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1. Full Text Type i IFN induces IL-10 production in an IL-27-Independent manner and blocks responsiveness to IFN-γ for production of IL-12 and bacterial killing in mycobacterium tuberculosis-infected macrophages
by McNab, Finlay W and Ewbank, John and Howes, Ashleigh and Moreira-Teixeira, Lucia and Martirosyan, Anna and Ghilardi, Nico and Saraiva, Margarida and O'Garra, Anne
Journal of Immunology, ISSN 0022-1767, 10/2014, Volume 193, Issue 7, pp. 3600 - 3612
Tuberculosis, caused by the intracellular bacterium Mycobacterium tuberculosis, currently causes similar to 1.4 million deaths per year, and it therefore... 
LISTERIA-MONOCYTOGENES | INTERFERON-GAMMA | DENDRITIC CELLS | IL-1-BETA PRODUCTION | NITRIC-OXIDE SYNTHASE | IMMUNE-RESPONSES | MURINE MACROPHAGES | PERITONEAL-MACROPHAGES | IMMUNOLOGY | HUMAN MONOCYTES | VIRAL-INFECTION | Macrophages - pathology | Interleukin-12 - genetics | Macrophage Activation - immunology | Tumor Necrosis Factor-alpha - genetics | Mycobacterium tuberculosis - immunology | Interleukin-1beta - immunology | Interferon Type I - immunology | Mice, Knockout | Tuberculosis - immunology | Interleukins - genetics | Animals | Tuberculosis - genetics | Interferon-gamma - immunology | Interleukin-10 - genetics | Interleukins - immunology | Interleukin-12 - immunology | Tumor Necrosis Factor-alpha - immunology | Interferon Type I - genetics | Mice | Interferon-gamma - genetics | Interleukin-10 - immunology | Macrophages - immunology | Macrophages - microbiology | Tuberculosis - pathology | Infectious Disease and Host Response
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2. Full Text Human XCR1+ dendritic cells derived in vitro from CD34 + progenitors closely resemble blood dendritic cells, including their adjuvant responsiveness, contrary to monocyte-derived dendritic cells
by Balan, Sreekumar and Ollion, Vincent and Colletti, Nicholas and Chelbi, Rabie and Montanana-Sanchis, Frédéric and Liu, Hong and Manh, Thien-Phong Vu and Sanchez, Cindy and Savoret, Juliette and Perrot, Ivan and Doffin, Anne-Claire and Fossum, Even and Bechlian, Didier and Chabannon, Christian and Bogen, Bjarne and Asselin-Paturel, Carine and Shaw, Michael and Soos, Timothy and Caux, Christophe and Valladeau-Guilemond, Jenny and Dalod, Marc
Journal of Immunology, ISSN 0022-1767, 08/2014, Volume 193, Issue 4, pp. 1622 - 1635
Human monocyte-derived dendritic cell (MoDC) have been used in the clinic with moderately encouraging results. Mouse XCR1(+) DC excel at cross-presentation,... 
KINASE 3 LIGAND | IMMUNE-RESPONSE | STEM-CELLS | HEPATITIS-C VIRUS | INTERFERON-LAMBDA | GENERATION | ANTIGEN CROSS-PRESENTATION | IMMUNOLOGY | EXPRESSION | LANGERHANS CELLS | CUTTING EDGE | Imidazoles - immunology | Cell Line | Green Fluorescent Proteins | Toll-Like Receptor 3 | Adjuvants, Immunologic - pharmacology | Toll-Like Receptor 4 | Dendritic Cells - immunology | Humans | Gene Expression Profiling | Monocytes - immunology | Antigen Presentation - immunology | Lipopolysaccharides - immunology | Blood Cells - immunology | Receptors, G-Protein-Coupled - immunology | Cell Differentiation - immunology | Phenotype | Antigens, CD34 - immunology | Cross-Priming - immunology | Killer Cells, Natural - immunology | T-Lymphocytes - immunology | Poly I-C - immunology | Cell Culture Techniques | Clinical and Human Immunology
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3. Full Text Mycobacterium tuberculosis Decreases Human Macrophage IFN-γ responsiveness through miR-132 and miR-26a
by Ni, Bin and Rajaram, Murugesan V.S and Lafuse, William P and Landes, Michelle B and Schlesinger, Larry S
Journal of Immunology, ISSN 0022-1767, 11/2014, Volume 193, Issue 9, pp. 4537 - 4547
IFN-gamma-activated macrophages play an essential role in controlling intracellular pathogens; however, macrophages also serve as the cellular home for the... 
