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imm-h004 (16) 16
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Neurotoxicology, ISSN 0161-813X, 12/2019, Volume 75, pp. 221 - 232
This study aimed to explore effects and mechanisms of 004 (IMM-H004), a novel coumarin derivative, in OKA (okadaic acid)-induced AD (Alzheimer’s disease)-like... 
Neuroprotection | Okadaic acid | Alzheimer’s disease | Tau protein | IMM-H004
Journal Article
Journal of Chromatography B, ISSN 1570-0232, 02/2018, Volume 1074-1075, pp. 16 - 24
IMM-H004 is a novel neuroprotective agent and its glucuronide metabolite IMM-H004G has similar protective effects against cerebral ischemic injury and . A... 
LC-MS/MS | Glucuronide metabolite | Microdialysis | Pharmacokinetics | IMM-H004 | CHEMISTRY, ANALYTICAL | BIOCHEMICAL RESEARCH METHODS | COUMARIN DERIVATIVE COMPOUND | CEREBRAL-ISCHEMIA | PROTECTS
Journal Article
International Immunopharmacology, ISSN 1567-5769, 05/2019, Volume 70, pp. 69 - 79
Journal Article
Journal of Stroke and Cerebrovascular Diseases, ISSN 1052-3057, 12/2018, Volume 27, Issue 12, pp. 3396 - 3403
IMM-H004 [7-hydroxy-5-methoxy-4-methyl-3-(4-methylpiperazin-1-yl)-coumarin] is a novel derivative of coumarin, which played neuroprotective roles in brain... 
apoptosis | IMM-H004 | coumarin | oxidative stress | hydrogen peroxide | STEM-CELLS | INDUCED APOPTOSIS | NEUROSCIENCES | PROTECTS | GLUTATHIONE | H2O2-INDUCED OXIDATIVE STRESS | ROS | DISEASE | PERIPHERAL VASCULAR DISEASE | IMM H004 | CEREBRAL-ISCHEMIA | Index Medicus
Journal Article
Journal Article
by Zhang, ZQ and Liu, DD and Jiang, JW and Song, XY and Zou, XW and Chu, SF and Xie, KB and Dai, JG and Chen, NH and Sheng, L and Li, Y
FRONTIERS IN PHARMACOLOGY, ISSN 1663-9812, 06/2019, Volume 10, p. 631
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 1/2017, Volume 54, Issue 1, pp. 524 - 540
Journal Article
Journal Article
Journal of Stroke and Cerebrovascular Diseases, ISSN 1052-3057, 10/2017, Volume 26, Issue 10, pp. 2065 - 2073
Journal Article
CNS Neuroscience & Therapeutics, ISSN 1755-5930, 03/2015, Volume 21, Issue 3, pp. 280 - 288
Summary Aims Compound IMM‐H004 (7‐hydroxy‐5‐methoxy‐4‐methyl‐3‐[4‐methylpiperazin‐1‐yl]‐2H‐chromen‐2‐one) is a new synthetic derivative of coumarin, and... 
Neuroprotection | Global cerebral ischemia | Hippocampus | IMM‐H004 | Apoptosis | IMM-H004 | GERBIL HIPPOCAMPUS | NMDA RECEPTOR | FOCAL CEREBRAL-ISCHEMIA | FOREBRAIN ISCHEMIA | NEUROSCIENCES | DELAYED NEURONAL DEATH | STRAND BREAKS | PYRAMIDAL NEURONS | DNA FRAGMENTATION | PHARMACOLOGY & PHARMACY | TEMPORAL PROFILE | SYNAPSIN-II | Disks Large Homolog 4 Protein | Free Radical Scavengers - pharmacology | Neurons - pathology | Antipyrine - pharmacology | Caspase 3 - metabolism | Learning Disorders - physiopathology | Male | Intracellular Signaling Peptides and Proteins - metabolism | CA1 Region, Hippocampal - drug effects | Synapsins - metabolism | Learning Disorders - pathology | CA1 Region, Hippocampal - pathology | Neuroprotective Agents - pharmacology | Antipyrine - analogs & derivatives | Neurons - physiology | Membrane Proteins - metabolism | Cell Death - drug effects | Edaravone | Drug Evaluation, Preclinical | Neurons - drug effects | Disease Models, Animal | Maze Learning - physiology | Spatial Memory - physiology | bcl-2-Associated X Protein - metabolism | Learning Disorders - drug therapy | Brain Ischemia - physiopathology | Random Allocation | Maze Learning - drug effects | Rats, Sprague-Dawley | Coumarins - pharmacology | Animals | Spatial Memory - drug effects | Cell Death - physiology | Brain Ischemia - drug therapy | Brain Ischemia - pathology | CA1 Region, Hippocampal - physiopathology | Nootropic Agents - pharmacology | Antioxidants | Ischemia | Analysis
Journal Article