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Journal of Clinical Investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1019 - 1031
Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis, ALI is also a major... 
C-REACTIVE PROTEIN | INFLAMMATORY-RESPONSE | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis | of STAT3 and production of the neutrophil attractant CXCL1 in pancreatic acinar cells. Examination of human samples revealed expression of IL-6 in combination with soluble IL-6 receptor was a reliable predictor of ALI in SAP. These results demonstrate that IL-6 trans-signaling is an essential mediator of ALI in SAP across | INTERLEUKIN-6 | RESPIRATORY-DISTRESS-SYNDROME | PREDICTION | species and suggest that therapeutic inhibition of IL-6 may prevent SAP-associated ALI | ACUTE-PHASE RESPONSE | ALI is also a major complication in severe acute pancreatitis (SAP). The pathophysiology of SAP-associated ALI is poorly understood, but elevated serum levels of IL-6 is a reliable marker for disease severity. Here, we used a mouse model of acute pancreatitis-associated (AP-associated) ALI to determine the role of IL-6 in ALI lethality. Il6-deficient mice had a lower death rate compared with wild-type mice with AP, while mice injected with IL-6 were more likely to develop lethal ALI. We found that inflammation-associated NF-kappa B induced myeloid cell secretion of IL-6, and the effects of secreted IL-6 were mediated by complexation with soluble IL-6 receptor, a process known as trans-signaling. IL-6 trans-signaling stimulated phosphorylation | BLOCKADE | INHIBITOR | SEVERITY | Phosphorylation | Humans | NF-kappa B - metabolism | Pancreatitis - complications | Receptors, Interleukin-8B - antagonists & inhibitors | Benzenesulfonates - pharmacology | Interleukin-6 - physiology | Pancreatitis - immunology | Acute Lung Injury - metabolism | Chemokine CXCL1 - metabolism | STAT3 Transcription Factor - metabolism | Acinar Cells - metabolism | Aminosalicylic Acids - pharmacology | Signal Transduction | Mice, Inbred C57BL | Pancreas - pathology | Mice, Transgenic | Acute Lung Injury - pathology | Interleukin-6 - secretion | Animals | Myeloid Cells - secretion | Receptors, Interleukin-8B - metabolism | Myeloid Cells - metabolism | Acute Lung Injury - immunology | Pancreatitis - pathology | Mice | Phenylurea Compounds - pharmacology | Protein Processing, Post-Translational | Pancreatitis - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Acute Lung Injury - etiology | Receptors, Interleukin-6 - metabolism | Lung diseases | Pancreatitis | Genetic aspects | Research | Health aspects | Risk factors | Interleukin-6 | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Surgery | Kirurgi
Journal Article
Cell Reports, ISSN 2211-1247, 02/2016, Volume 14, Issue 7, pp. 1761 - 1773
Interleukin (IL)-11 has been shown to be a crucial factor for intestinal tumorigenesis, lung carcinomas, and asthma. IL-11 is thought to exclusively mediate... 
ADAM10 | ADAM17 | interleukin-11 | signal transduction | proteolysis | Signal transduction | Interleukin-11 | Proteolysis | MURINE INTERLEUKIN-11 | INFLAMMATION | GLYCOPROTEIN 130 | FAMILY CYTOKINE | SOLUBLE IL-6 | RECEPTOR ALPHA-CHAIN | EXPRESSION | TUMORIGENESIS | IL-6 RECEPTOR | CELL BIOLOGY
Journal Article
International Journal of Biological Sciences, ISSN 1449-2288, 2012, Volume 8, Issue 9, pp. 1237 - 1247
Journal Article
Cancer Research, ISSN 0008-5472, 02/2016, Volume 76, Issue 4, pp. 866 - 876
Oncogenic KRAS mutations occur frequently in lung adenocarcinoma. The signaling pathways activated by IL6 promote Kras-driven lung tumorigenesis, but the basis... 
