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Molecular Informatics, ISSN 1868-1743, 05/2016, Volume 35, Issue 5, pp. 199 - 206
Journal Article
Peptide Science, ISSN 0006-3525, 11/2015, Volume 104, Issue 6, pp. 753 - 763
ABSTRACT Peptide‐based antiviral therapeutics has gradually paved their way into mainstream drug discovery research. Experimental determination of peptides'... 
prediction | peptide | machine learning | antiviral | IC50
Journal Article
BIOPOLYMERS, ISSN 0006-3525, 11/2015, Volume 104, Issue 6, pp. 753 - 763
Peptide-based antiviral therapeutics has gradually paved their way into mainstream drug discovery research. Experimental determination of peptides' antiviral... 
REGRESSION | COLLECTION | peptide | VIRUS | CLASSIFICATION | machine learning | ANTITUMOR | POTENT ACTIVITY | LIBRARIES | BIOPHYSICS | DATABASE | antiviral | IC50 | prediction | WEB SERVER | TOOL
Journal Article
Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 2, pp. 481 - 492.e7
Journal Article
Autophagy, ISSN 1554-8627, 11/2014, Volume 10, Issue 11, pp. 2021 - 2035
Autophagy has been implicated in the progression and chemoresistance of various cancers. In this study, we have shown that osteosarcoma Saos-2 cells lacking... 
ACTB, actin, beta | LC3B | MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3beta | antiautophagy compounds | BECN1, beclin 1, autophagy related | IC50, half maximal inhibitory concentration | ATG, autophagy-related | PtdIns3K, phosphatidylinositol 3-kinase class III | NCI, National Cancer Institute | DMEM, Dulbecco's modified Eagle medium | in silico docking | HRP, horseradish peroxidase | RPS6KB1, ribosomal protein S6 kinase, 70kDa, polypeptide 1 | GABARAPL2, GABA(A) receptor-associated protein-like 2 | PVDF, polyvinylidene difluoride | RLU, relative luciferase units | MP, melting point | NMR, nuclear magnetic resonance | 3MA, 3-methyladenine | RFP, red fluorescent protein | AV, autophagic vacuole | CMPase, cytidine monophosphatase | GFP, green fluorescent protein | MTOR, mechanistic target of rapamycin | SEM, standard error of the mean | ULK1/2, unc-51-like autophagy activating kinase 1/2 | GST, glutathione S-transferase | PLA2, phospholipase A2 | ATG4B, autophagy-related 4B, cysteine protease | and xenografts | ECL, enhanced chemiluminescence | IP, intraperitoneal | PtdIns3P, phosphatidylinositol 3-phosphate | FYVE, zinc-finger domain named after 4 cysteine-rich proteins: FAB1, YOTB, VAC1, and EEA1 | dNGLUC, Gaussia luciferase | ATG4B | RPS6, ribosomal protein S6 | osteosarcoma | In silico docking | Antiautophagy compounds | Osteosarcoma | Xenografts | PROTEIN | xenografts | MECHANISM | ISOLATED RAT HEPATOCYTES | CANCER-THERAPY | CELL BIOLOGY | SARCOMA-CELLS | HEPATOCELLULAR-CARCINOMA | DEGRADATION | C-JUN | TUMORIGENESIS | LC3 | Green Fluorescent Proteins - metabolism | Neoplasm Transplantation | Autophagy-Related Proteins | Catalytic Domain | TOR Serine-Threonine Kinases - metabolism | Humans | Gene Expression Regulation, Neoplastic | Phosphatidylinositol 3-Kinases - metabolism | Autophagy | Lipids - chemistry | Animals | Cysteine Endopeptidases - metabolism | Mice, Nude | Aminopyridines - pharmacology | Computer Simulation | Cysteine Proteinase Inhibitors - pharmacology | HEK293 Cells | Cell Line, Tumor | Female | Mice | Osteosarcoma - metabolism
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 05/2012, Volume 586, Issue 10, pp. 1459 - 1465
Journal Article
Gastroenterology, ISSN 0016-5085, 05/2019, Volume 156, Issue 6, pp. 1820 - 1833
Journal Article
International Journal of Molecular Sciences, ISSN 1422-0067, 12/2011, Volume 12, Issue 12, pp. 8626 - 8644
Journal Article
Antiviral Research, ISSN 0166-3542, 12/2015, Volume 124, pp. 77 - 82
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 09/2016, Volume 6, Issue 5, pp. 363 - 373
The kidney is a vital organ for the elimination of therapeutic drugs and their metabolites. Renal drug transporters, which are primarily located in the renal... 
Organic cations | Organic anions | Drug-drug interactions | Nephrotoxicity | Renal drug transporters | ORGANIC ANION TRANSPORTER | MULTIDRUG-RESISTANCE PROTEINS | KIDNEY PROXIMAL TUBULES | CISPLATIN-INDUCED NEPHROTOXICITY | FUNCTIONAL-CHARACTERIZATION | CLINICAL PHARMACOKINETICS | INTESTINAL P-GLYCOPROTEIN | CATION TRANSPORTER-2 | MOLECULAR-IDENTIFICATION | TISSUE DISTRIBUTION | PHARMACOLOGY & PHARMACY | NSAID, non-steroidal anti-inflammatory drugs | CHO, Chinese hamster ovary | URAT, urate transporter | P-gp, P-glycoprotein | GSH, glutathione | DDIs, drug–drug interactions | HEK, human embryonic kidney | IC50, half maximal inhibitory concentration | SNP, single-nucleotide polymorphism | Review | Cmax, maximum plasma concentration | MPP+, 1-methyl-4-phenylpyridimium | OCTN, Organic zwitterions | SLC, solute carrier | TEA, tetraethylammonium | ABC, ATP-binding cassette | AUC, area under the plasma concentration curve | MRP, multidrug resistance-associated protein | NBD, nucleotide-binding domain | Drug–drug interactions | ITC, International Transporter Consortium | OA, organic anion | OAT or Oat, organic anion transporters | OC, organic cation | ATP, adenosine triphosphate | TMD, transmembrane domain | CL, plasma clearance | FDA, U.S. Food and Drug Administration | MSD, membrane-spanning domain | MW, molecular weight | NME, new molecular entity | BBB, blood–brain barrier | cation transporters | PAH, p-aminohippurate | Ki, inhibitory constant | OATP or Oatp, organic anion-transporting peptide | fe, fraction of the absorbed dose excreted unchanged in urine | MATE, multidrug and toxin extrusion protein | CLR, renal clearance | OCT or Oct, organic cation transporter
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 08/2016, Volume 113, pp. 24 - 35
Journal Article