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1. Full Text Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial
by Stupp, Roger and Taillibert, Sophie and Kanner, Andrew and Read, William and Steinberg, David M and Lhermitte, Benoit and Toms, Steven and Idbaih, Ahmed and Ahluwalia, Manmeet S and Fink, Karen and Di Meco, Francesco and Lieberman, Frank and Zhu, Jay-Jiguang and Stragliotto, Giuseppe and Tran, David D and Brem, Steven and Hottinger, Andreas F and Kirson, Eilon D and Lavy-Shahaf, Gitit and Weinberg, Uri and Kim, Chae-Yong and Paek, Sun-Ha and Nicholas, Garth and Bruna, Jordi and Hirte, Hal and Weller, Michael and Palti, Yoram and Hegi, Monika E and Ram, Zvi
JAMA : the journal of the American Medical Association, ISSN 0098-7484, 12/2017, Volume 318, Issue 23, pp. 2306 - 2316
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Dacarbazine - adverse effects | Follow-Up Studies | Dacarbazine - therapeutic use | Mitosis | Humans | Middle Aged | Male | Electric Stimulation Therapy | Chemoradiotherapy | Glioblastoma - radiotherapy | Glioblastoma - surgery | Antineoplastic Agents, Alkylating - therapeutic use | Disease-Free Survival | Dacarbazine - analogs & derivatives | Survival Analysis | Adult | Female | Aged | Maintenance Chemotherapy | Temozolomide | Antineoplastic Agents, Alkylating - adverse effects | Glioblastoma - drug therapy | Chemotherapy | Usage | Patient outcomes | Dosage and administration | Drug therapy | Glioblastoma multiforme | Cancer | Statistical analysis | Toxicity | Glioblastoma | Central nervous system | Clinical trials | Cell division | Nervous system | Maintenance | Patients | Survival | Scalp | Skin | Portable equipment | Electric fields | Tumors | Index Medicus | Abridged Index Medicus | Original Investigation | Research
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2. Full Text Larynx preservation clinical trial design: Key issues and recommendations—A consensus panel summary
by Lefebvre, Jean‐Louis and Ang, K. Kian and Larynx Preservation Consensus Pane and Larynx Preservation Consensus Panel and on behalf of the Larynx Preservation Consensus Panel
Head & neck, ISSN 1043-3074, 04/2009, Volume 31, Issue 4, pp. 429 - 441
head and neck | guidelines | laryngeal | carcinoma | larynx preservation | hypopharyngeal | Head and neck | Laryngeal | Larynx preservation | Carcinoma | Hypopharyngeal | Guidelines | Otorhinolaryngology | Life Sciences & Biomedicine | Surgery | Science & Technology | Otorhinolaryngology. Stomatology | Biological and medical sciences | Medical sciences | Hypopharyngeal Neoplasms - surgery | Guidelines as Topic | Laryngeal Neoplasms - surgery | Carcinoma, Squamous Cell - pathology | Humans | Hypopharyngeal Neoplasms - physiopathology | Carcinoma, Squamous Cell - surgery | Survival Rate | Combined Modality Therapy | Hypopharyngeal Neoplasms - mortality | Carcinoma, Squamous Cell - physiopathology | Laryngectomy | Laryngeal Neoplasms - pathology | Deglutition | Disease-Free Survival | Clinical Trials, Phase III as Topic - standards | Carcinoma, Squamous Cell - mortality | Laryngeal Neoplasms - mortality | Hypopharyngeal Neoplasms - pathology | Larynx - physiopathology | Speech | Laryngeal Neoplasms - physiopathology | Index Medicus
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3. Full Text The Next Generation of Sepsis Clinical Trial Designs: What Is Next After the Demise of Recombinant Human Activated Protein C?
