X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (6154) 6154
animals (5708) 5708
nf-kappa b - metabolism (5530) 5530
nf-kappab inhibitor alpha (3635) 3635
mice (3622) 3622
i-kappa b proteins - metabolism (3567) 3567
i-kappa b kinase - metabolism (2743) 2743
phosphorylation (2554) 2554
signal transduction (2139) 2139
cell line (1905) 1905
male (1837) 1837
activation (1814) 1814
nf-kappa-b (1758) 1758
cells, cultured (1717) 1717
nf-kappa b - antagonists & inhibitors (1528) 1528
inflammation (1412) 1412
biochemistry & molecular biology (1406) 1406
i-kappa b proteins (1323) 1323
rats (1285) 1285
apoptosis (1251) 1251
dna-binding proteins - metabolism (1244) 1244
cell biology (1237) 1237
protein-serine-threonine kinases - metabolism (1227) 1227
female (1216) 1216
expression (1213) 1213
signal transduction - drug effects (1202) 1202
cell line, tumor (1141) 1141
nf-kappa b - genetics (1139) 1139
i-kappa b kinase (1119) 1119
immunology (1114) 1114
nf-κb (1010) 1010
tumor necrosis factor-alpha - pharmacology (981) 981
tumor necrosis factor-alpha - metabolism (960) 960
nf-kappa b (940) 940
i-kappa b kinase - genetics (930) 930
transfection (911) 911
i-kappa b proteins - genetics (887) 887
blotting, western (882) 882
cell nucleus - metabolism (878) 878
transcription factor rela - metabolism (829) 829
phosphorylation - drug effects (812) 812
apoptosis - drug effects (803) 803
rna, messenger - metabolism (791) 791
lipopolysaccharides - pharmacology (775) 775
mice, inbred c57bl (730) 730
protein binding (706) 706
gene-expression (673) 673
proteins (666) 666
gene expression (647) 647
gene expression regulation (632) 632
enzyme activation (625) 625
mice, knockout (602) 602
dose-response relationship, drug (586) 586
molecular sequence data (575) 575
hela cells (563) 563
nf-kappa b - physiology (561) 561
time factors (556) 556
signal transduction - physiology (544) 544
oncology (540) 540
pharmacology & pharmacy (538) 538
i-kappa b kinase - antagonists & inhibitors (521) 521
research article (520) 520
cytokines (511) 511
oxidative stress (510) 510
mutation (507) 507
cells (504) 504
rats, sprague-dawley (503) 503
macrophages - metabolism (490) 490
tumor cells, cultured (488) 488
inhibition (486) 486
rna, messenger - genetics (485) 485
reverse transcriptase polymerase chain reaction (482) 482
cancer (479) 479
mitogen-activated protein kinases - metabolism (466) 466
gene expression regulation - drug effects (463) 463
transcription factors (463) 463
enzyme inhibitors - pharmacology (461) 461
amino acid sequence (452) 452
disease models, animal (452) 452
dna-binding proteins - genetics (441) 441
kinases (438) 438
tumor-necrosis-factor (429) 429
alpha (424) 424
cell survival - drug effects (424) 424
down-regulation (424) 424
cytokines - metabolism (423) 423
base sequence (420) 420
macrophages - drug effects (420) 420
protein (412) 412
anti-inflammatory agents - pharmacology (411) 411
inflammation - metabolism (408) 408
up-regulation (408) 408
protein-serine-threonine kinases - genetics (404) 404
multidisciplinary sciences (402) 402
models, biological (400) 400
enzyme activation - drug effects (390) 390
macrophages (382) 382
research (380) 380
transcription factor (379) 379
transcription factor rela (377) 377
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (9587) 9587
Chinese (138) 138
Japanese (54) 54
French (6) 6
Russian (5) 5
Dutch (1) 1
German (1) 1
Hungarian (1) 1
Korean (1) 1
Polish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular cell, ISSN 1097-2765, 2010, Volume 40, Issue 1, pp. 63 - 74
As part of the genotoxic stress response, cells activate the transcription factor NF-κB... 
MOLECULAR-MECHANISM | POLY(ADP-RIBOSYL)ATION | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | DOUBLE-STRAND BREAKS | POLYUBIQUITIN CHAINS | ATM | BINDING | NEMO | PROTEIN-KINASES | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Calcium - metabolism | Inhibitor of Apoptosis Proteins - genetics | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | DNA Breaks, Double-Stranded | Cell Nucleus - enzymology | DNA-Binding Proteins - metabolism | Cytosol - enzymology | Ubiquitination | Transfection | I-kappa B Kinase - metabolism | RNA Interference | Time Factors | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Inhibitor of Apoptosis Proteins - metabolism | TNF Receptor-Associated Factor 6 - genetics | Protein-Serine-Threonine Kinases - metabolism | Recombinant Proteins - metabolism | Tumor Suppressor Proteins - metabolism | Signal Transduction | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Hep G2 Cells | Protein Transport | Ubiquitin-Protein Ligases | Poly(ADP-ribose) Polymerases - metabolism | NF-kappa B - genetics | Ubiquitin-Conjugating Enzymes - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Protein Binding | DNA Damage | HeLa Cells | Mutation | Poly (ADP-Ribose) Polymerase-1 | Adaptor Proteins, Signal Transducing - metabolism
Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 471, Issue 7340, pp. 637 - 641
Journal Article
Molecular cell, ISSN 1097-2765, 2010, Volume 40, Issue 1, pp. 75 - 86
Activation of the transcription factor NF-κB by multiple genotoxic stimuli modulates cancer cell survival... 
