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PLoS ONE, ISSN 1932-6203, 07/2017, Volume 12, Issue 7, p. e0179431
Cytokines are potent immune modulating agents but are not ideal medicines in their natural form due to their short half-life and pleiotropic systemic effects.... 
LIGAND-BINDING | ALPHA-RECEPTOR | MULTIDISCIPLINARY SCIENCES | LONG-TERM SAFETY | COMPLEXES | REGULATORY T-CELLS | MODULATION THERAPIES | IL-2 | CYTOKINE | HIGH-DOSE INTERLEUKIN-2 | RENAL-CELL CARCINOMA | Neoplasms - metabolism | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Interleukin-2 Receptor beta Subunit - metabolism | Interleukin Receptor Common gamma Subunit - metabolism | Transplantation, Homologous | T-Lymphocytes, Regulatory - immunology | STAT5 Transcription Factor - metabolism | Neoplasms - therapy | Interleukin Receptor Common gamma Subunit - agonists | CD8-Positive T-Lymphocytes - metabolism | Female | Interleukin-2 - analogs & derivatives | Phosphorylation - drug effects | Polyethylene Glycols - pharmacology | Models, Theoretical | Tumor Microenvironment - drug effects | Interleukin-2 - pharmacokinetics | Interleukin-2 Receptor beta Subunit - agonists | Mice, Inbred C57BL | Polyethylene Glycols - pharmacokinetics | Receptors, Interleukin-2 - metabolism | Mice, Inbred C3H | Tumor Microenvironment - immunology | T-Lymphocytes, Regulatory - drug effects | Algorithms | Animals | Interleukin-2 Receptor alpha Subunit - agonists | Interleukin-2 Receptor alpha Subunit - metabolism | Prodrugs - pharmacokinetics | Neoplasms - immunology | CD8-Positive T-Lymphocytes - drug effects | Cell Line, Tumor | Drug Liberation | Interleukin-2 - pharmacology | Mice, Inbred BALB C | Kinetics | CD8-Positive T-Lymphocytes - immunology | Prodrugs - pharmacology | Receptors, Interleukin-2 - agonists | Physiological aspects | Care and treatment | Interleukin-2 | Immunotherapy | Patient outcomes | Cancer | Polyethylenes | Conjugates | CD8 antigen | Interleukin | Lymphocytes T | Anticancer properties | Proteins | Biological effects | Cell activation | Immunology | Interleukin 2 | Lymphocytes | Polyethylene glycol | Modelling | Drug dosages | Immune system | Interleukin 2 receptors | Pharmacodynamics | Cytokines | Immunoregulation | Melanoma | Radioactive half-life | Pharmacology | Affinity | Ligands | Mutation | Pharmacokinetics | In vitro methods and tests | Tumors
Journal Article
Immunity, ISSN 1074-7613, 01/2013, Volume 38, Issue 1, pp. 13 - 25
Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays pivotal roles in the immune response. Discovered as a T cell growth... 
