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Seminars in immunology, ISSN 1044-5323, 03/2015, Volume 27, Issue 2, pp. 85 - 101
Highlights • Type I interferon represents the first line of innate host defense against a number of invading pathogens that also instructs adaptive immunity. •... 
Allergy and Immunology | Virus | Evasion mechanism | Signaling | Bacteria | Interferon | IFN-stimulated genes | Viruses - classification | Bacteria - immunology | Immune Evasion | Virus Diseases - immunology | Signal Transduction | Bacterial Infections - immunology | Bacteria - classification | Virus Diseases - virology | Viruses - immunology | Interferon Type I - immunology | Bacterial Infections - microbiology | Index Medicus | WNV, West Nile virus | CPSF6, cleavage and polyadenylation specificity factor subunit 6 | IKK, inhibitor of kB kinase | SIV, simian immunodeficiency virus | CDNs, cyclic dinucleotides | JEV, Japanese encephalitis virus | AIM2, absent in melanoma 2 | pDCs, plasmacytoid dendritic cells | RT, reverse transcription | β, IFN-I | dsRNA, double-strand RNA | ITIM, immunoreceptor tyrosine-based inhibition motif | TIR, Toll-Interleukin-1 receptor | IFN-α | IFI16, interferon gamma-interferon-inducible protein 16 | MDA5, melanoma differentiation-associated gene-5 | ssDNA, single-stranded DNA | PLP, papain-like protease | TRAF, TNF receptor associated factor | MAPKs, mitogen-activated protein kinases | LRRFIP1, extrachromosomal histone | NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells | iNOS, inducible nitric oxide synthase 1 | dNTPase, deoxynucleotide triphosphate triphosphohydrolase | mRNA, messenger RNA | RNA, ribonucleic acid | miR, microRNA | TRIF, TIR domain-containing adaptor inducing IFN-β | SARS, severe acute respiratory syndrome | DAI, DNA-dependent activator of IFN-regulatory factors | TREX1, three prime repair exonuclease 1 | IFITM, IFN-induced transmembrane protein | STING, stimulator of IFN genes protein | TLRs, Toll-like receptors | NADPH, nicotinamide adenine dinucleotide phosphate | PACT, PKR-associated activator | MERS, Middle East respiratory syndrome | TRIM, tripartite motif | LPS, lipopolysaccharide | CypA, cyclophilin A | CoV, Coronavirus | IRF, IFN regulatory factor | ISRE, IFN-stimulated response element | PAMP, pathogen-associated molecular pattern | ISGF3, interferon-stimulated gene factor 3 | NSP, nonstructural protein | DCs, dendritic cells | MyD88, myeloid differentiation primary response gene 88 | CARD, caspase recruitment domain | HCV, hepatitis C virus | IRAK, IL-1R-associated kinases | DHX, DEAH box protein | CLRs, C-type lectin receptors | cIAP, cellular inhibitors of apoptosis | PKR, double-stranded RNA-activated protein kinase | RIP, receptor-interacting serine-threonine kinase | MAVS, mitochondrial antiviral signaling protein | ssRNA, single-stranded RNA | Type II IFN, IFN-II | DENV, dengue virus | H2B, leucine rich repeat (in FLII) interacting protein | NO, nitric oxide | SLFN11, schlafen family member 11 | SAMHD1, SAM domain and HD domain-containing protein 1 | DDX, DEAD box protein | tRNA, transfer RNA | DNA, deoxyribonucleic acid | ASC, apoptosis-associated speck-like protein containing a CARD | RIG-I, retinoic acid-inducible gene 1 | APOBEC, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like | IFN, interferon | PRR, pattern-recognition receptors | NLRP3, NACHT LRR and PYD domains-containing protein 3 | IFIT, IFN-induced tetratricopeptide repeat proteins | STAT, signal transducer and activator of transcription | cGAS, cyclic GMP-AMP synthase | NLRs, nucleotide-binding oligomerization domain-like receptors | RLRs, (RIG)-I-like receptors | HIV-1, human immunodeficiency virus 1 | NOD, nucleotide-binding oligomerization domain | MAM, mitochondrial associated membranes | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | IPS1, IFN-β-promoter stimulator 1 | ISGs, IFN stimulated genes | ISG15, IFN-stimulated gene 15 | ER, endoplasmic reticulum | TBK1, TANK-binding kinase 1
Journal Article
Journal of leukocyte biology, ISSN 0741-5400, 07/2009, Volume 86, Issue 1, pp. 23 - 32
Recent findings concerning the biology of IFN‐λs and their pathophysiological roles in viral infection, cancer, and immune responses of the innate and adaptive... 
