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Gastroenterology, ISSN 0016-5085, 10/2019, Volume 157, Issue 4, pp. 1019 - 1031.e7
Although ustekinumab is an effective therapy for moderate to severe Crohn’s disease (CD), its effects on the microscopic manifestations of CD are unknown. We... 
IBD | anti-IL12 | anti-IL23 | Inflammatory Bowel Diseases
Journal Article
Clinical Rheumatology, ISSN 0770-3198, 7/2016, Volume 35, Issue 7, pp. 1857 - 1863
We have reported that helper T type 17 (Th17) cells increased in patients with Behcet’s disease (BD). It remains obscure how Th17 cells increase in the... 
IFNγ | Medicine & Public Health | IL23 | Rheumatology | IL17 | IL23 receptor | Behcet’s disease | Th17 cells
Journal Article
Gastroenterology, ISSN 0016-5085, 2017, Volume 153, Issue 1, pp. 77 - 86.e6
Background & Aims MEDI2070 is a human monoclonal antibody that selectively inhibits interleukin 23 (IL23), a cytokine implicated in the pathogenesis of Crohn’s... 
Gastroenterology and Hepatology | IL22 | Phase II | Clinical Trial | IL23
Journal Article
Journal of the Egyptian Womenʼs Dermatologic Society, ISSN 1687-1537, 05/2016, Volume 13, Issue 2, pp. 71 - 76
BACKGROUNDA role for hepatitis C virus (HCV) infection in psoriasis has been proposed, but the underlying pathogenic mechanisms are still undetermined.... 
HCV | IL12 | IL23 | poriasis
Journal Article
Expert Opinion on Investigational Drugs, ISSN 1354-3784, 08/2018, Volume 27, Issue 8, pp. 649 - 660
Journal Article
Drug Development Research, ISSN 0272-4391, 12/2015, Volume 76, Issue 8, pp. 428 - 431
Preclinical Research Psoriatic arthritis (PsA) is a chronic inflammatory seronegative spondyloarthritis associated with psoriasis. While TNF‐α inhibitors have... 
Ustekinumab | psoriatic arthritis | psoriasis | IL12/IL23
Journal Article
Journal Article
Dermatologic Therapy, ISSN 1396-0296, 07/2019, Volume 32, Issue 4, pp. e12954 - n/a
A 40‐year‐old man with chronic history of refractory palmoplantar psoriasis presented with new onset of well‐demarcated oval erythematous asteatotic plaques on... 
dermatitis | psoriasis | IL23 | guselkumab | Th17 | palmoplantar | nummular | PUSTULOSIS | ECZEMA | DERMATOLOGY | Skin | Inflammation | Psoriasis | Dermatitis
Journal Article
Clinical Gastroenterology and Hepatology, ISSN 1542-3565, 02/2016, Volume 14, Issue 2, pp. 242 - 250.e2
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 08/2018, Volume 20, Issue 8, pp. 1859 - 1867
Aims: Our current understanding of the pathogenesis of type 1 diabetes (T1D) arose, in large part, from studies using the non-obese diabetic (NOD) mouse model.... 
type 1 diabetes | inflammatory pathways | human islets | short‐duration T1D | IL23 | T1D | functional genomics | IL23/p19 | RNA‐sequencing | RNA-sequencing | short-duration T1D | POPULATION | COMBINATION THERAPY | MOUSE | MELLITUS | PANCREATIC-ISLETS | MODELS | RNA-SEQ | ENDOCRINOLOGY & METABOLISM | p19 | INSULITIS | T-CELLS | Islets of Langerhans - drug effects | Interleukin-23 Subunit p19 - antagonists & inhibitors | Diabetes Mellitus, Type 1 - prevention & control | Humans | Diabetes Mellitus, Type 1 - metabolism | Antibodies, Monoclonal - therapeutic use | Male | Gene Expression Profiling | Interleukin-23 Subunit p19 - metabolism | Islets of Langerhans - metabolism | Interleukin-23 Subunit p19 - genetics | Adult | Female | Diabetes Mellitus, Type 1 - immunology | Child | Islets of Langerhans - pathology | Diabetes Mellitus, Type 1 - physiopathology | Gene Expression Regulation | Islets of Langerhans - immunology | Immunity, Innate | Disease Progression | Proof of Concept Study | Disease-Free Survival | Animals | Mice, Inbred NOD | Tissue Donors | Cadaver | Cluster Analysis | Genetic research | Gene expression | Type 1 diabetes | Genes | Analysis | Translation | Genomic analysis | Therapeutic applications | Diabetes mellitus | Data processing | Innate immunity | Diabetes mellitus (insulin dependent) | Inflammation | Ribonucleic acid--RNA | Rodents | Monoclonal antibodies | Diabetes | Pancreas
Journal Article
GASTROENTEROLOGY, ISSN 0016-5085, 10/2019, Volume 157, Issue 4, pp. 1019 - 1019
BACKGROUND & AIMS: Although ustekinumab is an effective therapy for moderate to severe Crohn's disease (CD), its effects on the microscopic manifestations of... 
