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Journal of Clinical Investigation, ISSN 0021-9738, 10/2012, Volume 122, Issue 10, pp. 3563 - 3578
The strength and duration of NF-kappa B signaling are tightly controlled by multiple negative feedback mechanisms. However, in cancer cells, these feedback... 
UBIQUITINATION | MEDICINE, RESEARCH & EXPERIMENTAL | STEM-CELLS | KINASE | BREAST-CANCER PROGRESSION | PROGNOSTIC MARKER | ALPHA | CELL-PROLIFERATION | PATIENT SURVIVAL | EXPRESSION | A20 | Phosphorylation | MicroRNAs - antagonists & inhibitors | Deubiquitinating Enzyme CYLD | Humans | Brain Neoplasms - pathology | NF-kappa B - metabolism | Cell Line, Tumor - drug effects | Cell Line, Tumor - transplantation | Neoplasm Proteins - metabolism | Brain Neoplasms - metabolism | Glioma - metabolism | RNA - genetics | Glioma - genetics | Smad Proteins - biosynthesis | Ubiquitination - drug effects | I-kappa B Kinase - metabolism | Glioma - pathology | Tumor Suppressor Proteins - genetics | Neovascularization, Pathologic - physiopathology | Transcription, Genetic | Neoplasm Proteins - genetics | Cell Line, Tumor - metabolism | Genes, Reporter | NF-KappaB Inhibitor alpha | RNA, Neoplasm - physiology | Neoplasm Invasiveness | Neoplasm Proteins - biosynthesis | Transforming Growth Factor beta - physiology | Brain Neoplasms - genetics | MicroRNAs - biosynthesis | Smad Proteins - genetics | RNA - biosynthesis | Transforming Growth Factor beta - pharmacology | Tumor Suppressor Proteins - physiology | Animals | RNA, Neoplasm - biosynthesis | Signal Transduction - drug effects | Mice, Nude | RNA, Neoplasm - genetics | Mice | MicroRNAs - genetics | Protein Processing, Post-Translational | MicroRNAs - physiology | Tumor Suppressor Proteins - biosynthesis | I-kappa B Proteins - deficiency
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2010, Volume 430, Issue 1, pp. 141 - 149
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, p. e57208
Background: Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to neuronal damage and behavioral impairment. Toll-like... 
SYSTEM | ACTIVATION | INHIBITION | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | SPINAL-CORD-INJURY | RELEASE | NITRIC-OXIDE-SYNTHASE | NF-KAPPA-B | EXPRESSION | NEUROPROTECTION | Nitric Oxide Synthase Type II - biosynthesis | I-kappa B Proteins - immunology | Cerebral Cortex - pathology | MAP Kinase Kinase 4 - immunology | NF-kappa B - metabolism | Brain Injuries - metabolism | Interleukin-1beta - genetics | Tyrosine - analogs & derivatives | Inflammation - metabolism | Tryptases - immunology | NF-KappaB Inhibitor alpha | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - immunology | Brain Injuries - genetics | Poly(ADP-ribose) Polymerases - biosynthesis | Tyrosine - immunology | Mice, Knockout | Tyrosine - metabolism | Cerebral Cortex - immunology | Tryptases - biosynthesis | MAP Kinase Kinase 4 - genetics | Mice | Poly (ADP-Ribose) Polymerase-1 | Poly(ADP-ribose) Polymerases - immunology | Toll-Like Receptor 4 - biosynthesis | NF-kappa B - immunology | Brain Infarction - metabolism | Brain Infarction - pathology | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Cerebral Cortex - metabolism | Glial Fibrillary Acidic Protein | MAP Kinase Kinase 4 - metabolism | Brain Injuries - immunology | Nitric Oxide Synthase Type II - immunology | Nerve Tissue Proteins - biosynthesis | Interleukin-1beta - biosynthesis | Tryptases - genetics | Nerve Tissue Proteins - immunology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | Interleukin-1beta - immunology | Inflammation - immunology | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Animals | Poly(ADP-ribose) Polymerases - genetics | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Brain Infarction - immunology | Inflammation - genetics | Brain Infarction - genetics | Brain Injuries - pathology | Tyrosine - genetics | Brain | Brain damage | Brain research | Neurons | Injuries | Neuroprotection | Animal models | Traumatic brain injury | Bax protein | Bcl-2 protein | Control methods | Kinases | Proteins | Signal transduction | Receptors | Head injuries | Animal tissues | Toll-like receptors | Immune system | Translocation | NF-κB protein | Glial fibrillary acidic protein | Cortex | Poly(ADP-ribose) polymerase | JNK protein | Inflammation | TLR4 protein | IL-1β | Trauma | Nitric-oxide synthase | Chymase | Augmentation | Signaling | Injury prevention | Tryptase | Nitrotyrosine | Apoptosis
Journal Article
Oncogene, ISSN 0950-9232, 03/2003, Volume 22, Issue 9, pp. 1365 - 1370
We have demonstrated that nuclear factor-kappaB (NF-kappaB) is constitutively activated in human pancreatic adenocarcinoma and human pancreatic cancer cell... 
