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IMMUNITY, ISSN 1074-7613, 07/2015, Volume 43, Issue 1, pp. 15 - 28
When type III interferon (IFN-lambda; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be... 
IFN-LAMBDA | SIGNAL-TRANSDUCTION | NOROVIRUS INFECTION | III INTERFERON | DIFFERENTIAL EXPRESSION | STIMULATED GENES | CHRONIC HEPATITIS-C | SUSCEPTIBILITY LOCI | ANTIVIRAL ACTIVITY | IMMUNOLOGY | GENOME-WIDE ASSOCIATION
Journal Article
SCIENCE TRANSLATIONAL MEDICINE, ISSN 1946-6234, 04/2015, Volume 7, Issue 284
Although interferon-lambda [also known as type III interferon or interleukin-28 (IL-28)/IL-29] restricts infection by several viruses, its inhibitory mechanism... 
IFN-LAMBDA | MEDICINE, RESEARCH & EXPERIMENTAL | NERVOUS-SYSTEM | IMMUNITY | RESPONSES | IN-VITRO | REPLICATION | MECHANISM | ENCEPHALITIS | ANTIVIRAL ACTIVITY | INFECTION | CELL BIOLOGY
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 07/2015, Volume 16, Issue 7, pp. 698 - 698
The epithelium is the main entry point for many viruses, but the processes that protect barrier surfaces against viral infections are incompletely understood.... 
IFN-LAMBDA | ROR-GAMMA-T | EPITHELIAL-CELLS | DENDRITIC CELLS | MURINE NOROVIRUS INFECTION | INNATE IMMUNE-RESPONSE | HOST-DEFENSE | ANTIVIRAL ACTIVITY | STAT1 ACTIVATION | IMMUNOLOGY | BETA T-CELLS
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 05/2019, Volume 20, Issue 5, pp. 593 - 593
Interferon-lambda (IFN-lambda) acts on mucosal epithelial cells and thereby confers direct antiviral protection. In contrast, the role of IFN-lambda in... 
IFN-LAMBDA | DETERMINES | VIRUS | EPITHELIAL-CELLS | DENDRITIC CELLS | PROTECTION | INFLAMMATION | INDUCTION | IMMUNOLOGY | TYPE-2 | ADJUVANT
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 09/2019, Volume 10
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 09/2019, Volume 10
Journal Article
HEPATOLOGY, ISSN 0270-9139, 05/2013, Volume 57, Issue 5, pp. 1705 - 1715
The polymorphisms in the interleukin (IL)-28B (interferon-lambda [IFN]-lambda 3) gene are strongly associated with the efficacy of hepatitis C virus (HCV)... 
IFN-LAMBDA | GENETIC-VARIATION | IMMUNE-RESPONSE | IL28B | CLEARANCE | ACTIVATION | REPLICATION | RECOGNITION | GASTROENTEROLOGY & HEPATOLOGY | CULTURE | VIRAL-INFECTION
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 08/2019, Volume 20, Issue 8, pp. 1035 - 1035
Type III interferon (IFN-lambda) is important for innate immune protection at mucosal surfaces and has therapeutic benefit against influenza A virus (IAV)... 
IFN-LAMBDA | ANTIVIRAL PROTECTION | RESPONSES | III INTERFERON | HETEROSUBTYPIC IMMUNITY | LUNGS | MICE | INDUCTION | IMMUNOLOGY | EXPRESSION | ANTIGEN
Journal Article
GUT, ISSN 0017-5749, 02/2018, Volume 67, Issue 2, pp. 362 - 371
Objective The clinical significance of polymorphisms in the interleukin-28B gene encoding interferon (IFN)-lambda 3, which has antiviral effects, is known in... 