PHAGOCYTOSIS | ACTIVATION | INTERFERON-GAMMA | IMMUNE-RESPONSES | KINASE | SUSCEPTIBILITY | INFECTION | IMMUNOLOGY | DEPENDENT GENE-TRANSCRIPTION | COMPLEMENT RECEPTORS | INNATE IMMUNITY | Cell Line | Reproducibility of Results | Humans | RNA, Messenger - genetics | Mycobacterium tuberculosis - immunology | Gene Expression Profiling | Receptors, IgG - metabolism | HLA-DR Antigens - genetics | Gene Expression Regulation - drug effects | Tuberculosis - immunology | p300-CBP Transcription Factors - metabolism | Macrophages - metabolism | Receptors, IgG - genetics | RNA Interference | Tuberculosis - genetics | p300-CBP Transcription Factors - genetics | Macrophages - drug effects | HLA-DR Antigens - immunology | MicroRNAs - genetics | 3' Untranslated Regions | Binding Sites | Interferon-gamma - pharmacology | Macrophages - immunology
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4. Full Text The effects of airway microbiome on corticosteroid responsiveness in asthma
by Goleva, Elena and Jackson, Leisa P and Harris, J. Kirk and Robertson, Charles E and Sutherland, E. Rand and Hall, Clifton F and Good Jr, James T and Gelfand, Erwin W and Martin, Richard J and Leung, Donald Y. M
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 11/2013, Volume 188, Issue 10, pp. 1193 - 1201
Rationale: The role of airway microbiome in corticosteroid response in asthma is unknown. Objectives: To examine airway microbiome composition in patients with... 
Corticosteroids | Asthma | Microbiome | COMMENSAL BACTERIA | FIBEROPTIC BRONCHOSCOPY | MACROPHAGES | STEROID-RESISTANT ASTHMA | asthma | LIPOPOLYSACCHARIDES | microbiome | corticosteroids | RESPIRATORY SYSTEM | PROTEIN-KINASE PHOSPHATASE-1 | LIPID-A | DISEASE | RECEPTOR-BETA | GLUCOCORTICOID-INSENSITIVE ASTHMA | CRITICAL CARE MEDICINE | Biomarkers - metabolism | Asthma - microbiology | Drug Administration Schedule | Anti-Asthmatic Agents - therapeutic use | Humans | Middle Aged | RNA, Ribosomal, 16S - analysis | Male | Treatment Outcome | Genetic Markers | Adrenal Cortex Hormones - therapeutic use | Asthma - drug therapy | Sequence Analysis, DNA | Case-Control Studies | Bronchoalveolar Lavage Fluid - microbiology | Microbiota | Drug Resistance - physiology | Adult | DNA, Bacterial - analysis | Female | Macrophages, Alveolar - metabolism | Real-Time Polymerase Chain Reaction | Prednisone - therapeutic use
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5. Full Text TCR signaling intensity controls CD8+ T cell responsiveness to TGF‐β
by Arumugam, Vidhyalakshmi and Bluemn, Theresa and Wesley, Erin and Schmidt, Amanda M and Kambayashi, Taku and Malarkannan, Subramaniam and Riese, Matthew J
Journal of Leukocyte Biology, ISSN 0741-5400, 11/2015, Volume 98, Issue 5, pp. 703 - 712
Enhancing TCR signal strength can attenuate TGFβ‐mediated transcriptional changes and functions in CD8+ T cells, independent of changes to canonical TGFβ... 
diacylglycerol kinase ζ | Smad2 | Diacylglycerol | Diacylglycerol kinase ζ | ACTIVATION | IMMUNE CELLS | METASTASIS | TRANSDUCTION | PROLIFERATION | DIACYLGLYCEROL KINASES | IMMUNOLOGY | CANCER | CELL BIOLOGY | GROWTH-FACTOR-BETA | INHIBITION | PATHWAY | diacylglycerol kinase zeta | HEMATOLOGY | Transforming Growth Factor beta - immunology | CD8-Positive T-Lymphocytes - cytology | Signal Transduction - genetics | Diacylglycerol Kinase - genetics | Mice, Knockout | Diacylglycerol Kinase - immunology | Signal Transduction - immunology | Smad2 Protein - immunology | Animals | Transforming Growth Factor beta - genetics | Smad2 Protein - genetics | Receptors, Antigen, T-Cell - immunology | Mice | Receptors, Antigen, T-Cell - genetics | CD8-Positive T-Lymphocytes - immunology | Spotlight on Leading Edge Research
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6. Full Text IL-10 critically modulates B cell responsiveness in rankl -/- mice
by Marrella, Veronica and Lo Iacono, Nadia and Fontana, Elena and Sobacchi, Cristina and Sic, Heiko and Schena, Francesca and Sereni, Lucia and Castiello, Maria Carmina and Poliani, Pietro Luigi and Vezzoni, Paolo and Cassani, Barbara and Traggiai, Elisabetta and Villa, Anna
Journal of Immunology, ISSN 0022-1767, 05/2015, Volume 194, Issue 9, pp. 4144 - 4153
The immune and the skeletal system are tightly interconnected, and B lymphocytes are uniquely endowed with osteo-interactive properties. In this context,... 