Angiogenesis | NF-κB | Tumorigenesis | Pancreatic cancer | IκBα | APOPTOSIS | METASTASIS | angiogenesis | ADENOCARCINOMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | INTERLEUKIN-8 | CELL BIOLOGY | pancreatic cancer | NF-kappa B | ONCOLOGY | I kappa B alpha | GENETICS & HEREDITY | tumorigenesis | PROTEINS | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | PANCREATIC-CANCER CELLS | Interleukin-8 - genetics | Neoplasm Transplantation | Vascular Endothelial Growth Factor A | Phosphorylation | Adenocarcinoma - pathology | Pancreatic Neoplasms - metabolism | Vascular Endothelial Growth Factors | Humans | Pancreatic Neoplasms - blood supply | Protein Processing, Post-Translational - genetics | Gene Expression Regulation, Neoplastic | Recombinant Fusion Proteins - physiology | Tumor Cells, Cultured - transplantation | I-kappa B Proteins - physiology | Intercellular Signaling Peptides and Proteins - biosynthesis | I-kappa B Proteins - genetics | Promoter Regions, Genetic - genetics | Luciferases - genetics | Adenocarcinoma - metabolism | Neovascularization, Pathologic - prevention & control | Lymphokines - biosynthesis | Neoplasm Proteins - genetics | Genes, Reporter | Recombinant Fusion Proteins - biosynthesis | bcl-X Protein | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Interleukin-8 - biosynthesis | Neoplasm Proteins - biosynthesis | Pancreatic Neoplasms - pathology | Tumor Cells, Cultured - metabolism | Endothelial Growth Factors - biosynthesis | Genes, bcl-2 | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Adenocarcinoma - blood supply | Tumor Necrosis Factor-alpha - pharmacology | Animals | Mice, Nude | NF-kappa B - physiology | Neovascularization, Pathologic - genetics | Mice | Mutation | Proto-Oncogene Proteins c-bcl-2 - genetics | Luciferases - biosynthesis
Journal Article
Medical oncology (Northwood, London, England), 09/2010, Volume 27, Issue 3, p. 833
The purpose of the present study is to evaluate the effects of arsenic trioxide (ATO) on human acute promyelocytic leukemia NB-4 cells. Microculture... 
