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ikkβ (119) 119
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Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 26, pp. 10344 - 10352
Activation of IκB kinase β (IKKβ) is a central event in the NF-κB-mediated canonical pro-inflammatory pathway. Numerous studies have reported that... 
Protein Structure and Folding | inhibition mechanism | molecular docking | trans autophosphorylation | autophosphorylation | B14 | IKKβ | vaccinia virus | virus | protein kinase
Journal Article
MOLECULAR CANCER THERAPEUTICS, ISSN 1535-7163, 07/2016, Volume 15, Issue 7, pp. 1504 - 1514
Journal Article
Journal of the American Heart Association, ISSN 2047-9980, 01/2018, Volume 7, Issue 1, p. n/a
Background Vascular calcification was previously considered as an advanced phase of atherosclerosis; however, recent studies have indicated that such... 
atherosclerosis | vascular biology | IKKβ | nuclear factor‐κB | vascular calcification | CARDIAC & CARDIOVASCULAR SYSTEMS | nuclear factor-kappa B | IKK-BETA | STATINS | IKK beta | CORONARY-ARTERY CALCIFICATION | ANTIINFLAMMATORY AGENTS | NUCLEAR-FACTOR | BONE-FORMATION | CALCIUM | GENE-EXPRESSION | PROGRESSION
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2011, Volume 46, Issue 4, pp. 1245 - 1253
Journal Article
Chinese Medical Journal, ISSN 0366-6999, 11/2016, Volume 129, Issue 22, pp. 2703 - 2707
Background: Cervical cancer is the second most common cancer of woman in the world, and human papillomavirus (HPV) infection plays an important role in the... 
Lipopolysaccharide | IKKβ | Cervical Cancer | P21 | P53 | TARGET | APOPTOSIS | ACTIVATION | INHIBITOR PS1145 | IKK-BETA | NF-B | ALPHA | p21 | p53 | MEDICINE, GENERAL & INTERNAL | IKK beta | INVASION | EXPRESSION | CARCINOMA | Original
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 10/2006, Volume 12, Issue 19, pp. 5887 - 5894
Purpose: The purpose of this study is to delineate the biological significance of IκB kinase (IKK) β inhibition in multiple myeloma cells in the context of... 
MLN120B | NF-κB | multiple myeloma | IKKβ | growth inhibition | ADHESION | ACTIVATED PROTEIN-KINASE | BIOLOGIC SEQUELAE | ONCOLOGY | INDUCED APOPTOSIS | DRUG-RESISTANCE | MODEL | MULTIDRUG-RESISTANCE | INTERLEUKIN-6 | MARROW STROMAL CELLS | MODULATION
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 2, pp. 523 - 540
Reactive oxygen and nitrogen species change cellular responses through diverse mechanisms that are now being defined. At low levels, they are signalling... 
Mitochondrion | Oxidative stress | Redox signalling | Neurodegeneration | Autophagy | Nitrative stress | autophagy | CHAPERONE-MEDIATED AUTOPHAGY | ANTIOXIDANT RESPONSIVE ELEMENTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPOFUSCINOSES BATTEN-DISEASE | neurodegeneration | AMYOTROPHIC-LATERAL-SCLEROSIS | mitochondrion | redox signalling | MOTOR-NEURON DEGENERATION | MANGANESE SUPEROXIDE-DISMUTASE | nitrative stress | SMOOTH-MUSCLE-CELLS | PATHOGENIC DJ-1 MUTATIONS | HYPOXIA-INDUCED AUTOPHAGY | oxidative stress | COMPLEX-I DEFICIENCY | Protein Kinases - metabolism | Transcription, Genetic - drug effects | Cardiovascular Diseases - physiopathology | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Reactive Nitrogen Species - metabolism | Humans | Oxidative Stress - physiology | Hydrogen Peroxide - pharmacology | Oncogene Proteins - metabolism | Nitric Oxide - physiology | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondria - metabolism | Mitochondria - pathology | Parkinson Disease - physiopathology | Lysosomes - physiology | Protein Deglycase DJ-1 | Animals | Signal Transduction - physiology | TOR Serine-Threonine Kinases - physiology | Neoplasms - physiopathology | AMPK, 5′-AMP-activated protein kinase | NBR1, neighbour of BRCA1 (breast cancer early-onset 1) | NGF, nerve growth factor | LC3, light chain 3 | NOX, NADPH oxidase | EM, electron microscopy | TOR, target of rapamycin | ULK, unc (unco-ordinated family member)-51-like kinase | mtDNA, mitochondrial DNA | mTOR, mammalian target of rapamycin | IKKβ, IκB kinase β | LRRK2, leucine-rich repeat kinase 2 | NAC, N-acetyl-L-cysteine | Nrf2, nuclear factor-erythroid 2-related factor 2 | PI3P, phosphatidylinositol 3-phosphate | ECH, enoyl-CoA hydratase | BNIP3L, BNIP3-like | Drp1, dynamin-related protein 1 | tfLC3, tandem fluorescently tagged LC3 | NF-κB, nuclear factor κB | BAG, Bcl-2-associated athanogene | Keap1, Kelch-like ECH-associated protein 1 | PE, phosphatidylethanolamine | 3-MA, 3-methyladenine | UCP, uncoupling protein | IκB, inhibitor of nuclear factor κB | FIP200, focal adhesion kinase family-interacting protein of 200 kDa | PI3K, phosphoinositide 3-kinase | HNE, 4-hydroxynonenal | Review | ALS, amyotrophic lateral sclerosis | ATG, AuTophaGy-related | adenovirus E18 19-kDa-interacting protein | Tzb, trastuzumab | mETC, mitochondrial electron-transport chain | Rubicon, RUN domain- and cysteine-rich domain-containing beclin-1-interacting protein | VDAC, voltage-dependent anion channel | IP3, inositol 1,4,5-trisphosphate | RFP, red fluorescent protein | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PINK1, PTEN (phosphatase and tensin homologue deleted on chromosome 10)-induced kinase 1 | GFP, green fluorescent protein | LAMP, lysosome-associated membrane protein | JNK1, c-Jun N-terminal kinase 1 | TAC, transverse aortic constriction | GABARAP, GABAA (γ-aminobutyric acid type A)-receptor-associated protein | HIF-1, hypoxia-inducible factor 1 | NOS, nitric oxide synthase | siRNA, small interfering RNA | SOD, superoxide dismutase | RLS, reactive lipid species | RNS, reactive nitrogen species | ER, endoplasmic reticulum | TIGAR, TP53 (tumour protein 53)-induced glycolysis and apoptosis regulator | Vps34, vacuolar protein sorting 34 | BNIP, Bcl-2
Journal Article