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The American journal of gastroenterology, ISSN 0002-9270, 06/2019, Volume 114, Issue 6, pp. 1002 - 1003
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 05/2014, Volume 5
Influenza symptoms vary from mild disease to death; however, determinants of severity are unclear. Type I interferons (IFN alpha beta) are recognized as key... 
PLASMACYTOID DENDRITIC CELLS | A VIRUS | TRAIL | EPITHELIAL-CELLS | TYPE-1 INTERFERON | MULTIDISCIPLINARY SCIENCES | PERSISTENT LCMV INFECTION | H5N1 VIRUSES | ANTIVIRAL IMMUNITY | SIV INFECTION | IFN-ALPHA
Journal Article
CLINICAL CANCER RESEARCH, ISSN 1078-0432, 01/2019, Volume 25, Issue 2, pp. 524 - 532
Purpose: Interferon-alpha favors a Th1 shift in immunity, and combining with ipilimumab (ipi) at 3 or 10 mg/kg may downregulate CTLA4-mediated suppressive... 
SURVIVAL | MULTICENTER | THERAPY | ONCOLOGY | IMMUNOTHERAPY | COMBINED NIVOLUMAB | TREMELIMUMAB | TUMOR-REGRESSION | EXPRESSION | CELL CARCINOMA | IFN-ALPHA
Journal Article
Science Translational Medicine, ISSN 1946-6234, 01/2018, Volume 10, Issue 423, p. eaam8458
Systemic sclerosis (SSc) is a multisystem life-threatening fibrosing disorder that lacks effective treatment. The link between the inflammation observed in... 
MEDICINE, RESEARCH & EXPERIMENTAL | PATTERN-RECOGNITION | AUTOIMMUNITY | AMERICAN-COLLEGE | LUPUS-ERYTHEMATOSUS | SKIN FIBROSIS | RECEPTOR | ALPHA-PRODUCING CELLS | CLASSIFICATION CRITERIA | NUCLEIC-ACIDS | IFN-ALPHA | CELL BIOLOGY | Index Medicus
Journal Article
BLOOD, ISSN 0006-4971, 10/2007, Volume 110, Issue 8, pp. 2907 - 2915
Individuals with systemic lupus erythematosus (SLE) have a striking increase in premature atherosclerosis of unclear etiology. Accelerated endothelial cell... 
ENDOTHELIAL PROGENITOR CELLS | APOPTOSIS | INTERFERON-ALPHA | SIGNALING PATHWAYS | INHIBITION | DENDRITIC CELLS | HEMATOLOGY | EXPRESSION | ERYTHEMATOSUS | IFN-ALPHA | I INTERFERON
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 03/2006, Volume 176, Issue 6, pp. 3315 - 3319
The action of type I IFN (IFN-I) on APCs is well studied, but their direct effect on CD4 T cells is unclear. To address this, we transferred IFN-I... 
SIGNAL | IMMUNITY | ACTIVATION | DENDRITIC CELLS | GENE | IMMUNOLOGY | INTERFERONS | IL-12 | IFN-ALPHA | LYMPHOCYTES
Journal Article
IMMUNITY, ISSN 1074-7613, 07/2004, Volume 21, Issue 1, pp. 107 - 119
Natural interferon-producing cells (IPC) respond to viruses by secreting type I interferon (IFN) and interleukin-12 (IL-12). Toll-like receptor (TLR) 9... 
PLASMACYTOID DENDRITIC CELLS | NATURAL-KILLER-CELLS | MURINE CYTOMEGALOVIRUS-INFECTION | IFN-ALPHA-BETA | SIGNALING PATHWAY | TOLL-LIKE RECEPTORS | INTERFERON-PRODUCING CELLS | IMMUNOLOGY | BACTERIAL CPG-DNA | VIRAL-INFECTION | CUTTING EDGE
Journal Article
ARTHRITIS & RHEUMATOLOGY, ISSN 2326-5191, 03/2014, Volume 66, Issue 3, pp. 694 - 706
Objective. To examine whether topical treatment of wild-type mice with Toll-like receptor 7 (TLR-7) agonists leads to lupus-like autoimmunity. Methods.... 
PLASMACYTOID DENDRITIC CELLS | B-CELLS | CUTANEOUS LUPUS-ERYTHEMATOSUS | ALPHA PRODUCTION | MURINE LUPUS | RHEUMATOLOGY | AUTOANTIBODY PRODUCTION | SKIN INFLAMMATION | I INTERFERON | IFN-ALPHA | IMIQUIMOD
Journal Article
by Lu, M and Xia, LJ and Li, Y and Wang, XL and Hoffman, R
BLOOD, ISSN 0006-4971, 07/2014, Volume 124, Issue 5, pp. 771 - 779
The Philadelphia chromosomal-negative chronic myeloproliferative neoplasms (MPNs) originate at the level of the hematopoietic stem cell (HSC). The protracted... 
