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Immunity, ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 215 - 227
Journal Article
Cancer Cell, ISSN 1535-6108, 04/2016, Volume 29, Issue 4, pp. 494 - 507
Chronic active B cell receptor (BCR) signaling, a hallmark of the activated B cell-like (ABC) subtype of diffuse large B cell lymphoma (DLBCL), engages the... 
ANTAGONISTS INDUCE | APOPTOSIS | ACTIVATION | ONCOLOGY | CODING GENOME | CARD11 MUTATIONS | CHAIN ASSEMBLY COMPLEX | IKK COMPLEX | NF-KAPPA-B | SOMATIC MUTATIONS | SIGNALING COMPLEX | CELL BIOLOGY | Inhibitor of Apoptosis Proteins - genetics | Humans | NF-kappa B - metabolism | Neoplasm Proteins - antagonists & inhibitors | Gene Expression Profiling | Receptors, Antigen, B-Cell - metabolism | Ubiquitin-Protein Ligases - physiology | Inhibitor of Apoptosis Proteins - physiology | Multiprotein Complexes - metabolism | CARD Signaling Adaptor Proteins - metabolism | Ubiquitination - drug effects | Inhibitor of Apoptosis Proteins - antagonists & inhibitors | Neoplasm Proteins - genetics | B-Lymphocytes - metabolism | Triazoles - therapeutic use | NF-kappa B - antagonists & inhibitors | Dipeptides - therapeutic use | Lymphoma, Large B-Cell, Diffuse - drug therapy | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Mitochondrial Proteins - chemistry | Cell Line, Tumor | Indoles - therapeutic use | Mice, Inbred NOD | Mice | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Neoplasm Proteins - physiology | Ubiquitin-Protein Ligases - antagonists & inhibitors | Baculoviral IAP Repeat-Containing 3 Protein | Lymphoma, Large B-Cell, Diffuse - metabolism | Neoplasm Proteins - metabolism | Caspases - metabolism | I-kappa B Kinase - metabolism | Protein Processing, Post-Translational - drug effects | Bridged Bicyclo Compounds, Heterocyclic - therapeutic use | Indoles - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Dipeptides - pharmacology | Guanylate Cyclase - metabolism | Gene Dosage | Mice, SCID | Triazoles - pharmacology | Xenograft Model Antitumor Assays | B-Lymphocytes - drug effects | Animals | Intracellular Signaling Peptides and Proteins - chemistry | B-Cell CLL-Lymphoma 10 Protein | Lymphoma, Large B-Cell, Diffuse - classification | CRISPR-Cas Systems | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin | Care and treatment | Lymphomas | Ligases
Journal Article
Cancer Science, ISSN 1347-9032, 08/2017, Volume 108, Issue 8, pp. 1657 - 1666
Chromosomal translocation occurs in some cancer cells, which results in the expression of aberrant oncogenic fusion proteins that include BCR‐ABL in chronic... 
protein knockdown | E3 ubiquitin ligase | dasatinib | BCR‐ABL | LCL161 | BCR-ABL | CHRONIC MYELOGENOUS LEUKEMIA | RNA INTERFERENCE | CANCER-CELLS | UBIQUITIN LIGASE | TYROSINE KINASE | HYBRID SMALL MOLECULES | CHRONIC MYELOID-LEUKEMIA | SMALL-MOLECULE PROTACS | ONCOLOGY | PHILADELPHIA-CHROMOSOME | TARGETED DEGRADATION | Cell Survival - drug effects | Down-Regulation | Humans | Dasatinib - chemistry | Dasatinib - pharmacology | Protein Kinase Inhibitors - chemistry | Ubiquitination - drug effects | Proteolysis | K562 Cells | Cell Line, Tumor | Protein Binding | Ligands | Thiazoles - chemistry | Cell Proliferation - drug effects | Inhibitor of Apoptosis Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Fusion Proteins, bcr-abl - metabolism | Ubiquitin | Tyrosine | Snipers | Ligases | Analysis | Leukemia | Drug resistance | Polyols | BCR protein | Phosphorylation | Transcription | XIAP protein | Kinases | Proteins | Cell growth | Polyethylene glycol | Protein-tyrosine kinase | Medical research | Polyethylene | IAP protein | Imatinib | Research & development--R&D | Myeloid leukemia | Abl protein | Stat5 protein | Chronic myeloid leukemia | Proteasomes | Mutation | Binding sites | Apoptosis | Pharmaceuticals | Original
Journal Article
Immunity, ISSN 1074-7613, 06/2009, Volume 30, Issue 6, pp. 789 - 801
Cellular inhibitor of apoptosis proteins (cIAPs) block apoptosis, but their physiological functions are still under investigation. Here, we report that cIAP1... 
