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Seminars in Immunology, ISSN 1044-5323, 2015, Volume 27, Issue 2, pp. 85 - 101
Highlights • Type I interferon represents the first line of innate host defense against a number of invading pathogens that also instructs adaptive immunity. •... 
Allergy and Immunology | Virus | Evasion mechanism | Signaling | Bacteria | Interferon | IFN-stimulated genes | Viruses - classification | Bacteria - immunology | Immune Evasion | Virus Diseases - immunology | Signal Transduction | Bacterial Infections - immunology | Bacteria - classification | Virus Diseases - virology | Viruses - immunology | Interferon Type I - immunology | Bacterial Infections - microbiology | WNV, West Nile virus | CPSF6, cleavage and polyadenylation specificity factor subunit 6 | IKK, inhibitor of kB kinase | SIV, simian immunodeficiency virus | CDNs, cyclic dinucleotides | JEV, Japanese encephalitis virus | AIM2, absent in melanoma 2 | pDCs, plasmacytoid dendritic cells | RT, reverse transcription | β, IFN-I | dsRNA, double-strand RNA | ITIM, immunoreceptor tyrosine-based inhibition motif | TIR, Toll-Interleukin-1 receptor | IFN-α | IFI16, interferon gamma-interferon-inducible protein 16 | MDA5, melanoma differentiation-associated gene-5 | ssDNA, single-stranded DNA | PLP, papain-like protease | TRAF, TNF receptor associated factor | MAPKs, mitogen-activated protein kinases | LRRFIP1, extrachromosomal histone | NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells | iNOS, inducible nitric oxide synthase 1 | dNTPase, deoxynucleotide triphosphate triphosphohydrolase | mRNA, messenger RNA | RNA, ribonucleic acid | miR, microRNA | TRIF, TIR domain-containing adaptor inducing IFN-β | SARS, severe acute respiratory syndrome | DAI, DNA-dependent activator of IFN-regulatory factors | TREX1, three prime repair exonuclease 1 | IFITM, IFN-induced transmembrane protein | STING, stimulator of IFN genes protein | TLRs, Toll-like receptors | NADPH, nicotinamide adenine dinucleotide phosphate | PACT, PKR-associated activator | MERS, Middle East respiratory syndrome | TRIM, tripartite motif | LPS, lipopolysaccharide | CypA, cyclophilin A | CoV, Coronavirus | IRF, IFN regulatory factor | ISRE, IFN-stimulated response element | PAMP, pathogen-associated molecular pattern | ISGF3, interferon-stimulated gene factor 3 | NSP, nonstructural protein | DCs, dendritic cells | MyD88, myeloid differentiation primary response gene 88 | CARD, caspase recruitment domain | HCV, hepatitis C virus | IRAK, IL-1R-associated kinases | DHX, DEAH box protein | CLRs, C-type lectin receptors | cIAP, cellular inhibitors of apoptosis | PKR, double-stranded RNA-activated protein kinase | RIP, receptor-interacting serine-threonine kinase | MAVS, mitochondrial antiviral signaling protein | ssRNA, single-stranded RNA | Type II IFN, IFN-II | DENV, dengue virus | H2B, leucine rich repeat (in FLII) interacting protein | NO, nitric oxide | SLFN11, schlafen family member 11 | SAMHD1, SAM domain and HD domain-containing protein 1 | DDX, DEAD box protein | tRNA, transfer RNA | DNA, deoxyribonucleic acid | ASC, apoptosis-associated speck-like protein containing a CARD | RIG-I, retinoic acid-inducible gene 1 | APOBEC, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like | IFN, interferon | PRR, pattern-recognition receptors | NLRP3, NACHT LRR and PYD domains-containing protein 3 | IFIT, IFN-induced tetratricopeptide repeat proteins | STAT, signal transducer and activator of transcription | cGAS, cyclic GMP-AMP synthase | NLRs, nucleotide-binding oligomerization domain-like receptors | RLRs, (RIG)-I-like receptors | HIV-1, human immunodeficiency virus 1 | NOD, nucleotide-binding oligomerization domain | MAM, mitochondrial associated membranes | SOCS, suppressor of cytokine signaling | JAK, Janus kinase | IPS1, IFN-β-promoter stimulator 1 | ISGs, IFN stimulated genes | ISG15, IFN-stimulated gene 15 | ER, endoplasmic reticulum | TBK1, TANK-binding kinase 1
Journal Article
Journal Article
Cytokine and Growth Factor Reviews, ISSN 1359-6101, 2014, Volume 25, Issue 5, pp. 563 - 576
Abstract During the immune response, striking the right balance between positive and negative regulation is critical to effectively mount an anti-microbial... 