by Opal, Steven M and Dellinger, R Phillip and Vincent, Jean-Louis and Masur, Henry and Angus, Derek C
Critical care medicine, ISSN 0090-3493, 07/2014, Volume 42, Issue 7, pp. 1714 - 1721
clinical trial design | tumor necrosis factor antibody | septic shock | severe sepsis | sepsis | intensive care units | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Infectious diseases | Bacterial diseases | Human bacterial diseases | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy | Biological and medical sciences | Intensive care medicine | Emergency and intensive care: infection, septic shock | Medical sciences | Bacterial sepsis | Recombinant Proteins - therapeutic use | Drug Evaluation, Preclinical - methods | Sepsis - drug therapy | Fibrinolytic Agents - therapeutic use | Humans | Biomarkers | Clinical Trials, Phase II as Topic - methods | Research Design | Protein C - therapeutic use | Clinical Trials, Phase III as Topic - methods | Index Medicus | Abridged Index Medicus
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4. Full Text Influenza antivirals currently in late‐phase clinical trial
by Koszalka, Paulina and Tilmanis, Danielle and Hurt, Aeron C
Influenza and other respiratory viruses, ISSN 1750-2640, 05/2017, Volume 11, Issue 3, pp. 240 - 246
clinical trial | effectiveness | influenza | influenza virus | development | antiviral | Infectious Diseases | Life Sciences & Biomedicine | Science & Technology | Virology | Clinical Trials, Phase III as Topic | Humans | Influenza, Human - virology | Orthomyxoviridae - drug effects | Influenza, Human - drug therapy | Antiviral Agents - administration & dosage | Orthomyxoviridae - physiology | Clinical Trials, Phase II as Topic | Drugs | Medical research | Antiviral agents | Animal models | Pandemics | Clinical trials | Viruses | Infections | Patients | Polymerase | Oseltamivir | Molecular modelling | Influenza | Monoclonal antibodies | In vitro methods and tests | Index Medicus | Expert
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5. Full Text Genomic alteration-driven clinical trial designs in oncology
by Simon, Richard
Annals of internal medicine, ISSN 0003-4819, 08/2016, Volume 165, Issue 4, pp. 270 - 278
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Genomics | Humans | Clinical Trials, Phase I as Topic - methods | Clinical Trials as Topic - methods | Clinical Trials, Phase II as Topic - methods | Research Design | Clinical Trials, Phase IV as Topic - methods | Precision Medicine - methods | Clinical Trials, Phase III as Topic - methods | Neoplasms - drug therapy | Evaluation | Care and treatment | Innovations | Clinical trials | Genotype | Testing | Cancer | Oncology | Cancer therapies | Research methodology | Index Medicus | Abridged Index Medicus
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6. Full Text Randomized phase II/III clinical trial of elpamotide for patients with advanced pancreatic cancer: PEGASUS‐PC Study
by Yamaue, Hiroki and Tsunoda, Takuya and Tani, Masaji and Miyazawa, Motoki and Yamao, Kenji and Mizuno, Nobumasa and Okusaka, Takuji and Ueno, Hideki and Boku, Narikazu and Fukutomi, Akira and Ishii, Hiroshi and Ohkawa, Shinichi and Furukawa, Masayuki and Maguchi, Hiroyuki and Ikeda, Masafumi and Togashi, Yosuke and Nishio, Kazuto and Ohashi, Yasuo
Cancer science, ISSN 1347-9032, 07/2015, Volume 106, Issue 7, pp. 883 - 890
phase II/III | elpamotide | Advanced pancreatic cancer | peptide vaccine | immunotherapy | Peptide vaccine | Elpamotide | Immunotherapy | Phase II/III | Life Sciences & Biomedicine | Oncology | Science & Technology | Adenocarcinoma - pathology | Carcinoma, Adenosquamous - pathology | Double-Blind Method | Cancer Vaccines - administration & dosage | Deoxycytidine - administration & dosage | Humans | Middle Aged | Pancreatic Neoplasms - pathology | Peptide Fragments - administration & dosage | Kaplan-Meier Estimate | Carcinoma, Adenosquamous - drug therapy | Male | Treatment Outcome | Adenocarcinoma - drug therapy | Pancreatic Neoplasms - drug therapy | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Carcinoma, Adenosquamous - mortality | Adult | Female | Aged | Pancreatic Neoplasms - mortality | Vascular Endothelial Growth Factor Receptor-2 - administration & dosage | Deoxycytidine - analogs & derivatives | Adenocarcinoma - mortality | Statistical analysis | Gemcitabine | Peptides | Toxicity | Clinical trials | Metastasis | Radiation therapy | Cancer therapies | Survival | Patients | Blood | Metastases | Angiogenesis | Chemotherapy | Pancreatic cancer | Medical prognosis | Vascular endothelial growth factor receptor 2 | Vascular endothelial growth factor | Index Medicus | phase II | III | Original
