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Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 12/2017, Volume 199, Issue 11, pp. 3808 - 3820
Type-III interferons (IFNs) are important mediators of antiviral immunity. IFN-λ4 is a unique type-III IFN because it is produced only in individuals who carry... 
IFN | HCV | SOCS1 | IFNL4 | ISG | IFN-λ4
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 6/2017, Volume 65, Issue 6, pp. 2124 - 2125
Journal Article
Scandinavian Journal of Gastroenterology, ISSN 0036-5521, 09/2019, Volume 54, Issue 9, pp. 1172 - 1175
Introduction: IFNL4 rs12979860 genotype CC is associated with increased ALT activity and liver stiffness in hepatitis C virus (HCV) genotype (G) 3 infection... 
cross-sectional study | Liver fibrosis | ALT activity | IFNL4 genotype | cirrhosis | hepatitis C genotype
Journal Article
JOURNAL OF HEPATOLOGY, ISSN 0168-8278, 11/2015, Volume 63, Issue 5, pp. 1103 - 1110
Background & Aims: Genetic polymorphisms within the interferon lambda (IFN-lambda) region are strongly associated with hepatitis C virus (HCV) clearance; the... 
Viral clearance | RIBAVIRIN TREATMENT | GENOTYPE | CHRONIC HEPATITIS-C | Innate immunity | RECEPTOR | IL28B | GENETIC-VARIATION | Treatment | THERAPY | HIV | Interferon lambda | PEGYLATED INTERFERON | Genetics | IFNL4 | GASTROENTEROLOGY & HEPATOLOGY | IFNL3 | EXPRESSION
Journal Article
by Su, QJ and Wang, X and Zhou, RH and Guo, L and Liu, H and Li, JL and Ho, WZ
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, ISSN 0300-9475, 11/2018, Volume 88, Issue 5
The recently discovered IFN-4 has been found to have antiviral activity against several viruses. However, it's unknown whether IFN-4 can inhibit HIV infection.... 
REPLICATION | GENE | ANTIVIRAL ACTIVITY | IMMUNOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | IFNL4 | INTERFERONS | EXPRESSION | LAMBDA
Journal Article
by Huang, P and Yao, YA and Yue, M and Tian, T and Chen, HB and Chen, MZ and Wang, JE and Zhang, Y and Yu, RB
SCIENTIFIC REPORTS, ISSN 2045-2322, 02/2017, Volume 7
Recent many studies indicated a novel dinucleotide variant in ss469415590 (TT vs.Delta G) of interferon-lambda 4 (IFNL4) gene strongly associated with... 
IL28B | THERAPY | MULTIDISCIPLINARY SCIENCES | PEGYLATED INTERFERON | ALPHA | INFECTION | POLYMORPHISM | RIBAVIRIN | IFNL4 | EXPRESSION | ASSOCIATION
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 11/2018, Volume 24, Issue 21, pp. 5471 - 5481
Purpose: Men of African ancestry experience an excessive prostate cancer mortality that could be related to an aggressive tumor biology. We previously... 
GENE | ONCOLOGY | STAT1 | RESISTANCE | RISK | LEUKEMIA | EXPRESSION | RADIATION | BREAST | immune therapy | African-American | disease recurrence | interferon signature | IFNL4 | Prostate cancer | gene expression | IDO1
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 02/2019, Volume 219, Issue 5, pp. 772 - 776
Abstract An interferon λ4 gene (IFNL4) knockout allele (rs368234815; TT) is associated with spontaneous and IFN-α–dependent cure of hepatitis C virus... 
HIV-1 | CLEARANCE | INFECTIOUS DISEASES | IFNA | MICROBIOLOGY | POLYMORPHISM | IMMUNOLOGY | IFNL4 | USP18 | HEPATITIS-C | high exposed seronegatives
Journal Article
Hepatitis Monthly, ISSN 1735-143X, 12/2015, Volume 15, Issue 12, pp. 1 - 12
Context: There is growing evidence that interferon lambda 4 (IFNL4) polymorphism is related to sustained virological response (SVR) in hepatitis C virus (HCV)... 
Genetic | Rs368234815 | Hepatitis C | IFNL4 | Meta-analysis | Polymorphism | Meta-Analysis | TELAPREVIR | RIBAVIRIN | VIROLOGICAL RESPONSE | IL28B | THERAPY | IFNL4 POLYMORPHISM | PEGYLATED INTERFERON | CLINICAL-TRIALS | INFECTION | HCV | GASTROENTEROLOGY & HEPATOLOGY
Journal Article
Gastroenterology, ISSN 0016-5085, 01/2019, Volume 156, Issue 2, pp. 400 - 417
Hepatitis C virus (HCV) and hepatitis B virus (HBV) infections can lead to cirrhosis, end-stage liver disease, and hepatocellular carcinoma. Over the past... 
IFNL4 | Epidemiology | Fibrosis | Hepatocellular Carcinoma | INHIBITORY RECEPTOR GENES | INTERFERON-LAMBDA | FIBROSIS PROGRESSION | ANTIGEN CLASS-II | HEPATOCELLULAR-CARCINOMA | PEGINTERFERON ALPHA-2A | HLA-DP | PEGYLATED INTERFERON | CLASS-II ALLELES | GASTROENTEROLOGY & HEPATOLOGY | GENOME-WIDE ASSOCIATION
Journal Article
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, ISSN 0732-8893, 09/2018, Volume 92, Issue 1, pp. 34 - 36
In direct acting antiviral (DAA)-treated HCV genotype 1, the sustained virologic response rate with the Delta G/Delta G genotype of IFNL4 rs368234815 (86.8%)... 
HCV CLEARANCE | hepatitis C virus, DAA therapy, Veterans | INFECTIOUS DISEASES | VIRUS | VARIANTS | MICROBIOLOGY | RIBAVIRIN | SVR | IL28B | THERAPY | INFECTION | IFNL4 | ASSOCIATION
Journal Article
Open Forum Infectious Diseases, ISSN 2328-8957, 2014, Volume 1, Issue 3, pp. ofu110 - ofu110
Treatment of hepatitis C virus (HCV) infection with ledipasvir/sofosbuvir promises tremendous benefits, but high cost may impede implementation of this... 
Clinical trial | Direct-acting antiviral agents | Gender | Hepatitis C virus | IFNL4 | Cost-effectiveness
Journal Article
GENE, ISSN 0378-1119, 07/2018, Volume 664, pp. 168 - 180
Genetic variants at the interferon lambda (IFNL) locus have been associated with several human phenotypes in both disease and health. In chronic hepatitis C... 
HCV CLEARANCE | INTERLEUKIN 28B | STIMULATED GENES | CHRONIC HEPATITIS-C | rs117648444 | RIBAVIRIN THERAPY | VIRUS TYPE-1 | IFN-RBV | rs368234815 | SUSTAINED VIROLOGICAL RESPONSE | GENETIC-VARIATION | IFNL SNP | IFNL4 RS368234815 | GENETICS & HEREDITY | HCV | Causal variants | IFN-lambda 4 | SPONTANEOUS CLEARANCE
Journal Article
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