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Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2012, Volume 55, Issue 17, pp. 7759 - 7771
Cryptosporidium parvum and related species are zoonotic intracellular parasites of the intestine. Cryptosporidium is a leading cause of diarrhea in small... 
CHEMISTRY, MEDICINAL | PROTEIN | NITRILES | IMP DEHYDROGENASE | HOMINIS | IDENTIFICATION | APICOMPLEXAN | DISCOVERY | GENOME | CHILDREN | IMP Dehydrogenase - metabolism | Cryptosporidium parvum - enzymology | IMP Dehydrogenase - antagonists & inhibitors | Humans | Enzyme Inhibitors - pharmacology | Structure-Activity Relationship | Urea - pharmacology
Journal Article
Biochemistry, ISSN 0006-2960, 09/2016, Volume 55, Issue 37, pp. 5279 - 5288
Inosine-5′-monophosphate dehydrogenase (IMPDH) catalyzes the conversion of inosine 5′-monophosphate (IMP) to xanthosine 5′-monophosphate (XMP). The enzyme is... 
EXPLORER | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACID DEHALOGENASE | ALGORITHM | INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE | IMP DEHYDROGENASE | DYNAFIT | PROGRAM | Models, Molecular | Kinetics | IMP Dehydrogenase - antagonists & inhibitors | Bacillus anthracis - enzymology | X-ray crystallography | Bacillus anthracis | Usage | Enzyme inhibitors | Research
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 07/2017, Volume 114, Issue 29, pp. E5986 - E5994
Journal Article
Biochemistry, ISSN 0006-2960, 08/2012, Volume 51, Issue 31, pp. 6148 - 6163
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2016, Volume 60, Issue 11, pp. 6679 - 6691
T-705 (favipiravir) is a new antiviral agent in advanced clinical development for influenza therapy. It is supposed to act as an alternative substrate for the... 
NUCLEOTIDE POOL | IN-VITRO | NEURAMINIDASE INHIBITORS | MECHANISM | TRANSCRIPTION | BIOLOGICAL EVALUATION | POLYMERASE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTION | ANTIVIRAL AGENT | LETHAL MUTAGENESIS | DNA-Directed RNA Polymerases - antagonists & inhibitors | Influenza A Virus, H3N2 Subtype - drug effects | Humans | Influenza A Virus, H3N2 Subtype - metabolism | Reassortant Viruses - genetics | Reassortant Viruses - drug effects | Structure-Activity Relationship | Influenza A Virus, H3N2 Subtype - genetics | IMP Dehydrogenase - genetics | Influenza A Virus, H1N1 Subtype - growth & development | Viral Proteins - metabolism | Influenza A Virus, H3N2 Subtype - growth & development | RNA, Viral - antagonists & inhibitors | Antiviral Agents - chemistry | Madin Darby Canine Kidney Cells | Influenza A Virus, H1N1 Subtype - genetics | Influenza A Virus, H1N1 Subtype - metabolism | Amides - pharmacology | A549 Cells | Virus Replication - drug effects | Antiviral Agents - pharmacology | Reassortant Viruses - metabolism | RNA, Viral - biosynthesis | Viral Proteins - genetics | Viral Proteins - antagonists & inhibitors | DNA-Directed RNA Polymerases - genetics | Ribavirin - chemistry | Influenza A Virus, H1N1 Subtype - drug effects | Chick Embryo | Reassortant Viruses - growth & development | IMP Dehydrogenase - metabolism | Pyrazines - chemistry | Animals | Mutation - drug effects | Sequence Analysis, RNA | IMP Dehydrogenase - antagonists & inhibitors | Gene Expression Regulation, Viral | Dogs | Amides - chemistry | DNA-Directed RNA Polymerases - metabolism | Pyrazines - pharmacology | Ribavirin - pharmacology
Journal Article