MOLIMMUNO | CELLS | ACTIVATION | C-IAP1 | PROTEIN | DROSOPHILA IMD PATHWAY | IN-VIVO | KINASE | IMMUNOLOGY | POLYUBIQUITINATION | NF-KAPPA-B | RIP2 | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Receptors, Pattern Recognition - immunology | Inhibitor of Apoptosis Proteins - genetics | Nod1 Signaling Adaptor Protein - agonists | Colitis - pathology | Baculoviral IAP Repeat-Containing 3 Protein | Nod1 Signaling Adaptor Protein - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Receptors, Pattern Recognition - agonists | Nod2 Signaling Adaptor Protein - agonists | Inhibitor of Apoptosis Proteins - metabolism | Colitis - immunology | Receptor-Interacting Protein Serine-Threonine Kinases - immunology | Cytokines - immunology | Cytokines - metabolism | Mice, Inbred C57BL | Nod2 Signaling Adaptor Protein - immunology | Ubiquitination - immunology | Nod1 Signaling Adaptor Protein - immunology | Immunity, Innate | Mice, Knockout | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Ubiquitin-Protein Ligases | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Apoptosis - immunology | Colitis - enzymology | Nod2 Signaling Adaptor Protein - metabolism | Signal Transduction - drug effects | Inhibitor of Apoptosis Proteins - immunology | Mice | Ubiquitin | Oligomers | Ligases | Physiological aspects | Crohn's disease | Colitis | Apoptosis | Medical research | Enzymes | Statistical analysis | Cytokines | Kinases | Proteins | Inflammatory bowel disease | Genotype & phenotype | Insects | Bacteria | Gram-negative bacteria | Chemokines | Immune system
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14524 - 14529
NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved in sensing the presence of pathogens and are a component of the... 
Proteins | HEK293 cells | HCT116 cells | Plasmids | Cell lines | Antibodies | Reporter genes | Ligands | Immunoblotting | Apoptosis | CYTOCHROME-C | NEGATIVE BACTERIAL-INFECTION | ACTIVATION | HOST RECOGNITION | MULTIDISCIPLINARY SCIENCES | ALPHA-DEPENDENT APOPTOSIS | IAP | CELL-SURVIVAL | PROTEIN XIAP | NF-KAPPA-B | DROSOPHILA INHIBITOR | RNA, Small Interfering - genetics | Immunoprecipitation | Luciferases - metabolism | Humans | NF-kappa B - metabolism | Nod2 Signaling Adaptor Protein - genetics | Green Fluorescent Proteins - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Nod1 Signaling Adaptor Protein - metabolism | Recombinant Fusion Proteins - metabolism | Luciferases - genetics | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Transfection | Interleukin-8 - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | Gene Expression | Enzyme-Linked Immunosorbent Assay | Signal Transduction | HCT116 Cells | Reverse Transcriptase Polymerase Chain Reaction | X-Linked Inhibitor of Apoptosis Protein - genetics | NF-kappa B - genetics | Nod2 Signaling Adaptor Protein - metabolism | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Mutation | Nod1 Signaling Adaptor Protein - genetics | Research | Immunity | Biological Sciences
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 2012, Volume 31, Issue 1, pp. 58 - 58
Background: This study was performed to investigate the effect of microRNA-203 (miR-203) on cell proliferation and migration in triple-negative breast cancer... 
Lim and SH3 domain protein 1 | MiR-203 | Proliferation | Migration | baculoviral IAP repeat-containing protein 5 | Triple-negative breast cancer | APOPTOSIS | Lim and SH3 domain | SURVIVIN | protein 1 | LIM | INHIBITION | GENE | ONCOLOGY | EXPRESSION | RNA, Small Interfering - genetics | Receptors, Estrogen - metabolism | Cytoskeletal Proteins - genetics | Inhibitor of Apoptosis Proteins - genetics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | LIM Domain Proteins - biosynthesis | MicroRNAs - metabolism | LIM Domain Proteins - metabolism | RNA, Messenger - metabolism | Cell Movement - genetics | Breast Neoplasms - metabolism | Receptors, Progesterone - metabolism | Transfection | Cytoskeletal Proteins - metabolism | Female | Inhibitor of Apoptosis Proteins - metabolism | Cell Growth Processes - genetics | Cytoskeletal Proteins - biosynthesis | Inhibitor of Apoptosis Proteins - biosynthesis | Down-Regulation | RNA, Messenger - genetics | MicroRNAs - biosynthesis | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | LIM Domain Proteins - genetics | Adaptor Proteins, Signal Transducing - biosynthesis | MicroRNAs - genetics | Adaptor Proteins, Signal Transducing - metabolism | RNA, Small Interfering - administration & dosage | Cell proliferation | Medicine, Experimental | Medical research | Breast cancer | MicroRNA | Luciferase | Proteins | Cell culture | Experiments | Cell adhesion & migration | Triple-negative breast cancer, MiR-203 | baculoviral IAP repeat-containing protein 5, Lim and SH3 domain protein 1, Proliferation, Migration
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 1, pp. 11 - 20
ML-IAP (melanoma inhibitor of apoptosis) is a potent anti-apoptotic protein that is strongly up-regulated in melanoma and confers protection against a variety... 
