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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 01/2007, Volume 104, Issue 2, pp. 654 - 659
We demonstrate a heteromeric D1-D2 dopamine receptor signaling complex in brain that is coupled to G(q)/11 and requires agonist binding to both receptors for G... 
SKF83959 | PROTEIN | MULTIDISCIPLINARY SCIENCES | calcium signaling | calcium/calmodulin-dependent protein kinase II alpha | SCHIZOPHRENIA | D-1 | heterooligomerization | D-1-LIKE
Journal Article
Nature Communications, ISSN 2041-1723, 12/2016, Volume 7, Issue 1, p. 13837
Identifying genetic biomarkers of synthetic lethal drug sensitivity effects provides one approach to the development of targeted cancer therapies. Mutations in... 
CANCER-CELLS | ACTIVATION | REPAIR | DNA-DAMAGE CHECKPOINT | SCREEN | SWI/SNF COMPLEXES | PROTEIN-KINASE | STABILITY | MULTIDISCIPLINARY SCIENCES | RESISTANCE | TOPOISOMERASE II-ALPHA
Journal Article
NUCLEIC ACIDS RESEARCH, ISSN 0305-1048, 01/2016, Volume 44, Issue 1, pp. 164 - 174
The tumor suppressor p53 functions predominantly as a transcription factor by activating and downregulating gene expression, leading to cell cycle arrest or... 
CYCLIN-B1 TRANSCRIPTION | TOPOISOMERASE-II-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROMOTER ELEMENTS | DOWN-REGULATION | TRANSCRIPTIONAL REPRESSION | HUMAN CANCER-CELLS | IONIZING-RADIATION | B-MYB | TUMOR-SUPPRESSOR P53 | DREAM COMPLEX
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 04/2011, Volume 54, Issue 7, pp. 2391 - 2398
The topoisomerase-Il alpha inhibition and antiproliferative activity of alpha-heterocyclic thiosemicarbazones and their corresponding copper(II) complexes have... 
COPPER(II) COMPLEXES | BREAST-CANCER CELLS | RIBONUCLEOTIDE REDUCTASE | CHEMISTRY, MEDICINAL | PROLIFERATION | MECHANISMS | HETEROCYCLIC CARBOXALDEHYDE THIOSEMICARBAZONES | CATALYTIC-ACTIVITY | ANTITUMOR-ACTIVITY | CYTOTOXICITY | II-ALPHA
Journal Article