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1. Full Text Nasal IL-4+ CXCR5+ CD4+ T follicular helper cell counts correlate with local IgE production in eosinophilic nasal polyps
by Zhang, Ya-Na, MD, PhD and Song, Jia, MD and Wang, Hai, MD and Wang, Heng, MD, PhD and Zeng, Ming, MD, PhD and Zhai, Guan-Ting, MD and Ma, Jin, MD and Li, Zhi-Yong, MD and Liao, Bo, MD and Wang, Bao-Feng, MD and Zhen, Zhen, MD, PhD and Wang, Nan, MD, PhD and Cao, Ping-Ping, MD, PhD and Lin, Peng, MD and Ning, Qin, MD, PhD and Liu, Zheng, MD, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2015, Volume 137, Issue 2, pp. 462 - 473
Background Locally produced IgE contributes to the initiation and development of eosinophilic inflammation in eosinophilic nasal polyps independent of systemic... 
Allergy and Immunology | B cell | IgE | IL-4 | eosinophil | ectopic lymphoid structure | nasal polyp | T follicular helper cell | DENDRITIC CELLS | IMMUNOLOGY | CHRONIC RHINOSINUSITIS | ALLERGY | INFLAMMATION | DISEASE | MEMORY TFH CELLS | ANTIBODY-RESPONSES | BLOOD | T-Lymphocyte Subsets - immunology | Eosinophilia - metabolism | Humans | Immunoglobulin E - biosynthesis | Nasal Mucosa - pathology | Nasal Polyps - diagnosis | Eosinophilia - pathology | Immunoglobulin E - immunology | T-Lymphocytes, Helper-Inducer - immunology | Nasal Mucosa - metabolism | Nasal Polyps - metabolism | B-Lymphocytes - metabolism | Nasal Polyps - immunology | Antibody Formation - immunology | Nasal Polyps - pathology | Receptors, CXCR5 - metabolism | T-Lymphocytes, Helper-Inducer - metabolism | Interleukin-4 - metabolism | Immunophenotyping | Phenotype | B-Lymphocytes - immunology | Eosinophilia - immunology | Nasal Mucosa - immunology | T-Lymphocyte Subsets - metabolism | Biomarkers | Lymphocyte Count | Proteins | Immunoglobulins | Cytokines | Lymphocytes | Rodents | T cell receptors | Inflammation | Patients
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2. Full Text Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates T(H)2 cytokine production
by Doherty, TA and Khorram, N and Lund, S and Mehta, AK and Croft, M and Broide, DH
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ISSN 0091-6749, 07/2013, Volume 132, Issue 1, pp. 205 - 213
Background: Cysteinyl leukotrienes (CysLTs) contribute to asthma pathogenesis, in part through cysteinyl leukotriene receptor 1 (CysLT1R). Recently discovered... 
IMMUNITY | INDUCED AIRWAY INFLAMMATION | IL-4 | IMMUNOLOGY | Asthma | CUTTING EDGE | CysLT1R | type 2 innate lymphoid cells | ALLERGY | MOUSE MODEL | cysteinyl leukotrienes | HUMAN MAST-CELLS | NATURAL HELPER-CELLS | PROSTAGLANDIN D-2 | T-CELLS
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3. Full Text IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function
by Noval Rivas, Magali, PhD and Burton, Oliver T., PhD and Oettgen, Hans C., MD, PhD and Chatila, Talal, MD, MSc
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 138, Issue 3, pp. 801 - 811.e9
Background Food allergy is a major health issue, but its pathogenesis remains obscure. Group 2 innate lymphoid cells (ILC2s) promote allergic inflammation.... 
