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JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 08/2019, Volume 203, Issue 3, pp. 676 - 685
To understand and dissect the mechanisms driving human NK cell proliferation, we exploited the methodology used in cell therapy to numerically expand NK cells... 
NATURAL-KILLER-CELLS | ACTIVATION | LYMPHOID DEVELOPMENT | EXPANSION | RECEPTOR | DELTA-T-CELLS | IL-15R-ALPHA | IMMUNOLOGY | PROMOTES | MICE LACKING | IL-21
Journal Article
Cancer Research, ISSN 0008-5472, 12/2015, Volume 75, Issue 24, pp. 5187 - 5193
Preclinical models revealed that the immune system can mediate rejection of established tumors, but direct evidence in humans has been limited to largely... 
METASTATIC MELANOMA | HOMEOSTASIS | ACTIVATION | INHIBITION | ONCOLOGY | INTERLEUKIN-2 THERAPY | IL-15 | GENERATION | IL-15R-ALPHA | ANTITUMOR-ACTIVITY | IPILIMUMAB | Stem Cells - immunology | Immunotherapy, Adoptive - methods | Neoplasms - therapy | Animals | Neoplasms - immunology | Humans | Interleukin-15 - immunology | T-Lymphocytes - transplantation
Journal Article
Blood, ISSN 0006-4971, 07/2013, Volume 121, Issue 3, pp. 476 - 484
In the present study, Hu-Mik beta 1, a humanized mAb directed at the shared IL-2/IL-15R beta subunit (CD122) was evaluated in patients with T-cell large... 
RHEUMATOID-ARTHRITIS | RECEPTOR-BETA-CHAIN | INTERLEUKIN-15 | IN-VIVO | ACTIVATED KILLER-CELLS | ANTIBODY | PROLIFERATION | CYTOKINE | IL-15R-ALPHA | HEMATOLOGY | CELIAC-DISEASE | Lymphoid Neoplasia
Journal Article
Biomaterials, ISSN 0142-9612, 2016, Volume 105, pp. 195 - 205
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2015, Volume 112, Issue 31, pp. 9692 - 9697
The development and homeostasis of gamma delta T cells is highly dependent on distinct cytokine networks. Here we examine the role of IL-15 and its unique... 
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | NATURAL-KILLER | MULTIDISCIPLINARY SCIENCES | gamma delta T cells | MOUSE | IL-7 | CUTTING EDGE | IL-15R alpha | INTERFERON-GAMMA | INFLAMMATION | TRANS-PRESENTATION | MICE | IL-15R-ALPHA | REQUIREMENT
Journal Article
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, ISSN 0905-7188, 01/2018, Volume 28, Issue 1, pp. 116 - 125
In vitro and in vivo studies described the myokine IL-15 and its receptor IL-15R as anabolic/anti-atrophy agents, however, the protein expression of IL-15R has... 
muscle protein synthesis | strength training | SPORT SCIENCES | ENDURANCE | MITOCHONDRIAL | breakdown | INCREASES | IL-15 | CYTOKINE | RECEPTOR-ALPHA | Myokines | RESPONSES | IL-15R axis | IL-15R-ALPHA DEFICIENCY | INTERLEUKIN-15 | IL-15 ACTIVITY | ALTERS | Muscles | Protein biosynthesis | Musculoskeletal system | Exercise | Protein synthesis | Sports medicine
Journal Article
Journal of experimental medicine, ISSN 0022-1007, 2009, Volume 206, Issue 1, pp. 25 - 34
The in vivo requirements for human natural killer (NK) cell development and differentiation into cytotoxic effectors expressing inhibitory receptors for... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | NATURAL-KILLER-CELLS | SEVERE COMBINED IMMUNODEFICIENCY | HUMAN-DISEASE | INTERLEUKIN-15 | COMPLEXES | SOLUBLE IL-15R-ALPHA | INHIBITORY RECEPTORS | MICE | IMMUNOLOGY | HELIX FACTOR ID3 | Interleukin-15 - administration & dosage | Recombinant Fusion Proteins - pharmacology | Humans | bcl-X Protein - genetics | Receptors, Interleukin-15 - metabolism | Transplantation, Heterologous | Recombinant Fusion Proteins - metabolism | Receptors, Interleukin-15 - genetics | Retroviridae - genetics | Antigens, Differentiation - metabolism | Animals, Newborn | Cell Survival - drug effects | Transduction, Genetic | Mice, Inbred C57BL | Lymphoid Tissue - metabolism | Hematopoietic Stem Cells - metabolism | DNA-Binding Proteins - genetics | Interleukin Receptor Common gamma Subunit - genetics | Mice, Knockout | Interleukin-15 - pharmacology | Killer Cells, Natural - cytology | Lymphoid Tissue - cytology | Animals | Receptors, Interleukin-15 - agonists | Cell Differentiation - drug effects | Mice, Nude | Hematopoietic Stem Cells - cytology | Recombinant Fusion Proteins - genetics | Cell Proliferation - drug effects | Killer Cells, Natural - drug effects | Mice | Mice, Inbred BALB C | Hematopoietic Stem Cell Transplantation - methods | Killer Cells, Natural - metabolism | bcl-X Protein - metabolism | Brief Definitive Reports
Journal Article
by Zhao, MQ and Luo, MY and Xie, YQ and Jiang, H and Cagliero, C and Li, NH and Ye, H and Wu, MY and Hao, S and Sun, TY and Yang, H and Zhang, MX and Lin, T and Lu, HL and Zhu, JW
BIOMEDICINE & PHARMACOTHERAPY, ISSN 0753-3322, 04/2019, Volume 112
Recombinant human interleukin-15 (IL-15) is a potent cancer immunotherapeutic candidate due to its excellent immune stimulating effects. Previous work... 
MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | COMPLEX | Mammalian expression | IL-15 | IL-15 complex | PROLIFERATION | RECEPTOR-ALPHA | Immunotherapy | INTERLEUKIN-15 | PURIFICATION | PHARMACOLOGY & PHARMACY | IL-15R-ALPHA | PD-1 | EXPRESSION
Journal Article
Journal of cell science, ISSN 0021-9533, 11/2018, Volume 131, Issue 21, p. jcs218313
The pro-inflammatory cytokine interleukin-15 (IL15) and its receptor a (IL15RA) participate in the regulation of musculoskeletal function and metabolism.... 
Myokine | IL15RA | Mitochondria | Microscopy | OPA1 | IL15 | Ultrastructure | Interleukin | Fatigue | Cardiolipin | Fiber type | HOMEOSTASIS | SUBPOPULATIONS | PROTEOME | AUTOPHAGY | INTERLEUKIN-15 RECEPTOR | CELL BIOLOGY | SKELETAL-MUSCLE | IL-15R-ALPHA DEFICIENCY | ENDURANCE EXERCISE | MODULATION | 132
Journal Article
Blood, ISSN 0006-4971, 10/2006, Volume 108, Issue 7, pp. 2135 - 2136
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 03/2014, Volume 92, Issue 3, pp. 210 - 213
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 10/2004, Volume 200, Issue 7, pp. 825 - 834
Journal Article
Immunology Letters, ISSN 0165-2478, 10/2017, Volume 190, pp. 159 - 168
Journal Article
BLOOD, ISSN 0006-4971, 07/2012, Volume 120, Issue 1, pp. 1 - 2
In this issue of Blood, Bergamaschi and colleagues demonstrate that effectively all circulating IL-15 found in the serum of humans and mice is associated with... 
CELLS | HOMEOSTASIS | MEMORY | INTERLEUKIN-15 | IL-15 | TRANS-PRESENTATION | IL-15R-ALPHA | HEMATOLOGY | EXPRESSION
Journal Article
Journal of Immunology, ISSN 0022-1767, 10/2009, Volume 183, Issue 8, pp. 5261 - 5269
Although Syk has been reported to be associated with IL-2R alpha and IL-15R alpha in some hematopoietic cells, its association has never been investigated in... 
IMMUNORECEPTOR | APOPTOSIS | ACTIVATION | PHAGOCYTOSIS | INTERLEUKIN-15 | IN-VIVO | IL-15R-ALPHA CHAIN | RECEPTOR | PROTEIN-TYROSINE KINASE | IMMUNOLOGY | EXPRESSION
Journal Article