RHEUMATOID-ARTHRITIS | REGULATORY FUNCTION | BONE LOSS | AUTOIMMUNITY | IMMUNE-RESPONSES | MARGINAL ZONE | RECEPTOR ACTIVATOR | GERMINAL CENTER | IMMUNOLOGY | T-CELLS | PLASMA-CELLS | RANK Ligand - immunology | Animals | B-Lymphocytes - immunology | RANK Ligand - deficiency | Mice | Interleukin-10 - immunology | Mice, Knockout
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7. Full Text Indicators of responsiveness to immune checkpoint inhibitors
by Shields, Bradley D and Mahmoud, Fade and Taylor, Erin M and Byrum, Stephanie D and Sengupta, Deepanwita and Koss, Brian and Baldini, Giulia and Ransom, Seth and Cline, Kyle and Mackintosh, Samuel G and Edmondson, Ricky D and Shalin, Sara and Tackett, Alan J
Scientific Reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, pp. 807 - 12
Modulation of the immune system can produce anti-tumor responses in various cancer types, including melanoma. Recently, immune checkpoint inhibitors (ICI), in... 
RESPONSES | TO-MESENCHYMAL TRANSITION | MELANOMA | THERAPY | MULTIDISCIPLINARY SCIENCES | PHENOTYPE | PROGNOSTIC-SIGNIFICANCE | ANTI-PD-1 | BLOCKADE | CANCER | EXPRESSION | Immune response | Mesenchyme | PD-1 protein | Melanoma | Lymphocytes T | Metastasis | Patients | E-cadherin | Metastases | Disease resistance | CTLA-4 protein | Immune checkpoint | Lysine | Monoclonal antibodies | Epigenetics | Methylation | Histone H3 | Tumors | Cancer
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8. Full Text Airway Responsiveness in Mild to Moderate Childhood Asthma: Sex Influences on the Natural History
by Tantisira, Kelan G and Colvin, Ryan and Tonascia, James and Strunk, Robert C and Weiss, Scott T and Fuhlbrigge, Anne L and Childhood Asthma Management Program Research Group and Childhood Asthma Management Progra and Childhood Asthma Management Program Research Group
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 08/2008, Volume 178, Issue 4, pp. 325 - 331
Rationale: Airway responsiveness is a prognostic marker for asthma symptoms in later life. Objectives: To evaluate characteristics responsible for persistence... 
Bronchoconstriction | FEV | Methacholine | YOUNG-ADULTS | MANAGEMENT PROGRAM | RISK-FACTORS | BRONCHIAL RESPONSIVENESS | SERUM IGE | LUNG-FUNCTION | PULMONARY-FUNCTION | bronchoconstriction | PC20 | RESPIRATORY SYSTEM | INHALED HISTAMINE | FEV1 | RESPIRATORY SYMPTOMS | methacholine | VITAL CAPACITY | CRITICAL CARE MEDICINE | Prognosis | Prospective Studies | Age Factors | Bronchodilator Agents - administration & dosage | Follow-Up Studies | Forced Expiratory Volume - drug effects | Humans | Bronchial Provocation Tests | Child, Preschool | Male | Puberty - physiology | Vital Capacity - drug effects | Bronchial Hyperreactivity - physiopathology | Female | Child | Methacholine Chloride | Asthma - epidemiology | Bronchoconstriction - physiology | Asthma - physiopathology | Double-Blind Method | Forced Expiratory Volume - physiology | Nedocromil - administration & dosage | Disease Progression | Sex Ratio | Vital Capacity - physiology | Adolescent | Least-Squares Analysis | Bronchial Hyperreactivity - epidemiology | Anti-Asthmatic Agents - administration & dosage | Budesonide - administration & dosage | Cohort Studies | A. Asthma and Allergy
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9. Full Text Improving responsiveness of health systems to non-communicable diseases
by Atun, Rifat, Prof and Jaffar, Shabbar, Prof and Nishtar, Sania, FRCP and Knaul, Felicia M, PhD and Barreto, Mauricio L, Prof and Nyirenda, Moffat, Prof and Banatvala, Nicholas, FFPH and Piot, Peter, Prof
Lancet, The, ISSN 0140-6736, 2013, Volume 381, Issue 9867, pp. 690 - 697
  NCDs consist of a vast group of conditions, but in terms of premature mortality, emphasis has been on cardiovascular disease, cancer, diabetes, and chronic... 