Transcription, Genetic - drug effects | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Histone Acetyltransferases - biosynthesis | Humans | Heat-Shock Proteins - biosynthesis | Cell Line, Tumor - drug effects | Heat-Shock Proteins - genetics | RNA, Messenger - biosynthesis | Cell Line, Tumor - pathology | Lipocalins - genetics | Caspase 3 - genetics | Lysine Acetyltransferase 5 | Neoplasm Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - biosynthesis | Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis | NF-kappa B - antagonists & inhibitors | Ataxia Telangiectasia Mutated Proteins | I-kappa B Kinase - biosynthesis | Protein-Serine-Threonine Kinases - biosynthesis | Ubiquitin-Protein Ligases | Oxides - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - biosynthesis | Tumor Protein p73 | RNA, Neoplasm - biosynthesis | Lipocalin-2 | RNA, Neoplasm - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Tumor Suppressor Proteins - biosynthesis | Acute-Phase Proteins - biosynthesis | Lipocalins - biosynthesis | Microtubule-Associated Proteins - genetics | bcl-X Protein - genetics | Histone Acetyltransferases - genetics | Baculoviral IAP Repeat-Containing 3 Protein | Acute-Phase Proteins - genetics | Proto-Oncogene Proteins - biosynthesis | Sirtuin 1 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Nuclear Proteins - biosynthesis | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Caspase 3 - biosynthesis | bcl-X Protein - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Cell Line, Tumor - metabolism | Inhibitor of Apoptosis Proteins - biosynthesis | Neoplasm Proteins - biosynthesis | Arsenicals - pharmacology | Carrier Proteins - biosynthesis | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Sirtuin 1 - biosynthesis | Proto-Oncogene Proteins - genetics | Cell Cycle Proteins - biosynthesis | I-kappa B Kinase - genetics | DNA-Binding Proteins - genetics | Microtubule-Associated Proteins - biosynthesis | X-Linked Inhibitor of Apoptosis Protein - genetics | Carrier Proteins - genetics | DNA-Binding Proteins - biosynthesis
Journal Article
Inflammation, ISSN 0360-3997, 6/2014, Volume 37, Issue 3, pp. 956 - 965
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2012, Volume 13, Issue 6, pp. 543 - 550
Type I interferon is an integral component of the antiviral response, and its production is tightly controlled at the levels of transcription and translation.... 
SIGNALING PATHWAYS | INHIBITION | REDISTRIBUTION | DEPHOSPHORYLATION | INVOLVEMENT | NITRIC-OXIDE | INITIATION-FACTOR 4E | BINDING PROTEIN EIF4E | EUKARYOTIC TRANSLATION | IMMUNOLOGY | BETA | Phosphorylation | Protein Biosynthesis | I-kappa B Proteins - immunology | NF-kappa B - immunology | Eukaryotic Initiation Factor-4E - metabolism | Immunoblotting | NF-kappa B - metabolism | I-kappa B Proteins - biosynthesis | Interferon Type I - immunology | I-kappa B Proteins - genetics | Interferon Type I - biosynthesis | Vesicular Stomatitis - metabolism | Eukaryotic Initiation Factor-4E - immunology | Female | Electrophoretic Mobility Shift Assay | Vesicular stomatitis Indiana virus - physiology | NF-KappaB Inhibitor alpha | Specific Pathogen-Free Organisms | Mice, Inbred C57BL | RNA, Messenger - genetics | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Vesicular Stomatitis - genetics | Vesicular Stomatitis - immunology | Immunity, Innate - immunology | Animals | Virus Replication | RNA, Messenger - chemistry | Mice | Vesicular Stomatitis - virology | Vesicular stomatitis Indiana virus - immunology | Vesicular stomatitis Indiana virus | I-kappa B Proteins | Immunity, Innate | Eukaryotic Initiation Factor-4E | Interferon Type I | Life Sciences | Human health and pathology | NF-kappa B | Infectious diseases | Vesicular Stomatitis | RNA, Messenger
Journal Article
Science, ISSN 0036-8075, 03/2015, Volume 347, Issue 6227, pp. 1217 - U17
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2013, Volume 190, Issue 10, pp. 5142 - 5151
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2004, Volume 172, Issue 4, pp. 2332 - 2340
Macrophages produce an array of proinflammatory mediators at sites of inflammation and contribute to the development of inflammatory responses. Important roles... 
