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Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 4/2018, Volume 24, Issue 7, pp. 1525 - 1535
Preclinical experiments demonstrated that Interleukin-15 (IL-15) can control homeostasis and stimulate natural killer (NK) and antigen-specific CD8 + T cell... 
IL-15 | Solid Tumor | Phase 1 | Outpatient | Subcutaneous
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 04/2019, Volume 112, p. 108677
Recombinant human interleukin-15 (IL-15) is a potent cancer immunotherapeutic candidate due to its excellent immune stimulating effects. Previous work... 
IL-15 complex | PD-1 | Mammalian expression | Immunotherapy
Journal Article
Frontiers in Immunology, 2013, Volume 4
Aging | IL-15 | IL-2 | CD25 | Bim
Journal Article
BLOOD, ISSN 0006-4971, 01/2012, Volume 119, Issue 2, pp. 422 - 433
Human mucosal associated invariant T (MAIT) CD8(+) and Tc17 cells are important tissue-homing cell populations, characterized by high expression of CD161... 
POPULATION | THYMUS | NATURAL-KILLER | HOMEOSTASIS | CD161 EXPRESSION | BIOLOGY | IL-15 | DEFINES | HEMATOLOGY | SUBSET | CUTTING EDGE
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 08/2017, Volume 140, Issue 2, pp. 553 - 564.e4
Gain-of-function (GOF) mutations affecting the coiled-coil domain or the DNA-binding domain of signal transducer and activator of transcription 1 cause chronic... 
signal transducer and activator of transcription 5 | IL-15 | Natural killer cells | cytotoxic activity | signal transducer and activator of transcription 1 | candidiasis | PROLIFERATION | IMMUNOLOGY | CHRONIC MUCOCUTANEOUS CANDIDIASIS | DEFICIENCY | FUNGAL-INFECTIONS | HYPER-IGE SYNDROME | GENE | ALLERGY | UNDERLIE | IL-17 IMMUNITY | CYTOTOXICITY | PRIMARY IMMUNODEFICIENCY | Gene Expression | Phosphorylation | Candidiasis, Chronic Mucocutaneous - genetics | Humans | Middle Aged | Candidiasis, Chronic Mucocutaneous - immunology | Male | STAT1 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | STAT1 Transcription Factor - metabolism | Adolescent | Killer Cells, Natural - immunology | Adult | Female | Killer Cells, Natural - drug effects | Killer Cells, Natural - metabolism | Mutation | Child | Cytokines - pharmacology | Medical colleges | Care and treatment | Killer cells | Bacterial infections | Mycoses | Genetic aspects | Genetic transcription | Analysis | Cell proliferation | Pathogenesis | Helper cells | Cytotoxicity | Stimulation | Infections | Activation | Lymphocytes T | Kinases | Proteins | Fungi | α-Interferon | Interleukin 2 | Lymphocytes | Bacteria | Stat1 protein | Deoxyribonucleic acid--DNA | Binding | Pathogens | Interleukin 2 receptors | Cytokines | Chronic mucocutaneous candidiasis | Functional analysis | Stat5 protein | Interleukin 15 | Patients | Studies | γ-Interferon | Degranulation | Interferon | Viral infections
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2018, Volume 115, Issue 26, pp. E5980 - E5989
Journal Article
Cytokine, ISSN 1043-4666, 12/2011, Volume 56, Issue 3, pp. 804 - 810
Journal Article
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, ISSN 0905-7188, 01/2018, Volume 28, Issue 1, pp. 116 - 125
In vitro and in vivo studies described the myokine IL-15 and its receptor IL-15R as anabolic/anti-atrophy agents, however, the protein expression of IL-15R has... 
muscle protein synthesis | strength training | SPORT SCIENCES | ENDURANCE | MITOCHONDRIAL | breakdown | INCREASES | IL-15 | CYTOKINE | RECEPTOR-ALPHA | Myokines | RESPONSES | IL-15R axis | IL-15R-ALPHA DEFICIENCY | INTERLEUKIN-15 | IL-15 ACTIVITY | ALTERS | Muscles | Protein biosynthesis | Musculoskeletal system | Exercise | Protein synthesis | Sports medicine
Journal Article
Expert Review of Clinical Immunology, ISSN 1744-666X, 12/2014, Volume 10, Issue 12, pp. 1689 - 1701
IL-15 is a 14-15 kDa member of the four -helix bundle of cytokines that acts through a heterotrimeric receptor involving IL-2/IL-15R , c and the IL-15 specific... 
CD40 | IL-15 receptor α | IL-2/IL-15R β | Malignant melanoma | Renal cell cancer | IL-15 | γc IL-2 | NATURAL-KILLER-CELLS | renal cell cancer | SOLUBLE IL-15R-ALPHA | IL-2 | IMMUNOLOGY | ANTITUMOR-ACTIVITY | CD8(+) T-CELLS | c IL-2 | SIGNAL-TRANSDUCTION | IL-15R | malignant melanoma | NK CELLS | MARROW-DERIVED CELLS | IN-VIVO | IL-15 receptor | RECEPTOR-ALPHA-CHAIN | TRANS-PRESENTATION
Journal Article
by Zhao, MQ and Luo, MY and Xie, YQ and Jiang, H and Cagliero, C and Li, NH and Ye, H and Wu, MY and Hao, S and Sun, TY and Yang, H and Zhang, MX and Lin, T and Lu, HL and Zhu, JW
BIOMEDICINE & PHARMACOTHERAPY, ISSN 0753-3322, 04/2019, Volume 112
Recombinant human interleukin-15 (IL-15) is a potent cancer immunotherapeutic candidate due to its excellent immune stimulating effects. Previous work... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | COMPLEX | Mammalian expression | IL-15 | IL-15 complex | PROLIFERATION | RECEPTOR-ALPHA | Immunotherapy | INTERLEUKIN-15 | PURIFICATION | PHARMACOLOGY & PHARMACY | IL-15R-ALPHA | PD-1 | EXPRESSION
Journal Article
Frontiers in Immunology, ISSN 1664-3224, 2013, Volume 4, Issue MAY, p. 107
Beyond midlife, the immune system shows aging features and its defensive capability becomes impaired, by a process known as immunosenescence that involves many... 
T-cells | IL-15 | Immunosenescence | Inflammation | NKRs | CMV | immunosenescence | inflammation | IMMUNOLOGY
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2018, Volume 24, Issue 22, pp. 5552 - 5561
Purpose: IL15 induces the activation and proliferation of natural killer (NK) and memory CD8 thorn T cells and has preclinical antitumor activity. Given the... 
HUMAN INTERLEUKIN-15 | ONCOLOGY | IL-15 SUPERAGONIST COMPLEX | NK | FUSION COMPLEX | T-CELLS
Journal Article