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il-37 (171) 171
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1. Full Text Interleukin-37 Inhibits Colon Carcinogensis During Chronic Colitis
by Mountford, Steffeni and Ringleb, Andrea and Schwaiger, Rahel and Mayr, Doris and Kobold, Sebastian and Dinarello, Charles A and Bufler, Philip
Frontiers in Immunology, ISSN 1664-3224, 11/2019, Volume 10
Inflammatory bowel disease increases the risk of developing colon cancer. Interleukin (IL-) 37 is a fundamental inhibitor of innate immunity by reducing... 
chronic colitis | IL-37 | cytokines | carcinogenesis | inflammation
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2. Full Text Role of Interleukin 37 as a Novel Proangiogenic Factor in Juvenile Idiopathic Arthritis
by El-Barbary, Amal Mohamad and Hussein, Manal Shawky and Almedany, Samah Hamdy and Rageh, Elsayed Mohamad and Alsalawy, Alaa Mohamed and Aboelhawa, Marwa Ahmed and Elkholy, Radwa Mostafa and Shafik, Noha Mohamed and Elharoun, Ahmed Shukry
JCR: Journal of Clinical Rheumatology, ISSN 1076-1608, 03/2019, Volume 25, Issue 2, pp. 85 - 90
OBJECTIVEThe aim of this study was to investigate interleukin 37 (IL-37) levels in the serum and synovial fluid of patients with juvenile idiopathic arthritis... 
VASCULAR MORPHOLOGY | ANGIOGENESIS | IL-37 | ANTIINFLAMMATORY CYTOKINE | MECHANISMS | SERUM | RHEUMATOLOGY | juvenile idiopathic arthritis | PROTECTS | ULTRASOUND | vascular endothelial growth factor | DISEASE | power Doppler ultrasound | IL-37 mRNA expression | synovial fluid IL-37 | EXPRESSION | Interleukins | Rheumatoid arthritis in children | Genetic aspects | Research | Neovascularization | Gene expression | Pediatric research
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3. Full Text IL‐37 requires IL‐18Rα and SIGIRR/IL‐1R8 to diminish allergic airway inflammation in mice
by Lunding, L and Webering, S and Vock, C and Schröder, A and Raedler, D and Schaub, B and Fehrenbach, H and Wegmann, M
Allergy, ISSN 0105-4538, 04/2015, Volume 70, Issue 4, pp. 366 - 373
Background Interleukin (IL) 37 has been described as a negative regulator of innate immunity, as it reduces the activation and cytokine production of different... 
animal models, asthma | IL‐18 receptor | SIGIRR/IL‐1R8 | IL‐37 | IL-18 receptor | IL-37 | SIGIRR/IL-1R8 | CELLS | CYTOKINES | RECEPTOR-RELATED PROTEIN | EXPERIMENTAL ASTHMA | INJURY | INDUCTION | IMMUNOLOGY | IL-18 receptor IL-37 | IL-18 RECEPTOR | ALLERGY | MOUSE MODEL | EOSINOPHILIA | LYMPHOCYTES | Inflammation - pathology | Leukocytes, Mononuclear - metabolism | Interleukin-1 - blood | Humans | Receptors, Interleukin-1 - genetics | Bronchoalveolar Lavage Fluid - immunology | Child, Preschool | Respiratory Hypersensitivity - pathology | Asthma - immunology | Interleukin-18 Receptor alpha Subunit - genetics | Female | Bronchoalveolar Lavage Fluid - cytology | Child | Cytokines - blood | Disease Models, Animal | Interleukin-1 - metabolism | Cytokines - metabolism | Respiratory Hypersensitivity - metabolism | Inflammation - immunology | Asthma - genetics | Interleukin-18 Receptor alpha Subunit - metabolism | Mice, Knockout | Receptors, Interleukin-1 - metabolism | Respiratory Hypersensitivity - genetics | Animals | Adolescent | Inflammation - genetics | Mice | Asthma - pathology
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4. Full Text IL-37 expression reduces lean body mass in mice by reducing food intake
by Kuipers, Eline N and Dam, van, Anea D and Ballak, Dov B and Wit, de, Ellemiek A and Dinarello, Charles A and Stienstra, Rinke and Diepen, van, Janna A and Rensen, Patrick C.N and Boon, Mariëtte R
International Journal of Molecular Sciences, ISSN 1661-6596, 2018, Volume 19, Issue 8
The human cytokine interleukin (IL)-37 is an anti-inflammatory member of the IL-1 family of cytokines. Transgenic expression of IL-37 in mice protects them... 
