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COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, ISSN 1943-0264, 12/2009, Volume 1, Issue 6, pp. 183 - 192
The nuclear factor NF-kappa B pathway has long been considered a prototypical proinflammatory signaling pathway, largely based on the role of NF-kappa B in the... 
RHEUMATOID-ARTHRITIS | CHRONIC INTESTINAL INFLAMMATION | LYMPHOTOXIN-BETA-RECEPTOR | DENDRITIC CELLS | STAT1-MEDIATED GENE ACTIVATION | TUMOR-ASSOCIATED MACROPHAGES | SPLENIC MICROARCHITECTURE | IKK-ALPHA | T-CELLS | INNATE IMMUNITY | CELL BIOLOGY | 040
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 11/2008, Volume 8, Issue 11, pp. 837 - 848
Research on the biological function of nuclear factor-kappa B (NF-kappa B), a key mediator of inducible transcription in the immune system, has traditionally... 
KINASE-ALPHA | TUMOR-NECROSIS-FACTOR | TRANSCRIPTIONAL ACTIVITY | AU-RICH ELEMENTS | NEGATIVE REGULATION | ALPHA-MEDIATED PHOSPHORYLATION | INDUCIBLE NUCLEAR-PROTEIN | TOLL-LIKE RECEPTORS | IKK-ALPHA | IMMUNOLOGY | DEPENDENT GENE-EXPRESSION
Journal Article
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, ISSN 1943-0264, 10/2009, Volume 1, Issue 4, pp. 5 - 18
Nuclear factor-kappa B (NF-kappa B) consists of a family of transcription factors that play critical roles in inflammation, immunity, cell proliferation,... 
KINASE-ALPHA | DNA-BINDING | BETA-TRCP | UBIQUITIN LIGASE | CRYSTAL-STRUCTURE | INDUCIBLE NUCLEAR-PROTEIN | GENE-EXPRESSION | IKK-ALPHA | SIGNALING MODULE | DEPENDENT DEGRADATION | CELL BIOLOGY | 040
Journal Article
Nature, ISSN 0028-0836, 06/2003, Volume 423, Issue 6940, pp. 659 - 663
NF-κB is a principal transcriptional regulator of diverse cytokine-mediated processes and is tightly controlled by the IκB kinase complex (IKK-α/β/γ). IKK-β... 
ACTIVATION | HISTONE H3 | PHOSPHORYLATION | ACETYLATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | IKK-ALPHA | INDUCTION | NEMO/IKK-GAMMA | BETA
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 2005, Volume 30, Issue 1, pp. 43 - 52
Nuclear factor-κB (NF-κB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-κB... 
TERMINAL PEST DOMAIN | KINASE-ALPHA | SELECTIVE-INHIBITION | TRANSCRIPTIONAL ACTIVITY | P65 SUBUNIT | TYROSINE PHOSPHORYLATION | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | IKK-ALPHA | TRANSACTIVATION DOMAIN
Journal Article
Cancer Research, ISSN 0008-5472, 12/2010, Volume 70, Issue 24, pp. 10464 - 10473
The role of mammary epithelial cell (MEC) NF-kappa B in tumor progression in vivo is unknown, as murine NF-kappa B components and kinases either are required... 
INITIATING CELLS | BREAST-CANCER CELLS | ONCOLOGY | CYCLIN D1 | SIGNALING PATHWAY | MACROPHAGES | IN-VIVO | GROWTH | IKK-ALPHA | GLAND | INDUCIBLE EXPRESSION | NF-κB | Ponasterone A | inducible transgenics | ErbB2
Journal Article
by Ding, J and Huang, SL and Wang, Y and Tian, Q and Zha, RP and Shi, HB and Wang, QF and Ge, C and Chen, TY and Zhao, YJ and Liang, LH and Li, JJ and He, XH
HEPATOLOGY, ISSN 0270-9139, 08/2013, Volume 58, Issue 2, pp. 654 - 666
Nuclear factor kappa B (NF-B) is an important factor linking inflammation and tumorigenesis. In this study we experimentally demonstrated through a... 
CELL LUNG-CANCER | BREAST-CANCER | PROTEIN | PHOSPHORYLATION | CHRONIC LYMPHOCYTIC-LEUKEMIA | SUPPRESSES TUMORIGENICITY | IKK-ALPHA | IDENTIFICATION | GASTROENTEROLOGY & HEPATOLOGY | NF-KAPPA-B | EXPRESSION
Journal Article
Nature, ISSN 0028-0836, 09/1999, Volume 401, Issue 6748, pp. 82 - 85
Activation of the nuclear transcription factor NF-κB by inflammatory cytokines requires the successive action of NF-κB-inducing kinase (NIK) and an IκB-kinase... 