Allergy and Immunology | Anaphylaxis | group 2 innate lymphoid cells | nuocytes | regulatory T cells | oral tolerance | IL-4 | IL-13 | innate lymphoid cells | mast cells | food allergy | IL-33 | IMMUNITY | CYTOKINES | PROTEIN | RECEPTOR | INDUCTION | IMMUNOLOGY | regulatory T cells | PATHOGENESIS | POTENT | ALLERGY | TRANSCRIPTION FACTOR GATA3 | INSIGHTS | Interleukin-4 - immunology | Mast Cells - immunology | Animals | Food Hypersensitivity - immunology | Lymphocytes - immunology | Coculture Techniques | Cells, Cultured | Mice, Transgenic | Interleukin-4 - genetics | Immunity, Innate | T cells | Food allergy | Allergens | Analysis | Proteins | Food allergies | Biotechnology | Antigens | Flow cytometry | Transcription factors | Cytokines | Lymphocytes | Bone marrow | Food | ILC2 | Regulatory T Cells | Oral Tolerance | Food Allergy | Innate Lymphoid Cells | Nuocytes | Mast Cells
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4. Full Text Targeting IgE production in mice and humans
by Wu, Lawren C and Scheerens, Heleen
Current Opinion in Immunology, ISSN 0952-7915, 2014, Volume 31, Issue 1, pp. 8 - 15
Highlights • IgE+ B cells in mice are predisposed to differentiate into short-lived plasma cells. • IgE+ B cells in mice do not persist in germinal centers. •... 
Allergy and Immunology | B-CELLS | MEMORY | IL-4 RECEPTOR | ALLERGEN | IMMUNOLOGY | ASTHMATIC-PATIENTS | SECRETING CELLS | C-EPSILON-MX | PLASMA-CELLS | IMMUNOGLOBULIN-E | ANTI-IGE | Hypersensitivity - therapy | Humans | Hypersensitivity - immunology | Interleukin-13 - immunology | Receptors, Cell Surface - immunology | Plasma Cells - pathology | Interleukin-4 - immunology | Animals | Immunoglobulin E - immunology | Hypersensitivity - pathology | Immunologic Memory | Mice | Plasma Cells - immunology | Immunoglobulin E | B cells
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5. Full Text Ameliorative effect of acetylshikonin on ovalbumin (OVA)‐induced allergic rhinitis in mice through the inhibition of Th2 cytokine production and mast cell histamine release
by Fan, Xi‐Hui and Cheng, Lei and Yan, Ai‐Hui
APMIS, ISSN 0903-4641, 10/2019, Volume 127, Issue 10, pp. 688 - 695
Acetylshikonin has long been known as an anti‐inflammatory and antioxidative reagent. However, the anti‐allergic effect has not been studied. The aim of this... 
cytokine | Acetylshikonin | histamine | allergic rhinitis | IMMUNITY | IFN-GAMMA | IL-4 | SHIKONIN DERIVATIVES | MICROBIOLOGY | MECHANISMS | INTERLEUKIN-10 | IMMUNOLOGY | PATHOLOGY | SUPPRESSION | PATHOGENESIS | REGULATORY T-CELLS | Ovalbumin | Rhinitis | Cytokines | Aluminum | Hyperplasia | Interleukin | Immunoglobulin G | Hypersensitivity | Oral administration | Immunoglobulin E | Lymphocytes T | Inflammation | Histamine | Tumor necrosis factor | Allergic rhinitis | Nose | Aluminum hydroxide | Reagents | Mice | Interferon | Inhibition | Stains | Enzyme-linked immunosorbent assay
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6. Full Text Interleukin 12 induces stable priming for interferon γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones
by Manetti, Roberto and Manetti, Roberto and Gerosa, Franca and Gerosa, Franca and Giudizi, Maria Grazia and Giudizi, Maria Grazia and Biagiotti, Roberta and Biagiotti, Roberta and Parronchi, Paola and Parronchi, Paola and Piccinni, Marie-Pierre and Piccinni, Marie-Pierre and Sampognaro, Salvatore and Sampognaro, Salvatore and Maggi, Enrico and Maggi, Enrico and Romagnani, Sergio and omagnani, Sergio R and Trinchieri, Giorgio and Trinchieri, Giorgio
Journal of Experimental Medicine, ISSN 0022-1007, 04/1994, Volume 179, Issue 4, pp. 1273 - 1283
Interleukin 12 (IL-12) facilitates the generation of a T helper type 1 (Th1) response, with high interferon gamma (IFN-gamma) production, while inhibiting the... 
