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Journal Article
AMERICAN JOURNAL OF HUMAN GENETICS, ISSN 0002-9297, 12/2010, Volume 87, Issue 6, pp. 866 - 872
We performed homozygosity mapping in two recently reported pedigrees from Portugal and Mexico with an autosomal-recessive auto-inflammatory syndrome... 
COMPLEX | HYPER-GAMMA-GLOBULINEMIA | IMMUNOPROTEASOME | DNA | GENETICS & HEREDITY | MICE | INFECTION | LMP7 | MUSCULAR-ATROPHY | CLEAVAGE
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2019, Volume 182, p. 111646
The immunoproteasome, a specialized form of proteasome, is mainly expressed in lymphocytes and monocytes of jawed vertebrates and responsible for the... 
Immunoproteasome inhibitors | KZR-616 | Hematologic malignancies | Autoimmune diseases | Selective
Journal Article
Molecular Immunology, ISSN 0161-5890, 09/2019, Volume 113, pp. 22 - 30
The 20S immunoproteasome (IP) is an interferon(IFN)-γ − and tumor necrosis factor (TNF) −inducible variant of the 20S constitutive proteasome (CP) in which all... 
LMP2 | FAT10 | 20S proteasome | LMP7 | Immunoproteasome | PA28αβ
Journal Article
International Immunology, ISSN 0953-8178, 01/2003, Volume 15, Issue 12, pp. 1415 - 1421
Treatment of melanoma cell lines with IFN-[gamma] induces the switch from proteasome (PS) to immunoproteasome (iPS). This finding has profound implications for... 
immunoproteasomes
Journal Article
Journal of neuroinflammation, ISSN 1742-2094, 2016, Volume 13, Issue 1, p. 202
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 12/2019, Volume 137, pp. 34 - 45
Hypertensive cardiac remodeling is a major cause of heart failure. The immunoproteasome is an inducible form of the proteasome and its catalytic subunit β5i... 
PTEN | β5i | Cardiac remodeling | DOCA-salt | Immunoproteasome catalytic subunit
Journal Article
Hypertension, ISSN 0194-911X, 01/2019, Volume 73, Issue 1, pp. 92 - 101
Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and increases the risk of stroke, heart failure, and death. Ang II (angiotensin II)... 
AT1R associated protein | atrial fibrillation | immunoproteasome | catalytic subunit β5 | mice | angiotensin II
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 02/2019, Volume 62, Issue 3, pp. 1626 - 1642
Subunit-selective proteasome inhibitors are valuable tools to assess the biological and medicinal relevance of individual proteasome active sites. Whereas the... 
YEAST | CHEMISTRY, MEDICINAL | MECHANISM | CRYSTAL-STRUCTURE | IMMUNOPROTEASOME | SUBSTRATE | KNOWLEDGE | SITES | GENERATION | BORTEZOMIB | 20S PROTEASOMES
Journal Article
Brain Behavior and Immunity, ISSN 0889-1591, 08/2019, Volume 80, pp. 35 - 43
Proteolysis as mediated by one of the major cellular protein degradation pathways, the ubiquitin–proteasome system (UPS), plays an essential role in learning... 
Fear learning | β5i/LMP7 | Anxiety | Mouse model | Behavior | Immunoproteasome | Stress
Journal Article
Acta Neuropathologica Communications, ISSN 2051-5960, 12/2017, Volume 5, Issue 1, pp. 1 - 16
Abstract The immunoproteasome (iP) represents a specialized type of proteasomes, which plays an important role in the clearance of oxidant-damaged proteins... 
Inflammation | Alzheimer’s disease | Immunoproteasome | Proteasome | Microglia
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 08/2016, Volume 59, Issue 15, pp. 7177 - 7187
This work reports the development of highly potent and selective inhibitors of the beta 5c catalytic activity of human constitutive proteasomes. The work... 
20S PROTEASOME | MULTIPLE-MYELOMA | CELLS | CARFILZOMIB | CHEMISTRY, MEDICINAL | AMINO-ACIDS | IMMUNOPROTEASOME | SUBSTRATE | RESISTANCE | PROTEOLYSIS | BORTEZOMIB
Journal Article
JOURNAL OF VIROLOGY, ISSN 0022-538X, 08/2019, Volume 93, Issue 15
Acute respiratory infection with mouse adenovirus type 1 (MAV-1) induces activity of the immunoproteasome, an inducible form of the proteasome that shapes CD8... 
IMMUNITY | immunoproteasome | interferon gamma | VIRUS | neonatal immunology | respiratory viruses | RESPIRATORY-INFECTION | VIROLOGY | INTERFERON-GAMMA | adenovirus | THERAPEUTIC TARGET | PURIFICATION | T-CELLS
Journal Article