STAT3 ACTIVATION | INHIBITION | ONCOLOGY | GASTRIC TUMORIGENESIS | INFLAMMATION | GP130 | MUTATIONS | INTERLEUKIN-6 | CANCER | IL-6 | PROGRESSION | Lung Neoplasms - genetics | Up-Regulation | Animals | Signal Transduction | Cell Transformation, Neoplastic - genetics | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Cell Line, Tumor | Mice | Interleukin-6 - metabolism | Disease Models, Animal
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1725, pp. 127 - 140
Journal Article
Journal Article
by Jevnikar, Zala and Östling, Jörgen and Ax, Elisabeth and Calvén, Jenny and Thörn, Kristofer and Israelsson, Elisabeth and Öberg, Lisa and Singhania, Akul and Lau, Laurie C.K and Wilson, S.J and Wilson, Susan J and Ward, Jonathan A and Chauhan, Anoop and Sousa, Ana R and Sousa, A.R and De Meulder, B and De Meulder, Bertrand and Loza, M.J and Loza, Matthew J and Baribaud, F and Baribaud, Frédéric and Sterk, Peter J and Sterk, P.J and Chung, F.K and Chung, Kian Fan and Sun, K and Sun, Kai and Guo, Y and Guo, Yike and Adcock, Ian M and Adcock, I.M and Payne, Debbie and Dahlen, Barbro and Dahlen, S.E and Chanez, P and Chanez, Pascal and Shaw, D.E and Shaw, Dominick E and Krug, Norbert and Krug, N and Hohlfeld, Jens M and Hohlfeld, J.M and Sandström, T and Sandström, Thomas and Djukanovic, R and Djukanovic, Ratko and James, A.J and James, Anna and Hinks, Timothy S.C and Howarth, Peter H and Vaarala, Outi and van Geest, Marleen and van Geest, M and Olsson, Henric and Ahmed, H and Auffray, C and Bakke, P and Bansal, A.T and Bates, S and Bel, E.H and Bigler, J and Bisgaard, H and Boedigheimer, M.J and Bønnelykke, K and Brandsma, J and Brinkman, P and Bucchioni, E and Burg, D and Bush, A and Caruso, M and Chaiboonchoe, A and Compton, C.H and Corfield, J and D'Amico, A and Erpenbeck, V.J and Erzen, D and Fichtner, K and Fitch, N and Fleming, L.J and Formaggio, E and Fowler, S.J and Frey, U and Gahlemann, M and Geiser, T and Goss, V and Hashimoto, S and Haughney, J and Hedlin, G and Hekking, P.W and Higenbottam, T and Holweg, C and Horváth, I and Knowles, R and Knox, A.J and Lefaudeux, D and Manta, A and Matthews, J.G and Mazein, A and Meiser, A and Middelveld, R.J.M and ... and Unbiased Biomarkers Prediction Re and Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group and Medicinska fakulteten and Institutionen för folkhälsa och klinisk medicin and Umeå universitet
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 02/2019, Volume 143, Issue 2, pp. 577 - 590
Journal Article
JOURNAL OF INVESTIGATIVE DERMATOLOGY, ISSN 0022-202X, 05/2013, Volume 133, Issue 5, pp. 1212 - 1220
The molecular mechanisms behind the pathogenesis of postburn hypertrophic scar (HS) remain unclear. Here, we investigate the role of the IL-6... 
ACTIVATOR | GENE | STAT3 | RECEPTOR | INTERLEUKIN-6 | EXPRESSION | BURNS | CONNECTIVE-TISSUE | IL-6 | SIGNAL TRANSDUCER | DERMATOLOGY
Journal Article
Journal Article
Journal Article
Experimental Eye Research, ISSN 0014-4835, 01/2019, Volume 178, pp. 27 - 36
Vascular inflammation plays a critical role in the pathogenesis of diabetic retinopathy. Recently, Interleukin-6 (IL-6) trans-signaling via soluble IL-6... 
Trans-signaling | Inflammation | Endothelial cells | sgp130 | Interleukin-6 | ACTIVATION | HOMEOSTASIS | LUNG INJURY | RECEPTOR | IL-6 | MITOCHONDRIAL PERMEABILITY TRANSITION | BIOLOGY | NITRIC-OXIDE | OPHTHALMOLOGY | BLOCKADE | CONTRIBUTES
Journal Article