Internal Medicine | GLOBAL BURDEN | MEDICINE, GENERAL & INTERNAL | INTERVENTIONS | PRIMARY-CARE | SCALE-UP | FUND-SUPPORTED PROGRAMS | HIV | LOW-INCOME | CERVICAL-CANCER | CASE-MANAGEMENT | MULTIMORBIDITY | HIV Infections - prevention & control | Primary Prevention | Universal Coverage | Delivery of Health Care - organization & administration | Humans | Chronic Disease - economics | Health Priorities | Health Services Needs and Demand | Health Services Accessibility | Pharmaceutical Preparations - supply & distribution | Tuberculosis - prevention & control | Chronic Disease - therapy | Health Planning | Low income groups | Reproductive health | Cardiovascular disease | Information management | Patients | Developing countries--LDCs | Disease prevention | Gross Domestic Product--GDP | Hospitals | Tuberculosis | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Respiratory diseases | Society | Diabetes | Human resources | Community | Cancer | Chronic illnesses
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10. Full Text Gene-expression profiling to predict responsiveness to immunotherapy
by Jamieson, N.B and Maker, A.V
Cancer Gene Therapy, ISSN 0929-1903, 03/2017, Volume 24, Issue 3, pp. 134 - 140
Recent clinical successes with immunotherapy have resulted in expanding indications for cancer therapy. To enhance antitumor immune responses, and to better... 
MEDICINE, RESEARCH & EXPERIMENTAL | MUTATIONAL PROCESSES | CTLA-4 BLOCKADE | PD-1 BLOCKADE | PANCREATIC-CANCER | PHASE-III | CELL LUNG-CANCER | METASTATIC MELANOMA | THERAPY | ONCOLOGY | IMMUNE CHECKPOINT BLOCKADE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | IPILIMUMAB | Recurrence | Immunotherapy - methods | Prognosis | Antigens, Neoplasm - immunology | Humans | Gene Expression Regulation, Neoplastic | Transcriptome | Treatment Outcome | Combined Modality Therapy | Gene Expression Profiling | Genetic Markers | Molecular Targeted Therapy | Biomarkers, Tumor | Drug Resistance, Neoplasm - genetics | Neoplasms - therapy | Animals | Neoplasms - genetics | Neoplasms - immunology | DNA Damage | Mutation | Genomics - methods | Neoplasms - pathology | Immune response | Immunotherapy | Patient outcomes | Genetic aspects | Gene expression | Health aspects | Methods
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11. Full Text The role of DNA (de)methylation in immune responsiveness of Arabidopsis
by López Sánchez, Ana and Stassen, Joost H.M and Furci, Leonardo and Smith, Lisa M and Ton, Jurriaan
The Plant Journal, ISSN 0960-7412, 11/2016, Volume 88, Issue 3, pp. 361 - 374
Summary DNA methylation is antagonistically controlled by DNA methyltransferases and DNA demethylases. The level of DNA methylation controls plant gene... 
Arabidopsis thaliana | systemic acquired resistance | defence priming | Hyaloperonospora arabidopsidis | E‐MTAB‐3963 | transgenerational acquired resistance | DNA methylation | basal resistance | E-MTAB-3963 | ACID | RNA-POLYMERASE V | TRANSPOSABLE ELEMENTS | HISTONE ACETYLTRANSFERASE | PLANT SCIENCES | GETTING READY | INDUCED RESISTANCE | CALLOSE DEPOSITION | DEMETHYLATION | METHYLATION PATTERNS | PLANTS | Arabidopsis Proteins - genetics | Plant Immunity - genetics | Gene Expression Regulation, Plant - immunology | Plant Diseases - immunology | Arabidopsis - immunology | Gene Expression Regulation, Plant - genetics | DNA Methylation - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis Proteins - metabolism | Plant Diseases - genetics | Plant Immunity - immunology | DNA Methylation - physiology | Drug resistance in microorganisms | Transposons | DNA microarrays | Immune response | Methyltransferases | Analysis | Plant genetics | Genetic research | Methylation | Gene expression | Pathogens | Deoxyribonucleic acid--DNA | Botany | Original
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