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Immunity, ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 215 - 227
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 494 - 507
Chronic active B cell receptor (BCR) signaling, a hallmark of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), engages the... 
ANTAGONISTS INDUCE | APOPTOSIS | ACTIVATION | ONCOLOGY | CODING GENOME | CARD11 MUTATIONS | CHAIN ASSEMBLY COMPLEX | IKK COMPLEX | NF-KAPPA-B | SOMATIC MUTATIONS | SIGNALING COMPLEX | CELL BIOLOGY | Inhibitor of Apoptosis Proteins - genetics | Humans | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Receptors, Antigen, B-Cell - metabolism | Ubiquitin-Protein Ligases - physiology | Inhibitor of Apoptosis Proteins - physiology | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Ubiquitination - drug effects | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Neoplasm Proteins - genetics | B-Lymphocytes - metabolism | Triazoles - therapeutic use | NF-kappa B - antagonists & inhibitors | Dipeptides - therapeutic use | Lymphoma, Large B-Cell, Diffuse - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Mitochondrial Proteins - chemistry | Cell Line, Tumor | Indoles - therapeutic use | Mice, Inbred NOD | Mice | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Neoplasm Proteins - physiology | Ubiquitin-Protein Ligases - antagonists & inhibitors | Baculoviral IAP Repeat-Containing 3 Protein | Lymphoma, Large B-Cell, Diffuse - metabolism | Neoplasm Proteins - metabolism | Caspases - metabolism | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Dipeptides - pharmacology | Guanylate Cyclase - metabolism | Gene Dosage | Mice, SCID | Triazoles - pharmacology | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Animals | Intracellular Signaling Peptides and Proteins - chemistry | B-Cell CLL-Lymphoma 10 Protein | Lymphoma, Large B-Cell, Diffuse - classification | CRISPR-Cas Systems | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Care and treatment | Lymphomas | Ligases
Journal Article
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 2012, Volume 31, Issue 1, pp. 58 - 58
Background: This study was performed to investigate the effect of microRNA-203 (miR-203) on cell proliferation and migration in triple-negative breast cancer... 
Lim and SH3 domain protein 1 | MiR-203 | Proliferation | Migration | baculoviral IAP repeat-containing protein 5 | Triple-negative breast cancer | APOPTOSIS | Lim and SH3 domain | SURVIVIN | protein 1 | LIM | INHIBITION | GENE | ONCOLOGY | EXPRESSION | RNA, Small Interfering - genetics | Receptors, Estrogen - metabolism | Cytoskeletal Proteins - genetics | Inhibitor of Apoptosis Proteins - genetics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | LIM Domain Proteins - biosynthesis | MicroRNAs - metabolism | LIM Domain Proteins - metabolism | RNA, Messenger - metabolism | Cell Movement - genetics | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Transfection | Cytoskeletal Proteins - metabolism | Female | Inhibitor of Apoptosis Proteins - metabolism | Cell Growth Processes - genetics | Cytoskeletal Proteins - biosynthesis | Inhibitor of Apoptosis Proteins - biosynthesis | Down-Regulation | RNA, Messenger - genetics | MicroRNAs - biosynthesis | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | LIM Domain Proteins - genetics | Adaptor Proteins, Signal Transducing - biosynthesis | MicroRNAs - genetics | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - administration & dosage | Cell proliferation | Medicine, Experimental | Medical research | Breast cancer | MicroRNA | Luciferase | Proteins | Cell culture | Experiments | Cell adhesion & migration | Triple-negative breast cancer, MiR-203 | baculoviral IAP repeat-containing protein 5, Lim and SH3 domain protein 1, Proliferation, Migration
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 1, pp. 11 - 20
ML-IAP (melanoma inhibitor of apoptosis) is a potent anti-apoptotic protein that is strongly up-regulated in melanoma and confers protection against a variety... 