IL-37 | Energy metabolism | Food intake | High fat diet
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5. Full Text IL-37: A new player in the chronic rhinosinusitis arena
by Markov, Nikita and Simon, Hans-Uwe
Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 10/2019
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6. Elevated interleukin 37 expression associated with disease activity in HLA-B27 associated anterior uveitis and idio pathic anterior uveitis
by Zhao, B and Zhang, S and Chen, W and Zhang, R and Jiang, R and Zhang, R and Chen, L
Current Molecular Medicine, ISSN 1566-5240, 08/2017, Volume 17, Issue 7, pp. 460 - 467
Cytokines | Idiopathic AAU | IL-37 | HLA-B27 | PBMC | Acute anterior uveitis
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7. IL-37 protects myocardial ischemia reperfusion injury in mice through mediating inflammation response
by Xiao, Huaping and Li, Bingda and Yang, Xiaomin and Yin, Qiulin
Biomedical Research (India), ISSN 0970-938X, 2018, Volume 29, Issue 4, pp. 663 - 666
IL-37 | Inflammatory response | Neutrophil | Ischemia reperfusion injury
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8. Interleukin-37: A new molecular target for host-directed therapy of tuberculosis
by Liu, Haipeng and Ge, Baoxue
Future Microbiology, ISSN 1746-0913, 05/2017, Volume 12, Issue 6, pp. 465 - 468
IL-37 | host-directed therapy | Mycobacterium tuberculosis | tuberculosis | PULMONARY | IMMUNITY | IL-18R-ALPHA | MICROBIOLOGY | CYTOKINE | ALLERGIC AIRWAY INFLAMMATION | AUTOPHAGY | SUPPRESSION | IL-37 REQUIRES | MICE
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9. Full Text Production of functional human interleukin 37 using plants
by Alqazlan, Nadiyah and Diao, Hong and Jevnikar, Anthony M and Ma, Shengwu
Plant Cell Reports, ISSN 0721-7714, 3/2019, Volume 38, Issue 3, pp. 391 - 401
We demonstrate for the first time that a fully bioactive human IL-37, a newly discovered cytokine acting as a fundamental inhibitor of innate immunity, can be... 
Life Sciences | Biotechnology | Plant Biochemistry | Human IL-37 | Plant molecular farming | Genetic transformation | Cytokine | Recombinant protein | Plant Sciences | Anti-inflammatory property | Functional characterization | Cell Biology | IMMUNITY | IL-18R-ALPHA | CASPASE-1 | ISCHEMIA | ANTIINFLAMMATORY CYTOKINE | SUPPRESSION | PROTECTS | PLANT SCIENCES | INNATE INFLAMMATION | IL-37 REQUIRES | EXPRESSION | Genetically modified plants | Genetic engineering | Interleukins | Recombinant proteins | Analysis | Plants (botany) | Transformation | Soybeans | Immune response | Cytokines | Interleukin | Innate immunity | Functional analysis | Transgenic plants | Immunity | Biological activity | Plant cells | Proteins | Tobacco | Mathematical analysis | Bioreactors | Interleukin 1 | Autoimmune diseases | Fusion protein | Expression vectors
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10. Full Text Imbalanced production of IL-18 and its antagonist in human diseases, and its implications for HIV-1 infection
by Samarani, Suzanne and Allam, Ossama and Sagala, Patrick and Aldabah, Zainab and Jenabian, Mohammad-Ali and Mehraj, Vikram and Tremblay, Cécile and Routy, Jean-Pierre and Amre, Devendra and Ahmad, Ali
Cytokine, ISSN 1043-4666, 06/2016, Volume 82, pp. 38 - 51
IL-18 is a pleiotropic and multifunctional cytokine that belongs to the IL-1 family. It is produced as a biologically inactive precursor, which is cleaved into... 
