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European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2018, Volume 143, pp. 656 - 669
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 05/2017, Volume 323, pp. 74 - 80
Indoleamine 2,3-dioxygenase 1 (IDO1) plays a key role in the immune system by regulating tryptophan levels and T cell differentiation. Several tumor types... 
IDO inhibitors | Clinical trials | Aryl Hydrocarbon Receptor | AHR agonists | IDO1 | Cancer | DENDRITIC CELLS | KYNURENINE PATHWAY | AH RECEPTOR | TRYPTOPHAN CATABOLISM | INTERFERON-GAMMA | COLORECTAL-CANCER | THERAPEUTIC TARGET | DISEASE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | T-CELLS | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Cytochrome P-450 CYP1A1 - genetics | Basic Helix-Loop-Helix Transcription Factors - agonists | Basic Helix-Loop-Helix Transcription Factors - genetics | Risk Assessment | Humans | Enzyme Inhibitors - pharmacology | Receptors, Aryl Hydrocarbon - genetics | Enzyme Induction | Hep G2 Cells | Receptors, Aryl Hydrocarbon - agonists | Animals | Transfection | Basic Helix-Loop-Helix Transcription Factors - metabolism | Enzyme Inhibitors - toxicity | Receptors, Aryl Hydrocarbon - metabolism | Ligands | Transcription, Genetic | Mice | Cytochrome P-450 CYP1A1 - biosynthesis | Genes, Reporter | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Physiological aspects | Tryptophan | T cells | Xenobiotics | Cells | Herbicides | Medical colleges | Dioxin | Cytochrome P-450 | Index Medicus | DIOXIN | KYNURENINE | TRYPTOPHAN | NEOPLASMS | CLINICAL TRIALS | DMSO | SUBSTRATES | QUINOLINES | 60 APPLIED LIFE SCIENCES | LUCIFERASE | MEDICAL SURVEILLANCE | ENZYME ACTIVITY | XENOBIOTICS | HYDROXY COMPOUNDS | LIGANDS | METABOLISM | DRUGS | GENES | PHOSPHATES | CELL DIFFERENTIATION | MICE | RECEPTORS | BEARS
Journal Article
Gynecologic Oncology, ISSN 0090-8258, 09/2017, Volume 146, Issue 3, pp. 484 - 490
Indoleamine 2,3-dioxygenase-1 (IDO1) is a key regulator of immune tolerance in ovarian cancer. This study investigated efficacy and safety of the IDO1 enzyme... 
Epacadostat | IDO1 enzyme inhibitor | Tamoxifen | Ca-125 | Ovarian cancer | SURVIVAL | DIAGNOSIS | PROTEIN | PROGNOSIS | INDOLEAMINE 2,3-DIOXYGENASE | OBSTETRICS & GYNECOLOGY | ONCOLOGY | IMMUNOTHERAPY | EXPRESSION | T-CELLS | Recurrence | Neoplasms, Glandular and Epithelial - chemistry | Oximes - pharmacokinetics | Oximes - adverse effects | Peritoneal Neoplasms - blood | Humans | Middle Aged | Oximes - therapeutic use | Response Evaluation Criteria in Solid Tumors | Fatigue - chemically induced | Peritoneal Neoplasms - chemistry | Antineoplastic Agents, Hormonal - adverse effects | Early Termination of Clinical Trials | Fallopian Tube Neoplasms - blood | Neoplasms, Glandular and Epithelial - blood | Peritoneal Neoplasms - drug therapy | Fallopian Tube Neoplasms - chemistry | Exanthema - chemically induced | Antineoplastic Agents, Hormonal - therapeutic use | Adult | Female | Ovarian Neoplasms - drug therapy | Pruritus - chemically induced | Fallopian Tube Neoplasms - drug therapy | Drug Eruptions - etiology | Ovarian Neoplasms - chemistry | CA-125 Antigen - blood | Indoleamine-Pyrrole 2,3,-Dioxygenase - analysis | Ovarian Neoplasms - blood | Survival Rate | Sulfonamides - pharmacokinetics | Disease-Free Survival | Sulfonamides - therapeutic use | Tamoxifen - therapeutic use | Neoplasms, Glandular and Epithelial - drug therapy | Carcinoma, Ovarian Epithelial | Sulfonamides - adverse effects | Aged | Tamoxifen - adverse effects | Indoleamine-Pyrrole 2,3,-Dioxygenase - antagonists & inhibitors | Care and treatment | Chemotherapy | Enzyme inhibitors | Cancer | Medical research | Medicine, Experimental
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 03/2019, Volume 27, Issue 6, pp. 1087 - 1098
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important... 