SIGNAL-TRANSDUCTION | CELLS | TUMOR-NECROSIS-FACTOR | MESSENGER-RNA | TAK1 | PATHWAY | MONOCYTE-CHEMOATTRACTANT PROTEIN-1 | TYROSINE KINASE | GENE-EXPRESSION | P38-ALPHA | IMMUNOLOGY | Tetradecanoylphorbol Acetate - pharmacology | Humans | Receptor Protein-Tyrosine Kinases - physiology | I-kappa B Proteins - metabolism | Receptors, Mitogen - physiology | Interleukin-1 - biosynthesis | Trans-Activators - physiology | Discoidin Domain Receptors | Protein Isoforms - metabolism | Cattle | I-kappa B Proteins - antagonists & inhibitors | Trans-Activators - biosynthesis | Interleukin-8 - metabolism | p38 Mitogen-Activated Protein Kinases | Macrophages - immunology | Shc Signaling Adaptor Proteins | Carrier Proteins - physiology | Proteins - physiology | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins | Chemokine CCL4 | Chemokines - biosynthesis | Adaptor Proteins, Vesicular Transport - physiology | Interleukin-8 - biosynthesis | Macrophage Activation - immunology | Macrophage Inflammatory Proteins - metabolism | Receptors, Mitogen - metabolism | Receptor Protein-Tyrosine Kinases - metabolism | src Homology Domains - physiology | Protein Isoforms - physiology | Macrophages - enzymology | Cell Differentiation - immunology | Collagen Type I - physiology | Adaptor Proteins, Signal Transducing | Macrophages - metabolism | TNF Receptor-Associated Factor 6 | Animals | Src Homology 2 Domain-Containing, Transforming Protein 1 | Mitogen-Activated Protein Kinases - physiology | Up-Regulation - immunology | NF-kappa B - biosynthesis | NF-kappa B - physiology | Cell Line, Tumor | Chemokine CCL2 - biosynthesis | Macrophage Inflammatory Proteins - biosynthesis | Protein Structure, Tertiary - physiology
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2015, Volume 195, Issue 11, pp. 5404 - 5414
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 05/2015, Volume 82, pp. 1 - 12
Evidence suggests that upregulation of soluble epoxide hydrolase (sEH) is associated with the development of myocardial infarction, dilated cardiomyopathy,... 
NF-κB | sEH | MAPKs | NF-?B | CYTOCHROME-P450 GENE-EXPRESSION | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | KINASE | ARACHIDONIC-ACID METABOLISM | IN-VITRO | NF-kappa B | REDOX REGULATION | ENDOCRINOLOGY & METABOLISM | INDUCED CARDIAC-HYPERTROPHY | LEFT-VENTRICULAR MASS | TRANSCRIPTION FACTOR | Buthionine Sulfoximine - pharmacology | Up-Regulation | MAP Kinase Signaling System - physiology | Phosphorylation | Nitriles - pharmacology | Oxidative Stress | Cardiomegaly - pathology | JNK Mitogen-Activated Protein Kinases - metabolism | Epoxide Hydrolases - biosynthesis | Extracellular Signal-Regulated MAP Kinases - metabolism | I-kappa B Proteins - metabolism | I-kappa B Proteins - biosynthesis | RNA, Messenger - biosynthesis | Glutathione - biosynthesis | Thiocarbamates - pharmacology | Proline - pharmacology | Flavonoids - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Cell Line | Butadienes - pharmacology | NF-KappaB Inhibitor alpha | NF-kappa B p50 Subunit - antagonists & inhibitors | Atrial Natriuretic Factor - biosynthesis | NF-kappa B p50 Subunit - metabolism | Proline - analogs & derivatives | Cell Survival | Gene Expression Regulation - physiology | NF-kappa B p50 Subunit - biosynthesis | Natriuretic Peptide, Brain - biosynthesis | Rats | Antioxidants - pharmacology | Heart Failure - pathology | Epoxide Hydrolases - genetics | Myoblasts, Cardiac - metabolism | Animals | Transcription Factor RelA - metabolism | Enzyme Activation
Journal Article