X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
ido1 (144) 144
index medicus (120) 120
indoleamine 2,3-dioxygenase (77) 77
humans (67) 67
cancer (66) 66
tryptophan (65) 65
dendritic cells (53) 53
immunotherapy (51) 51
immunology (50) 50
expression (49) 49
indoleamine-pyrrole 2,3,-dioxygenase - metabolism (48) 48
oncology (47) 47
animals (46) 46
chemistry, medicinal (39) 39
mice (37) 37
biochemistry & molecular biology (35) 35
enzymes (32) 32
ido (31) 31
t-cells (27) 27
tryptophan catabolism (26) 26
female (25) 25
indoleamine-pyrrole 2,3,-dioxygenase - genetics (25) 25
inflammation (25) 25
mechanism (25) 25
dioxygenase (24) 24
indoleamine-pyrrole 2,3,-dioxygenase - antagonists & inhibitors (24) 24
derivatives (23) 23
discovery (23) 23
regulatory t-cells (23) 23
t cells (23) 23
analysis (22) 22
ido1 inhibitors (22) 22
indoleamine 2,3-dioxygenase 1 (22) 22
inhibition (22) 22
tryptophan - metabolism (22) 22
gene expression (21) 21
research (21) 21
tryptophan 2,3-dioxygenase (21) 21
aryl-hydrocarbon receptor (20) 20
crystal-structures (20) 20
3-dioxygenase (19) 19
article (19) 19
cells (19) 19
pharmacology & pharmacy (19) 19
structure-activity relationship (19) 19
tolerance (19) 19
tumors (19) 19
male (18) 18
cell biology (17) 17
immunosuppression (17) 17
indoleamine 2 (17) 17
interferon (17) 17
metabolism (17) 17
physiological aspects (17) 17
care and treatment (16) 16
enzyme inhibitors - pharmacology (16) 16
kynurenine pathway (16) 16
metabolites (16) 16
mice, inbred c57bl (16) 16
pd-l1 (16) 16
cancer immunotherapy (15) 15
cell line, tumor (15) 15
chemotherapy (15) 15
interferon-gamma (15) 15
lymphocytes (15) 15
2,3-dioxygenase 1 ido1 (14) 14
apoptosis (14) 14
chemistry, organic (14) 14
kynurenine (14) 14
protein (14) 14
enzyme inhibitors - chemistry (13) 13
ido2 (13) 13
metastasis (13) 13
neoplasms. tumors. oncology. including cancer and carcinogens (13) 13
resistance (13) 13
target (13) 13
clinical trials (12) 12
drug discovery (12) 12
genetic aspects (12) 12
medical research (12) 12
adult (11) 11
ifn-gamma (11) 11
immune escape (11) 11
immune response (11) 11
immuno-oncology (11) 11
indoleamine-pyrrole 2,3,-dioxygenase - immunology (11) 11
induction (11) 11
lymphocytes t (11) 11
melanoma (11) 11
middle aged (11) 11
original research (11) 11
signal transduction (11) 11
activation (10) 10
epacadostat (10) 10
heme (10) 10
kynurenine - metabolism (10) 10
molecular structure (10) 10
prognosis (10) 10
tryptophan degradation (10) 10
tryptophan metabolism (10) 10
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2019, Volume 34, Issue 1, pp. 1481 - 1488
Indoleamine 2,3-dioxygenase 1 (IDO1), a tryptophan catabolising enzyme, is known as a tumour cell survival factor that causes immune escape in several types of... 
flavonoid | Sophora flavescens | IDO1 inhibitor | Indoleamine 2,3-dioxygenase 1 (IDO1) | Indoleamine 2 | GAMMA | CHEMISTRY, MEDICINAL | IDO | BIOCHEMISTRY & MOLECULAR BIOLOGY | ROOTS | RECEPTOR | 3-dioxygenase 1 (IDO1)
Journal Article
Trends in Pharmacological Sciences, ISSN 0165-6147, 03/2018, Volume 39, Issue 3, pp. 307 - 325
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase 2 (TDO2) catalyze the commitment step of the kynurenine (KYN) metabolic pathway.... 
KYN | AhR | immuno-oncology | TDO2 | KYNase | IDO1 | MALIGNANT GLIOMA | ARYL-HYDROCARBON RECEPTOR | DENDRITIC CELL IMMUNOGENICITY | INDOLEAMINE 2,3-DIOXYGENASE | REGULATORY T-CELLS | PHARMACOLOGY & PHARMACY | INHIBITOR | EXPRESSION | 2,3-DIOXYGENASE 1 IDO1 | TRYPTOPHAN CATABOLISM | CUTTING EDGE
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 05/2017, Volume 8, Issue 5, pp. 486 - 491
A data-centric medicinal chemistry approach led to the invention of a potent and selective IDO1 inhibitor , INCB24360 (epacadostat). The molecular structure of... 
Epacadostat | data-centric medicinal chemistry | immuno-oncology | INCB24360 | IDO1
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 06/2016, Volume 300, pp. 13 - 24
Obesity is an increasingly urgent global problem, yet, little is known about its causes and less is known how obesity can be effectively treated. We showed... 