PROTEIN | POLYUBIQUITIN | ISOFORMS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NF-KAPPA-B | BINDING | CELL BIOLOGY | Protein-Serine-Threonine Kinases - deficiency | Humans | Male | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Ubiquitination | RNA Interference | Time Factors | Tumor Suppressor Proteins - deficiency | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | MAP Kinase Kinase Kinases - genetics | Cell Cycle Proteins - metabolism | Etoposide - pharmacology | Ubiquitin-Conjugating Enzymes - genetics | MAP Kinase Kinase Kinases - metabolism | Ataxia Telangiectasia Mutated Proteins | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Mice | DNA Damage | Enzyme Activation | Mutation | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Pyrones - pharmacology | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | Transfection | I-kappa B Kinase - metabolism | MAP Kinase Kinase Kinases - deficiency | Mice, Mutant Strains | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cell Line | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Morpholines - pharmacology | I-kappa B Kinase - genetics | DNA-Binding Proteins - genetics | Nerve Tissue Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Protein Binding | Adaptor Proteins, Signal Transducing - metabolism | Camptothecin - pharmacology | Ubiquitin | Ligases | Lysine | Oncology, Experimental | Automated teller machines | Research | Glutamate | Cancer
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 494 - 507
Chronic active B cell receptor (BCR) signaling, a hallmark of the activated B cell-like (ABC... 
ANTAGONISTS INDUCE | APOPTOSIS | ACTIVATION | ONCOLOGY | CODING GENOME | CARD11 MUTATIONS | CHAIN ASSEMBLY COMPLEX | IKK COMPLEX | NF-KAPPA-B | SOMATIC MUTATIONS | SIGNALING COMPLEX | CELL BIOLOGY | Inhibitor of Apoptosis Proteins - genetics | Humans | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Receptors, Antigen, B-Cell - metabolism | Ubiquitin-Protein Ligases - physiology | Inhibitor of Apoptosis Proteins - physiology | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Ubiquitination - drug effects | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Neoplasm Proteins - genetics | B-Lymphocytes - metabolism | Triazoles - therapeutic use | NF-kappa B - antagonists & inhibitors | Dipeptides - therapeutic use | Lymphoma, Large B-Cell, Diffuse - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Mitochondrial Proteins - chemistry | Cell Line, Tumor | Indoles - therapeutic use | Mice, Inbred NOD | Mice | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Neoplasm Proteins - physiology | Ubiquitin-Protein Ligases - antagonists & inhibitors | Baculoviral IAP Repeat-Containing 3 Protein | Lymphoma, Large B-Cell, Diffuse - metabolism | Neoplasm Proteins - metabolism | Caspases - metabolism | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Dipeptides - pharmacology | Guanylate Cyclase - metabolism | Gene Dosage | Mice, SCID | Triazoles - pharmacology | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Animals | Intracellular Signaling Peptides and Proteins - chemistry | B-Cell CLL-Lymphoma 10 Protein | Lymphoma, Large B-Cell, Diffuse - classification | CRISPR-Cas Systems | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Care and treatment | Lymphomas | Ligases
Journal Article
Nature genetics, ISSN 1546-1718, 2015, Volume 48, Issue 1, pp. 67 - 73
Journal Article
Nature cell biology, ISSN 1476-4679, 2004, Volume 6, Issue 2, pp. 97 - 105
Journal Article
Blood, ISSN 0006-4971, 06/2013, Volume 121, Issue 23, pp. 4718 - 4728
...), the signal transducer subunit of Hh pathway, contributes to NF-kappa B activation through recruiting G protein subunits G alpha i and G alpha 12 to activate PKC beta/CARMA1/TRAF6/NEMO signaling axis... 
RHO-GTPASE | HETEROTRIMERIC G-PROTEINS | SONIC HEDGEHOG | SIGNALING PATHWAY | PHOSPHORYLATION | CARMA1 | NECROSIS-FACTOR-ALPHA | KINASE-C | HEMATOLOGY | FAMILY | BETA | Protein Kinase C beta | RNA, Small Interfering - genetics | Cell Proliferation | Receptors, G-Protein-Coupled - metabolism | Humans | Hedgehog Proteins - metabolism | NF-kappa B - metabolism | Immunoenzyme Techniques | CARD Signaling Adaptor Proteins - metabolism | Protein Kinase C - metabolism | Smoothened Receptor | TNF Receptor-Associated Factor 6 - genetics | Neoplasm Proteins - genetics | Real-Time Polymerase Chain Reaction | Signal Transduction | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Receptors, G-Protein-Coupled - antagonists & inhibitors | Receptors, G-Protein-Coupled - genetics | Protein Kinase C - genetics | Immunoprecipitation | Luciferases - metabolism | Tissue Array Analysis | Heterotrimeric GTP-Binding Proteins - metabolism | Lymphoma, Large B-Cell, Diffuse - metabolism | Neoplasm Proteins - metabolism | Heterotrimeric GTP-Binding Proteins - genetics | CARD Signaling Adaptor Proteins - genetics | Caspases - metabolism | Hedgehog Proteins - genetics | I-kappa B Kinase - metabolism | Adult | Electrophoretic Mobility Shift Assay | Tumor Cells, Cultured | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Lymphoma, Large B-Cell, Diffuse - pathology | Caspases - genetics | RNA, Messenger - genetics | Guanylate Cyclase - metabolism | I-kappa B Kinase - genetics | NF-kappa B - genetics | B-Cell CLL-Lymphoma 10 Protein | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Guanylate Cyclase - genetics | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Lymphoma, Large B-Cell, Diffuse - genetics | Apoptosis | Lymphoid Neoplasia
Journal Article
Journal Article