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Toxicological Sciences, ISSN 1096-6080, 12/2005, Volume 88, Issue 2, pp. 285 - 286
Journal Article
Genes and Development, ISSN 0890-9369, 2000, Volume 14, Issue 23, pp. 3037 - 3050
The retinoblastoma protein, pRB, and the closely related proteins p107 and p130 are important regulators of the mammalian cell cycle. Biochemical and genetic... 
Rb | MEFs | control | Immortalization | Knock-out | G | Research Paper | G1 control | knock-out | immortalization
Journal Article
International Journal of Cancer, ISSN 0020-7136, 2/2017, Volume 140, Issue 4, pp. 877 - 887
TP53 mutations occur in half of all human tumours. Mutagen‐induced or spontaneous TP53 mutagenesis can be studied in vitro using the human TP53 knock‐in... 
mutation | Nutlin‐3a | immortalisation | Hupki | TP53 | Molecular Cancer Biology
Journal Article
Aging, ISSN 1945-4589, 05/2019, Volume 11, Issue 10, pp. 3012 - 3022
Aging is associated with a genome-wide change of DNA methylation (DNAm). "DNAm age" is defined as the predicted chronological age by the age estimator based on... 
DNA methylation | Hypoxia | Epigenetic clock | Immortalization | Epigenetic age
Journal Article
Cancer Research, ISSN 0008-5472, 09/2018, Volume 78, Issue 17, pp. 5107 - 5123
Cell-type origin is one of the factors that determine molecular features of tumors, but resources to validate this concept are scarce because of technical... 
PATHWAYS | TRANSITION | ACTIVATION | CANCER CELLS | TRANSCRIPTOME | ONCOLOGY | MAMMARY STEM-CELLS | IDENTIFICATION | EMT | IMMORTALIZATION | HIERARCHY | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 11/2012, Volume 31, Issue 46, pp. 4815 - 4827
Journal Article
CANCER SCIENCE, ISSN 1349-7006, 01/2018, Volume 109, pp. 643 - 643
Conference Proceeding
EMBO Molecular Medicine, ISSN 1757-4676, 02/2018, Volume 10, Issue 2, pp. 254 - 275
Transferring large or multiple genes into primary human stem/progenitor cells is challenged by restrictions in vector capacity, and this hurdle limits the... 
gene therapy | human artificial chromosomes | DMD | human muscle stem/progenitor cells | immortalisation | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | HUMAN SKELETAL-MUSCLE | LENTIVIRAL VECTORS | PLURIPOTENT STEM-CELLS | MYOGENIC CELLS | MOUSE MODEL | CLINICAL-TRIALS | LENTIVECTOR-MEDIATED TRANSFER | HUMAN TELOMERASE | MYOBLAST TRANSPLANTATION | Animals | Dystrophin - genetics | Chromosomes, Artificial, Human | Humans | Cells, Cultured | Models, Animal | Mice | Muscular Dystrophy, Duchenne - genetics | Mutation | Genetic Vectors | Muscular Dystrophy, Duchenne - therapy | Genetic Therapy - methods | Cell death | Duchenne muscular dystrophy | Genes | Muscles | Genetic aspects | Genetic engineering | Gene therapy | Cell differentiation | Dystrophin | Cell proliferation | Transformation | Telomerase reverse transcriptase | Transplantation | Recombinase | Muscular dystrophy | Ganciclovir | Rodents | Duchenne's muscular dystrophy | Transgenes | Chromosomes | Phenotypes | Translation | MyoD protein | Human artificial chromosomes | Artificial chromosomes | Progenitor cells | Cre recombinase | Skeletal muscle | Myoblasts | Stem cells | Dystrophy | Cell migration | Apoptosis | Index Medicus | Life Sciences | Stem Cells | progenitor cells | Genetics, Gene Therapy & Genetic Disease | Musculoskeletal System | human muscle stem
Journal Article
Transfusion Clinique et Biologique, ISSN 1246-7820, 09/2017, Volume 24, Issue 3, pp. 263 - 267
Population ageing and increase in cancer incidence may lead to a decreased availability of red blood cell units. Thus, finding an alternative source of red... 
Red blood cells | Transfusion | Immortalisation | Transgenesis
Journal Article
Biochimica et biophysica acta. Molecular and cell biology of lipids, 08/2019, pp. 158511 - 158511
Brown adipose tissue (BAT) is a potential target to treat cardiometabolic disorders because of its capacity to combust glucose and fatty acids for... 
Index Medicus
Journal Article
Scientific reports, ISSN 2045-2322, 12/2019, Volume 9, Issue 1, pp. 500 - 500
Robust in vitro lung models are required for risk assessment to measure key events leading to respiratory diseases. Primary normal human bronchial epithelial... 
TRANSFORMATION | AIRWAY | VIRUS | MULTIDISCIPLINARY SCIENCES | LINE | GENERATION | IMMORTALIZATION | EXPRESSION
Journal Article
BMC Cancer, 09/2019, Volume 19, Issue 1, pp. 1 - 16
Abstract Background Glioblastoma (GB) is considered one of the most lethal tumors. Extensive research at the molecular level may enable to gain more profound... 
In vivo model | Senescence | Immortalization | Glioblastoma | Apoptosis
Journal Article
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7498, pp. 91 - 95
Journal Article
GENES & DEVELOPMENT, ISSN 0890-9369, 01/2007, Volume 21, Issue 1, pp. 49 - 54
Genetic studies have demonstrated that Bmi1 promotes cell proliferation and stem cell self-renewal with a correlative decrease of p16(INK4a) expression. Here,... 
TRANSFORMATION | pRB | BMI-1 | transcriptional regulation | SELF-RENEWAL | PROLIFERATION | DEVELOPMENTAL BIOLOGY | BMI1 | CELL-CYCLE CONTROL | CANCER | CELL BIOLOGY | p16 | PRC2 | PRC1 | GENETICS & HEREDITY | SENESCENCE | INHIBITORS | IMMORTALIZATION | EXPRESSION
Journal Article