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Journal of Clinical Investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1019 - 1031
Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis, ALI is also a major... 
C-REACTIVE PROTEIN | INFLAMMATORY-RESPONSE | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis | of STAT3 and production of the neutrophil attractant CXCL1 in pancreatic acinar cells. Examination of human samples revealed expression of IL-6 in combination with soluble IL-6 receptor was a reliable predictor of ALI in SAP. These results demonstrate that IL-6 trans-signaling is an essential mediator of ALI in SAP across | INTERLEUKIN-6 | RESPIRATORY-DISTRESS-SYNDROME | PREDICTION | species and suggest that therapeutic inhibition of IL-6 may prevent SAP-associated ALI | ACUTE-PHASE RESPONSE | ALI is also a major complication in severe acute pancreatitis (SAP). The pathophysiology of SAP-associated ALI is poorly understood, but elevated serum levels of IL-6 is a reliable marker for disease severity. Here, we used a mouse model of acute pancreatitis-associated (AP-associated) ALI to determine the role of IL-6 in ALI lethality. Il6-deficient mice had a lower death rate compared with wild-type mice with AP, while mice injected with IL-6 were more likely to develop lethal ALI. We found that inflammation-associated NF-kappa B induced myeloid cell secretion of IL-6, and the effects of secreted IL-6 were mediated by complexation with soluble IL-6 receptor, a process known as trans-signaling. IL-6 trans-signaling stimulated phosphorylation | BLOCKADE | INHIBITOR | SEVERITY | Phosphorylation | Humans | NF-kappa B - metabolism | Pancreatitis - complications | Receptors, Interleukin-8B - antagonists & inhibitors | Benzenesulfonates - pharmacology | Interleukin-6 - physiology | Pancreatitis - immunology | Acute Lung Injury - metabolism | Chemokine CXCL1 - metabolism | STAT3 Transcription Factor - metabolism | Acinar Cells - metabolism | Aminosalicylic Acids - pharmacology | Signal Transduction | Mice, Inbred C57BL | Pancreas - pathology | Mice, Transgenic | Acute Lung Injury - pathology | Interleukin-6 - secretion | Animals | Myeloid Cells - secretion | Receptors, Interleukin-8B - metabolism | Myeloid Cells - metabolism | Acute Lung Injury - immunology | Pancreatitis - pathology | Mice | Phenylurea Compounds - pharmacology | Protein Processing, Post-Translational | Pancreatitis - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Acute Lung Injury - etiology | Receptors, Interleukin-6 - metabolism | Lung diseases | Pancreatitis | Genetic aspects | Research | Health aspects | Risk factors | Interleukin-6 | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Surgery | Kirurgi
Journal Article
International Immunology, ISSN 0953-8178, 12/2007, Volume 19, Issue 12, pp. 1431 - 1440
Naive CD4+ T cells rapidly proliferate to generate effector cells after encountering an antigen and small numbers survive as memory T cells in preparation for... 
IL-6 | Colitis
Journal Article
Journal Article
Molecular cancer therapeutics, ISSN 1535-7163, 9/2017, Volume 16, Issue 9, pp. 1898 - 1908
Inflammation mediated by activation of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling is a major cause of chemotherapy... 
Stat3 | IL-6 receptor | pancreatic cancer | chemoresistance | IL-6
Journal Article
Evaluation of the prognostic role of inflammatory markers: Tumor necrosis factor (TNF-a) and interleukin-6 (IL-6) - in patients with acute pancreatitis, 12/2003
Acute pancreatitis is one of the poorly understood common acute digestive tract disorders. It is not just difficult to diagnose, even the severity of the... 
Acute pancreatitis, IL-6, TNF-a
Journal
Cytokine and Growth Factor Reviews, ISSN 1359-6101, 2011, Volume 22, Issue 2, pp. 83 - 89
Journal Article
Biochimica et biophysica acta. Molecular cell research, ISSN 0167-4889, 2016, Volume 1863, Issue 6, pp. 1218 - 1227
Journal Article
Molecular cancer, ISSN 1476-4598, 2017, Volume 16, Issue 1, p. 57
Journal Article
Drug design, development and therapy, ISSN 1177-8881, 2016, Volume 10, pp. 2723 - 2728
Journal Article
International Journal of Biological Sciences, ISSN 1449-2288, 2012, Volume 8, Issue 9, pp. 1237 - 1247
Journal Article