MEDICINE, RESEARCH & EXPERIMENTAL | HUMAN-LYMPHOCYTES | STIMULATORY FACTOR | INVITRO | CD8 | HUMAN CD4 | IL-4 | SUBSETS | CYTOKINE | INDUCTION | IMMUNOLOGY | EXPRESSION
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7. Full Text Lactobacillus GG effect in increasing IFN-γ production in infants with cow's milk allergy
by Pohjavuori, Emma and Viljanen, Mirva and Korpela, Riitta and Kuitunen, Mikael and Tiittanen, Minna and Vaarala, Outi and Savilahti, Erkki and Pediatrik and Institutionen för molekylär och klinisk medicin and Barn- och ungdomskliniken i Linköping and Linköpings universitet and Barn- och kvinnocentrum and Östergötlands Läns Landsting and Hälsouniversitetet
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 07/2004, Volume 114, Issue 1, pp. 131 - 136
Background Probiotic bacteria are potentially beneficial to maturation of the infant's immune system. Objective To examine the role of probiotic bacteria in... 
IgE-associated | peripheral blood mononuclear cells | probiotic | IFN-γ | Lactobacillus GG | CMA | IL-4 | IL-5 | Cow's milk allergy | EHF | Colony-forming units | Extensively hydrolyzed whey formula | FACS | cfu | Cow's milk | SYSTEM | cow's milk allergy | CELLS | MICROFLORA | MANAGEMENT | PROBIOTICS | IMMUNOLOGY | TH2 CYTOKINE PROFILE | CHILDREN | ATOPIC-DERMATITIS | DISEASES | IFN-gamma | ALLERGY | ORAL TOLERANCE INDUCTION | Lactobacillus - immunology | Double-Blind Method | Humans | Infant | Male | Dermatitis, Atopic - therapy | Th1 Cells - immunology | Milk Hypersensitivity - immunology | Immunoglobulin E - immunology | Interferon-gamma - immunology | Milk Hypersensitivity - therapy | Dermatitis, Atopic - immunology | Female | Probiotics - therapeutic use | Cytokines - immunology | Medical and Health Sciences | Medicin och hälsovetenskap | lactobacillus GG | MEDICINE | MEDICIN
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8. Full Text Mast cell production and response to IL-4 and IL-13
by McLeod, Jamie J.A and Baker, Bianca and Ryan, John J
Cytokine, ISSN 1043-4666, 09/2015, Volume 75, Issue 1, pp. 57 - 61
IL-4 was identified as the first cytokine to be produced by mast cells and is responsible for promoting mast cell IL-13 production. IL-4 and IL-13 play a... 
IL-4 | Interleukin-4 | Mast cells | IL-13 | Interleukin-13 | FC-EPSILON-RI | STAT6 ISOFORM | BIOCHEMISTRY & MOLECULAR BIOLOGY | C-KIT | NECROSIS-FACTOR-ALPHA | FACTOR-I | IMMUNOLOGY | CUTTING EDGE | CELL BIOLOGY | CYTOKINE PRODUCTION | MESSENGER-RNA | NUCLEAR-FACTOR | GENE-EXPRESSION | Signal Transduction | Humans | Receptors, Interleukin-4 - metabolism | Gene Expression Regulation | Hypersensitivity - immunology | Interleukin-13 - immunology | Inflammation - immunology | Interleukin-4 - immunology | Animals | Immune System | Asthma - immunology | Mast Cells - cytology | Adrenal Cortex Hormones - metabolism | Mice | Cytokines - immunology
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9. Full Text IL-4Rα signaling in keratinocytes and early IL-4 production are dispensable for generating a curative T helper 1 response in Leishmania major-infected C57BL/6 mice
by Descatoire, Marc and Hurrell, Benjamin P and Govender, Melissa and Passelli, Katiuska and Martinez-Salazar, Berenice and Hurdayal, Ramona and Brombacher, Frank and Guler, Reto and Tacchini-Cottier, Fabienne
Frontiers in Immunology, ISSN 1664-3224, 10/2017, Volume 8, p. 1265
Experimental infection with the protozoan parasite Leishmania major has been extensively used to understand the mechanisms involved in T helper cell... 
