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European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111629
Targeting indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as an attractive approach for the development of cancer immunotherapy. In this study, a... 
Epacadostat | Phosphonamidate ester | IDO2 | IDO1 inhibitors | TDO
Journal Article
Journal of the American College of Surgeons, ISSN 1072-7515, 04/2018, Volume 226, Issue 4, pp. 596 - 603
Variation in an individual's genetic status can impact the development of pancreatic ductal adenocarcinoma; however, the majority of familial pancreatic... 
TARGET | SURGERY | GENE | INFLAMMATION | SUSCEPTIBILITY | RISK | IDO2
Journal Article
RSC Advances, ISSN 2046-2069, 2016, Volume 6, Issue 81, pp. 77577 - 77589
Indoleamine dioxygenase 2 (IDO2) is a newly discovered enzyme that contributes to tumor immune escape. Our previous studies demonstrated that small interfering... 
Photothermal therapy | siRNA | Gold nanorods | IDO2 | Folic acid | Melanoma
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 2/2014, Volume 192, Issue 3, pp. 1231 - 1240
Dendritic cells (DC) are professional antigen-presenting cells that have a role in the initiation of adaptive immune responses and tolerance. Among the... 
Human Dendritic Cells | Anergy | Suppression | Tolerance | Inflammation | IDO2 | IDO1
Journal Article
OncoImmunology, ISSN 2162-4011, 12/2012, Volume 1, Issue 9, pp. 1460 - 1468
Tryptophan catabolism by indoleamine 2,3-dioxygenase (IDO) alters inflammation and favors T-cell tolerance in cancer, but the underlying molecular mechanisms... 
amino acid starvation | immunomodulation | autophagy | IDO | stress signaling | mTOR | S6K | PKC-θ | IDO2 | TDO | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Stress signaling | Immunomodulation | Amino acid starvation | Autophagy | MTOR | PKC-theta | CELLS | INDOLEAMINE 2,3-DIOXYGENASE | KINASE | IMMUNOLOGY | SUPPRESSION | CANCER | ONCOLOGY | TRANSFER-RNA SYNTHETASE | INFLAMMATION | AMPK | EXPRESSION | Research Paper
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 2017, Volume 62, pp. 24 - 29
Highlights • Non-tumor cell IDO1 predominantly contributes to Kyn accumulation in mouse GBM. • Immune checkpoint blockade requires IDO1 for maximal survival... 
Psychiatry | Allergy and Immunology | Immunosuppression | Glioma | TDO2 | Tryptophan | Kynurenine | IDO2 | IDO1 | RESISTANCE MECHANISM | PSYCHIATRY | INDOLEAMINE 2,3-DIOXYGENASE | IMMUNOLOGY | NEUROSCIENCES | NIVOLUMAB | IPILIMUMAB | Enzymes | Gliomas | Medical colleges | Analysis | Immunotherapy | Brain tumors | T cells | glioma | immunosuppression | kynurenine | tryptophan
Journal Article
BBA - Proteins and Proteomics, ISSN 1570-9639, 12/2011, Volume 1814, Issue 12, pp. 1947 - 1954
Indoleamine 2,3-dioxygenase (IDO1) catalyzes the first step in tryptophan breakdown along the kynurenine pathway. Therapeutic inhibition of IDO1 is receiving... 
Human | Kinetics | Inhibition | IDO2 | IDO1 | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | OVARIAN-CANCER | ENDOMETRIAL CANCER | ENZYME | BIOPHYSICS | INTERFERON-GAMMA | GENE | MICE | TRYPTOPHAN DEGRADATION | EXPRESSION | T-CELLS | Tryptophan | Parathyroid hormone | Chemical properties
Journal Article