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Journal Article
Puerto Rico Health Sciences Journal, ISSN 0738-0658, 2014, Volume 33, Issue 4, pp. 177 - 183
Journal Article
Book Chapter
Journal Article
ACTA PHARMACEUTICA SINICA B, ISSN 2211-3835, 08/2014, Volume 4, Issue 4, pp. 241 - 247
Interferon (IFN) in combination with ribavirin has been the standard of care (SOC) for chronic hepatitis C for the past few decades. Although the current SOC... 
PHARMACOLOGY & PHARMACY | Interferon | Antiviral agent | Hepatitis C virus | Molecular mechanism | RIG-I, retinoic acid-inducible gene-I | dsRNA, double-stranded RNA | SVR, sustained virological response | GAS, IFN-γ-activated site | IFNAR2, interferon-alpha receptor 2 | PKR, protein kinase R | PRRs, pattern recognition receptors | STAT2, signal transducer and activator of transcription 2 | IL-10R2, interleukin-10 receptor 2 | PBMCs, peripheral blood mononuclear cells | ISG15, interferon-stimulated gene 15 | NKTCs, natural killer T cells | ISREs, IFN-stimulated response elements | IRF-3, interferon regulatory factor 3 | TLRs, Toll-like receptors | USP18, ubiquitin specific peptidase 18 | DNAM1, DNAX accessory molecule-1 | TYK2, tyrosine kinase 2 | RLRs, RIG-I-like receptors | IFNAR1, interferon-alpha receptor 1 | E2, envelop 2 | IFNGR2, interferon gamma receptor 2 | ISGs, IFN-stimulated genes | JAKs, Janus activated kinases | DCs, dendritic cells | RdRp, RNA dependent RNA polymerase | IFNL4, IFN-lambda 4 | Review | pDC, plasmacytoid dendritic cell | MAVS, mitochondrial antiviral signaling protein | CHC, chronic hepatitis C | STAT1, signal transducer and activator of transcription 1 | IL-29, interleukin-29 | MDA-5, melanoma differentiation-associated gene-5 | OAS, 2′-5′-oligoadenylate synthetase | GWAS, genome-wide association studies | NKCs, natural killer cells | SOC, standard of care | IFN, interferon | ISGF3, IFN-stimulated gene factor 3 | IRGs, IFN regulatory genes | PAMPs, pathogen-associated molecular patterns | SNPs, single-nucleotide polymorphisms | MHC, major histocompatibility complex | IFN-α, interferon-α | TH1, T-helper-1 | TH2, T-helper-2 | IFNGR1, interferon gamma receptor 1
Journal Article
Biopolymers and Cell, ISSN 0233-7657, 2014, Volume 30, Issue 5, pp. 400 - 402
Aim. To determine genotype and allele disribution for the IFNL4 gene ss469415590 and examine it for linkage with the IL28B gene rs12979860 in Ukrainian... 
Rs12979860 | IFNL4 | Linkage disequilibrium | Ss469415590 | rs12979860 | ss469415590 | linkage disequilibrium
Journal Article
Open Forum Infectious Diseases, ISSN 2328-8957, 2014, Volume 1, Issue 3, pp. ofu110 - ofu110
Treatment of hepatitis C virus (HCV) infection with ledipasvir/sofosbuvir promises tremendous benefits, but high cost may impede implementation of this... 
Clinical trial | Direct-acting antiviral agents | Gender | Hepatitis C virus | IFNL4 | Cost-effectiveness
Journal Article
HEPATITIS MONTHLY, ISSN 1735-143X, 10/2014, Volume 14, Issue 10, p. e22649
Background: About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously Differences in host genetics affect the outcome... 
SPONTANEOUS VIRAL CLEARANCE | VIRUS-INFECTION | INTERLEUKIN 28B | HCV INFECTION | GENETIC-VARIATION | TRANSMISSION | THERAPY | Genetic polymorphism | GENOTYPE 4 | IL28B GENOTYPE | Hepatitis C | GASTROENTEROLOGY & HEPATOLOGY | ASSOCIATION | Human IFNL4 Protein | Human IFNL4 protein
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e93011
Aims: Genome-wide association studies highlighted single nucleotide polymorphisms (SNPs) within the IFNL3/IL28B locus predict the treatment outcome for... 