INFLAMMATORY-BOWEL-DISEASE | MANAGEMENT | anti-IL12 | anti-IL23 | Inflammatory Bowel Diseases | BIOPSY | IBD | INFLIXIMAB | GASTROENTEROLOGY & HEPATOLOGY | MAINTENANCE THERAPY | REMISSION | INDEXES | Medicine, Experimental | Medical research | Care and treatment | Analysis | Gastrointestinal diseases
Journal Article
CLINICAL IMMUNOLOGY, ISSN 1521-6616, 12/2018, Volume 197, pp. 86 - 95
Background and aims: Mucosal gene expression have not been fully enlightened in inflammatory bowel disease (IBD). Aim of this study was to define IL23A, IL17A,... 
IMMUNITY | CYTOKINES | Expression profiling | CROHNS-DISEASE | ULCERATIVE-COLITIS | INTERLEUKIN-23 | INDUCTION | IMMUNOLOGY | Inflammatory bowel disease | MUCOSA | MAINTENANCE | IL23/IL17/TLR9 | EPITHELIAL-CELLS | TOLL-LIKE RECEPTORS
Journal Article
Autoimmunity Highlights, ISSN 2038-0305, 6/2014, Volume 5, Issue 1, pp. 9 - 19
Psoriasis and psoriatic arthritis represent two paradigmatic conditions characterized by chronic inflammation and possibly autoimmunity, despite the absence of... 
Biomedicine | Immunology | Psoriasis | IL12 | IL23 | Inflammation | IL17 | Psoriatic arthritis
Journal Article
Journal of China Pharmaceutical University, ISSN 1000-5048, 12/2013, Volume 44, Issue 6, pp. 583 - 588
Journal Article
mAbs, ISSN 1942-0862, 07/2015, Volume 7, Issue 4, pp. 778 - 791
Herein, we describe the generation and characterization of BI 655066, a novel, highly potent neutralizing anti-interleukin-23 (IL23) monoclonal antibody in... 
BI 655066 | pharmacokinetic profile | immunogen design | biophysical assessment | humanization | IL23 | IL23R | MONOCLONAL-ANTIBODY | variable heavy | phosphate-buffered saline | IL-23 | AUC | V-H | analytical ultracentrifugation | Chemical Computing Group | SPR | HCLF | INTERLEUKIN-17 | surface plasmon resonance | glycine | Janus kinase 2 | JAK2 | Th17 | CDRs | electro-osmotic flow | PBS | UV | complementarity-determining regions | IL12 | DISTINCT | Interleukin 12 | SEC | INFLAMMATION | tyrosine | high concentration liquid formulation | PSORIASIS | C-H | MEDICINE, RESEARCH & EXPERIMENTAL | C | RU | goat anti-human IgG gamma antibody | Interleukin-23 | F | size-exclusion chromatography | G | RECEPTOR | electrospray ionization | IL12 receptor subunit beta 1 | constant kappa | V | Y | tyk2 | ESI | T helper 17 cells | IL12RB1 | pharmacokinetic | DMF | ADCC | EOF | T-CELLS | CHARGE | resonance units | constant region | phenylalanine | CCG | antibody-dependent cell-mediated cytotoxicity | dimethylformamide | GAHA | ultraviolet | variable kappa | variable | IL23 receptor | tyrosine kinase 2 | PK | Psoriasis - immunology | Interleukin-23 Subunit p19 - antagonists & inhibitors | Psoriasis - drug therapy | Antibodies, Monoclonal - pharmacology | Humans | Antibodies, Monoclonal - pharmacokinetics | Macaca fascicularis | Antibodies, Neutralizing - pharmacology | Crohn Disease - immunology | Drug Delivery Systems | Antibodies, Neutralizing - immunology | Animals | Crohn Disease - drug therapy | Th17 Cells - immunology | Interleukin-23 Subunit p19 - immunology | Antibodies, Monoclonal - immunology
Journal Article
CURRENT PHARMACEUTICAL DESIGN, ISSN 1381-6128, 2019, Volume 25, Issue 1, pp. 25 - 31
Over the past decades, the advent of anti-TNF agents has dramatically changed the treatment algorithms for IBD. However, primarily and more importantly,... 
IL-12 FAMILY | monoclonal antibody anti-IL23 | Crohn's disease | IL-23 | inflammatory bowel disease | MAINTENANCE THERAPY | Th17 cell pathway cytokines | PATHOGENESIS | SUBCUTANEOUS USTEKINUMAB | REFRACTORY CROHNS-DISEASE | EXPERIMENTAL COLITIS | PHARMACOLOGY & PHARMACY | ulcerative colitis | REAL-WORLD EXPERIENCE | EPIDEMIOLOGY | TH17 CELLS
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 09/2015, Volume 192, Issue 6, pp. 727 - 736
Journal Article
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