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by Ally, Adrian and Balasundaram, Miruna and Carlsen, Rebecca and Chuah, Eric and Clarke, Amanda and Dhalla, Noreen and Holt, Robert A and Jones, Steven J.M and Lee, Darlene and Ma, Yussanne and Marra, Marco A and Mayo, Michael and Moore, Richard A and Mungall, Andrew J and Schein, Jacqueline E and Sipahimalani, Payal and Tam, Angela and Thiessen, Nina and Cheung, Dorothy and Wong, Tina and Brooks, Denise and Robertson, A. Gordon and Bowlby, Reanne and Mungall, Karen and Sadeghi, Sara and Xi, Liu and Covington, Kyle and Shinbrot, Eve and Wheeler, David A and Gibbs, Richard A and Donehower, Lawrence A and Wang, Linghua and Bowen, Jay and Gastier-Foster, Julie M and Gerken, Mark and Helsel, Carmen and Leraas, Kristen M and Lichtenberg, Tara M and Ramirez, Nilsa C and Wise, Lisa and Zmuda, Erik and Gabriel, Stacey B and Meyerson, Matthew and Cibulskis, Carrie and Murray, Bradley A and Shih, Juliann and Beroukhim, Rameen and Cherniack, Andrew D and Schumacher, Steven E and Saksena, Gordon and Pedamallu, Chandra Sekhar and Chin, Lynda and Getz, Gad and Noble, Michael and Zhang, Hailei and Heiman, David and Cho, Juok and Gehlenborg, Nils and Voet, Douglas and Lin, Pei and Frazer, Scott and Defreitas, Timothy and Meier, Sam and Lawrence, Michael and Kim, Jaegil and Creighton, Chad J and Muzny, Donna and Doddapaneni, HarshaVardhan and Hu, Jianhong and Wang, Min and Morton, Donna and Korchina, Viktoriya and Han, Yi and Dinh, Huyen and Lewis, Lora and Bellair, Michelle and Liu, Xiuping and Santibanez, Jireh and Glenn, Robert and Lee, Sandra and Hale, Walker and Parker, Joel S and Wilkerson, Matthew D and Hayes, D. Neil and Reynolds, Sheila M and Shmulevich, Ilya and Zhang, Wei and Liu, Yuexin and Iype, Lisa and Makhlouf, Hala and Torbenson, Michael S and Kakar, Sanjay and Yeh, Matthew M and Jain, Dhanpat and Kleiner, David E and Dhanasekaran, Renumathy and El-Serag, Hashem B and Yim, Sun Young and Weinstein, John N and Mishra, Lopa and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu
Cell (Cambridge), ISSN 0092-8674, 2017, Volume 169, Issue 7, pp. 1327 - 1341.e23
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 10/2012, Volume 3, Issue 10, pp. 850 - 855
Optimization of a series of R132H IDH1 inhibitors from a high throughput screen led to the first potent molecules that show robust tumor 2-HG inhibition in a... 
R132H IDH1 inhibitors | Mutant IDH1 | tumor 2-HG | GLIOMAS | CHEMISTRY, MEDICINAL | MUTATIONS | DIFFERENTIATION | ONCOMETABOLITE 2-HYDROXYGLUTARATE
Journal Article
by Brat, Daniel J and Verhaak, Roel G. W and Aldape, Kenneth D and Yung, W. K. Alfred and Salama, Sofie R and Cooper, Lee A. D and Rheinbay, Esther and Miller, C. Ryan and Vitucci, Mark and Morozova, Olena and Robertson, A. Gordon and Noushmehr, Houtan and Laird, Peter W and Cherniack, Andrew D and Akbani, Rehan and Huse, Jason T and Ciriello, Giovanni and Poisson, Laila M and Barnholtz-Sloan, Jill S and Berger, Mitchel S and Brennan, Cameron and Colen, Rivka R and Colman, Howard and Flanders, Adam E and Giannini, Caterina and Grifford, Mia and Iavarone, Antonio and Jain, Rajan and Joseph, Isaac and Kim, Jaegil and Kasaian, Katayoon and Mikkelsen, Tom and Murray, Bradley A and O'Neill, Brian Patrick and Pachter, Lior and Parsons, Donald W and Sougnez, Carrie and Sulman, Erik P and Vandenberg, Scott R and Van Meir, Erwin G and Von Deimling, Andreas and Zhang, Hailei and Crain, Daniel and Lau, Kevin and Mallery, David and Morris, Scott and Paulauskis, Joseph and Penny, Robert and Shelton, Troy and Sherman, Mark and Yena, Peggy and Black, Aaron and Bowen, Jay and Dicostanzo, Katie and Gastier-Foster, Julie and Leraas, Kristen M and Lichtenberg, Tara M and Pierson, Christopher R and Ramirez, Nilsa C and Taylor, Cynthia and Weaver, Stephanie and Wise, Lisa and Zmuda, Erik and Davidsen, Tanja and Demchok, John A and Eley, Greg and Ferguson, Martin L and Hutter, Carolyn M and Shaw, Kenna R. Mills and Ozenberger, Bradley A and Sheth, Margi and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Zhining and Yang, Liming and Zenklusen, Jean Claude and Ayala, Brenda and Baboud, Julien and Chudamani, Sudha and Jensen, Mark A and Liu, Jia and Pihl, Todd and Raman, Rohini and Wan, Yunhu and Wu, Ye and Ally, Adrian and Auman, J. Todd and Balasundaram, Miruna and Balu, Saianand and Baylin, Stephen B and Beroukhim, Rameen and Bootwalla, Moiz S and Bowlby, Reanne and Bristow, Christopher A and Brooks, Denise and Butterfield, Yaron and Carlsen, Rebecca and Carter, Scott and Chin, Lynda and Chu, Andy and ... and The Cancer Genome Atlas Research Network and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
The New England journal of medicine, ISSN 1533-4406, 2015, Volume 372, Issue 26, pp. 2481 - 2498
Journal Article
Journal of Cancer, ISSN 1837-9664, 2018, Volume 9, Issue 6, pp. 998 - 1005
Background. Recent studies have shown that isocitrate dehydrogenase 1/2 (IDH1/2)-activating mutations occur in a variety of cancers, including acute myeloid... 
chondrosarcoma | IDH1/2 mutation; AmpliSeq Cancer Hotspot Panel | Next-generation sequencing | IDH1/2 mutation | IDH2 MUTATIONS | PROGNOSTIC-FACTORS | GENE | ONCOLOGY | next-generation sequencing | AmpliSeq Cancer Hotspot Panel | DEDIFFERENTIATED CHONDROSARCOMA | ACUTE MYELOID-LEUKEMIA | BONE
Journal Article
Acta neuropathologica communications, ISSN 2051-5960, 2016, Volume 4, Issue 1, p. 79
Journal Article
Oncotarget, ISSN 1949-2553, 12/2018, Volume 9, Issue 98, pp. 37097 - 37111
The presence of an ( ) mutation in gliomas is associated with favorable outcomes compared to gliomas without the mutation ( wild-type, WT). The underlying... 
Isocitrate dehydrogenase (IDH1/2) mutation | Transgelin-2 | Glioma | Invasion | Glioblastoma
Journal Article