Inhibitor of apoptosis (IAP) | Smac/DIABLO (second mitochondrial activator of caspases/direct IAP binding protein with low pI) | X-linked IAP (XIAP) | Melanoma inhibitor of apoptosis (ML-IAP) | Apoptosis | SMAC/DIABLO | ACTIVATION | HID | BIOCHEMISTRY & MOLECULAR BIOLOGY | apoptosis | inhibitor of apoptosis (IAP) | PEPTIDE | melanoma inhibitor of apoptosis (ML-IAP) | STRUCTURAL BASIS | BIR DOMAIN | MELANOMA INHIBITOR | NMR STRUCTURE | PROTEIN XIAP | BINDING | Adaptor Proteins, Signal Transducing - chemistry | Caspase 9 | Humans | Cysteine Proteinase Inhibitors - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Mitochondrial Proteins - genetics | Neoplasm Proteins - metabolism | Recombinant Fusion Proteins - metabolism | Cysteine Proteinase Inhibitors - genetics | Caspases - metabolism | Mitochondrial Proteins - metabolism | Protein Engineering | Carrier Proteins - chemistry | Cysteine Proteinase Inhibitors - chemistry | X-Linked Inhibitor of Apoptosis Protein | Neoplasm Proteins - genetics | Binding Sites | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Electron Spin Resonance Spectroscopy | Inhibitor of Apoptosis Proteins | Intracellular Signaling Peptides and Proteins | Models, Molecular | Neoplasm Proteins - chemistry | Recombinant Fusion Proteins - chemistry | Caspase Inhibitors | Proteins - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mitochondrial Proteins - chemistry | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Kinetics | Proteins - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Ac-LEHD-AFC, acetyl-Leu-Glu-His-Asp-7-amido-4-fluoromethylcourmarin | BIR, baculoviral IAP repeat | PDB, Protein Data Bank | RMSD, root mean square deviation | CARD, caspase recruitment domain | Hid-FAM, 5-carboxyfluorescein-conjugated AVPFAKK | direct IAP binding protein with low pI | IAP, inhibitor of apoptosis | DIABLO (second mitochondrial activator of caspases | W310A etc., Trp310→Ala etc | AVP-diPhe-FAM, 5-carboxyfluorescein-conjugated AVP-diphenylalanine-AKK | ML-IAP, melanoma IAP | DTT, dithiothreitol | Ni-NTA, Ni2+-nitrilotriacetate | IPTG, isopropyl β-D-thiogalactoside | Smac, second mitochondrial activator of caspases | DIABLO, direct IAP binding protein with low pI | Smac | SPR, surface plasmon resonance | XIAP, X-linked IAP
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2007, Volume 282, Issue 36, pp. 26202 - 26209
X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a putative tumor suppressor in which expression is significantly reduced in human cancer... 
Microtubule-Associated Proteins - genetics | Apoptosis - drug effects | Inhibitor of Apoptosis Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Neuronal Apoptosis-Inhibitory Protein - genetics | Ubiquitin - metabolism | Multiprotein Complexes - genetics | Baculoviral IAP Repeat-Containing 3 Protein | Neoplasm Proteins - metabolism | Multiprotein Complexes - metabolism | Tumor Suppressor Proteins - genetics | Inhibitor of Apoptosis Proteins - metabolism | Neoplasm Proteins - genetics | Antiviral Agents - pharmacology | Tumor Suppressor Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Ubiquitin - genetics | Down-Regulation - drug effects | Neuronal Apoptosis-Inhibitory Protein - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Down-Regulation - physiology | Leupeptins - pharmacology | Mitosis - drug effects | Interferon-beta - pharmacology | Mitosis - physiology | Cysteine Proteinase Inhibitors - pharmacology | Adaptor Proteins, Signal Transducing - genetics | X-Linked Inhibitor of Apoptosis Protein - metabolism | Cell Line, Tumor | Apoptosis - physiology | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | CANCER-CELLS | SMAC/DIABLO | HYPERMETHYLATION | PROTEIN | XIAP-ASSOCIATED FACTOR-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | XAF1 EXPRESSION | TRAIL-INDUCED APOPTOSIS | MAMMALIAN-CELLS | UBIQUITIN-PROTEASOME PATHWAY
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 09/2012, Volume 19, Issue 9, pp. 876 - 883
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2004, Volume 384, Issue 2, pp. 201 - 232
The death morphology commonly known as apoptosis results from a post-translational pathway driven largely by specific limited proteolysis. In the last decade... 
