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Immunological Reviews, ISSN 0105-2896, 03/2016, Volume 270, Issue 1, pp. 152 - 164
Summary Recombinant immunotoxins (RITs) are chimeric proteins designed to treat cancer. They are made up of an Fv or Fab that targets an antigen on a cancer... 
neutralizing antibodies | mesothelioma | immunotherapy | anti‐drug antibodies | mesothelin | Mesothelin | Mesothelioma | Anti-drug antibodies | Neutralizing antibodies | Immunotherapy | anti-drug antibodies | ADVANCED SOLID TUMORS | IMMUNOLOGY | EXOTOXIN-A MUTANTS | SURFACE-EXPOSED RESIDUES | B-CELL | PHASE-I TRIAL | REDUCED IMMUNOGENICITY | SITE-SPECIFIC MANNER | T-CELL EPITOPE | PSEUDOMONAS EXOTOXIN | HEMATOLOGIC MALIGNANCIES | Epitope Mapping | Sequence Deletion | Virulence Factors - genetics | Humans | Immunosuppressive Agents - therapeutic use | Immunotoxins - adverse effects | Epitopes, B-Lymphocyte - immunology | Virulence Factors - immunology | Recombinant Fusion Proteins | Antibodies, Neutralizing - immunology | Neoplasms - therapy | Immunotoxins - administration & dosage | Immunoglobulin Fragments - therapeutic use | Bacterial Toxins - genetics | Immunotoxins - chemistry | Epitopes, T-Lymphocyte - immunology | Drug Therapy, Combination | Immunosuppressive Agents - administration & dosage | ADP Ribose Transferases - chemistry | ADP Ribose Transferases - immunology | Drug Administration Routes | Immunotoxins - immunology | Antibodies, Monoclonal, Humanized - therapeutic use | Exotoxins - chemistry | Polyethylene Glycols | Bacterial Toxins - immunology | Exotoxins - immunology | Clinical Trials as Topic | Virulence Factors - chemistry | Bacterial Toxins - chemistry | ADP Ribose Transferases - genetics | Immunotoxins - genetics | Animals | Genetic Engineering | Immunoglobulin Fragments - immunology | Immunotoxins - therapeutic use | Neoplasms - immunology | Exotoxins - genetics | Antibody Formation | Antigens - immunology | Mice | Antibodies, Monoclonal, Humanized - immunology | Biological products | Antibody-toxin conjugates | Health aspects | Index Medicus
Journal Article
The FEBS Journal, ISSN 1742-464X, 12/2011, Volume 278, Issue 23, pp. 4683 - 4700
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 29, pp. 11782 - 11787
Journal Article
1994, 2nd ed., Target organ toxicology series., ISBN 0781702194, xxi, 761
Book
2002, 1, Cellular and molecular mechanisms of toxin action, ISBN 6610102252, Volume 4, 288
Bacteria and plants produce powerful toxins that can cause a variety of diseases, some of which are lethal for many animal species. The mechanisms of action... 
Immunotoxins | Antitoxins | Toxins | Chimeric Proteins | Therapeutic use | pharmacology | Toxicology | Pharmacology | Cell Biology | Toxins-Therapeutic use
eBook
Journal of Clinical Oncology, ISSN 0732-183X, 04/2010, Volume 28, Issue 12, pp. 2085 - 2093
Journal Article
Journal Article
Immunopharmacology and immunotoxicology, ISSN 0892-3973, 1987
Journal
Applied Microbiology and Biotechnology, ISSN 0175-7598, 4/2017, Volume 101, Issue 7, pp. 2747 - 2766
D2C7-(scdsFv)-PE38KDEL (D2C7-IT) is a novel recombinant Pseudomonas exotoxin A-based immunotoxin (IT), targeting both wild-type epidermal growth factor... 
Life Sciences | Biotechnology | Malignant glioma | Microbiology | Recombinant immunotoxin | Microbial Genetics and Genomics | Mutant EGFR variant III | Good laboratory practice | Epidermal growth factor receptor | GROWTH-FACTOR-RECEPTOR | PROGNOSTIC VALUE | CANCER | HUMAN-BRAIN-TUMORS | HAIRY-CELL LEUKEMIA | AMPLIFICATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PSEUDOMONAS EXOTOXIN | EXPRESSION | STABILIZED FV-IMMUNOTOXINS | EGF RECEPTOR | Receptor, Epidermal Growth Factor - genetics | Virulence Factors - genetics | Drug Stability | Electrophoresis, Polyacrylamide Gel | Humans | Fermentation | ADP Ribose Transferases - genetics | Immunotoxins - genetics | Receptor, Epidermal Growth Factor - metabolism | Immunotoxins - therapeutic use | Escherichia coli - genetics | Exotoxins - genetics | Immunotoxins - metabolism | Cell Line, Tumor | Adult | Bacterial Toxins - genetics | Immunotoxins - chemistry | Glioblastoma - drug therapy | Clinical Trials, Phase I as Topic | Clinical Trials, Phase II as Topic | Quality Control | Clinical trials | Product development | Medical centers | Brain tumors | Quality control | Studies | Epidermal growth factor | Brain cancer | Analysis | Protein expression | Toxins | Genetic recombination | Index Medicus | recombinant immunotoxin | good laboratory practice | malignant glioma | epidermal growth factor receptor | mutant EGFR variant III
Journal Article
The Journal of Immunology, ISSN 0022-1767, 10/2007, Volume 179, Issue 7, pp. 4919 - 4928
Journal Article