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Cell Reports, ISSN 2211-1247, 12/2019, Volume 29, Issue 13, pp. 4471 - 4481.e6
During V(D)J recombination, RAG proteins introduce DNA double-strand breaks (DSBs) at recombination signal sequences (RSSs) that contain either 12- or 23-nt... 
ig repertoire | recombination signal sequence | END-seq | immunoglobulin | HTGTS | ig kappa locus | variable | RAG | recombination center | VDJ recombination | REARRANGEMENT | ELEMENTS | SEQUENCES | 12/23 RULE | BREAKS | V(D)J RECOMBINATION | GENOME-WIDE | DOMAINS | PROGRAM | CELL BIOLOGY
Journal Article
PLOS BIOLOGY, ISSN 1545-7885, 02/2014, Volume 12, Issue 2
During B cell development, the precursor B cell receptor (pre-BCR) checkpoint is thought to increase immunoglobulin light chain (Ig) locus accessibility to the... 
IG-KAPPA LOCUS | ALLELIC EXCLUSION | GENOMIC INTERACTIONS | BRUTONS TYROSINE KINASE | LYMPHOCYTE DEVELOPMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | DNA-BINDING PROTEINS | V(D)J RECOMBINATION | GENE REARRANGEMENT | HEAVY-CHAIN LOCUS | CHROMOSOME CONFORMATION CAPTURE
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 04/2011, Volume 11, Issue 4, pp. 251 - 263
Journal Article
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 08/1998, Volume 12, Issue 15, pp. 2305 - 2317
Deletion of the TCR beta transcriptional enhancer (EP) results in nearly complete inhibition of V(D)J recombination at the TCR beta locus and a block in alpha... 
TCRβ enhancer | Double-strand break repair | RSS accessibility | V(D)J recombination | V(D)I recombination | TCR beta enhancer | IG-KAPPA | double-strand break repair | MOUSE | DEPENDENT PROTEIN-KINASE | DEVELOPMENTAL BIOLOGY | THYMOCYTES | CELL BIOLOGY | REARRANGEMENT | IN-VITRO | GENE | GENETICS & HEREDITY | MICE | T-CELL DEVELOPMENT | TARGETED DELETION
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 03/1999, Volume 96, Issue 6, pp. 3000 - 3005
The Ig heavy chain (IgH) constant region (C-H) genes are organized from 5' to 3' in the order C mu, C delta, C gamma 3, C gamma 1, C gamma 2b, C gamma 2a, C... 
REARRANGEMENT | CELLS | 3' END | IG-KAPPA | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GENE-EXPRESSION | ENHANCER | DEFICIENT MICE | TARGETED DELETION | BETA-GLOBIN LOCUS | Immunoglobulin genes | Mice | Genetic aspects | Research | Gene mutations | Analysis
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 05/2017, Volume 17, Issue 5, pp. 281 - 294
Journal Article
IMMUNITY, ISSN 1074-7613, 03/2002, Volume 16, Issue 3, pp. 453 - 463
Many mammalian genes, including those encoding antigen receptors, contain more than one enhancer element. Deleting one element often does not prevent... 
REARRANGEMENT | IG-KAPPA | ALPHA-BETA | TRANSCRIPTION | RECEPTOR ALPHA/DELTA LOCUS | MATRIX ATTACHMENT REGIONS | HEAVY-CHAIN LOCUS | IMMUNOLOGY | TARGETED DELETION | BETA-GLOBIN LOCUS | SWITCH RECOMBINATION
Journal Article
Journal Article