T helper 1 | Leishmania | T helper 2 | IL-4 | Keratinocytes | Mast cells | T helper cell differentiation | IL-4Rα | INTERLEUKIN (IL)-4 | DENDRITIC CELLS | MAST-CELLS | SUSCEPTIBILITY | IL-4R alpha | keratinocytes | DEFICIENT MICE | IMMUNOLOGY | mast cells | BALB/C MICE | CUTANEOUS LEISHMANIASIS | CYTOKINE PRODUCTION | DIFFERENTIATION | EXPRESSION
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10. Full Text Suppressor of cytokine signaling 1 is a positive regulator of TGF-β-induced prostaglandin production in human follicular dendritic cell-like cells
by Cho, Whajung and Kim, Youngmi and Kim, Jini and Park, Seongji and Park, Deokbum and Kim, Byung-Chul and Jeoung, Dooil and Kim, Young-Myeong and Choe, Jongseon
Journal of Immunology, ISSN 0022-1767, 05/2015, Volume 194, Issue 9, pp. 4287 - 4297
PGs are emerging as important immune modulators. Since our report on the expression of PG synthases in human follicular dendritic cells, we investigated the... 
B-CELLS | IFN-GAMMA | IMMUNE-RESPONSES | E SYNTHASE-1 | IL-4 | GERMINAL CENTER | IMMUNOLOGY | EXPRESSION | PROMOTE | CYCLOOXYGENASES | HELPER T-CELLS | Gene Expression | Phosphorylation | Signal Transduction | Dendritic Cells, Follicular - metabolism | Humans | Cells, Cultured | Suppressor of Cytokine Signaling 1 Protein | Suppressor of Cytokine Signaling Proteins - genetics | Prostaglandins - biosynthesis | Smad3 Protein - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Gene Knockdown Techniques | Protein Transport | Transforming Growth Factor beta - pharmacology | Dendritic Cells, Follicular - immunology | Cyclooxygenase 2 - metabolism | Dendritic Cells, Follicular - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Suppressor of Cytokine Signaling Proteins - metabolism | Transforming Growth Factor beta - metabolism
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11. Full Text Interferon Regulatory Factor 4 Differentially Regulates the Production of Th2 Cytokines in naïve vs. Effector/Memory CD4⁺ T Cells
by Kiri Honma and Daisuke Kimura and Norio Tominaga and Mana Miyakoda and Toshifumi Matsuyama and Katsuyuki Yui
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2008, Volume 105, Issue 41, pp. 15890 - 15895
Interferon regulatory factor (IRF) 4 is a member of the IRF family of transcription factors and plays critical roles in the development of CD4⁺ T cells into... 
T lymphocytes | Antigens | Cytokines | Interferons | Cell lines | Cultured cells | Infections | Mice | Gene expression regulation | T cell antigen receptors | IL-4 | Nippostrongyrus brasiliensis | siRNA | FACTOR FAMILY | PHENOTYPE DEVELOPMENT | MECHANISM | IRF FAMILY | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | IL-4 EXPRESSION | HOST-DEFENSE | STAT6 | MICE | TRANSCRIPTION FACTOR | CD4-Positive T-Lymphocytes - immunology | Animals | Gene Expression Regulation - immunology | Interferon Regulatory Factors - physiology | Immunologic Memory | Mice, Inbred BALB C | Th2 Cells - immunology | Interferon Regulatory Factors - deficiency | Cytokines - biosynthesis | Mice, Knockout | Biological Sciences
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12. Full Text Interleukin-4 Production by Follicular Helper T Cells Requires the Conserved Il4 Enhancer Hypersensitivity Site V
by Vijayanand, Pandurangan and Seumois, Grégory and Simpson, Laura J and Abdul-Wajid, Sarah and Baumjohann, Dirk and Panduro, Marisella and Huang, Xiaozhu and Interlandi, Jeneen and Djuretic, Ivana M and Brown, Daniel R and Sharpe, Arlene H and Rao, Anjana and Ansel, K. Mark
Immunity, ISSN 1074-7613, 02/2012, Volume 36, Issue 2, pp. 175 - 187
Follicular helper T cells (Tfh cells) are the major producers of interleukin-4 (IL-4) in secondary lymphoid organs where humoral immune responses develop.... 
