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Journal Article
Molecular Aspects of Medicine, ISSN 0098-2997, 06/2014, Volume 37, Issue 100, pp. 57 - 76
Hepatobiliary bile salt (BS) transporters are critical determinants of BS homeostasis controlling intracellular concentrations of BSs and their enterohepatic... 
Nuclear receptors | ATB-binding cassette transporters | Cholestasis | ORGANIC-SOLUTE-TRANSPORTER | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | VITAMIN-D-RECEPTOR | NA+/TAUROCHOLATE-COTRANSPORTING POLYPEPTIDE | ORPHAN NUCLEAR RECEPTOR | EXPORT PUMP BSEP | CONSTITUTIVE ANDROSTANE RECEPTOR | PRIMARY BILIARY-CIRRHOSIS | ALPHA-OST-BETA | FARNESOID-X-RECEPTOR | FAMILIAL INTRAHEPATIC CHOLESTASIS | Cholestasis - genetics | Transcriptional Activation - genetics | Cholestasis - therapy | Humans | Gene Expression Regulation | Bile Acids and Salts - metabolism | Symporters - metabolism | Organic Anion Transporters, Sodium-Dependent - genetics | Cholestasis - pathology | ATP-Binding Cassette Transporters - genetics | Biological Transport | ATP Binding Cassette Subfamily B Member 11 | Membrane Transport Proteins - genetics | Symporters - genetics | ATP-Binding Cassette Transporters - metabolism | Membrane Transport Proteins - metabolism | Organic Anion Transporters, Sodium-Dependent - metabolism | Genetic aspects | Genetic transcription | MAF, musculo-aponeurotic fibrosacroma | TNF-α, tumor necrosis factor alpha | NDRG2, NMYC downstrean-regulated gene 2 | RARα (NR1B1), retinoic acid receptor | IL-6, interleukin 6 | ABC, ATP-binding cassette | DCA, deoxycholic acid | GGT, gamma-glutamyl transpeptidase | CARM1, co-activator-associated arginine methyltransferase 1 | SRC2, steroid receptor co-activator 2 | TCDCA, taurochenodeoxycholic acid | MRP2 (ABCC2), multidrug resistance-associated protein 2 | SREBP1, sterol regulatory element-binding protein 1 | ASBT (SLC10A2), apical sodium-dependent bile acid transporter | CA, cholic acid | UDCA, ursodeoxycholic acid | FGF15, fibroblast growth factor 19 | MARE, MAF recognition element | TβMCA, β-tauromuricholic acid | VDR (NR1I1), vitamin D receptor | CBDL, common bile duct ligation | STAT-5, signal transducer and activator of transcription 5 | MCL-1, myeloid cell leukemia factor 1 | PPARγ (NR1C3), peroxisome proliferator-activated receptor gamma | FXRE, FXR response element | LXR (NR1H3), liver X receptor | CtBP, C-terminal binding protein | OSTβ (SLC51A | SHP (NR0B2), short heterodimer partner | PL, phospholipid | BCRP (ABCG2), breast cancer resistance protein | TUDCA, tauroursodeoxycholic acid | OATP, organic anion transporting polypeptide | TCA, taurocholic acid | NTCP (SLC10A1), Na+-taurocholate cotransporting polypeptide solute carrier family 10 member 1 | PSC, primary sclerosing cholangitis | LRH1 (NR5A2), liver receptor homologue 1 | LPS, lipopolysaccharide | MRP3 (ABCC3), multidrug resistance-associated protein 3 | SLC51B), organic solute transporter alpha | TGR5, G protein coupled bile acid receptor | MDR2 (ABCB4), multidrug resistance protein 2 | FXR, farnesoid X receptor (NR1H4) | IR-1, inverse repeat 1 | OCA, obeticholic acid | MRP4 (ABCC4), multidrug resistance-associated protein 4 | AE2 (SLC4A2), anion exchanger 2 | NF-κB, nuclear factor kappa-B | CCl4, carbone tetrachloride | AMPK, AMP-activated protein kinase | ALP, alkaline phosphatase | PPARα (NR1C1), peroxisome proliferator-activated receptor alpha | Review | DILI, drug-induced liver injury | JNK, c-Jun N-terminal