Antitumor activity | Dual inhibitor | 1H-Indazoles | Cancer immunotherapy | Tryptophan 2,3-dioxygenase (TDO) | Indoleamine 2,3-dioxygenase 1 (IDO1)
Journal Article
by Yang, LL and Chen, Y and He, JL and Njoya, EM and Chen, JJ and Liu, SY and Xie, CQ and Huang, WZ and Wang, F and Wang, ZY and Li, YZ and Qian, S
BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 03/2019, Volume 27, Issue 6, pp. 1087 - 1098
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important... 
CHEMISTRY, MEDICINAL | Dual inhibitor | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | Antitumor activity | 1H-Indazoles | Cancer immunotherapy | Tryptophan 2,3-dioxygenase (TDO) | Indoleamine 2,3-dioxygenase 1 (IDO1)
Journal Article
Archiv der Pharmazie, ISSN 0365-6233, 11/2019, Volume 352, Issue 11, pp. e1900165 - n/a
A series of imidazole derivatives were designed following rational drug design, and synthesized through microwave‐assisted one‐pot multicomponent reactions.... 
imidazole | IDO1 inhibitors | microwave | one‐pot | one-pot | CHEMISTRY, MEDICINAL | INDOLEAMINE 2,3-DIOXYGENASE | CRYSTAL-STRUCTURES | PHARMACOLOGY & PHARMACY | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | 2,3-DIOXYGENASE 1 IDO1 | DISCOVERY
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2019, Volume 27, Issue 14, pp. 3135 - 3144
Two series of novel aryl-acrylic derivatives were designed, synthesized, and screened in enzymatic and cellular inhibitory activities. All compounds showed... 
Aryl-acrylic derivatives | Synthesis | IDO1 inhibitors | Structure-activity relationship | KYNURENINE | TARGET | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDOLEAMINE 2,3-DIOXYGENASE | CHEMISTRY, ORGANIC | MECHANISMS | CANCER | DISCOVERY | POTENT | FERULIC ACID | PATHWAY | Derivatives (Financial instruments) | Analysis
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111629
Targeting indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as an attractive approach for the development of cancer immunotherapy. In this study, a... 
Epacadostat | Phosphonamidate ester | IDO2 | IDO1 inhibitors | TDO
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 12/2011, Volume 1814, Issue 12, pp. 1947 - 1954
Indoleamine 2,3-dioxygenase (IDO1) catalyzes the first step in tryptophan breakdown along the kynurenine pathway. Therapeutic inhibition of IDO1 is receiving... 
Human | Kinetics | Inhibition | IDO2 | IDO1 | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | OVARIAN-CANCER | ENDOMETRIAL CANCER | ENZYME | BIOPHYSICS | INTERFERON-GAMMA | GENE | MICE | TRYPTOPHAN DEGRADATION | EXPRESSION | T-CELLS | Tryptophan | Parathyroid hormone | Chemical properties
Journal Article
Toxicology and applied pharmacology, ISSN 0041-008X, 5/2017, Volume 323, pp. 74 - 80
Indoleamine 2,3-dioxygenase 1 (IDO1) plays a key role in the immune system by regulating tryptophan levels and T cell differentiation. Several tumor types... 
Aryl Hydrocarbon Receptor | IDO Inhibitors | AHR Agonists | Clinical Trials | IDO1 | Cancer
Journal Article