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Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 05/2017, Volume 18, Issue 5, pp. 285 - 298
Journal Article
Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 5/2018, Volume 200, Issue 9, pp. 3231 - 3243
Natural killer (NK) cells are cytotoxic lymphocytes important in defense against viral infection and cancer. NK cells mediate cytotoxicity predominantly... 
Cytotoxicity | Immunological synapse | LAMP1 | Lytic granules | Live cell imaging
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 06/2012, Volume 197, Issue 6, pp. 775 - 787
Activation of T cells by antigen-presenting cells involves assembly of signaling molecules into dynamic microclusters (MCs) within a specialized membrane... 
MICROCLUSTERS | COMPLEX | MYOSIN IIA | IMMUNE SYNAPSE | REORGANIZATION | COSTIMULATION | IMMUNOLOGICAL SYNAPSE FORMATION | ALDRICH-SYNDROME PROTEIN | ANTIGEN RECEPTOR | LYMPHOCYTES | CELL BIOLOGY
Journal Article
Cancer immunology research, ISSN 1478-6354, 11/2014, Volume 2, Issue 11, pp. 1023 - 1033
T-cell activation requires interaction of T-cell antigen receptors with proteins of the major histocompatibility complex (antigen). This interaction takes... 
immunological synapse | inhibition | signaling | adhesion | RHEUMATOLOGY | activation | Animals | Neoplasms - immunology | Humans | Immunotherapy | Immunological Synapses - immunology | Tumor Escape - immunology
Journal Article
Current protocols in immunology, 06/2019, Volume 125, Issue 1, p. e72
This unit describes methods for quantifying phagocytosis and imaging the immunological synapse between T cells and antigen-presenting cells (APCs), with both... 
Journal Article
TRENDS IN IMMUNOLOGY, ISSN 1471-4906, 08/2018, Volume 39, Issue 8, pp. 596 - 609
T lymphocytes use alpha beta T cell receptors (TCRs) to recognize sparse antigenic peptides bound to MHC molecules(pMHCs) arrayed on antigen-presenting cells... 
ADHESION | TCR | ACTIVATION | COMPLEX | SINGLE-MOLECULE | MHC | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | CATCH BONDS | PEPTIDE | ANTIGEN
Journal Article
SEMINARS IN ONCOLOGY, ISSN 0093-7754, 08/2015, Volume 42, Issue 4, pp. 640 - 655
T and natural killer (NK) lymphocytes are considered the main effector players in the immune response against tumors. Full activation of T and NK lymphocytes... 
IMMUNOSTIMULATORY MONOCLONAL-ANTIBODIES | GROWTH-FACTOR RECEPTOR | TUMOR-NECROSIS-FACTOR | ONCOLOGY | IN-VIVO | REGULATORY T-CELLS | SINGLE-CHAIN FV | ANTITUMOR IMMUNITY | TARGETING 4-1BB COSTIMULATION | IMMUNOLOGICAL SYNAPSE | VIRAL-INFECTION
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 05/2014, Volume 15, Issue 5, pp. 465 - 465
Regulatory T (T-reg) cells, which maintain immune homeostasis and self-tolerance, form an immunological synapse (IS) with antigen-presenting cells (APCs).... 
LOCALIZATION | IN-VITRO | ACTIVATION | DENDRITIC CELLS | COLITIS | TCR STOP-SIGNAL | IMMUNOLOGY | IMMUNOLOGICAL SYNAPSE | FOXP3 | CTLA-4 FUNCTION | ANTIGEN
Journal Article
NATURE IMMUNOLOGY, ISSN 1529-2908, 05/2018, Volume 19, Issue 5, pp. 487 - 487
T cell antigen recognition requires T cell antigen receptors (TCRs) engaging MHC-embedded antigenic peptides (pMHCs) within the contact region of a T cell with... 
ACTIVATION | FLUORESCENCE | STOICHIOMETRY | SINGLE-MOLECULE MICROSCOPY | RECEPTOR-CD3 COMPLEX | IMMUNOLOGY | LIGAND-SPECIFIC OLIGOMERIZATION | IMMUNOLOGICAL SYNAPSE | PLASMA-MEMBRANE | PEPTIDE | REVEALS
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2018, Volume 9
Endocytosis of surface receptors and their polarized recycling back to the plasma membrane are central to many cellular processes, such as cell migration,... 
INTERNALIZATION | CARGO | REGGIE-1/FLOTILLIN-2 | MULTIDISCIPLINARY SCIENCES | DYNAMICS | TRAFFICKING | FLOTILLIN-1 | IMMUNOLOGICAL SYNAPSE | PROTEINS | OLIGOMERIZATION | PLASMA-MEMBRANE
Journal Article