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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/2008, Volume 105, Issue 12, pp. 4808 - 4813
Multiple signaling pathways are engaged by the type I and II IFN receptors, but their specific roles and possible coordination in the generation of... 
TRANSCRIPTIONAL ACTIVATION | ACTIVATED PROTEIN-KINASE | I INTERFERONS | SIGNALING PATHWAY | PHOSPHATIDYLINOSITOL 3-KINASE | PKC-DELTA | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | AKT | KINASE-C-DELTA | P70 S6 KINASE
Journal Article
Journal of Virology, ISSN 0022-538X, 02/2010, Volume 84, Issue 4, pp. 2063 - 2077
Journal Article
PLoS Pathogens, ISSN 1553-7366, 01/2018, Volume 14, Issue 1, p. e1006867
Interferon-gamma (IFN-gamma) represents one of the most important innate immunity responses in a host to combat infections of many human viruses including... 
NMI PROTEIN | JAK-STAT | IFN-GAMMA | ESCHERICHIA-COLI | MICROBIOLOGY | CATALYTIC RNA SUBUNIT | STAT INTERACTOR | REPLICATION | VIROLOGY | DEGRADATION | INFECTION | EXPRESSION | PARASITOLOGY
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64868
Epstein-Barr virus (EBV) is an oncogenic virus that is associated with the pathogenesis of several human lymphoid malignancies, including Hodgkin's lymphoma.... 
REED-STERNBERG CELLS | HODGKINS-DISEASE | SIGNALING PATHWAY | IFN-GAMMA | MULTIDISCIPLINARY SCIENCES | PANCREATIC-CANCER | CHRONIC LYMPHOCYTIC-LEUKEMIA | GROWTH-IN-VITRO | NF-KAPPA-B | EXPRESSION | LATENT MEMBRANE PROTEIN-1 | Cell Transformation, Viral - drug effects | Hodgkin Disease - metabolism | Signal Transduction | Hodgkin Disease - genetics | Herpesvirus 4, Human - physiology | Humans | Interleukin-4 - metabolism | Transcriptome | Interferon Regulatory Factors - genetics | Gene Expression Profiling | CD40 Ligand - immunology | Gene Expression Regulation - drug effects | Interleukin-4 - pharmacology | Lymphocyte Activation - genetics | Lymphocyte Activation - immunology | CD40 Ligand - pharmacology | Lymphocyte Activation - drug effects | B-Lymphocytes - virology | Cell Line, Tumor | Interferons - metabolism | Cell Transformation, Viral - genetics | Viral Matrix Proteins - metabolism | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | Infection | Analysis | Genes | Physiological aspects | Lymphomas | Interferon | Epstein-Barr virus | B cells | Biological response modifiers | Health aspects | Cell proliferation | Lymphocyte receptors | Cell culture | Biotechnology | Transformation | Disease | Transcription | Pathogenesis | Viruses | Stimulation | Infections | Activation | Malignancy | CD40L protein | Proteins | Interleukin 4 | Cell activation | Lymphoblasts | Medical research | Cytokines | Blood & organ donations | Lymphoblastoid cell lines | Gene expression | Lymphoma | Virology | Lymphocytes B | Transformations | Cancer | Tumors
Journal Article
Journal Article
FEBS Journal, ISSN 1742-464X, 12/2007, Volume 274, Issue 24, pp. 6456 - 6468
Matrix metalloproteinase‐9 (MMP‐9) displays a preference for a broad range of substrates including extracellular matrix proteins and cytokines. MMP‐9 plays an... 
MMP | interferon | gene regulation | transcription factors | signal transduction | Signal transduction | Transcription factors | Interferon | Gene regulation | PROMOTER ACTIVITY | TRANSCRIPTIONAL ACTIVATION | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | NECROSIS-FACTOR-ALPHA | MATRIX METALLOPROTEINASES | SIGNALING PATHWAY | GELATINASE-B | NF-KAPPA-B | IV COLLAGENASE EXPRESSION | INNATE IMMUNITY | Transcriptional Activation - genetics | Luciferases - metabolism | Tetradecanoylphorbol Acetate - pharmacology | Gene Expression - drug effects | Humans | Immunoblotting | NF-kappa B - metabolism | RNA, Messenger - metabolism | Recombinant Fusion Proteins - metabolism | Luciferases - genetics | Matrix Metalloproteinase 9 - metabolism | STAT1 Transcription Factor - metabolism | Transfection | Interferon-Stimulated Gene Factor 3 - genetics | Matrix Metalloproteinase 9 - genetics | Interferon-Stimulated Gene Factor 3 - metabolism | Protein Binding - drug effects | Phosphorylation - drug effects | RNA, Messenger - genetics | Binding Sites - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | STAT1 Transcription Factor - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | Tyrosine - metabolism | Interferon-beta - pharmacology | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | STAT2 Transcription Factor - genetics | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | STAT2 Transcription Factor - metabolism | HeLa Cells | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2004, Volume 101, Issue 21, pp. 7994 - 7998
IκB kinase (IKK), discovered as the major activator of NF-κB, plays additional roles in signaling. By using mouse embryo fibroblasts (MEFs) lacking both the α... 
