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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2011, Volume 108, Issue 16, pp. 6474 - 6479
AKT activation requires phosphorylation of the activation loop (T308) by 3-phosphoinositide-dependent protein kinase 1 (PDK1) and the hydrophobic motif (S473)... 
Phosphorylation | Cell growth | HEK293 cells | Cell lines | HeLa cells | Antibodies | Myocardium | Muscles | Gene expression regulation | Insulin | IKK-related protein kinase | Protein kinase B | Cancer | FORKHEAD TRANSCRIPTION FACTOR | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | CELL-SURVIVAL | IDENTIFICATION | RAPTOR | RICTOR-MTOR COMPLEX | PATHWAY | ABLATION | cancer | protein kinase B | REVEALS | Biological Sciences
Journal Article
Seminars in Cancer Biology, ISSN 1044-579X, 06/2019, Volume 56, pp. 12 - 24
The inhibitory kappa B kinases (IKKs) and IKK related kinases are crucial regulators of the pro-inflammatory transcription factor, nuclear factor kappa B... 
IKK related kinase | Cancer therapy | Inhibitory kappa B kinase | IKK inhibitor | Nuclear factor kappa B | PROTEASOME INHIBITION | ANTITUMOR-ACTIVITY | SALIVARY-GLAND TUMORS | EPITHELIAL-MESENCHYMAL TRANSITION | CELL LUNG-CANCER | BREAST-CANCER | B-ALPHA KINASE | IKK-RELATED KINASES | ONCOLOGY | GENE-EXPRESSION | TRANSCRIPTION FACTOR
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 05/2009, Volume 284, Issue 21, pp. 14136 - 14146
TANK-binding kinase 1 (TBK1) and I kappa B kinase epsilon (IKK epsilon) regulate the production of Type 1 interferons during bacterial and viral infection, but... 
ACTIVATION | SIGNALING PATHWAY | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IKK-RELATED KINASE | TRANSCRIPTION | INNATE | ANTIVIRAL IMMUNITY | BINDING | TANK | VIRAL-INFECTION
Journal Article
Journal of Neuroinflammation, ISSN 1742-2094, 05/2015, Volume 12, Issue 1, p. 100
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2014, Volume 24, Issue 4, pp. 1138 - 1143
The discovery and optimization of a series of 6-aryl-azabenzimidazole inhibitors of TBK1 and IKK-ε is described. Various internal azabenzimidazole leads and... 
Azabenzimidazole | TBK1 | Kinase inhibitor | IKK-ε | ACTIVATION | CHEMISTRY, MEDICINAL | PHOSPHORYLATION | CHEMISTRY, ORGANIC | CANCER | TANK | EPSILON | IKK-epsilon | POTENT | IKK-RELATED KINASES | AURORA KINASES | INNATE IMMUNITY
Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2007, Volume 26, Issue 14, pp. 3451 - 3462
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2016, Volume 17, Issue 7, pp. 806 - 815
Journal Article