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Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 09/2011, Volume 128, Issue 3, pp. 655 - 664
Background: Behet disease (BD) is a chronic systemic inflammatory disorder of unknown etiology. Objective: To determine the nature of T cells driving... 
regulatory T cells | Behet disease | autoimmunity | vasculitis | IL-21
Journal Article
NATURE, ISSN 0028-0836, 05/2008, Volume 453, Issue 7192, pp. 236 - U14
T helper cells that produce IL- 17 (T(H)17 cells) promote autoimmunity in mice and have been implicated in the pathogenesis of human inflammatory diseases. At... 
PATHWAYS | RESPONSES | ACTIVATION | AUTOIMMUNE INFLAMMATION | INTERLEUKIN-17 | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | GENERATION | CYTOKINE | REPRESSOR | IL-21
Journal Article
Immunology and Cell Biology, ISSN 0818-9641, 11/2009, Volume 87, Issue 8, pp. 590 - 600
Journal Article
IMMUNITY, ISSN 1074-7613, 06/2011, Volume 34, Issue 6, pp. 932 - 946
The nature of follicular helper CD4(+) T (Tfh) cell differentiation remains controversial, including the minimal signals required for Tfh cell differentiation... 
B-CELLS | ACTIVATION | SAP | IN-VIVO | HUMORAL IMMUNITY | CD28 | COMMON VARIABLE IMMUNODEFICIENCY | GERMINAL-CENTERS | IMMUNOLOGY | C-MAF | IL-21
Journal Article
Nature Reviews Immunology, ISSN 1474-1733, 06/2013, Volume 13, Issue 6, pp. 412 - 426
Antibody production is an important feature of the vertebrate immune system. Antibodies neutralize and clear pathogens, thereby protecting against infectious... 
CXC CHEMOKINE RECEPTOR-5 | GERMINAL CENTER B | HUMAN NAIVE | FOLLICULAR-HELPER-CELLS | HUMORAL IMMUNITY | INDUCIBLE COSTIMULATOR | IL-21 RECEPTOR | INTERLEUKIN 21 | IMMUNOLOGY | ANTIBODY-RESPONSES | CUTTING EDGE
Journal Article
JOURNAL OF INFECTIOUS DISEASES, ISSN 0022-1899, 04/2018, Volume 217, Issue 8, pp. 1323 - 1333
Background. In the current study, we determined the effects of interleukin (IL)-21 on human natural killer (NK) cells and monocyte responses during... 
cytokine | MYCOBACTERIUM-TUBERCULOSIS | INTRACELLULAR PATHOGEN | NKT CELLS | INFECTIOUS DISEASES | NK cells | ACTIVATION | tuberculosis | IL-21 RECEPTOR | MICROBIOLOGY | IMMUNOLOGY | IL-21 | INTERFERON-GAMMA | RESISTANCE | BACTERIUM | MICE | human | EXPRESSION
Journal Article
PLOS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9
Follicular helper T cells (T-FH) represent a distinct subset of CD4(+) T cells specialized in providing help to B lymphocytes, which may play a central role in... 
POPULATION | MULTIDISCIPLINARY SCIENCES | IGD | PHENOTYPE | CD27 | CELLS EXPRESS | INCREASED FREQUENCY | IL-21 | ERYTHEMATOSUS | BLOOD
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2018, Volume 501, Issue 1, pp. 92 - 99
Patients with DOCK8 deficiency are at increased susceptibility to develop allergic diseases such as food allergy and asthma. Here, we aimed to analyze the... 
Allergic asthma | Ovalbumin | DOCK8 gene | IL-21 | Murine model | Index Medicus
Journal Article
Experimental Cell Research, ISSN 0014-4827, 01/2019, Volume 374, Issue 1, pp. 69 - 75
Type I natural killer T (NKT) cells are attractive candidates for cancer immunotherapy. In this study, we examined the characteristics of type I NKT cells in... 
Acute lymphoblastic leukemia | Natural killer T cells | IL-21
Journal Article
Cytokine, ISSN 1043-4666, 01/2020, Volume 125, pp. 154814 - 154814
Enhancement of the magnitude or affinity of protective antibodies (Abs) induced by vaccine adjuvant is highly desirable to prevent challenging pathogens such... 
DNA vaccine | MVA | Antibody avidity | IL-21 | Index Medicus
Journal Article
Rheumatology (United Kingdom), ISSN 1462-0324, 2014, Volume 53, Issue 7, pp. 1159 - 1160
Journal Article
Molecular Immunology, ISSN 0161-5890, 10/2019, Volume 114, pp. 369 - 377
The prevalence of IgE-mediated food allergy is increasing in the whole wide world which often causes skin and gastrointestinal tract symptoms, or even fatal... 
Food allergy | IL-17A | Aicda | IL-21 | STAT3 | Index Medicus
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2008, Volume 9, Issue 6, pp. 641 - 649
T-H-17 cells are interleukin 17 (IL-17)-secreting CD4(+) T helper cells involved in autoimmune disease and mucosal immunity. In naive CD4(+) T cells from mice,... 
INTERLEUKIN-17 PRODUCTION | PEDIATRIC CROHNS-DISEASE | INFLAMMATORY-BOWEL-DISEASE | TGF-BETA | MULTIPLE-SCLEROSIS | HUMAN TH17 CELLS | IL-21 RECEPTOR | IMMUNOLOGY | IL-17 PRODUCTION | AUTOIMMUNE ENCEPHALOMYELITIS | CUTTING EDGE
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 02/2014, Volume 5
During our life, we are surrounded by continuous threats from a diverse range of invading pathogens. Our immune system has evolved multiple mechanisms to... 
autoimmune diseases | SYSTEMIC-LUPUS-ERYTHEMATOSUS | SEVERE COMBINED IMMUNODEFICIENCY | differentiation | human B cells | RECOMBINANT CD40 LIGAND | CUTTING EDGE IL-21 | HUMAN B-CELLS | NECROSIS-FACTOR-ALPHA | IMMUNOLOGY | plasma cells | IL-21 | HELPER T-CELLS | IN-VITRO | HUMAN NAIVE | COMMON GAMMA-CHAIN | cytokines | immunodeficiency
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 10/2013, Volume 210, Issue 11, pp. 2181 - 2190
Interleukin (IL) 17-producing T helper (T(H)17) cells have been selected through evolution for their ability to control fungal and bacterial infections. It is... 
SELECTIVE-INHIBITION | MEDICINE, RESEARCH & EXPERIMENTAL | ROR-GAMMA | HELPER-CELLS | TRANSCRIPTION | T(H)17 | REGULATORY T-CELLS | DIFFERENTIATION | IMMUNOLOGY | T-H-17 CELLS | TH17 | IL-21
Journal Article
Nature Immunology, ISSN 1529-2908, 11/2008, Volume 9, Issue 11, pp. 1297 - 1306
The molecular mechanisms underlying the differentiation of interleukin 17-producing T helper cells (T-H-17 cells) are still poorly understood. Here we show... 
GROWTH-FACTOR-BETA | TGF-BETA | IFN-GAMMA | SUSCEPTIBILITY | GENE-EXPRESSION | BINDING-SITE | RECEPTOR | INDUCTION | IMMUNOLOGY | ARTHRITIS | IL-21
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 7/2014, Volume 193, Issue 2, pp. 797 - 806
We have investigated the dynamics of germinal center (GC) formation in lymphoid tissues following acute SIV infection. SIV induces a marked follicular... 
Follicular hyperplasia | Ki67 | Germinal center | IL-21
Journal Article
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