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7. Full Text Adverse Event Reporting in Cancer Clinical Trial Publications
by Shanthi Sivendran and Asma Latif and Russell B. McBride and Kristian D. Stensland and Juan Wisnivesky and Lindsay Haines and William K. Oh and Matthew D. Galsky
Journal of clinical oncology, ISSN 0732-183X, 01/2014, Volume 32, Issue 2, pp. 83 - 89
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Tumors | Clinical Trials, Phase III as Topic - standards | Adverse Drug Reaction Reporting Systems - standards | Humans | Linear Models | Publications - standards | Research Report - standards | Neoplasms - drug therapy | Randomized Controlled Trials as Topic - standards | Index Medicus
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8. Full Text Shifting patterns in the interpretation of phase III clinical trial outcomes in advanced non-small-cell lung cancer: the bar is dropping
by Sacher, Adrian G and Sacher, Adrian G and Le, Lisa W and Le, Lisa W and Leighl, Natasha B and Leighl, Natasha B
Journal of clinical oncology, ISSN 0732-183X, 2014, Volume 32, Issue 14, pp. 1407 - 1411
Life Sciences & Biomedicine | Oncology | Science & Technology | Tumors of the respiratory system and mediastinum | Biological and medical sciences | Multiple tumors. Solid tumors. Tumors in childhood (general aspects) | Medical sciences | Tumors | Pneumology | Lung Neoplasms - drug therapy | Clinical Trials, Phase III as Topic - standards | Lung Neoplasms - mortality | Humans | Clinical Trials, Phase III as Topic - trends | Research Design - standards | Treatment Outcome | Carcinoma, Non-Small-Cell Lung - drug therapy | Research Design - trends | Carcinoma, Non-Small-Cell Lung - mortality | Index Medicus
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9. Full Text Efficacy and safety of rVIII-Singlechain : Results of a phase 1/3 multicenter clinical trial in severe hemophilia A
by Mahlangu, Johnny and Kuliczkowski, Kazimierz and Karim, Faraizah Abdul and Stasyshyn, Oleksana and Kosinova, Marina V and Lepatan, Lynda Mae and Skotnicki, Aleksander and Boggio, Lisa N and Klamroth, Robert and Oldenburg, Johannes and Hellmann, Anzej and Santagostino, Elena and Baker, Ross I and Fischer, Kathelijn and Gill, Joan C and P'Ng, Stephanie and Chowdary, Pratima and Escobar, Miguel A and Khayat, Claudia Djambas and Rusen, Luminita and Bensen-Kennedy, Debra and Blackman, Nicole and Limsakun, Tharin and Veldman, Alex and Ledger, Katie St and Pabinger, Ingrid and AFFINITY Investigators and for the AFFINITY Investigators
Blood, ISSN 0006-4971, 08/2016, Volume 128, Issue 5, pp. 630 - 637
Clinical Trial, Phase III | Immunology | Hematology | Medicine(all) | Multicenter Study | Biochemistry | Clinical Trial, Phase I | Journal Article | Cell Biology | Life Sciences & Biomedicine | Science & Technology | Hemostasis - drug effects | Recombinant Proteins - therapeutic use | Demography | Factor VIII - pharmacokinetics | Humans | Middle Aged | Male | Recombinant Proteins - pharmacokinetics | Treatment Outcome | Recombinant Proteins - adverse effects | Recombinant Proteins - administration & dosage | Dose-Response Relationship, Drug | Young Adult | Administration, Intravenous | Hemorrhage - drug therapy | Adolescent | Factor VIII - administration & dosage | Adult | Factor VIII - adverse effects | Hemophilia A - prevention & control | Hemophilia A - drug therapy | Child | Factor VIII - therapeutic use | Index Medicus | Abridged Index Medicus | Clinical Trials and Observations
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