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Gut, ISSN 0017-5749, 08/2013, Volume 62, Issue 8, pp. 1122 - 1130
Objective Etrolizumab (rhuMAb β7, anti-β7, PRO145223) is a humanised monoclonal antibody targeting the β7 subunit of the heterodimeric integrins α4β7 and αEβ7,... 
IBD basic research | IBD clinical | Etrolizumab | apoptosis | IBD | MONOCLONAL-ANTIBODY | antibody targeted therapy | HUMANIZED ANTIBODY | CELL-ADHESION MOLECULE-1 | integrins | dendritic cells | genetics | safety | rhuMAb 7 | pharmacokinetics | inflammatory bowel disorders | LAMINA PROPRIA LYMPHOCYTES | ulcerative colitis | cytokines | immunology | T-CELLS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | CROHNS-DISEASE | cell cycle | signal transduction | IBD models | drug development | Crohn's disease | E-CADHERIN | IBD-genetics | autoimmune disease | INFLAMMATORY-BOWEL-DISEASE | arthritis | CD103(+) DENDRITIC CELLS | GASTROENTEROLOGY & HEPATOLOGY | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Gastrointestinal Agents - administration & dosage | Antibodies, Monoclonal - therapeutic use | Male | Antibodies, Monoclonal - blood | Dose-Response Relationship, Drug | Young Adult | Antibodies, Monoclonal, Humanized | Injections, Subcutaneous | Adult | Female | Colitis, Ulcerative - drug therapy | Severity of Illness Index | Double-Blind Method | Treatment Outcome | Colitis, Ulcerative - blood | Antibodies, Monoclonal - administration & dosage | Adolescent | Gastrointestinal Agents - therapeutic use | Aged | Gastrointestinal Agents - adverse effects | Gastrointestinal Agents - blood | Infusions, Intravenous | Headache | Immunoglobulins | Intravenous administration | Wound healing | Dendritic cells | Migration | Inflammation | Injection | Retention | Crohns disease | Cell adhesion & migration | Inflammatory bowel disease | Studies | Lymphocytes | Monoclonal antibodies | Remission | Pharmacokinetics | Chronic illnesses | Ulcerative colitis | Integrins | Index Medicus | Abridged Index Medicus | rhuMAb β7 | Inflammatory Bowel Disease | IBD–genetics | 1506
Journal Article
Frontiers in immunology, ISSN 1664-3224, 2015, Volume 6, p. 551
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by chronic relapsing intestinal inflammation. Although etiology remains... 
Inflammatory bowel disease | Epigenetics | Genetics | Crohn's disease | Early-onset IBD | IBD | genetics | EMERGING ROLE | early-onset IBD | MICRORNAS | IMMUNOLOGY | ASSOCIATION | inflammatory bowel disease | epigenetics | Epigenetic inheritance | Epidemiology | Gastrointestinal diseases | Genomics | Crohn’s Disease | Inflammatory Bowel Diseases | Early Onset IBD
Journal Article
Journal Article
Gut, ISSN 0017-5749, 06/2017, Volume 66, Issue 6, pp. 1060 - 1073
ObjectivePatients with Niemann–Pick disease type C1 (NPC1), a lysosomal lipid storage disorder that causes neurodegeneration and liver damage, can present with... 
