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International Journal of Cancer, ISSN 0020-7136, 01/2016, Volume 138, Issue 1, pp. 187 - 194
Glioblastoma is the most aggressive primary central nervous system malignancy with a poor prognosis in patients. Despite the need for better treatments against... 
anti‐PD‐1 | glioblastoma | IL‐15 superagonist | ALT‐803 | IL-15 superagonist | ALT-803 | anti-PD-1 | GLIOMAS | CANCER | RADIATION | CD8(+) T-CELLS | TEMOZOLOMIDE | ONCOLOGY | IMMUNOTHERAPY | IMMUNOSUPPRESSION | INTERLEUKIN-15 | BLOCKADE | EXPRESSION | T-Lymphocyte Subsets - immunology | Humans | Radiosurgery | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Central Nervous System Neoplasms - immunology | T-Lymphocyte Subsets - drug effects | Immunotherapy | Female | Glioblastoma - metabolism | Lymphocytes, Tumor-Infiltrating - metabolism | Antineoplastic Agents - pharmacology | Disease Models, Animal | Central Nervous System Neoplasms - metabolism | Antibodies, Monoclonal - pharmacology | Programmed Cell Death 1 Receptor - metabolism | Central Nervous System Neoplasms - therapy | Glioblastoma - therapy | Xenograft Model Antitumor Assays | Central Nervous System Neoplasms - pathology | Animals | Interleukin-15 - agonists | Glioblastoma - immunology | T-Lymphocyte Subsets - metabolism | Glioblastoma - pathology | Cell Line, Tumor | Immunologic Memory | Mice | Proteins - pharmacology | Glioblastoma - mortality | Central Nervous System Neoplasms - mortality | Lymphocytes, Tumor-Infiltrating - immunology | Killer cells | Immune response | Interleukins | Analysis | Health aspects | Glioblastoma multiforme | Cytokines | Medical prognosis | Immune system
Journal Article
Molecular Therapy, ISSN 1525-0016, 10/2018, Volume 26, Issue 10, pp. 2476 - 2486
Oncolytic immunotherapy is a promising novel therapeutic for cancer, and further preclinical studies may maximize its therapeutic efficacy. In this study, we... 
superagonist | oncolytic vicotherapy | oncolytic virus | immunotherapy | IL-15 | vaccinia virus | antitumor immunity | efficacy | immune checkpoint blockade | MEDICINE, RESEARCH & EXPERIMENTAL | MEMORY | MICROENVIRONMENT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | POXVIRUS | GENETICS & HEREDITY | VACCINIA VIRUS | COMBINATION | CANCER | CD8(+) T-CELLS | ESTABLISHED TUMORS | Recombinant Fusion Proteins - immunology | Interleukin-15 - administration & dosage | Immunotherapy - methods | Humans | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Interleukin-15 Receptor alpha Subunit - administration & dosage | Neoplasms - therapy | Neoplasms - genetics | Killer Cells, Natural - immunology | Female | Interferon-gamma - genetics | Recombinant Fusion Proteins - administration & dosage | Immunity, Innate - drug effects | Combined Modality Therapy | Interleukin-15 Receptor alpha Subunit - genetics | Xenograft Model Antitumor Assays | Immunity, Innate - immunology | Oncolytic Virotherapy - methods | Animals | Interleukin-15 - genetics | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Killer Cells, Natural - drug effects | Mice | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Neoplasms - pathology | Programmed Cell Death 1 Receptor - genetics | PD-1 protein | CD8 antigen | Genomics | Genes | Colorectal cancer | Viruses | Lymphocytes T | Kinases | Ovarian cancer | Proteins | Colon cancer | Efficiency | Lymphocytes | Immunotherapy | Interleukin 1 | Oncolysis | Colon | Fusion protein | Enzyme-linked immunosorbent assay | Antigens | Cytokines | Melanoma | Interleukin 15 | Biological activity | CD4 antigen | Studies | γ-Interferon | Antitumor activity | Chemokines | Apoptosis | Tumors | Original
Journal Article
Journal Article
Cytokine, ISSN 1043-4666, 12/2011, Volume 56, Issue 3, pp. 804 - 810
Journal Article
CANCER IMMUNOLOGY IMMUNOTHERAPY, ISSN 0340-7004, 04/2018, Volume 67, Issue 4, pp. 675 - 689
Natural killer (NK) cells are innate cytotoxic lymphocytes that play a fundamental role in the immunosurveillance of cancers. NK cells of cancer patients... 
NK cells | NATURAL-KILLER-CELLS | SUPERAGONIST | TGF-BETA | Tumor microenvironment | TGF-beta 1 | IL-15 | IMMUNOLOGY | CD8(+) T-CELLS | Immunosuppression | GROWTH-FACTOR-BETA | CANCER-PATIENTS | ANTI-PD-L1 ANTIBODY | GAMMA PRODUCTION | ONCOLOGY | IMMUNOTHERAPY | HUMAN INTERLEUKIN-15
Journal Article
Journal Article
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 04/2019, Volume 112, p. 108677
Recombinant human interleukin-15 (IL-15) is a potent cancer immunotherapeutic candidate due to its excellent immune stimulating effects. Previous work... 
IL-15 complex | PD-1 | Mammalian expression | Immunotherapy
Journal Article
OncoImmunology, ISSN 2162-4011, 02/2019, Volume 8, Issue 2, p. e1532764
Here we describe a novel bifunctional fusion protein, designated N-809. This molecule comprises the IL-15/IL15Rα superagonist complex containing the Fc-domain... 
anti-PD-L1 | cytokine | N-809 | carcinoma | immunotherapy | IL-15 | N-803 | ALT-803 | ADCC | checkpoint inhibitor | IFN-GAMMA | JAVELIN SOLID TUMOR | OPEN-LABEL | IMMUNOLOGY | ANTITUMOR-ACTIVITY | AVELUMAB | CANCER | ONCOLOGY | CARCINOEMBRYONIC ANTIGEN | HUMAN INTERLEUKIN-15 | T-CELLS
Journal Article
Journal Article
by Zhao, MQ and Luo, MY and Xie, YQ and Jiang, H and Cagliero, C and Li, NH and Ye, H and Wu, MY and Hao, S and Sun, TY and Yang, H and Zhang, MX and Lin, T and Lu, HL and Zhu, JW
BIOMEDICINE & PHARMACOTHERAPY, ISSN 0753-3322, 04/2019, Volume 112
Recombinant human interleukin-15 (IL-15) is a potent cancer immunotherapeutic candidate due to its excellent immune stimulating effects. Previous work... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | COMPLEX | Mammalian expression | IL-15 | IL-15 complex | PROLIFERATION | RECEPTOR-ALPHA | Immunotherapy | INTERLEUKIN-15 | PURIFICATION | PHARMACOLOGY & PHARMACY | IL-15R-ALPHA | PD-1 | EXPRESSION
Journal Article
Journal Article