Phosphorylation | Physical Sciences | Messenger RNA | RNA | Cytokines | Genes | Adenoviruses | Antivirals | Reagents | Tumor necrosis factors | Mice | TUMOR-NECROSIS-FACTOR | DEPENDENT PHOSPHORYLATION | IFN-GAMMA | PHOSPHATIDYLINOSITOL 3-KINASE | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | SEVERE LIVER DEGENERATION | INCONTINENTIA PIGMENTI | IKK-BETA | DEFICIENT MICE | NEMO/IKK-GAMMA | Biological Sciences
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2015, Volume 466, Issue 3, pp. 511 - 524
Evidence is accumulating for the existence of a signal transducer and activator of transcription 2 (STAT2)/interferon regulatory factor 9 (IRF9)-dependent,... 
Signal transduction | STAT transcription factor | Alternative interferon response pathway | Microarray | Cytokines/interferon | Host-pathogen interactions | cytokines/interferon | IMMUNE-RESPONSE | CELLS | ACTIVATION | CYTOKINES | signal transduction | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | alternative interferon response pathway | GAMMA-INTERFERON | ALPHA | host-pathogen interactions | microarray | DNA | GENE-EXPRESSION | INFECTION | Cell Line | STAT1 Transcription Factor - deficiency | Humans | Antiviral Agents - metabolism | Interferon-Stimulated Gene Factor 3, gamma Subunit - genetics | STAT1 Transcription Factor - genetics | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | Mice, Knockout | Animals | HEK293 Cells | STAT2 Transcription Factor - genetics | Cell Line, Tumor | Mice | STAT2 Transcription Factor - metabolism | Transcriptional Activation - physiology | IRF, interferon regulatory factor | U3C, TNFα, tumour necrosis factor α | WT, wild-type | ISG, interferon-stimulated gene | IRF9-U3C, U3C stably overexpressing human IRF9 | DUOX2, dual oxidase 2 | hST2-U3C, U3C stably overexpressing human STAT2 | qPCR, quantitative real-time PCR | IFI27, interferon alpha-inducible protein | CX3CL1, chemokine (C–X3–C motif) ligand 1 | HERC5, HECT and RLD domain-containing E3 ubiquitin protein ligase 5 | Migr1-U3C, U3C stably overexpressing Migr1 | cytokines | Ifit1, interferon-induced protein with tetratricopeptide repeats 1 | PKR, protein kinase, interferon-inducible double-stranded RNA-dependent activator | IFN, interferon | MS1KO, STAT1-deficient murine embryonic fibroblast cells | VSV, vesicular stomatitis Indiana virus | Migr1-MS1KO, MS1KO stably overexpressing Migr1 | STAT, signal transducer and activator of transcription | qRT-PCR, quantitative reverse transcription–PCR | MEF, murine embryonic fibroblast cells | OAS2, 2′-5′-oligoadenylate synthase 2 | EMCV, encephalomyocarditis virus | NLS, nuclear localization signal | SOCS1, suppressor of cytokine signalling 1 | interferon | mSTAT2-MS1KO, MS1KO stably overexpressing mouse STAT2 | HA, haemagglutinin | MX1, myxovirus (influenza virus) resistance 1, interferon-inducible protein | host–pathogen interactions | HDACi, histone deacetylase inhibitor | RIG-G, retinoic acid-induced gene G | MOI, multiplicity of infection | Ddx60, DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | CCL8, chemokine (C–C motif) ligand 8 | RSAD2, radical S-adenosylmethionine domain-containing 2 | ΔmSTAT2-MS1KO, MS1KO stably overexpressing mouse ΔmSTAT2 | ISRE, IFN-stimulated response element | ISGF3, interferon-stimulated gene factor 3
Journal Article
PLoS Genetics, ISSN 1553-7390, 08/2006, Volume 2, Issue 8, pp. e131 - 1206
The transcription factor signal transducer and activator of transcription-1 (STAT1) plays a key role in immunity against mycobacterial and viral infections.... 
PHOSPHORYLATED STAT-1 | INTERFERON-GAMMA-RECEPTOR | INHERITED INTERLEUKIN-12 DEFICIENCY | TARGETED DISRUPTION | GENETIC DISSECTION | VIRAL DISEASE | SIGNALING PATHWAY | CHAIN DEFICIENCY | BACILLE CALMETTE-GUERIN | IFN-GAMMA | GENETICS & HEREDITY | Humans | GPI-Linked Proteins | Child, Preschool | Infant | Male | Interferon-gamma - metabolism | DNA-Binding Proteins - metabolism | STAT1 Transcription Factor - metabolism | Transfection - methods | Genes, Dominant | DNA Mutational Analysis | Mycobacterium Infections - genetics | Adult | Female | Transcription, Genetic | Membrane Proteins - metabolism | Child | Interferon-alpha - metabolism | Mycobacterium Infections - etiology | Cell Cycle Proteins - metabolism | Cells, Cultured | Gene Expression Regulation | Models, Molecular | STAT1 Transcription Factor - genetics | Genes, Recessive | Interferon-Stimulated Gene Factor 3, gamma Subunit - metabolism | Immunity, Active - genetics | Models, Biological | Pedigree | Mutant Proteins - chemistry | Adolescent | Alleles | Protein Binding | Heterozygote | Mutation | Allelomorphism | Mycobacterial infections | Genetic aspects | Research | Health aspects | Interferon-Stimulated Gene Factor 3, gamma Subunit | Adaptive immunology | Life Sciences | Immunology | Interferon Type II | DNA-Binding Proteins | Immunity, Active | STAT1 Tra | Interferon-alpha | Mycobacterium Infections | Membrane Proteins | Mutant Proteins | Cell Cycle Proteins | Infectious Diseases | Genetics | Homo (Human) | Genetics of Disease | Proteins | Phosphorylation | Disease | Respiratory distress syndrome | Cloning | Kinases | Experiments | Viral infections
Journal Article