Advanced Basic Science | Ubiquitin | TRIM protein | Interferon | E3 ligase | TRIMmunity | IFN-BETA PRODUCTION | I INTERFERON INDUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELLULAR ANTIVIRAL RESPONSE | RIG-I | CELL BIOLOGY | DEPENDENT CYTOKINE EXPRESSION | FAMILIAL MEDITERRANEAN FEVER | INDUCIBLE GENE-I | NF-KAPPA-B | PATTERN-RECOGNITION RECEPTORS | E3 UBIQUITIN LIGASE | Invertebrates - classification | Animals | Signal Transduction | Humans | Adaptor Proteins, Signal Transducing - immunology | Membrane Proteins - immunology | Immunity, Innate | Ubiquitin - immunology | Amino Acid Motifs | Cytokines - immunology | Evolution, Molecular | Ligases | dsRNA, double-stranded RNA | TBK1, TANK-binding kinase | PIN1, prolyl isomerase 1 | 5′ppp-RNA, 5′-triphosphate RNA | ISG, interferon-stimulated gene | STAT, stimulator and activator of transcription | GART, gene encoding phosphoribosylglycinamide formyltransferase | TAK, TGFβ-activated kinase | TRAF, TNF receptor associated factor | NS1, influenza virus non structural 1 | PRR, pattern recognition receptor (PRR) | TLR, toll-like receptor | TNF, tumor necrosis factor | IFNαR, IFNα receptor | NLR, NOD-like receptor | OAS, 3–5 oligo adenylate synthetase | Ub, ubiquitin | MAVS, mitochondrial antiviral signaling | iNOS, inducible nitric oxide synthetase | IL, interleukin | PI3KC2β, phosphatidylinositol 3 kinase C2β | SeV, Sendai virus | CLR, C-type lectin receptor | IRF, IFN regulatory factor | PAMP, pathogen-associated molecular pattern | SUMO, small ubiquitin-like modifier | TCR, T cell receptor | MDA5, melanoma differentiation-associated protein 5 | NK, natural killer cell | RIG-I, retinoic acid inducible I | DC, dendritic cell | IKK, IκB kinase | NEMO, NFκB essential modulator | RING, really interesting new gene | DDX41, DEAD-box protein 41 | CARD, caspase activation and recruitment domain | STING, stimulator of interferon genes | MYD88, myeloid differentiation primary response gene 88 | MΦ, macrophage | NEDD8, neural precursor cell expressed developmentally down-regulated 8 | ROS, reactive oxygen species | ASC, apoptosis-associated speck-like protein containing a CARD | PBMC, peripheral blood mononuclear cell | TRIM, tripartite motif protein | IFN, interferon | NFκB, nuclear factor κB | TRIF, TIR-domain-containing adapter-inducing IFN | RLR, RIG-I-like receptor | MHC, major histocompatibility complex | IFITM, interferon-induced transmembrane protein | PHD, plant homeo domain | RBCC, RING-BBox-coiled coil (= tripartite motif) | JAK, Janus kinase | MEF, mouse embryonic fibroblast | ISG15, IFN-stimulated gene 15 | TAB, TGFβ-activated kinase binding protein | TUB, TRIM-ubiquitin body | AIM2, Absent in melanoma 2
Journal Article
Journal Article
Current Opinion in Pediatrics, ISSN 1040-8703, 12/2013, Volume 25, Issue 6, pp. 736 - 747
Purpose of reviewWe review the primary immunodeficiencies (PIDs) underlying an increasing variety of superficial and invasive fungal infections. We also stress... 
endemic mycosis | STAT1 | autoantibodies against GM-CSF | CARD9 | pneumocystosis | chronic mucocutaneous candidiasis | interleukin-17 | invasive aspergillosis | superficial and invasive fungal diseases | NADPH oxidase complex | primary immunodeficiencies | IFN-g/interleukin-12 | X-linked CD40L deficiency | deep dermatophytosis | Candida central nervous system infection | candidiasis | autoantibodies against IFN-g | autoantibodies against IFN | PNEUMOCYSTIS-CARINII-PNEUMONIA | DOMAIN-CONTAINING PROTEIN | CHRONIC GRANULOMATOUS-DISEASE | interleukin-12 | IFN | SIGNAL-TRANSDUCER | PEDIATRICS | DERMATOPHYTIC DISEASE | FUNCTION STAT1 MUTATIONS | INBORN-ERRORS | HYPER-IGE SYNDROME | AUTOSOMAL-DOMINANT | Humans | Genetic Diseases, Inborn - genetics | Interleukin-17 - immunology | Child, Preschool | Infant | Male | T-Lymphocytes, Helper-Inducer - immunology | Adult | Female | Immunologic Deficiency Syndromes - immunology | Child | Infant, Newborn | Autoantibodies | Disease Susceptibility | Immunity, Cellular - genetics | Immunologic Deficiency Syndromes - complications | Candidiasis, Chronic Mucocutaneous - genetics | Risk Factors | Aspergillosis - genetics | Candidiasis, Chronic Mucocutaneous - immunology | Genetic Diseases, Inborn - immunology | Pneumonia, Pneumocystis - immunology | Mycoses - genetics | Adolescent | Pneumonia, Pneumocystis - genetics | Immunologic Deficiency Syndromes - genetics | Mycoses - immunology | Aspergillosis - immunology | autoantibodies against IFN-γ | IL-12 | IFN-γ | primary immunodeficiencies (PIDs) | IL-17
Journal Article