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Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 54, pp. 91887 - 91901
The objective of the present study was to examine the potential role of ghrelin in degeneration of nucleus pulposus (NP). Lower expression levels of ghrelin... 
NF-κB signaling | Akt signaling | Nucleus pulposus | IL-1β | Ghrelin | CELLS | IL-1 | IL-1 beta | MODEL | INTERVERTEBRAL-DISC DEGENERATION | CELL BIOLOGY | ghrelin | IN-VITRO | nucleus pulposus | INFLAMMATION | GENE-THERAPY | MICE | TNF-ALPHA | NF-kappa B signaling | EXPRESSION
Journal Article
Journal Article
by Li, Y and Liu, MF and Zuo, ZY and Liu, J and Yu, X and Guan, Y and Zhan, RH and Han, QJ and Zhang, J and Zhou, RB and Sun, R and Tian, ZG and Zhang, C
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 07/2017, Volume 199, Issue 2, pp. 761 - 773
TLRs are key sensors for conserved bacterial molecules and play a critical role in host defense against invading pathogens. Although the roles of TLRs in... 
MOLECULAR-PATTERNS | RESPONSES | ACTIVATION | IMMUNE HOMEOSTASIS | EPITHELIAL-CELLS | RECOGNITION | SEROVAR TYPHIMURIUM INFECTION | TOLL-LIKE RECEPTORS | IMMUNOLOGY | EXPRESSION | INTRAEPITHELIAL LYMPHOCYTES | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Toll-Like Receptor 9 - genetics | Gastroenteritis - microbiology | NK Cell Lectin-Like Receptor Subfamily K - immunology | NF-kappa B - metabolism | Intestines - immunology | Salmonella Infections, Animal - immunology | Toll-Like Receptor 9 - immunology | Toll-Like Receptor 2 - deficiency | NK Cell Lectin-Like Receptor Subfamily K - metabolism | Interleukin-1beta - metabolism | Toll-Like Receptor 3 - deficiency | Gastroenteritis - immunology | Interleukin-1beta - secretion | Intestines - pathology | Salmonella typhimurium - immunology | Signal Transduction | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Toll-Like Receptor 9 - deficiency | Gene Expression Regulation | Interleukin-1beta - immunology | Toll-Like Receptor 3 - immunology | Inflammation | NK Cell Lectin-Like Receptor Subfamily K - genetics | Animals | NLR Family, Pyrin Domain-Containing 3 Protein - immunology | Epithelial Cells - immunology | Salmonella Infections, Animal - microbiology | Toll-Like Receptor 2 - immunology | Mice | Toll-Like Receptor 9 - metabolism | Intestines - cytology | Pathogens | Salmonella | NF-κB protein | Toxicity | Secretion | Digestive system | Epithelial cells | Homeostasis | Cytotoxicity | Infections | TLR4 protein | IL-1β | TLR9 protein | Proteins | Signaling | Lymphocytes | Intestine | Rodents | TLR2 protein | Toll-like receptors | Bacteria | Digestive tract | Immune system
Journal Article
Journal Article
Seminars in Immunology, ISSN 1044-5323, 2004, Volume 16, Issue 1, pp. 3 - 9
Toll-like receptors (TLRs) have been established to play an essential role in the activation of innate immunity by recognizing specific patterns of microbial... 
Signal transduction | Innate immunity | TLR | TIR domain | DOUBLE-STRANDED-RNA | signal transduction | IL-1 RECEPTOR | IMMUNOLOGY | CUTTING EDGE | DOMAIN-CONTAINING ADAPTER | IFN-BETA | REGULATORY FACTOR-3 | innate immunity | CELL ACTIVATION | TOLL-LIKE RECEPTORS | DEFECTIVE INTERLEUKIN-1 | NF-KAPPA-B | Toll-Like Receptor 2 | Toll-Like Receptor 3 | Receptors, Immunologic - physiology | Toll-Like Receptor 4 | Humans | Interleukin-1 Receptor-Associated Kinases | Interferon Regulatory Factor-3 | Signal Transduction - immunology | Toll-Like Receptors | Membrane Glycoproteins - physiology | Immunity, Innate - physiology | Receptors, Cell Surface - physiology | Membrane Glycoproteins - immunology | Carrier Proteins - physiology | Proteins - physiology | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Adaptor Proteins, Vesicular Transport - physiology | Protein-Serine-Threonine Kinases - physiology | Intracellular Signaling Peptides and Proteins | Myeloid Differentiation Factor 88 | I-kappa B Kinase | Receptors, Cell Surface - immunology | Antigens, Differentiation - physiology | Ubiquitin-Protein Ligases | Immunity, Innate - immunology | Adaptor Proteins, Signal Transducing | TNF Receptor-Associated Factor 6 | Animals | Models, Biological | Protein Kinases - physiology | Receptors, Interleukin-1 - physiology | Signal Transduction - physiology | Nuclear Proteins - physiology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2009, Volume 106, Issue 8, pp. 2735 - 2740
Journal Article
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 01/2019, Volume 139, Issue 1, pp. 146 - 156
The IL-1 signaling pathway has been shown to play a critical role in the pathogenesis of chronic, autoinflammatory skin diseases such as psoriasis. However,... 
INTERLEUKIN-1 | DELTA T-CELLS | IL-1 | HUMAN KERATINOCYTES | BETA | DERMATOLOGY
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 04/2019, Volume 105, Issue 4, pp. 783 - 795
IL‐1β is an important mediator of innate inflammatory responses and has been shown to contribute to liver injury in a number of etiologies. HIV patients have... 
IL‐1β | NLRP3 activation | HIV | TLR4 | liver macrophages | IL-1β | VIRUS | PROTEIN | INTERLEUKIN-1-BETA | SUSCEPTIBILITY | IL-1 beta | NLRP3 INFLAMMASOME | IMMUNOLOGY | BACTERIAL VAGINOSIS | CELL BIOLOGY | DISEASE | IMMUNE ACTIVATION | KUPFFER CELLS | MICROBIAL TRANSLOCATION | HEMATOLOGY
Journal Article