CLEARANCE | THERAPY | RIBAVIRIN | IFNL4 | PEGYLATED INTERFERON-ALPHA | MULTIDISCIPLINARY SCIENCES | Uzbekistan - epidemiology | Hepatitis C - drug therapy | Humans | Middle Aged | European Continental Ancestry Group | Hepatitis C - genetics | Male | Antiviral Agents - administration & dosage | Interferon-alpha - administration & dosage | Interleukins - genetics | Asian Continental Ancestry Group | Hepatitis C - epidemiology | Adult | Female | Polymorphism, Single Nucleotide | Hepacivirus | Virus diseases | Medical research | Care and treatment | Prognosis | Medicine, Experimental | Genetic aspects | Single nucleotide polymorphisms | Hepatitis C virus | Health aspects | Chromosomes | Prevalence studies (Epidemiology) | Haplotypes | Liver | Chronic infection | African Americans | Viruses | Leukocytes (mononuclear) | Infections | Genomes | Single-nucleotide polymorphism | Clinical outcomes | Hepatitis | Genotype & phenotype | Immunology | Acquired immune deficiency syndrome--AIDS | Polyethylene glycol | Human immunodeficiency virus--HIV | Peripheral blood mononuclear cells | Drug dosages | Public health | Deoxyribonucleic acid--DNA | Global health | Immunoglobulins | Cytokines | Patients | Ethnic factors | Virology | Medicine | Ethnicity | Gene frequency | Interferon | Hepatitis C | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | DNA | Human immunodeficiency virus
Journal Article
05/2014, ISBN 0123868831
In 2009, genome-wide association studies identified key roles for IL28B and ITPA polymorphisms in predicting HCV treatment outcomes using pegylated interferonα... 
Inosine triphosphatase | IL28B | Anemia | Interleukin-28B | Interferon | IFNL4 | Lambda | ITPA | Ribavirin
Book Chapter
Journal of Gastroenterology, ISSN 0944-1174, 12/2014, Volume 49, Issue 12, pp. 1548 - 1556
Older patients with chronic hepatitis C have a lower virological response to interferon (IFN) treatment compared to younger patients. The efficacy of... 
Medicine & Public Health | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Older patients | Telaprevir | Hepatitis C virus | IFNL4 | Surgical Oncology | RVR | PLUS RIBAVIRIN | VIRUS | COMBINATION THERAPY | ITPA POLYMORPHISM | GENETIC-VARIATION | HEPATOCELLULAR-CARCINOMA | CORE REGION | PEGYLATED INTERFERON | VIRAL RESPONSE | GASTROENTEROLOGY & HEPATOLOGY | GENOME-WIDE ASSOCIATION | Recombinant Proteins - therapeutic use | Multivariate Analysis | Predictive Value of Tests | Age Factors | Humans | Middle Aged | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Male | Polyethylene Glycols - therapeutic use | Oligopeptides - therapeutic use | Dose-Response Relationship, Drug | Young Adult | Interleukins - genetics | Ribavirin - administration & dosage | Adult | Female | Drug Therapy, Combination | Antiviral Agents - therapeutic use | Ribavirin - therapeutic use | Interferon-alpha - therapeutic use | Genotype | Treatment Outcome | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Polyethylene Glycols - administration & dosage | Recombinant Proteins - administration & dosage | Interferon-alpha - administration & dosage | Regression Analysis | Aged | Oligopeptides - administration & dosage | Polymorphism, Single Nucleotide | Care and treatment | Patient outcomes | Analysis | Physiological aspects | Hemoglobin | Aged patients | Genetic aspects | Interferon | Biological response modifiers | Hepatitis C | Ribavirin
Journal Article