HIV-1 | IL-18 | IL-18BP | IL-37 | AIDS | Inflammasome | cART | Caspase-1 | CART | DIABETES DEVELOPMENT | NATURAL-KILLER | IFN-GAMMA | BIOCHEMISTRY & MOLECULAR BIOLOGY | GAMMA-INDUCING FACTOR | NLRP3 INFLAMMASOME | IMMUNOLOGY | CELL BIOLOGY | INTERLEUKIN-18 BINDING-PROTEIN | I INFECTION | IL-37 REQUIRES | POTENTIAL ROLE | T-CELLS | Acquired Immunodeficiency Syndrome - immunology | HIV-1 - immunology | Interleukin-18 - immunology | Humans | Acquired Immunodeficiency Syndrome - pathology | Acquired Immunodeficiency Syndrome - drug therapy | Intercellular Signaling Peptides and Proteins - immunology | HIV (Viruses) | Health aspects
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11. Full Text Potential role of IL-37 signaling pathway in feedback regulation of autoimmune Hashimoto thyroiditis
by Ren, Cui-Ping and Sun, Li and Liu, Feng-Chun and Zuo, Chun-Lin and Liu, Miao and Gao, Wenda and Shen, Ji-Jia
Histochemistry and Cell Biology, ISSN 0948-6143, 12/2019, Volume 152, Issue 6, pp. 467 - 473
IL-37, the anti-inflammatory cytokine of the IL-1 family, plays several key roles in the regulation of autoimmune diseases. Yet, its role in Hashimoto’s... 
Biomedicine, general | Biochemistry, general | SIGIRR | Chronic lymphocytic thyroiditis | Biomedicine | Hashimoto’s thyroiditis | IL-37 | Developmental Biology | Cell Biology
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12. Full Text Interleukin-37 is increased in adult-onset Still’s disease and associated with disease activity
by Chi, Huihui and Liu, Dongzhou and Sun, Yue and Hu, Qiongyi and Liu, Honglei and Cheng, Xiaobing and Ye, Junna and Shi, Hui and Yin, Yufeng and Liu, Mengru and Wu, Xinyao and Zhou, Zhuochao and Teng, Jialin and Yang, Chengde and Su, Yutong
Arthritis Research & Therapy, ISSN 1478-6362, 12/2018, Volume 20, Issue 1, pp. 1 - 12
Abstract Background Interleukin (IL)-37 has been known to play an immunosuppressive role in various inflammatory disorders, but whether it participates in the... 
Peripheral blood mononuclear cells | IL-37 | Adult-onset Still’s disease | Cytokines
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13. Full Text The IL-37–Mex3B–Toll-like receptor 3 axis in epithelial cells in patients with eosinophilic chronic rhinosinusitis with nasal polyps
by Liu, Jin-Xin and Liao, Bo and Yu, Qi-Hong and Wang, Hai and Liu, Yi-Bo and Guo, Cui-Lian and Wang, Zhi-Chao and Li, Zhi-Yong and Wang, Zhe-Zheng and Ruan, Jian-Wen and Pan, Li and Yao, Yin and Chen, Cai-Ling and Wang, Heng and Liang, Yuxia and Zhen, Guohua and Liu, Zheng
Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 07/2019
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14. INTERLEUKIN-1 FAMILY CYTOKINES AND MAST CELLS: ACTIVATION AND INHIBITION
by Gallenga, CE and Pandolfi, F and Caraffa, A and Kritas, SK and Ronconi, G and Toniato, E and Martinotti, S and Conti, P
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, ISSN 0393-974X, 01/2019, Volume 33, Issue 1, pp. 1 - 6
This editorial focuses on recent progress reports on mast cells (MCs) and IL-1-family cytokines in the dynamics of inflammation. MCs are cells of... 
cytokine | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | PHYSIOLOGY | inflammation | ENDOCRINOLOGY & METABOLISM | inhibition | IL-37 | most cell | IMMUNOLOGY | SUPPRESSION | interieukin
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15. Full Text New insight into systemic mastocytosis mediated by cytokines IL-1β and IL-33: Potential inhibitory effect of IL-37
by Conti, Pio and Lauritano, Dorina and Caraffa, Alessandro and Gallenga, Carla Enrica and Kritas, Spyros K and Ronconi, Gianpaolo and Pandolfi, Franco
European Journal of Pharmacology, ISSN 0014-2999, 09/2019, Volume 858, p. 172473
Systemic mastocytosis in various forms is characterized by mast cell (MC) infiltration of the bone marrow and other internal organs. The most common form is... 