BETA-CHAIN | SEVERE COMBINED IMMUNODEFICIENCY | CYTOKINE RECEPTOR | IN-VIVO | REGULATORY T-CELLS | GENE-EXPRESSION | RECEPTOR-ALPHA-CHAIN | MONOCLONAL-ANTIBODY | IMMUNOLOGY | IL-2 RECEPTOR | GAMMA-CHAIN | T-Lymphocyte Subsets - immunology | Humans | X-Linked Combined Immunodeficiency Diseases - genetics | Interleukin Receptor Common gamma Subunit - metabolism | X-Linked Combined Immunodeficiency Diseases - immunology | Interleukin Receptor Common gamma Subunit - immunology | Leukemia-Lymphoma, Adult T-Cell - immunology | T-Lymphocytes, Regulatory - immunology | Receptors, Interleukin-2 - genetics | Interleukin-2 - physiology | T-Lymphocytes, Helper-Inducer - immunology | Immunotherapy | T-Lymphocytes, Helper-Inducer - cytology | CD8-Positive T-Lymphocytes - metabolism | Leukemia-Lymphoma, Adult T-Cell - therapy | Interleukin-2 - metabolism | Leukemia-Lymphoma, Adult T-Cell - genetics | Immune Tolerance | Receptors, Interleukin-2 - metabolism | X-Linked Combined Immunodeficiency Diseases - therapy | Interleukin Receptor Common gamma Subunit - genetics | Cell Differentiation - immunology | Animals | T-Lymphocyte Subsets - metabolism | Interleukin-15 - metabolism | Immunologic Memory | CD8-Positive T-Lymphocytes - immunology | Interleukins | T cells | Cell growth | T cell receptors | Cytokines | Kinases | Immune system
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2015, Volume 10, Issue 5, p. e0126765
4-1BB (CD137), a member of the tumor necrosis factor receptor superfamily (TNFRSF), is primarily expressed on activated T cells and is known to enhance... 
RESPONSES IN-VIVO | INTERLEUKIN-2 | ACTIVATION | IMMUNE-RESPONSES | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | IL-2 | INFECTION | COSTIMULATION | INDUCTION | PROGRESSION | Interleukin-2 - metabolism | Autocrine Communication | Gene Expression | Lymphocyte Activation | CD4-Positive T-Lymphocytes - metabolism | Receptors, Interleukin-2 - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Tumor Necrosis Factor Receptor Superfamily, Member 9 - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Mice, Knockout | CD4-Positive T-Lymphocytes - immunology | Receptors, Interleukin-2 - genetics | Animals | Signal Transduction - drug effects | CD8-Positive T-Lymphocytes - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | CD8-Positive T-Lymphocytes - immunology | Proto-Oncogene Proteins c-akt - metabolism | CD27 antigen | Cell proliferation | CD8 antigen | Lymphocytes T | Biology | Kinases | T-cell receptor | Cell activation | Cell growth | Immunology | CD30 antigen | Interleukin 2 | Lymphocytes | Cell cycle | CD25 antigen | Tumor necrosis factor-TNF | Autocrine signalling | Expansion | Interleukin 2 receptors | Immunological memory | Memory cells | Population growth | CD137 antigen | Cytokines | CD4 antigen | Tumor necrosis factor | Cell death | Monoclonal antibodies | Laboratory animals | Viral infections | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 34, pp. 20972 - 20983
T, B, and natural killer cells are required for normal immune response and are regulated by cytokines such as IL-2. These cell signals are propagated following... 
NATURAL-KILLER-CELLS | QUANTITATIVE PHOSPHOPROTEOMICS | PROTEIN | PATHWAY | SERINE/THREONINE PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | IL-2 RECEPTOR | IDENTIFICATION | HUMAN T-CELLS | GAMMA-CHAIN | RNA, Small Interfering - genetics | Phosphorylation | Humans | Interleukin-2 Receptor beta Subunit - metabolism | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Molecular Sequence Data | Threonine - metabolism | Proto-Oncogene Proteins c-akt - genetics | Janus Kinase 3 - antagonists & inhibitors | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Protein Phosphatase 1 - genetics | Interleukin-2 Receptor beta Subunit - genetics | Janus Kinase 3 - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-2 - metabolism | Amino Acid Sequence | Cell Line | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | Serine - metabolism | Interleukin-2 - genetics | Protein Phosphatase 1 - metabolism | Tyrosine - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Janus Kinase 3 - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | serine | JAK | interleukin 2 | threonine | cell signaling | STAT transcription factor | receptor phosphorylation | protein kinase | protein phosphatase | lymphocyte
Journal Article
Journal Article
Science, ISSN 0036-8075, 12/1993, Volume 262, Issue 5141, pp. 1880 - 1883
Journal Article
Immunity, ISSN 1074-7613, 05/2015, Volume 42, Issue 5, pp. 826 - 838
Journal Article