molecular cell, ISSN 1097-2765, 2010, Volume 40, Issue 1, pp. 75 - 86
.... This response is mediated by a conserved pathway involving the nuclear ATM kinase and cytoplasmic IκB kinase (IKK... 
PROTEIN | POLYUBIQUITIN | ISOFORMS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NF-KAPPA-B | BINDING | CELL BIOLOGY | Protein-Serine-Threonine Kinases - deficiency | Humans | Male | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | RNA Interference | Time Factors | Tumor Suppressor Proteins - deficiency | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | MAP Kinase Kinase Kinases - genetics | Cell Cycle Proteins - metabolism | Etoposide - pharmacology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Mice | DNA Damage | Enzyme Activation | Mutation | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Pyrones - pharmacology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Transfection | I-kappa B Kinase - metabolism | MAP Kinase Kinase Kinases - deficiency | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cell Line | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Morpholines - pharmacology | I-kappa B Kinase - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Camptothecin - pharmacology | Ubiquitin | Ligases | Lysine | Oncology, Experimental | Automated teller machines | Research | Glutamate | Cancer
Journal Article
The Journal of cell biology, ISSN 1540-8140, 2014, Volume 204, Issue 2, pp. 231 - 245
Journal Article
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 6/2014, Volume 111, Issue 23, pp. 8329 - 8329
Journal Article
Nature cell biology, ISSN 1476-4679, 2004, Volume 6, Issue 2, pp. 97 - 105
.... The pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha triggers a signalling cascade, converging on the activation of the transcription factor NF-kappa B, which forms the basis for numerous physiological and pathological processes... 
ACTIVATION | GENERATION | PROTEIN | P52 | KINASE | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Molecular Chaperones - metabolism | Humans | Tumor Necrosis Factor-alpha - genetics | NF-kappa B - metabolism | Tacrolimus Binding Proteins - metabolism | I-kappa B Proteins - metabolism | RNA Interference | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | HSP90 Heat-Shock Proteins - genetics | Chromatography, Affinity - methods | Receptors, Tumor Necrosis Factor - metabolism | Cell Line | Drosophila Proteins | Tumor Suppressor Proteins - metabolism | MAP Kinase Kinase Kinases - genetics | Cell Cycle Proteins - metabolism | I-kappa B Proteins - isolation & purification | Molecular Chaperones - genetics | MAP Kinase Kinase Kinases - metabolism | Proteome - analysis | Tumor Necrosis Factor-alpha - isolation & purification | Macromolecular Substances | Tacrolimus Binding Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | NF-kappa B - genetics | NF-kappa B - isolation & purification | Models, Biological | HSP90 Heat-Shock Proteins - metabolism | Signal Transduction - physiology | Enzyme Activation | MAP Kinase Kinase Kinase 3 | Mass Spectrometry - methods | Chaperonins
Journal Article
Molecular cell, ISSN 1097-2765, 2010, Volume 40, Issue 1, pp. 63 - 74
... phosphorylation and subsequent ubiquitination were implicated to activate the cytoplasmic IκB kinase (IKK) complex by unknown mechanisms... 
MOLECULAR-MECHANISM | POLY(ADP-RIBOSYL)ATION | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | DOUBLE-STRAND BREAKS | POLYUBIQUITIN CHAINS | ATM | BINDING | NEMO | PROTEIN-KINASES | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Calcium - metabolism | Inhibitor of Apoptosis Proteins - genetics | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | DNA Breaks, Double-Stranded | Cell Nucleus - enzymology | DNA-Binding Proteins - metabolism | Cytosol - enzymology | Ubiquitination | Transfection | I-kappa B Kinase - metabolism | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Inhibitor of Apoptosis Proteins - metabolism | TNF Receptor-Associated Factor 6 - genetics | Protein-Serine-Threonine Kinases - metabolism | Recombinant Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Hep G2 Cells | Protein Transport | Ubiquitin-Protein Ligases | Poly(ADP-ribose) Polymerases - metabolism | NF-kappa B - genetics | Ubiquitin-Conjugating Enzymes - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Protein Binding | DNA Damage | HeLa Cells | Mutation | Poly (ADP-Ribose) Polymerase-1 | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 3, p. e0150893
...), the main fibrogenic cell type of the liver. Serum amyloid A potently activated I.B kinase, c-Jun N-terminal kinase (JNK... 