MYELOFIBROSIS | POLYCYTHEMIA-VERA | THERAPY | MOLECULAR RESPONSES | MYELOPROLIFERATIVE NEOPLASMS | DISORDERS | MUTATIONS | ESSENTIAL THROMBOCYTHEMIA | HEMATOLOGY | IFN-ALPHA | P53
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 2013, Volume 4
Dendritic cells (DCs) and natural killer (NK) cells shape each other's functions early during immune responses. DCs activate NK cells and NK cells can mature... 
immunological synapse | IL-18 | IL-15 | DNAM-1 | IMMUNOLOGY | IL-12 | IFN-alpha | NKp30
Journal Article
Nature, ISSN 0028-0836, 04/2006, Volume 440, Issue 7086, pp. 949 - 953
The Toll-like receptor (TLR) family has important roles in microbial recognition and dendritic cell activation. TLRs 7 and 9 can recognize nucleic acids and... 
PLASMACYTOID DENDRITIC CELLS | ANTIVIRAL RESPONSE | IMMUNITY | ACTIVATION | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | IKK-ALPHA | INDUCTION | VIRAL-INFECTION | MICE LACKING | IFN-ALPHA
Journal Article
NATURE REVIEWS IMMUNOLOGY, ISSN 1474-1733, 09/2015, Volume 15, Issue 9, pp. 529 - 544
Nucleic acid sensing by innate receptors initiates immune defences against viruses and other pathogens. A hallmark of this response is the release of... 
PLASMACYTOID DENDRITIC CELLS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | CYCLIC GMP-AMP | DOUBLE-STRANDED-RNA | SMALL-MOLECULE INHIBITORS | DNA EXONUCLEASE TREX1 | ACTIVATE B-CELLS | TOLL-LIKE RECEPTORS | OF-FUNCTION MUTATIONS | IMMUNOLOGY | IFN-ALPHA PRODUCTION
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2018, Volume 201, Issue 8, pp. 2331 - 2344
Effective B cell responses such as cytokine secretion, proliferation, and Ab-specific responses are essential to clear hepatitis B virus (HBV) infection.... 
PLASMACYTOID DENDRITIC CELLS | ACTIVATION | PROTEIN | HUMAN-PAPILLOMAVIRUS TYPE-16 | INFECTION | FACTOR CREB | IMMUNOLOGY | PROMOTER | EXPRESSION | BLOOD MONONUCLEAR-CELLS | IFN-ALPHA
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2011, Volume 186, Issue 8, pp. 4794 - 4804
Endosomal TLRs play an important role in innate immune response as well as in autoimmune processes. In the therapy of systemic lupus erythematosus,... 
IMMUNOSTIMULATORY CPG-OLIGODEOXYNUCLEOTIDES | CELLS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | DNA | COMPLEXES | TOLL-LIKE RECEPTORS | H+-ATPASE | IFN-ALPHA INDUCER | IMMUNOLOGY | NUCLEIC-ACIDS | Humans | Toll-Like Receptor 9 - genetics | Toll-Like Receptor 3 - antagonists & inhibitors | Endosomes - metabolism | Quinolines - pharmacology | Chloroquine - pharmacology | Quinacrine - pharmacology | Transfection | Hydrogen-Ion Concentration - drug effects | HEK293 Cells | Toll-Like Receptors - antagonists & inhibitors | Toll-Like Receptor 3 - genetics | Culture Media - chemistry | Imidazoles - metabolism | Toll-Like Receptor 8 - agonists | Binding, Competitive | Toll-Like Receptor 7 - agonists | Toll-Like Receptor 7 - genetics | Cell Line | Antimalarials - metabolism | Toll-Like Receptor 7 - metabolism | Toll-Like Receptor 9 - antagonists & inhibitors | Cytokines - metabolism | Cells, Cultured | Imidazoles - pharmacology | Nucleic Acids - metabolism | Toll-Like Receptor 3 - metabolism | Toll-Like Receptors - agonists | Antimalarials - pharmacology | Quinolines - metabolism | Animals | Toll-Like Receptors - genetics | Culture Media - pharmacology | Toll-Like Receptor 8 - genetics | Endosomes - chemistry | Toll-Like Receptor 9 - metabolism | Toll-Like Receptor 8 - metabolism | Serum - chemistry | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 136, Issue 6, pp. 1476 - 1485
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 02/2008, Volume 205, Issue 2, pp. 315 - 322
Plasmacytoid predendritic cells (pDCs) are the main producers of type I interferon (IFN) in response to Toll-like receptor (TLR) stimulation.... 
RHEUMATOID-ARTHRITIS | MEDICINE, RESEARCH & EXPERIMENTAL | DENDRITIC CELLS | PHOSPHATIDYLINOSITOL 3-KINASE | TOLL-LIKE RECEPTORS | DISTINCT ROLES | KAPPA-B | IMMUNOLOGY | INTERFERON-ALPHA PRODUCTION | PHOSPHOINOSITIDE 3-KINASE | T-CELLS | IFN-ALPHA
Journal Article
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