Inhibitor of apoptosis (IAP) | Smac/DIABLO (second mitochondrial activator of caspases/direct IAP binding protein with low pI) | X-linked IAP (XIAP) | Melanoma inhibitor of apoptosis (ML-IAP) | Apoptosis | SMAC/DIABLO | ACTIVATION | HID | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | inhibitor of apoptosis (IAP) | PEPTIDE | melanoma inhibitor of apoptosis (ML-IAP) | STRUCTURAL BASIS | BIR DOMAIN | MELANOMA INHIBITOR | NMR STRUCTURE | PROTEIN XIAP | BINDING | Adaptor Proteins, Signal Transducing - chemistry | Caspase 9 | Humans | Cysteine Proteinase Inhibitors - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Mitochondrial Proteins - genetics | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Cysteine Proteinase Inhibitors - genetics | Caspases - metabolism | Mitochondrial Proteins - metabolism | Protein Engineering | Carrier Proteins - chemistry | Cysteine Proteinase Inhibitors - chemistry | X-Linked Inhibitor of Apoptosis Protein | Neoplasm Proteins - genetics | Binding Sites | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Electron Spin Resonance Spectroscopy | Inhibitor of Apoptosis Proteins | Intracellular Signaling Peptides and Proteins | Models, Molecular | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Caspase Inhibitors | Proteins - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mitochondrial Proteins - chemistry | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Kinetics | Proteins - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Ac-LEHD-AFC, acetyl-Leu-Glu-His-Asp-7-amido-4-fluoromethylcourmarin | BIR, baculoviral IAP repeat | PDB, Protein Data Bank | RMSD, root mean square deviation | CARD, caspase recruitment domain | Hid-FAM, 5-carboxyfluorescein-conjugated AVPFAKK | direct IAP binding protein with low pI | IAP, inhibitor of apoptosis | DIABLO (second mitochondrial activator of caspases | W310A etc., Trp310→Ala etc | AVP-diPhe-FAM, 5-carboxyfluorescein-conjugated AVP-diphenylalanine-AKK | ML-IAP, melanoma IAP | DTT, dithiothreitol | Ni-NTA, Ni2+-nitrilotriacetate | IPTG, isopropyl β-D-thiogalactoside | Smac, second mitochondrial activator of caspases | DIABLO, direct IAP binding protein with low pI | Smac | SPR, surface plasmon resonance | XIAP, X-linked IAP
Journal Article
FEBS Letters, ISSN 0014-5793, 05/2015, Volume 589, Issue 12, pp. 1369 - 1375
The ubiquitin-editing enzyme A20 suppresses nuclear factor-κB (NF-κB) activation and tumor necrosis factor-α (TNF-α)-induced apoptosis in a deubiquitinating... 
Ubiquitin | Tumor necrosis factor-α | Nuclear factor-κB | Apoptosis | receptor-interacting protein | interleukin-1 | TRAF | TRADD | PARP | HOIP | IκB kinase | IκB | NF-κB | transforming growth factor-β-activated kinase 1 | heme-oxidized iron regulatory protein-2 ubiquitin ligase-1 | TAK1 | HOIL-1 | Fas-associated protein with death domain | TNF-related apoptosis-inducing ligand | cIAP | FADD | HOIL-1-interacting protein | TNF receptor-associated factor | Poly (ADP-ribose) polymerase | TNF receptor-associated death domain | TRAIL | IL-1 | IKK | cellular inhibitor of apoptosis | nuclear factor-κB | TNF-α | tumor necrosis factor-α | RIP | inhibitor of κB | Nuclear factor-kappa B | ACTIVATION | COMPLEX | LINEAR POLYUBIQUITIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | CELL-DEATH | CELL BIOLOGY | Tumor necrosis factor-alpha | TUMOR-NECROSIS-FACTOR | BIOPHYSICS | INFLAMMATION | NF-KAPPA-B | RIP1 | Cysteine Endopeptidases - chemistry | Tumor Necrosis Factor-alpha - metabolism | Apoptosis - drug effects | Humans | Tumor Necrosis Factor-alpha - genetics | Ubiquitin-Protein Ligases - antagonists & inhibitors | Interleukin-1alpha - metabolism | NF-kappa B - metabolism | Baculoviral IAP Repeat-Containing 3 Protein | Intracellular Signaling Peptides and Proteins - metabolism | DNA-Binding Proteins - metabolism | Cysteine Endopeptidases - metabolism | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Tumor Necrosis Factor alpha-Induced Protein 3 | Inhibitor of Apoptosis Proteins - metabolism | Interleukin-1alpha - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Recombinant Proteins - metabolism | Cell Line | Cell Survival - drug effects | NF-kappa B - antagonists & inhibitors | Zinc Fingers | Enzyme Inhibitors - pharmacology | Ubiquitin-Protein Ligases - metabolism | Recombinant Proteins - chemistry | Mutant Proteins - metabolism | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Nuclear Proteins - chemistry | DNA-Binding Proteins - chemistry | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Cysteine Endopeptidases - genetics | Mutant Proteins - chemistry | Mice | Amino Acid Substitution
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2007, Volume 282, Issue 36, pp. 26202 - 26209
X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a putative tumor suppressor in which expression is significantly reduced in human cancer... 
CANCER-CELLS | SMAC/DIABLO | HYPERMETHYLATION | PROTEIN | XIAP-ASSOCIATED FACTOR-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | XAF1 EXPRESSION | TRAIL-INDUCED APOPTOSIS | MAMMALIAN-CELLS | UBIQUITIN-PROTEASOME PATHWAY | Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Neuronal Apoptosis-Inhibitory Protein - genetics | Ubiquitin - metabolism | Multiprotein Complexes - genetics | Baculoviral IAP Repeat-Containing 3 Protein | Neoplasm Proteins - metabolism | Multiprotein Complexes - metabolism | Tumor Suppressor Proteins - genetics | Inhibitor of Apoptosis Proteins - metabolism | Neoplasm Proteins - genetics | Antiviral Agents - pharmacology | Tumor Suppressor Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Ubiquitin - genetics | Down-Regulation - drug effects | Neuronal Apoptosis-Inhibitory Protein - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Down-Regulation - physiology | Leupeptins - pharmacology | Mitosis - drug effects | Interferon-beta - pharmacology | Mitosis - physiology | Cysteine Proteinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics
Journal Article
Radiation Oncology, ISSN 1748-717X, 06/2015, Volume 10, Issue 1, p. 131
Background: The mainstay of treatment in rectal cancer is neoadjuvant radio chemotherapy prior to surgery, in an attempt to downstage the tumour, allowing for... 