Zymogen | Caspase | Inhibitor | Protease | Inhibitor of apoptosis protein (IAP) | Apoptosis | INDUCED-PROXIMITY MODEL | VIRAL SERPIN CRMA | X-LINKED INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | inhibitor of apoptosis protein (IAP) | apoptosis | zymogen | caspase | INTERLEUKIN-1-BETA CONVERTING-ENZYME | protease | PROGRAMMED CELL-DEATH | TOLL-LIKE RECEPTOR-2 | inhibitor | ANTI-APOPTOTIC ACTIVITY | CYTOCHROME-C RELEASE | DEATH-EFFECTOR DOMAIN | SIGNALING COMPLEX DISC | Caspases - physiology | Enzyme Precursors - chemistry | Humans | Models, Molecular | Molecular Sequence Data | Substrate Specificity | Amino Acid Sequence - physiology | Structure-Activity Relationship | Caspase Inhibitors | Enzyme Precursors - metabolism | Animals | Caspases - metabolism | Protein Conformation | Molecular Structure | Caspases - chemistry | Enzyme Activation - physiology | CAD, caspase-activated DNase | FLICE, FADD-like ICE | TNF, tumour necrosis factor | CARD, LRR and NACHT-containing protein | Rip, receptor-interacting protein | DRONC, Drosophila Nedd2-like caspase | CARD-containing ICE-associated kinase | Ipaf | ICAD, inhibitor of CAD | CED, cell death-defective | DFF, DNA fragmentation factor | CARD, caspase-recruitment domain | APAF-1, apoptotic protease activating factor-1 | CLARP, caspase-like apoptosis-regulatory protein | DIABLO, direct IAP-binding protein with low pI | CLAN, ICE-protease-activating factor | RAIDD, caspase-2 and RipK1 domain-containing adaptor with death domain | ICE, interleukin-1β-converting enzyme | NALP1, NACHT, LRR and Pyrin domain containing 1 | ALPS, autoimmune lymphoproliferative syndrome | LRR, leucine-rich repeat | PYD- and CARD-containing molecule | NOD, nucleotide-binding and oligomerization domain-containing protein | NACHT, NTPase-domain named after NAIP, CIITA, HET-E and TP1 | S1, S2, …Sn and S1′, S2′, …Sm′ refer to the cognate pockets on the protease that accept these side chains | PYCARD, apoptosis-associated speck-like protein containing a CARD | PARP, poly(ADP-ribose) polymerase | P1, P2, …Pn and P1′, P2′, …Pm′ designate the side chains in substrates and inhibitors in the N- and C-terminal direction respectively from the P1–P1′ scissile peptide bond | TFPI, tissue factor pathway inhibitor | TLR, Toll-like receptor | serpin, serine protease inhibitor | RING, really interesting new gene | XIAP | DED, death effector domain | Review | PIDD, p53-induced protein with a death domain | TRAIL, TNF-related apoptosis-inducing ligand | IAP, inhibitor of apoptosis protein | NBD, nucleotide-binding domain | ASC | TRAF, TNF receptor-associated factor | BIRC4, X-linked IAP | DD, death domain | Smac, second mitochondrial activator of caspases | DIAP1, Drosophila inhibitor of apoptosis 1 | BIR, baculoviral IAP repeat | IBM, IAP binding motif | TRADD, TNFRSF1A-associated via death domain | CRADD | DISC, death-inducing signalling complex | FADD, Fas (TNFRSF6)-associated via death domain | FLIP, FLICE inhibitory protein | NF-κB, nuclear factor-κB | CARP, caspase-associated RING protein | CrmA, cytokine response modifier A | CARDIAK, Rip-like interacting CLARP kinase | RICK | Rip-associated protein with a death domain | baculoviral IAP repeat-containing 4
Journal Article