immunoregulation | IL‐29 | IL‐28 | IFN‐λ | IFN-λ | Immunoregulation | IL-29 | IL-28
Journal Article
Cytokine & growth factor reviews, ISSN 1359-6101, 04/2018, Volume 40, pp. 19 - 31
[Display omitted] •Induction and action of IFN during acute and chronic HIV-1 infection.•Host and viral factors influencing IFN response in HIV-1 infected... 
HIV-1 | IFN | PRR | ISGs | IFNα subtypes | SNP | Gut | IFNλ | IFNα receptor | Gender | Age | Microbiome | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | HIV Infections - immunology | HIV-1 - immunology | HIV Infections - pathology | Receptor, Interferon alpha-beta - immunology | Humans | Virus Replication - immunology | Gastrointestinal Microbiome - immunology | Interferon Type I - immunology | Host-Pathogen Interactions - immunology | Antiviral agents | Dendritic cells | Development and progression | HIV (Viruses) | Biological response modifiers | Cyclic guanylic acid | Proteins | Highly active antiretroviral therapy | Disease transmission | Interleukins | Ligases | Immunotherapy | Single nucleotide polymorphisms | Hepatitis C | Health aspects | Protein kinases | NF-κB, nuclear factor kappa-light-chain-enhancer of B cell | CPSF6, cleavage and polyadenylation specificity factor subunit 6 | pDCs, plasmacytoid dendritic cells | IFI16, IFNγ-inducible protein | PKR, protein kinase R | PRRs, pattern recognition receptors | SAMHD1, sterile alfa motif and histidine | killer | Mx2, and myxovirus resistance 2 | PDL-1, programmed death-ligand 1 | Bak, Bcl-2 homologous antagonist | MIP-3α, macrophage inflammatory protein 3α | RIG1, retinoic acid inducible gene 1 protein | aspartic acid domain containing protein 1 | ISGs, IFNstimulated genes | IFITMs, IFN-induced transmembrane proteins | SOCS3, suppressor of cytokine signaling 3 | DCs, dendritic cells | BST-2, bone marrow stromal antigen 2 | HCV, hepatitis C virus | CCL20, chemokine (C-C motif) ligand 20 | APOBEC, apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3 | IFNAR, IFNA receptor | JAK-STAT, Janus kinase | signal transducer and activator of transcription | cGAS, cyclic guanosine monophosphate-adenosine monophosphate synthasec | MYD88, myeloid differentiation primary response gene 88 | MSM, men who have sex with men | IRFs, IFN regulatory factors | TF, transmitted founder | IFN, interferon | TRAIL, tumor necrosis factor (TNF)-related apoptosis-inducing ligand | DR5, death receptor5 | IP10, IFNγ-inducible protein 10 | IL-10, interleukin-10 | HAART, highly active antiretroviral therapy | TLR, toll-like receptors | GALT, gut-associated lymphoid tissue | SNP, single nucleotide polymorphism | 2-5 OAS, 2′-5′-oligoadenylate synthetase | LCMV, lymphocytic choriomeningitis virus | TREX1, intracellular enzyme 3′ repair exonuclease
Journal Article