Rectal cancer | Inhibitor of apoptosis proteins | Neoadjuvant radio chemotherapy | Apoptosis | CELLS | TUMOR PROGRESSION | CASPASE INHIBITION | PREOPERATIVE CHEMORADIOTHERAPY | KAPPA-B | ONCOLOGY | COLORECTAL-CANCER | ALPHA-DEPENDENT APOPTOSIS | CHEMORADIATION | PROGNOSTIC-SIGNIFICANCE | EXPRESSION | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | Apoptosis - drug effects | Apoptosis - radiation effects | Inhibitor of Apoptosis Proteins - genetics | X-Linked Inhibitor of Apoptosis Protein - analysis | Humans | Middle Aged | Male | Rectal Neoplasms - chemistry | Baculoviral IAP Repeat-Containing 3 Protein | Mitochondrial Proteins - genetics | Chemoradiotherapy | Fluorouracil - therapeutic use | Ubiquitin-Protein Ligases - analysis | Adult | Antimetabolites, Antineoplastic - pharmacology | Female | Neoadjuvant Therapy | Rectal Neoplasms - pathology | Gene Expression Regulation, Neoplastic - drug effects | Neoplasm Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Inhibitor of Apoptosis Proteins - analysis | X-Linked Inhibitor of Apoptosis Protein - biosynthesis | Inhibitor of Apoptosis Proteins - biosynthesis | Mitochondrial Proteins - analysis | Biomarkers, Tumor - analysis | Neoplasm Proteins - biosynthesis | Intracellular Signaling Peptides and Proteins - analysis | Mitochondrial Proteins - biosynthesis | Intracellular Signaling Peptides and Proteins - biosynthesis | Rectal Neoplasms - therapy | Ubiquitin-Protein Ligases - biosynthesis | X-Linked Inhibitor of Apoptosis Protein - genetics | Antimetabolites, Antineoplastic - therapeutic use | Radiation Tolerance - physiology | Neoplasm Proteins - analysis | Aged | Biomarkers, Tumor - genetics | Fluorouracil - pharmacology | Gene Expression Regulation, Neoplastic - radiation effects | Ubiquitin-Protein Ligases - genetics | Drug Resistance, Neoplasm - physiology | Biomarkers, Tumor - biosynthesis | Proteins | Colorectal cancer | Adjuvant treatment | Development and progression | Drug therapy | Tumors | Cancer
Journal Article
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 09/2012, Volume 19, Issue 9, pp. 876 - 883
Journal Article
Apoptosis, ISSN 1360-8185, 9/2007, Volume 12, Issue 9, pp. 1543 - 1568
Apoptosis has been accepted as a fundamental component in the pathogenesis of cancer, in addition to other human diseases including neurodegeneration, coronary... 
Biochemistry, general | TNFR | TRAF | Oncology | NFkB | Virology | Cell Biology | Biomedicine | Cancer Research | IAPs | Caspases | Smac | Knock out mice | Apoptosis | Cancer | NEURONAL APOPTOSIS | X-LINKED INHIBITOR | SERINE-PROTEASE OMI/HTRA2 | MITOCHONDRIA-DERIVED ACTIVATOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | knock out mice | INDUCED PROXIMITY MODEL | apoptosis | CELL BIOLOGY | CELL LUNG-CANCER | SPINAL MUSCULAR-ATROPHY | IN-VIVO | cancer | CYTOCHROME-C RELEASE | caspases | CASPASE ACTIVATION | Caspases - physiology | Proto-Oncogene Proteins c-bcl-2 - physiology | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Humans | Neoplasm Proteins - physiology | Serine Endopeptidases - physiology | Neoplasm Proteins - antagonists & inhibitors | Inhibitor of Apoptosis Proteins - physiology | X-Linked Inhibitor of Apoptosis Protein - antagonists & inhibitors | Neoplasms - genetics | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Oligonucleotides, Antisense - therapeutic use | Intracellular Signaling Peptides and Proteins - therapeutic use | Mitochondrial Proteins - therapeutic use | Peptide Termination Factors - physiology | Mitochondrial Proteins - physiology | Neoplasm Proteins - therapeutic use | Microtubule-Associated Proteins - antagonists & inhibitors | Caspase Inhibitors | High-Temperature Requirement A Serine Peptidase 2 | Neoplasms - drug therapy | Animals | Protein Kinases - physiology | Checkpoint Kinase 1 | Enzyme Activation | Genetic Vectors | Intracellular Signaling Peptides and Proteins - physiology | Proteins | Cancer therapies
Journal Article