kinase | GR (NR3C1), glucocorticoid receptor | BS, bile salt | IL-1β, interleukin-1 beta | cAMP, cyclic adenosine monophosphate | PGC-1α, peroxisome proliferator-activated receptor gamma coactivator-1 alpha | RXRα (NR2B1), retinoid X receptor | VPAC-1, vasoactive intestinal polypeptide activated receptor | ASCOM, activating signal cointegrator-2-containing complex | ICP, intrahepatic cholestasis of pregnancy | GCA, glycocholic acid | MDR1 (ABCB1), multidrug resistance protein 1 | NRF2, nuclear factor erythroid 2-related factor 2 | beta | ALT, alanine aminotransferase | LCA, litocholic acid | BRIC2, benign recurrent intrahepatic cholestasis type 2 | OSTα | CDCA, chenodeoxycholic acid | PBC, primary biliary cirrhosis | HNF1α, hepatocyte nuclear factor 1 alpha | GRE, glucocorticoid response element | TαMCA, α-tauromuricholic acid | FGF19 | PFIC2, progressive familial intrahepatic cholestasis type 2 | PXR (NR1I2), pregnane X receptor | BSEP (ABCB11), bile salt export pump | TPN, total parenteral nutrition | HNF4α, hepatocyte nuclear factor 4 alpha
Journal Article
Biochimie, ISSN 0300-9084, 12/2015, Volume 119, pp. 175 - 182
Interleukin (IL)-6 and IL-11 are the only canonical members of the IL-6 family of cytokines that induce signaling through a homodimer of the common β-receptor... 
Signal transduction | Proliferation | Interleukin-11 | Proteolysis | Plasticity | Interleukin-6 | ACTIVATION | HUMAN IL-6 RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | GP130 | LEUKEMIA INHIBITORY FACTOR | CYTOKINE | SIGNAL-TRANSDUCTION | ONCOSTATIN-M | GLYCOPROTEIN 130 | CILIARY NEUROTROPHIC FACTOR | BINDING | Protein Subunits | Receptors, Interleukin-6 - chemistry | Cell Proliferation | Cytokine Receptor gp130 - genetics | Humans | Interleukin-11 Receptor alpha Subunit - agonists | Cytokine Receptor gp130 - agonists | Interleukin-6 Receptor alpha Subunit - metabolism | Interleukin-6 Receptor alpha Subunit - agonists | Protein Interaction Domains and Motifs | Interleukin-11 Receptor alpha Subunit - genetics | Binding Sites | Interleukin-6 - metabolism | Peptide Fragments - genetics | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Cell Line | Peptide Fragments - metabolism | Cytokine Receptor gp130 - metabolism | Interleukin-6 - genetics | Signal Transduction | Receptors, Interleukin-6 - genetics | Cytokine Receptor gp130 - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Interleukin-11 - genetics | Interleukin-11 - metabolism | Interleukin-11 Receptor alpha Subunit - metabolism | Interleukin-6 Receptor alpha Subunit - chemistry | Interleukin-6 Receptor alpha Subunit - genetics | Peptide Fragments - chemistry | Animals | Interleukin-11 Receptor alpha Subunit - chemistry | Peptide Fragments - agonists | Ligands | Mice | Receptors, Interleukin-6 - agonists | Receptors, Interleukin-6 - metabolism
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 08/2018, Volume 9, p. 1986
There is growing evidence that tumor necrosis factor (TNF) receptor-associated factors (TRAFs) bind to unconventional membrane-bound receptors in many cell... 
FACTOR FAMILY | NECROSIS-FACTOR RECEPTOR | MEMBERS | PROTEIN | RECOGNITION | TRAF2 | IMMUNOLOGY | IL-6 | autoimmunity | inflammation | STRUCTURAL BASIS | TRAF5 | T(H)17 | TRAF FAMILY | GENES | EXPRESSION | LYMPHOCYTES | Research | T cells | Cell differentiation | Tumor necrosis factor | Interleukin-6 | TH17
Journal Article
The Lancet, ISSN 0140-6736, 03/2012, Volume 379, Issue 9822, pp. 1214 - 1224
Journal Article