APOPTOSIS | HUMAN NEUTROPHILS | ACUTE-PHASE REACTANT | RAT-LIVER FIBROSIS | MULTIDISCIPLINARY SCIENCES | SECRETION | MONOCYTE CHEMOTACTIC PROTEIN-1 | A SAA PROTEIN | NF-KAPPA-B | EXPRESSION | INTESTINAL EPITHELIAL-CELLS | Cholestasis - genetics | Cholestasis - metabolism | Serum Amyloid A Protein - pharmacology | Carbon Tetrachloride | Humans | Hepatic Stellate Cells - metabolism | Male | NF-kappa B - metabolism | Liver Cirrhosis - chemically induced | Proto-Oncogene Proteins c-akt - genetics | Matrix Metalloproteinase 9 - metabolism | Ligation | MAP Kinase Kinase 4 - metabolism | I-kappa B Kinase - metabolism | Matrix Metalloproteinase 9 - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Liver Cirrhosis - metabolism | Chemokine CCL2 - metabolism | Chemokine CCL5 - metabolism | Cell Death - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Liver Cirrhosis - genetics | Hepatic Stellate Cells - pathology | Disease Models, Animal | Hepatic Stellate Cells - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Gene Expression Regulation | Rats | Chemokine CCL2 - genetics | Inflammation | I-kappa B Kinase - genetics | Rats, Sprague-Dawley | Cholestasis - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | NF-kappa B - genetics | Chemokine CCL5 - genetics | Liver Cirrhosis - pathology | MAP Kinase Kinase 4 - genetics | Cell Proliferation - drug effects | Mice, Inbred BALB C | Primary Cell Culture | Mitogen-Activated Protein Kinase 1 - metabolism | Biochemistry | RNA | Cell death | Luciferase | Cell proliferation | Animal models | Transcription factors | Transcription | RANTES | Liver | Carbon tetrachloride | Cytotoxicity | AKT protein | Kinases | Caspase-3 | Proteins | Signal transduction | Immunology | Rodents | Hepatology | Gastroenterology | Fibroblasts | Amyloid | NF-κB protein | Stellate cells | Cytokines | Mortality | Neutrophils | Extracellular signal-regulated kinase | c-Jun protein | Caspase | Poly(ADP-ribose) polymerase | CCL4 protein | Bile duct | Gelatinase B | Medicine | Antibiotics | Hepatocytes | Surgeons | Skin | Annexin V | Monocyte chemoattractant protein 1 | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2010, Volume 107, Issue 30, pp. 13450 - 13455
.... Endothelial transcriptome microarray analysis of miR-10a knockdown in cultured human aortic endothelial cells (HAEC) identified IκB/NF-κB... 
Untranslated regions | Up regulation | Phenotypes | MicroRNA | Genes | Atherosclerosis | Gene expression regulation | Endothelial cells | Binding sites | Endothelium | NF-κB | β-transducing repeat-containing gene | Mitogen-activated kinase kinase kinase 7 | Hemodynamics | TRANSCRIPTION FACTORS | ACTIVATION | ANGIOGENESIS | FLUID SHEAR-STRESS | MULTIDISCIPLINARY SCIENCES | mitogen-activated kinase kinase kinase 7 | ATHEROSCLEROSIS | hemodynamics | FLOW | NF-kappa B | REGIONS | beta-transducing repeat-containing gene | NF-KAPPA-B | EXPRESSION | PORCINE AORTA | Oligonucleotide Array Sequence Analysis | Atherosclerosis - genetics | Homeodomain Proteins - metabolism | Humans | MicroRNAs - metabolism | NF-kappa B - metabolism | Gene Expression Profiling | I-kappa B Proteins - metabolism | Gene Knockdown Techniques | beta-Transducin Repeat-Containing Proteins - metabolism | Swine | Aorta, Thoracic - pathology | beta-Transducin Repeat-Containing Proteins - genetics | Endothelium - pathology | Cell Line | Genetic Predisposition to Disease | NF-KappaB Inhibitor alpha | Endothelial Cells - metabolism | MAP Kinase Kinase Kinases - genetics | Cells, Cultured | Aorta, Thoracic - metabolism | In Situ Hybridization, Fluorescence | MAP Kinase Kinase Kinases - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Phenotype | Animals | Endothelium - metabolism | Inflammation - genetics | MicroRNAs - genetics | Endothelial Cells - pathology | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2001, Volume 98, Issue 15, pp. 8774 - 8779
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2008, Volume 321, Issue 5889, pp. 663 - 668
Journal Article