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European Journal of Immunology, ISSN 0014-2980, 01/2019, Volume 49, Issue 1, pp. 8 - 10
Journal Article
ANNALS OF THE RHEUMATIC DISEASES, ISSN 0003-4967, 06/2019, Volume 78, pp. 57 - 58
Conference Proceeding
BRITISH JOURNAL OF DERMATOLOGY, ISSN 0007-0963, 12/2015, Volume 173, Issue 6, pp. 1431 - 1439
Background There is a dearth of information on the precise pathogenesis of hidradenitis suppurativa (HS), but immune dysregulation is implicated. Objectives To... 
PATHOGENESIS | IMMUNITY | THERAPY | CD4 T-CELLS | DENDRITIC CELLS | INFLAMMATION | DISEASE | IL-17 | IL-1-BETA | PSORIASIS | DERMATOLOGY
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 03/2019, Volume 105, Issue 3, pp. 433 - 436
Discussion on a new RIPK3‐dependent pathway to cell death and cytokine secretion independent of the canonical necroptosis and inflammasome machinery in... 
NLRP3 INFLAMMASOME | IMMUNOLOGY | IL-1-BETA SECRETION | HEMATOLOGY | IL-1-SS | CELL BIOLOGY
Journal Article
BRITISH JOURNAL OF DERMATOLOGY, ISSN 0007-0963, 03/2016, Volume 174, Issue 3, pp. 514 - 521
Background The pathogenesis of the chronic inflammatory skin disease hidradenitis suppurativa (HS, also known as acne inversa) involves epidermal alterations... 
PATHOGENESIS | CYTOKINES | PYODERMA-GANGRENOSUM | SWEETS-SYNDROME | SKIN DISEASES | IL-1-BETA | SECRETION | INFLAMMATORY BOWEL DISEASES | EXPRESSION | PSORIASIS | DERMATOLOGY
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2015, Volume 194, Issue 11, pp. 5472 - 5487
PGE(2) is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation... 
PROTEIN-KINASE-A | INTERLEUKIN-1 PRODUCTION | PROSTANOID RECEPTORS | IL-1-BETA PRODUCTION | ADENYLYL-CYCLASE | SILICA CRYSTALS | PERITONEAL-MACROPHAGES | PHOSPHOLIPASE A | IMMUNOLOGY | NALP3 INFLAMMASOME | CUTTING EDGE
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2009, Volume 360, Issue 23, pp. 2467 - 2470
Interleukin-1 is a highly active proinflammatory cytokine that causes not only fever, anorexia, and other constitutional symptoms but also tissue damage and... 
PATHOGENESIS | MEDICINE, GENERAL & INTERNAL | PROTEIN | INHIBITION | GENE | IL-1 | IL-1-BETA | ANAKINRA | OSTEOARTHRITIS | ASSOCIATION | RECEPTOR ANTAGONIST
Journal Article
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 04/2006, Volume 176, Issue 7, pp. 3877 - 3883
Human IL-1 family proteins are key mediators of the host response to infections, injury, and immunologic challenges. The mechanism by which IL-1 activates... 
EXTRACELLULAR ATP | RHEUMATOID-ARTHRITIS | IMMUNE-SYSTEM | IL-1-BETA RELEASE | NUCLEOTIDE RECEPTOR | INTERLEUKIN-1-BETA SECRETION | ATP-BINDING-SITE | GAMMA-INDUCING FACTOR | MICROGLIAL CELLS | IMMUNOLOGY | HUMAN MONOCYTES
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2007, Volume 322, Issue 1, pp. 8 - 15
We have demonstrated that caspase- 1- deficient ( caspase-1(-/-)) mice are functionally and histologically protected against cisplatin- induced acute renal... 
CASPASE-1-DEFICIENT MICE | APOPTOSIS | CASPASE-1 | IFN-GAMMA | DEFICIENT | INJURY | PHARMACOLOGY & PHARMACY | IL-1-BETA | ACUTE TUBULAR-NECROSIS | CONVERTING-ENZYME | NEPHROTOXICITY
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 07/2019, Volume 203, Issue 1, pp. 236 - 246
Inflammation plays a pivotal role in the pathophysiology of gastric aspiration-induced acute lung injury (ALI). However, its mechanism remains unclear. In this... 
PATHOGENESIS | APOPTOSIS | ACTIVATION | PROTEIN | MICE DEFICIENT | CASPASE-1 | PNEUMONITIS | IL-1-BETA | NLRP3 INFLAMMASOME | IMMUNOLOGY
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7575, pp. 666 - 671
Journal Article
Nature Medicine, ISSN 1078-8956, 2015, Volume 21, Issue 3, pp. 248 - 257
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 04/2019, Volume 202, Issue 8, pp. 2348 - 2359
The type I IFNs (IFN-alpha and -beta) are important for host defense against viral infections. In contrast, their role in defense against nonviral pathogens is... 
RESPONSES | CYTOSOLIC SURVEILLANCE PATHWAY | INTERFERON | IL-1-BETA PRODUCTION | DNA | NITRIC-OXIDE | INNATE | RESISTANCE | INFECTION | INDUCTION | IMMUNOLOGY
Journal Article
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 04/2004, Volume 172, Issue 8, pp. 4987 - 4994
The release of IL-1beta is a tightly controlled process that requires induced synthesis of the precursor pro-IL-1beta and a second stimulus that initiates... 
IL-1-BETA-CONVERTING ENZYME | CELLS | PROTEIN | LL-37 | LIPOPOLYSACCHARIDE | MEMBRANES | ANTIMICROBIAL PEPTIDES | IMMUNOLOGY | MOUSE MACROPHAGES | ATP | HUMAN-MONOCYTES
Journal Article