IBD-GENETICS | IBD CLINICAL | IMMUNODEFICIENCY | IBD BASIC RESEARCH | Crohn'S DISEASE | MIGLUSTAT THERAPY | PATHOGENESIS | APOPTOSIS | DENDRITIC CELLS | MACROPHAGES | SUSCEPTIBILITY | ILEAL MUCOSA | PHAGOSOME PROTEOME | GASTROENTEROLOGY & HEPATOLOGY | BOWEL-DISEASE | INNATE IMMUNITY | Tumor Necrosis Factor-alpha - metabolism | Crohn Disease - genetics | X-Linked Inhibitor of Apoptosis Protein - deficiency | Humans | Child, Preschool | Lysosomes | Male | Nod2 Signaling Adaptor Protein - genetics | Leukocytes, Mononuclear | Pyridazines - pharmacology | Niemann-Pick Disease, Type C - physiopathology | Autophagy - drug effects | Crohn Disease - complications | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Young Adult | Gentamicins - pharmacology | Adult | Bacteria | Female | Genetic Diseases, X-Linked - genetics | Autophagy - genetics | Child | Receptor-Interacting Protein Serine-Threonine Kinase 2 - antagonists & inhibitors | Macrophages - physiology | Granuloma - genetics | Cells, Cultured | Chlorpromazine - pharmacology | Imidazoles - pharmacology | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | X-Linked Inhibitor of Apoptosis Protein - genetics | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Granuloma - pathology | Nod2 Signaling Adaptor Protein - metabolism | Crohn Disease - pathology | Dopamine Antagonists - pharmacology | Adolescent | X-Linked Inhibitor of Apoptosis Protein - metabolism | Macrophages - drug effects | Anti-Bacterial Agents - pharmacology | Protein Kinase Inhibitors - pharmacology | Mutation | Niemann-Pick Disease, Type C - complications | Niemann-Pick Disease, Type C - genetics | Autophagy (Cytology) | Inflammatory bowel diseases | Gastrointestinal diseases | Causes of | Colorectal diseases | Crohn's disease | Research | Niemann-Pick disease | Salmonella | Granuloma | Muramyl dipeptide | Liver | XIAP protein | Kinases | Macrophages | Autophagy | Defects | Genotype & phenotype | Cell activation | Intestine | Neurodegeneration | Npc1 protein | Age | NOD2 protein | Oligomerization | Dendritic cells | Cytokines | Blood & organ donations | Inflammation | Patients | Crohns disease | Studies | Inflammatory bowel disease | Monocytes | Proteomics | Colitis | Adapter proteins | Phagocytosis | Apoptosis | IBD - GENETICS | CROHN'S DISEASE | Inflammatory Bowel Disease | 1506
Journal Article
Inflammatory bowel diseases, ISSN 1078-0998, 03/2015, Volume 21, Issue 5, pp. 963 - 972
Journal Article
Gut, ISSN 0017-5749, 01/2012, Volume 61, Issue 1, pp. 78 - 85
ObjectiveMesenteric fat hyperplasia is a hallmark of Crohn's disease (CD), and C reactive protein (CRP) is correlated with disease activity. The authors... 
INFLAMMATORY-BOWEL-DISEASE | ADIPONECTIN | TOLL-LIKE RECEPTOR | ENDOSCOPIC SEVERITY | PREADIPOCYTES | INTERLEUKIN-6 | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | ADIPOSE-TISSUE | HUMAN ADIPOCYTES | INNATE IMMUNITY | Mesentery - metabolism | Tumor Necrosis Factor-alpha - metabolism | Prospective Studies | Abdominal Fat - microbiology | Humans | Crohn Disease - metabolism | Lipopolysaccharides - metabolism | Male | C-Reactive Protein - metabolism | Escherichia coli - metabolism | Adult | Crohn Disease - microbiology | Female | Ileitis - metabolism | Escherichia coli - physiology | Interleukin-6 - metabolism | Cell Line | Mesentery - microbiology | Colitis, Ulcerative - metabolism | Bacterial Translocation | Abdominal Fat - metabolism | Animals | Colitis, Ulcerative - microbiology | Ileitis - microbiology | Mice | Lymph Nodes - microbiology | Adipose tissues | C-reactive protein | Causes of | Development and progression | Crohn's disease | Genetic aspects | Research | Gene expression | Health aspects | Lymphatic system | Cytokines | Biosynthesis | Inflammation | Adipocytes | Crohns disease | Streptococcus infections | Proteins | Studies | Inflammatory bowel disease | Body mass index | Genotype & phenotype | Biopsy | Rodents | Surgery | Bacteria | Tumor necrosis factor-TNF | Gram-negative bacteria | IBD basic research | antibiotic therapy | bacterial adherence | 2,4,6-trinitrobenzene sulfonic acid | TNF-alpha | IBD clinical | IBD | bacterial overgrowth | anti-bacterial peptide | Helicobacter pylori | acute hepatitis | bacterial translocation | antibiotics: clinical trials | ulcerative colitis | cytokines | Inflammatory Bowel Disease | gut inflammation | mucosal immunology | IBD models | bacteraemia | azathioprine | anti-bacterial mucosal immunity | bacterial infection | genetic polymorphisms | C Reactive protein | thiopurine methyltransferase | alcoholic liver disease | antibacterial peptide | cell biology | 6-mercaptopurine | mesenteric fat | non-ulcer dyspepsia | small intestine | bacterial pathogenesis | gastric neoplasia | 1506 | non-alcoholic steatohepatitis
Journal Article
Journal of internal medicine, ISSN 0954-6820, 2012, Volume 272, Issue 5, pp. 411 - 429
Journal Article