HELMINTH INFECTION | CYTOKINE PRODUCTION | TH2 CELLS | MAST-CELLS | GENE-EXPRESSION | TYPE-2 IMMUNITY | GATA3 EXPRESSION | IL-4 PRODUCTION | COORDINATE REGULATOR | IMMUNOLOGY | ALLERGIC DISEASES | T-Lymphocyte Subsets - immunology | Promoter Regions, Genetic | Sequence Deletion | Immunity, Humoral - genetics | NFATC Transcription Factors - metabolism | Hypersensitivity - immunology | Interleukin-4 - deficiency | Th2 Cells - immunology | Binding Sites - genetics | Mice, Knockout | Interleukin-4 - biosynthesis | Animals | Enhancer Elements, Genetic | T-Lymphocytes, Helper-Inducer - immunology | Conserved Sequence | Hypersensitivity - genetics | Transcription, Genetic | Mice | Mice, Inbred BALB C | Interleukin-4 - genetics | Cytokines - genetics | Lung - immunology | Allergy | Immunoglobulins | Chromatin | Interleukins | Immunoglobulin G | Immunoglobulin E | Protection and preservation | T cells | Gene expression | Allergic reaction
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13. Full Text Human circulating group 2 innate lymphoid cells can express CD154 and promote IgE production
by Maggi, Laura, PhD and Montaini, Gianni, BSc and Mazzoni, Alessio, PhD and Rossettini, Beatrice, BSc and Capone, Manuela, PhD and Rossi, Maria Caterina, PhD and Santarlasci, Veronica, MD and Liotta, Francesco, MD and Rossi, Oliviero, MD and Gallo, Oreste, MD and De Palma, Raffaele, MD and Maggi, Enrico, MD and Cosmi, Lorenzo, MD and Romagnani, Sergio, MD and Annunziato, Francesco, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 3, pp. 964 - 976.e4
Background Protection against helminths consists of adaptive responses by TH 2 cells and innate responses by group 2 innate lymphoid cells (ILC2s), with these... 
Allergy and Immunology | Group 2 innate lymphoid cell | CD154 | IgE | IL-4 | IL-5 | IL-13 | Toll-like receptor | TH2 | Cell Line | Nasal Polyps - immunology | Cell Count | GATA3 Transcription Factor - immunology | Humans | Middle Aged | Toll-Like Receptors - immunology | Hypersensitivity - immunology | Male | CD40 Ligand - immunology | Young Adult | Immunoglobulin E - immunology | Lymphocytes - immunology | Receptors, Retinoic Acid - immunology | Toll-Like Receptors - genetics | Adolescent | Adult | Female | Cytokines - immunology | Immunoglobulin E | Methylation | B cells | Antigens | Ligands | Cytokines | Allergies
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14. Full Text BDCA3 expression is associated with high IFN‐λ production by CD34+‐derived dendritic cells generated in the presence of GM‐CSF, IL‐4, and/or TGF‐β
by der Aa, Evelyn and de Laar, Lianne and Janssen, Harry L.A and Montfoort, Nadine and Woltman, Andrea M
European Journal of Immunology, ISSN 0014-2980, 05/2015, Volume 45, Issue 5, pp. 1471 - 1481
High BDCA3 expression is associated with a specific human IFN‐λ‐producing dendritic cell (DC) subset. However, BDCA3 has also been detected on other DC... 
Human | IFN | BDCA3 | CD34 | GM‐CSF/IL‐4/TNF‐β‐driven culture system | derived dendritic cells | CD34 + -derived dendritic cells | GM-CSF/IL-4/TNF-β-driven culture system | Gene Expression | Poly I-C - pharmacology | Antigens, CD34 - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Dendritic Cells - immunology | Humans | Interleukin-4 - metabolism | RNA, Messenger - genetics | Antigens, Surface - genetics | Cells, Cultured | Receptors, Mitogen - metabolism | Hematopoietic Stem Cells - metabolism | RNA, Messenger - metabolism | Hematopoietic Stem Cells - classification | Lipopolysaccharide Receptors - metabolism | Lectins, C-Type - metabolism | Dendritic Cells - classification | Hematopoietic Stem Cells - immunology | Cell Differentiation - drug effects | Antigens, CD1 - metabolism | Antigens, Surface - metabolism | Transforming Growth Factor beta - metabolism | Dendritic Cells - metabolism | Interferon-gamma - biosynthesis
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