SIGNAL-TRANSDUCTION | COMPLEX | INDUCED APOPTOSIS | PHOSPHORYLATION | 3-KINASE | MULTIDISCIPLINARY SCIENCES | IKK-ALPHA | TNF | BETA
Journal Article
Trends in Immunology, ISSN 1471-4906, 2008, Volume 29, Issue 10, pp. 469 - 478
NF-κB (nuclear factor-κB) transcription factors have multiple critical roles in the regulation of immune responses. In unstimulated cells, NF-κB proteins are... 
Allergy and Immunology | LYS63-LINKED POLYUBIQUITINATION | IMMUNE-RESPONSE | SIGNALING PATHWAYS | UBIQUITIN-CONJUGATING ENZYME | ALPHA-DEPENDENT APOPTOSIS | GENE-EXPRESSION | IKK-ALPHA | TNF-ALPHA | IMMUNOLOGY | DEUBIQUITINATING ENZYME CYLD | CUTTING EDGE
Journal Article
Nature, ISSN 0028-0836, 04/2006, Volume 440, Issue 7086, pp. 949 - 953
The Toll-like receptor (TLR) family has important roles in microbial recognition and dendritic cell activation. TLRs 7 and 9 can recognize nucleic acids and... 
PLASMACYTOID DENDRITIC CELLS | ANTIVIRAL RESPONSE | IMMUNITY | ACTIVATION | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | IKK-ALPHA | INDUCTION | VIRAL-INFECTION | MICE LACKING | IFN-ALPHA
Journal Article
Neuron, ISSN 0896-6273, 2007, Volume 55, Issue 6, pp. 942 - 957
Previously formed memories are susceptible to disruption immediately after recall due to a necessity to be reconsolidated after retrieval. Protein translation... 
SYSNEURO | DNA | MOLNEURO | INDUCED GENE-EXPRESSION | ACTIVATION | LONG-TERM-MEMORY | ACETYLATION | HISTONE ACETYLTRANSFERASE ACTIVITY | IKK-ALPHA | C-REL | TRANSCRIPTION FACTOR | PROTEIN-SYNTHESIS | NEUROSCIENCES | RETRIEVAL
Journal Article
Blood, ISSN 0006-4971, 01/2007, Volume 109, Issue 2, pp. 703 - 710
Chronic lymphocytic leukemia (CLL) B cells express BR3, the specific receptor for the B cell-activating factor of tumor necrosis factor family (BAFF). CLL... 
APOPTOSIS | NURSELIKE CELLS | SIGNALING PATHWAY | NECROSIS-FACTOR FAMILY | RECEPTOR SUPERFAMILY | IKK-ALPHA | PROINFLAMMATORY CYTOKINES | HEMATOLOGY | AUTOIMMUNE-DISEASE | TNF FAMILY | MEMBER
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 02/2018, Volume 9
Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers. While we previously identified KRAS mutations as molecular culprits... 
SURVIVAL | TUMOR-NECROSIS-FACTOR | B INHIBITORS | ACTIVATION | RAS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | GROWTH | IKK-ALPHA | CANCER | PROMOTES
Journal Article
Immunity, ISSN 1074-7613, 2002, Volume 17, Issue 4, pp. 525 - 535
The lymphotoxin-β receptor (LTβR) plays critical roles in inflammation and lymphoid organogenesis through activation of NF-κB. In addition to activation of the... 
BREAST-CANCER CELLS | KINASE COMPLEX | TUMOR-NECROSIS-FACTOR | TRANSCRIPTIONAL ACTIVITY | ALPHA-DEFICIENT MICE | SEVERE LIVER DEGENERATION | SPLENIC MICROARCHITECTURE | IKK-ALPHA | IMMUNOLOGY | ABNORMAL-DEVELOPMENT | SECONDARY LYMPHOID-TISSUES
Journal Article
Canadian Journal of Cardiology, ISSN 0828-282X, 04/2019, Volume 35, Issue 4, pp. 490 - 500
The IκB kinase (IKK) complex has been found to have critical functions in cancer and the immune system. In particular, IKKα, which is a member of the IKK... 
ACTIVATION | CARDIAC & CARDIOVASCULAR SYSTEMS | IKK-ALPHA | INHIBITION | MONOCYTE | INFLAMMATORY RESPONSE
Journal Article
Physiological Reviews, ISSN 0031-9333, 04/2010, Volume 90, Issue 2, pp. 495 - 511
NF-κB is a ubiquitiously expressed transcription factor that plays vital roles in innate immunity and other processes involving cellular survival,... 
KINASE-ALPHA | TRANSCRIPTION FACTORS | GROWTH-FACTOR-BETA | PHYSIOLOGY | NITRIC-OXIDE SYNTHASE | NUCLEAR EXPORT SIGNAL | NECROSIS-FACTOR-ALPHA | IKK-ALPHA | TRANSACTIVATION DOMAIN | TNF-ALPHA | MUSCLE GENE-EXPRESSION
Journal Article