IL28B | LAMIVUDINE | CLEARANCE | THERAPY | CHRONIC HEPATITIS-B | IFN-LAMBDA-S | C VIRUS | COMBINATION | GASTROENTEROLOGY & HEPATOLOGY | PEGINTERFERON | ASSOCIATION
Journal Article
Journal of Immunology, ISSN 0022-1767, 2019, Volume 202, Issue 6, pp. 1845 - 1858
Asthma exacerbations are triggered by rhinovirus infections. We employed a systems biology approach to delineate upper-airway gene network patterns underlying... 
IFN-LAMBDA | TRIAL | RESPONSES | TYPE-2 INFLAMMATION | INDUCED ASTHMA EXACERBATIONS | GENE-EXPRESSION | INFECTION | MODEL | IMMUNOLOGY | IRF-7 | HYPERRESPONSIVENESS
Journal Article
Journal Article
International Journal of Antimicrobial Agents, ISSN 0924-8579, 09/2019
Journal Article
NATURE REVIEWS IMMUNOLOGY, ISSN 1474-1733, 10/2019, Volume 19, Issue 10, pp. 614 - 625
Type III interferon (IFN-lambda) was initially thought to have functions similar to those of the type I interferons (IFN-alpha and IFN-beta). New findings have... 
IFN-LAMBDA | ANTIVIRAL PROTECTION | CELLS | ACTIVATION | LOCUS POLYMORPHISMS | VIRUS-INFECTION | III INTERFERONS | GENE-EXPRESSION | CYTOKINE | IMMUNOLOGY | HEPATITIS-C
Journal Article
BLOOD, ISSN 0006-4971, 06/2009, Volume 113, Issue 23, pp. 5829 - 5838
IFN-lambda 1 (IL-29) plays a novel, emerging role in the inhibition of human Th2 responses. Here, we demonstrate that both naive and memory human CD4(+) T... 
IFN-LAMBDA | CYTOKINE PRODUCTION | DENDRITIC CELLS | IN-VIVO | DISTINCT | SUBSETS | GENERATION | DIFFERENTIATION | HEMATOLOGY | TRANSCRIPTION FACTOR | ANTIGEN
Journal Article
by Zhang, SY and Kodys, K and Li, K and Szabo, G
GASTROENTEROLOGY, ISSN 0016-5085, 02/2013, Volume 144, Issue 2, pp. 414 - 414
BACKGROUND & AIMS: The type III interferons (IFN-lambda s: interleukin [IL]-28a, IL-28b, and IL-29) have important roles in hepatitis C virus (HCV) infection,... 
IFN-LAMBDA | NK Cells | IL-28B SNP | INNATE | INFLUENZA | RIBAVIRIN | NKT Cells | GENETIC-VARIATION | IL28B | DCS | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Viral Immune Regulation
Journal Article
GENES AND IMMUNITY, ISSN 1466-4879, 03/2009, Volume 10, Issue 2, pp. 125 - 131
Type III interferon (IFN) or IFN-lambda is a recently discovered family of IFNs that signal through the same downstream transcription factors as type I IFN but... 
IFN-LAMBDA | protein refolding | CELLS | antiviral | GENETICS & HEREDITY | cytokines | IMMUNOLOGY | interferon | IFN-LAMBDA-1/IL-29 | EXPRESSION
Journal Article
Gastroenterology, ISSN 0016-5085, 2010, Volume 138, Issue 4, pp. 1338 - 1345.e7
Journal Article
by Liu, MQ and Zhou, DJ and Wang, X and Zhou, W and Ye, L and Li, JL and Wang, YZ and Ho, WZ
PLOS ONE, ISSN 1932-6203, 04/2012, Volume 7, Issue 4
Background: Interferon lambda 3 (IFN-lambda 3) is a newly identified cytokine with antiviral activity, and its single nucleotide polymorphisms are strongly... 
IFN-LAMBDA | GENETIC-VARIATION | IL28B | RECRUITMENT | ACTIVATION | RECOGNITION | INTERFERON-LAMBDA | MULTIDISCIPLINARY SCIENCES | ALPHA | INDUCTION | HUMAN-IMMUNODEFICIENCY-VIRUS
Journal Article
Journal Article
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