Aryl hydrocarbon receptor | Obesity | TLR2/TGFβ/PI3K/NF-κB/IDO1/AHR axis | α-Naphthoflavone and CH-223191 | Liver steatosis | TOLL-LIKE-RECEPTORS | METABOLIC SYNDROME | DENDRITIC CELLS | INDOLEAMINE 2,3-DIOXYGENASE | LOW-DENSITY-LIPOPROTEIN | DIOXIN RECEPTOR | TLR2/TGF beta/PI3K/NF-kappa B/IDO1/AHR axis | alpha-Naphthoflavone and CH-223191 | REGULATORY T-CELLS | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | NF-KAPPA-B | ADIPOSE-TISSUE | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Signal Transduction | Kynurenine - biosynthesis | Mice, Inbred C57BL | Fatty Liver - prevention & control | Male | Toll-Like Receptor 2 - metabolism | Animals | Adiposity | Benzoflavones - pharmacology | Lipids - blood | Obesity - prevention & control | Intra-Abdominal Fat - drug effects | Mice | Azo Compounds - pharmacology | Diet, Western | Transforming Growth Factor beta - metabolism | Hepatocytes - drug effects | Lipoproteins, LDL | Pyrazoles - pharmacology | Index Medicus | KYNURENINE | TRYPTOPHAN | METABOLITES | QUINOLINES | 60 APPLIED LIFE SCIENCES | LUCIFERASE | GROWTH FACTORS | HYDROXY COMPOUNDS | INHIBITION | DIET | LIGANDS | METABOLISM | LIVER | LIVER CELLS | MICE | METABOLIC DISEASES | RECEPTORS | LIPOPROTEINS | Aryl Hydrocarbon Receptor | NF-κB | PI3K | TGFβ | AHR axis | TLR2 | IDO1
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2018, Volume 115, Issue 13, pp. 3249 - 3254
For cancer cells to survive and proliferate, they must escape normal immune destruction. One mechanism by which this is accomplished is through immune... 
Kynurenine | Heme | Cancer | IDO1 | MECHANISM | heme | MULTIDISCIPLINARY SCIENCES | kynurenine | CELL-PROLIFERATION | TRYPTOPHAN CATABOLISM | DISCOVERY | 1 IDO1 INHIBITORS | SOLUBLE GUANYLYL CYCLASE | INFLAMMATION | DIOXYGENASE | cancer | BINDING | Immune response | Metabolites | Oncology, Experimental | Cancer cells | Physiological aspects | Oxidoreductases | Research | Biological Sciences | Physical Sciences
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 11/2018, Volume 140, Issue 44, pp. 14538 - 14541
Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an important heme-containing enzyme that is a key drug target for cancer immunotherapy. Several hIDO1 inhibitors... 
CRYSTAL-STRUCTURES | MECHANISM | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY | IDO1
Journal Article
Applied Immunohistochemistry and Molecular Morphology, ISSN 1541-2016, 2019, p. 1
Developments in genomic pathology have led to novel molecular classification schemes in gastric cancers. Two of these new subtypes, Epstein-Barr virus... 
WARS | gastric cancer | molecular subtype | IDO1
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111629
Targeting indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as an attractive approach for the development of cancer immunotherapy. In this study, a... 
Epacadostat | Phosphonamidate ester | IDO2 | IDO1 inhibitors | TDO
Journal Article
Phytomedicine, ISSN 0944-7113, 10/2019, Volume 63, p. 153055
Indoleamine 2,3-dioxygenase 1 (IDO1), an important intracellular rate-limiting enzyme in the development of Hepatic fibrosis (HF), and has been proposed as a... 
Hepatic fibrosis | Danshensu | JAK2-STAT3 signaling | IDO1
Journal Article
Immunity, ISSN 1074-7613, 02/2017, Volume 46, Issue 2, pp. 233 - 244
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2019, Volume 162, pp. 455 - 464
Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of... 
Diaryl oalkylhydroxylamines | Dual inhibitor | TDO inhibition | IDO2 inhibition | Pan inhibition | IDO1 inhibition | Antitumor therapy | CHEMISTRY, MEDICINAL | MECHANISM | DISCOVERY | B-CELLS | LUNG-CANCER | IMMUNOTHERAPY | SUBSTRATE | TUMORAL IMMUNE RESISTANCE | TRYPTANTHRIN DERIVATIVES | IDO1 | INSIGHTS
Journal Article
Oncotarget, ISSN 1949-2553, 07/2019, Volume 10, Issue 44, p. 4546
Treatment options and risk stratification for esophageal adenocarcinomas (EAC) currently rely on pathological criteria such as tumor staging. However, with... 
Journal Article
International Immunopharmacology, ISSN 1567-5769, 01/2018, Volume 54, pp. 118 - 124
MuS110 and MT110 are BiTE antibodies bispecific for CD3 and EpCAM, which is the most frequently and highly expressed tumor-associated antigen on breast cancer.... 
Breast cancer | MT110 | EpCAM | D-1MT | IDO1
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2019, Volume 383, Issue 2, p. 111508
Immunotherapy and personalized medicine therapeutics are emerging as promising approaches in the management of head and neck squamous cell carcinoma (HNSCC).... 
Immunotherapy | PD-L1 | Head and neck cancer | Personalized medicine | In vitro | Microfuidic chip | IDO1
Journal Article
Trends in Molecular Medicine, ISSN 1471-4914, 11/2018, Volume 24, Issue 11, pp. 931 - 941
Although significant progress has been made in understanding autoimmunity, no immunotherapy to effectively halt immune-mediated destruction of β cells in type... 
PD-L1 | PD1 | indoleamine 2,3-dioxygenase 1 (IDO1) | type 1 diabetes (T1D) | immune checkpoints | personalized therapy | MEDICINE, RESEARCH & EXPERIMENTAL | DENDRITIC CELLS | TOLERANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDOLEAMINE 2,3-DIOXYGENASE | CANCER | TRYPTOPHAN CATABOLISM | CELL BIOLOGY | ARYL-HYDROCARBON RECEPTOR | IDO | DISEASE | C-PEPTIDE | CTLA-4
Journal Article