Mastocytosis | IL-37 | Inflammation | Mast cells | IL-1 | IL-33 | IMMUNITY | ACTIVATION | MAST-CELLS | INJURY | RELEASE | SUPPRESSION | RESPONSES | PHARMACOLOGY & PHARMACY | UPDATE | INFLAMMATORY CYTOKINES
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16. Full Text Interleukin 37 expression inhibits STAT3 to suppress the proliferation and invasion of human cervical cancer cells
by Wang, Sen and An, Weifang and Yao, Yunhong and Chen, Renhuai and Zheng, Xiaoxuan and Yang, Wanyong and Zhao, Yi and Hu, Xinrong and Jiang, Enping and Bie, Yanhong and Chen, Zhangquan and Ouyang, Ping and Zhang, He and Xiong, Hui
Journal of Cancer, ISSN 1837-9664, 2015, Volume 6, Issue 10, pp. 962 - 969
Objectives: The most recently discovered cytokine interleukin 37 (IL-37) received growing attention. Its function on tumor is largely unknown. Here, we... 
Proliferation | Interleukin 37 | Cervical cancer | Invasion | ONCOLOGY | IL-37 | INNATE IMMUNITY
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17. MESENCHYMAL STEM CELLS AND IL-37: A POWERFUL COMBINATION
by Gugliandolo, A and Caraffa, A and Gallenga, CE and Kritas, SK and Ronconi, G and Trubiani, O and Conti, P and Mazzon, E
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, ISSN 0393-974X, 07/2019, Volume 33, Issue 4, pp. 1019 - 1022
Mesenchymal stem cells (MSCs) are able to exert immunomodulatory and anti-inflammatory actions. Thanks to these properties, MSCs may be a promising alternative... 
MEDICINE, RESEARCH & EXPERIMENTAL | PHYSIOLOGY | inflammation | mesenchymal stem cells | ENDOCRINOLOGY & METABOLISM | IL-37 | IMMUNOLOGY | STROMAL CELLS
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18. IL-37: A new anti-inflammatory cytokine of the IL-1 family
by Boraschi, Diana and Lucchesi, Davide and Hainzl, Stefan and Leitner, Maria and Maier, Elisabeth and Mangelberger, Doris and Oostingh, Gertie J and Pfaller, Tobias and Pixner, Claudia and Posselt, Gernot and Italiani, Paola and Nold, Marcel F and Nold-Petry, Claudia A and Bufler, Philip and Dinarello, Charles A
European Cytokine Network, ISSN 1148-5493, 09/2011, Volume 22, Issue 3, pp. 127 - 147
The IL-1 family of cytokines encompasses eleven proteins that each share a similar beta-barrel structure and bind to Ig- like receptors. Some of the IL-1-like... 
IL-37 | Inflammation | IL-1 cytokines | IL-1F7 | IL-18 | IL-18BP | INHIBITORY MEMBER | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERLEUKIN-1 RECEPTOR FAMILY | BINDING-PROTEIN | IMMUNOLOGY | CELL BIOLOGY | LINKED MENTAL-RETARDATION | inflammation | CHROMATIN PROTEIN HMGB1 | ACCESSORY PROTEIN | ENDOTHELIAL-CELLS | NF-KAPPA-B | AUTOIMMUNE-DISEASE | INNATE IMMUNITY
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19. Full Text Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation
by Cavalli, G and Koenders, M.I and Kalabokis, V and Kim, J and Tan, A.C and Garlanda, C and Mantovani, A and Dagna, L and Joosten, L.A.B and Dinarello, C.A
Rheumatology, ISSN 1462-0324, 2016, Volume 55, Issue 2, pp. 2220 - 2229
OBJECTIVES: The IL-1 family member IL-37 was recently characterized as a fundamental inhibitor of innate inflammation. We investigated the effects of... 
TNF-a | Immunotherapy | Rheumatoid arthritis | Cytokine | Neutrophils | IL-1b | Chemokines | cytokine | B-LYMPHOCYTE STIMULATOR | RHEUMATOID-ARTHRITIS | DENDRITIC CELLS | TNF-alpha | IL-37 | RECEPTOR | IL-1 beta | NECROSIS-FACTOR-ALPHA | RHEUMATOLOGY | chemokines | rheumatoid arthritis | CELL-WALL ARTHRITIS | NEGATIVE REGULATOR | GM-CSF | immunotherapy | IN-VIVO | neutrophils
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20. Full Text Study of down regulation of IL-37 expression in breast cancer tumoral tissues and its association with grade 3 tumor
by Farsani, Marzieh Ghafari and Reiisi, Somayeh and Peymani, Maryam
Scientific Journal of Kurdistan University of Medical Sciences, ISSN 1560-652X, 09/2018, Volume 23, Issue 4, pp. 67 - 76
IL-37 | Real time PCR | Gene expression | Brest cancer
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